Productive Nanosystems: Launching the Technology Roadmap Don’t miss this once-in-a-lifetime event!

Don’t miss this once-in-a-lifetime event! Productive Nanosystems: Launching the Technology Roadmap

October 9–10, 2007 DoubleTree Hotel Crystal City–National Airport Arlington, Virginia USA

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Images courtesy of Nanorex Productive Nanosystems: Launching the Technology Roadmap October 9–10, 2007 DoubleTree Hotel Crystal City–National Airport Arlington, Virginia USA

For 20 years, researchers have explored the amazing promise of SPECIAL FEATURE: atomically-precise manufacturing. Now, for the first time, the Technology Roadmap for Productive Nanosystems will show the way Feynman Prize Luncheon forward, and the payoffs along the road, to this ultimate The Feynman Prizes are given for advances in in two technological revolution. categories: experimental and theoretical. Established in 1993, the Over the last two years, under Battelle’s leadership, and hosted by Feynman Prizes in nanotechnology are awarded to researchers four U.S. National Laboratories, researchers from academia, whose recent work has most advanced the achievement of government, and industry have met to chart paths toward advanced, Feynman’s goal for nanotechnology: the construction of atomically- atomically-precise manufacturing. The resulting roadmap reveals precise products through the use of systems. The crucial challenges and unexpected opportunities in the next steps forward. Join us for two intensive days with leading experts as we 2007 winners will be announced and prizes will be presented during explore the power of advanced “bottom-up” . the luncheon. Program Committee Why You Need to Be There Co-Chairs This unique event will address your questions, show how to fulfill • Jim Von Ehr, Founder, Zyvex Group the enormous promise of nanotechnology, and explore a wide range • Alex Kawczak, Vice President, Nanostructured Materials and of applications: BioProducts, Battelle • Super-efficient energy collection and storage • Medical devices to detect and treat diseases at their earliest stages • Next-generation computation Members • Advanced sensors • K. Eric Drexler, Chief Technical Advisor, Nanorex • High-performance aerospace materials • Keith Firman, School of Biological Sciences, University of • Intelligent materials and devices Portsmouth, UNITED KINGDOM • Many other technologies • Khiang Wee Lim, Executive Director, Institute of Materials Research and Engineering (IMRE), SINGAPORE Who Should Attend? • Manish Mehta, Director, Collaborative Programs, National Center for Manufacturing Sciences Anyone interested in unlocking the potential of productive • , Vice President, Foresight Nanotech Institute nanosystems should attend, including: • John Randall, Vice President, Zyvex Labs • Research and development • Christian Schafmeister, Department of Chemistry, Temple University • Design and engineering • Tihamer Toth-Fejel, Research Engineer, General Dynamics • Manufacturing management • Strategic planning • Public policy makers Endorsed by: • Technology transfer specialists • New product and business development • Economic development • Educators • Media

The full spectrum of organizations involved in nanotechnology will be represented at this event including corporations, research institutions, investors, economic development organizations, public policy groups, educators, and government agencies. Media Sponsors: Bonus: The Roadmap on CD Following the event, SME will provide participants with access to presentations and technical papers from the event through a private website. In conjunction with Foresight Nanotech Institute and Battelle, participants at the event will receive a CD-ROM containing the Technology Roadmap for Productive Nanosystems. Corporate Sponsors: Acknowledgements The organizers of the Technology Roadmap for Productive Nanosystems would like to thank the Roadmap Partners: Biotechnology Industry Organization, Electric Power Research Institute, Organized by: NanoBusiness Alliance, Nano Science and Technology Institute, SEMI, and the Society of Manufacturing Engineers. Special thanks also goes to The Waitt Family Foundation and Sun Microsystems for financial support of the project. Conference Agenda

