medRxiv preprint doi: https://doi.org/10.1101/2021.08.20.21262371; this version posted August 23, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. Dynamics of gut microbiome – mediated bile acid metabolism in progression to islet autoimmunity Santosh Lamichhane1,10, Partho Sen1,2,10, Alex M. Dickens1,3, Marina Amaral Alves1,4, Taina Härkönen5, Jarno Honkanen5, Tommi Vatanen6,7, Ramnik J. Xavier7, Tuulia Hyötyläinen8, Mikael Knip5,9,*, Matej Orešič1,2,* 1Turku Bioscience Centre, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland 2School of Medical Sciences, Örebro University, 702 81 Örebro, Sweden 3Department of Chemistry, University of Turku, 20520 Turku, Finland 4Walter Mors Institute of Research on Natural Products, Federal University of Rio de Janeiro, 21941-599 Rio de Janeiro, Brazil 5Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Finland 6The Liggins Institute, University of Auckland, Auckland, New Zealand 7The Broad Institute of MIT and Harvard, Cambridge, MA, USA 8School of Science and Technology, Örebro University, Örebro, Sweden 9Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland 10Equal contribution *Correspondence: Professor Mikael Knip, M.D., Ph.D., Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland. Email:
[email protected] Professor Matej Orešič, Ph.D., Turku Bioscience Centre, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland.