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VITEK® MS Microbiology Powered by Mass Spectrometry DELIVER ACTIONABLE RESULTS to CLINICIANS to SUPPORT INFORMED TREATMENT DECISIONS

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VITEK® MS Microbiology Powered by Mass Spectrometry DELIVER ACTIONABLE RESULTS to CLINICIANS to SUPPORT INFORMED TREATMENT DECISIONS VITEK® MS Microbiology Powered by