Tuesday, October 9 10:00 AM – 10:30 AM 12:00 PM – 12:30 PM Atomic Precision Patterned Atomic KEYNOTE: Mapping Roads to Layer Epitaxy: A Path to Advanced Nanotechnologies 7:45 AM – 8:45 AM The Roadmap project has surveyed Check-in and Registration Atomically-Precise Manufacturing and Productive Nanosystems capabilities and prospects for the design and fabrication of atomically- 8:45 AM – 9:00 AM A precursor to productive nanosystems is an precise functional Welcome and Opening atomically-precise manufacturing (APM) nanosystems. Progress can Remarks process including be quantified by Jim Von Ehr, Founder, Zyvex atomically-precise performance metrics and Group depassivation lithography using a scanning tunneling charted in terms of microscope (STM) and successive generations of atomic layer epitaxy (ALE) enabling technologies. in a crystalline material Increasing complexity will demand an system. This presentation increasing focus on system-level design and development. 9:00 AM – 9:30 AM will describe efforts to develop atomic K. Eric Drexler, Chief Technical Advisor, Toward Productive precision patterned ALE of Si, early commercial applications of this technology, Nanorex Nanosystems: Launching the approaches to dramatically improve the Technology Roadmap throughput of the process, and plans to 12:30 PM – 2:00 PM Productive molecular machine systems can extend atomic precision patterned ALE to Feynman Prize Luncheon enable economical, large-scale fabrication of include other semiconductors, insulators, products built with atomic precision. and metals. 2:00 PM – 2:30 PM However, a daunting John Randall, Vice President, Zyvex Labs Engineering Atomically-Precise implementation gap Devices to Transform Molecular separates the 10:30 AM – 11:00 AM Structures nanostructures of today Break Computational design methods for proteins from the complex with novel ligand-binding sites and enzyme productive nanosystems 11:00 AM – 11:30 AM activities have been needed. How can this gap Biological Molecular Motors for developed and be narrowed and eventually Bionanotechnology experimentally validated. closed? The development of tools to build A few well-known molecular motors will be Starting with a protein of these systems will require several described, their potential known structure, the set of intermediate stages, each building on the uses within nano devices mutations necessary to alter results of the previous stage, and each will be illustrated, and work or introduce ligand-binding having its own commercial applications. with an unusual molecular or enzyme activity in that Alex Kawczak, Vice President, motor that provides a link structure are predicted. These designs can Nanostructured Materials and BioProducts, between the biological be produced by oligonucleotide-directed Battelle world and the silicon mutagenesis and heterologous protein world—acting as a expression. Biosensors for a wide variety of 9:30 AM – 10:00 AM molecular dynamo—will be presented. ligands, including TNT, nerve agent The Building Blocks of Molecular Potential application in areas as diverse as surrogates, and metabolites have been Nanotechnology biosensing, drug delivery, responsive constructed. A new technology for constructing large materials, and single molecule drug Homme Hellinga, Department of molecules with designed three-dimensional screening will be discussed. Biochemistry, Duke University shapes and designed function has been Keith Firman, School of Biological Sciences, developed. The molecular University of Portsmouth, UNITED KINGDOM 2:30 PM – 3:00 PM building block methodology New Synthetic Strategies to Build (syntheses of rigid 11:30 AM – 12:00 PM Protein Based Nanomaterials molecular building blocks Atomistic Modeling of NanoScale The small size of new device components coupled through pairs of Systems make it difficult to position them into bonds), the automated Molecular dynamics simulations of protein functional assemblies using synthesis of structures for several microseconds of existing patterning macromolecules, the simulated time can be performed in matters techniques. As one solution, computer-aided design methodology, and of weeks on next the protein shells of two some developing applications will be generation massively viruses have been converted presented. An outline of how this parallel computers. into scaffolds that can technology could lead to the development Inorganic clusters, such as position nanoscale objects of sophisticated those used in supported with excellent spatial will be discussed. metal catalysts, will be resolution. This has been used to synthesize Christian Schafmeister, Department of supported by prediction of arrays of fluorescent molecules as well as Chemistry, Temple University the geometrical using core/shell materials for applications in arrangement of the atoms or the optical diagnostic imaging. These and other absorption probability. Recent results in applications of the new materials will be both areas obtained using large scale presented. parallelism, and limitations which still exist Matthew B. Francis, Department of For complete description in the ability to predict atomic scale Chemistry, University of California, Berkeley of all presentations, visit properties, will be discussed. www.sme.org/nanosystems. James W. Davenport, Director, Computational Science Center, Brookhaven National Laboratory 3:00 PM – 3:30 PM Wednesday, October 10 9:30 AM – 10:00 AM DNA Nanotube-Enabled Alignment Atomic-Scale Device of Membrane Proteins for NMR Fabrication in Silicon 7:45 AM – 8:00 AM A complete fabrication strategy towards Structure Determination Coffee and refreshments The construction of atomically-precise, atomic-scale device fabrication in silicon using phosphorus as a dopant in combination with micron-length nanostructures that enable 8:00 AM – 8:30 AM scanning probe lithography structure determination of Nanophase Materials: A membrane proteins, which and high purity crystal represent the majority of Persistent Enabler growth will be demonstrated. drug targets, will be Nanophase materials have been credited with This process has been used to presented. Detergent- enabling functional property control for both fabricate conducting resistant liquid crystals of 0.8- natural and synthetic nanoscale wires with widths µm-long DNA nanotubes that structures. The advent of down to ~8 nm, tunnel enable weak alignment of nanoscopy tools has allowed junctions, single electron detergent-reconstituted ζ-ζ transmembrane the pursuit of productive transistors, and arrays of domain of the T-cell receptor have been nanosystems. This quantum dots in silicon. An overview of the generated. The use of DNA nanotube struts presentation will focus on devices made with this technology and some to self-assemble icosahedral cages that are recent examples of functional of the challenges to achieving atomically- 100 nanometers in diameter and future nanosystems related to precise devices will be presented. application as encapsulation devices and drug polymer synthesis and applications in Michelle Simmons, School of Physics, delivery vehicles will also be discussed. photonics, energy conversion, and renewable University of New South Wales, AUSTRALIA William M. Shih, Harvard Medical School and materials. Department of Cancer Biology, Dana-Farber Dennis W. Smith, Jr., Department of 10:00 AM – 10:30 AM Cancer Institute Chemistry, Clemson University Break

3:30 PM – 4:00 PM 8:30 AM – 9:00 AM 10:30 AM – 11:00 AM Break Single-Atom Manipulation and the Nanotechnology in Singapore: Chemistry of Towards Atomic-Scale 4:00 PM – 4:30 PM Central to advanced molecular manufacturing Manufacturing is the expectation of single-atom control for Multifunctional Carbon The Agency for Science, Technology and the fabrication of Nanotube-Based Systems: Linking Research (A*STAR) of Singapore has identified nanostructures and, Synthesis and Function several strategic areas that eventually, productive Translating the properties observed for include nanomagnetics, nanosystems. Quantum individual nanostructures to macroscale nano/micro fabrication, chemical studies of candidate composites has proven nanophotonics, and single-atom assembly difficult. This presentation nanobiomimetics with structures are an important will address the roadmap applications in engineering design tool, providing both a from nanoscale synthesis to sciences and human health. means to design optimization, and the ability macroscale functionality, For example, at IMRE, to predict failure rates and defect structures starting with fundamental activities in atomic scale associated with potentially reactive molecular understanding of nanotube technology focus on atomic scale species. and nanohorn synthesis manipulation and miniature scanning probe- Damian G. Allis, Research Fellow, ICPRFP; gained through in situ time-resolved type devices. Senior Scientist, Nanorex; and Theorist in characterization of their growth. Effects of Khiang Wee Lim, Executive Director, Institute Residence, Syracuse University processing and assembly on the path toward of Materials Research and Engineering (IMRE), functional macroscale systems will be SINGAPORE 9:00 AM – 9:30 AM illustrated with several examples. Biological and Nanoscale Systems David B. Geohegan, Distinguished Research 11:00 AM – 11:30 AM Staff Member, Oak Ridge National Laboratory The need to understand and engineer systems Information Technology: Toward the on similar scales presents a mutually beneficial merging of bio- and nano-sciences. Atomic Scale 4:30 PM – 5:30 PM New lithographic processes, combined with PANEL DISCUSSION: Pathways This convergence can result in an unprecedented increasingly sophisticated processes of natural MODERATOR: Jim Von Ehr, Founder, Zyvex understanding of biological pattern formation (templated and directed Group function and opportunities to self-assembly), will enable us to learn to build Multiple technologies are competing—and apply biology’s engineering objects with complex cooperating—in the drive to achieve principles. An example of this structure defined down to atomically-precise manufacturing. This panel will be presented, the atomic scale. This will will debate how these R&D pathways interact highlighting how the physical require judicious choice of and converge and how each pathway will be characteristics of the cell can building blocks, clever accelerated by unique achievements and be mimicked with nanomaterials to create dynamical steering of the payoffs in fields ranging from medicine to novel analytical devices and to reveal details self-assembly process, and new materials to computation. of natural cell function. design of structures that are Mitchel J. Doktycz, Research Staff, Oak Ridge tolerant of some defects. Although this is a PANELISTS: National Laboratory long-term vision, sophisticated self-assembly • Christian E. Schafmeister, Department of processes are already beginning to enter Chemistry, Temple University high-volume semiconductor manufacturing. • John Randall, Vice President, Zyvex Labs Thomas Theis, Director, Physical Sciences, IBM • K. Eric Drexler, Chief Technical Advisor, Watson Research Center Nanorex • Keith Firman, School of Biological Sciences, University of Portsmouth 11:30 AM – 12:00 PM 2:15 PM – 2:45 PM 3:45 PM – 4:45 PM Feynman Prize Winner: Theory Molecular Design of Solid State PANEL DISCUSSION: Applications The 2007 winner will present the award- Lighting for Energy Efficiency MODERATOR: Pearl Chin, President, winning work in the area of theory. Solid-state lighting based on inorganic Foresight Nanotech Institute Previous winners include: III-nitride light emitting diodes is already Work toward productive nanosystems • Erik Winfree and Paul Rothemund, achieving market penetration in niche results in new commercial applications at California Institute of Technology segments. Examples from virtually every step. The increasing ability to • Christian Joachim, Center Nationale de la semiconductor technology control matter to atomic Recherche Scientifique, FRANCE and biology will be used to precision enables major • David Baker, University of Washington and illustrate the importance of leaps in power generation Brian Kuhlman, University of North molecular scale precision for and storage, computation Carolina high efficiency solid-state density and efficiency, high • Don Brenner, North Carolina State lighting. The challenges, performance sensors, and University progress, and remaining materials for aerospace that • Mark Ratner, Northwestern University roadblocks to a viable organic solid-state outperform past • Uzi Landman, Georgia Tech lighting technology will be discussed. achievements by surprising factors. This • , Zyvex and Stephen Walch, Paul E. Burrows, Laboratory Fellow, Pacific panel will explore the possibilities from ELORET NASA Ames Northwest National Laboratory near-term and practical to longer-term and visionary. 12:00 PM – 12:30 PM 2:45 PM – 3:15 PM Feynman Prize Winner: A Comparison of Nanotechnology- PANELISTS: Experimental Malcolm R. O’Neill, Enabled Photovoltaic Materials former CTO, Lockheed The 2007 winner will present the award- and Devices with Near-Term Martin; and Chairman, winning work in the area of experimental. Commercialization Potential Board on Army S&T, Previous winners include: Several photovoltaic technologies that are The National Academies • Christian Schafmeister, University of viable for near-term commercialization, Pittsburgh within approximately five years, will be • Homme Hellinga, Duke University compared and contrasted. • Carlo Montemagno, University of Not all of these are Thomas Theis, California at Los Angeles nanotechnology-enabled Director, Physical Sciences, • Chad Mirkin, Northwestern University technologies. The prospects IBM Research • Charles Lieber, Harvard University of such technologies being • Stan Williams and Philip Kuekes, HP Labs deployed in wide-scale and James Heath, University of California photovoltaic applications in at Los Angeles the near term will be • Phaedon Avouris, IBM examined. Several of these technologies are • Reza Ghadiri, Scripps Research Institute being developed through the Wright Center Papu Maniar, for Photovoltaics Innovation and Advanced Materials and 12:30 PM – 1:45 PM Commercialization (PVIC), a program funded Nanotechnology Manager, Luncheon by the Ohio Third Frontier Program. Motorola Robert J. Davis, Director, Nanotech West 1:45 PM – 2:15 PM Laboratory, The Ohio State University Low Cost, Atomically-Precise Manufacturing of Defense 3:15 PM – 3:45 PM Systems: Progress and Applications Break J. Storrs Hall, Productive nanosystems based on molecular Research Fellow, Institute machines are the only known technological for Molecular approach that can satisfy Manufacturing the manufacturing objective of making large objects to atomic precision www.sme.org/nanosystems at a lower cost. Productive nanosystems will allow the 4:45 PM – 5:00 PM manufacture of structural Closing Remarks materials that approach their theoretical strength limits—about 100 times stronger than today’s metals and plastics—enabling the DoD to substantially LOCATION AND LODGING Location/Hotel Amenities: The Doubletree Hotel reduce energy consumption and DoubleTree Hotel Crystal City is a full service, upscale contemporary environmental pollution. Crystal City–National Airport hotel featuring spacious, well-appointed rooms David R. Forrest, Engineer, Naval Surface 300 Army Navy Drive and suites with a long list of amenities, including Warfare Center and President, Institute for Arlington, VA 22202-2891 USA high-speed internet access, fitness room, indoor heated pool, and sight seeing tours. A popular Molecular Manufacturing Room Reservations: Call the hotel directly at destination with locals as well as visitors, the +1 (703) 416-4100 and mention SME and this DoubleTree's Skydome Lounge is the area's only event to receive the reduced room rate of revolving rooftop lounge featuring excellent views $169/per night (single and double). Rooms that of the Capital and the Potomac. are not reserved by September 17, 2007, will be released. After this date, room availability and Visit www.sme.org/nanosystems to make SME's reduced rate cannot be guaranteed. reservations online and for driving directions. Productive Nanosystems: Launching the Technology Roadmap October 9–10, 2007 DoubleTree Hotel Crystal City–National Airport • Arlington, Virginia USA

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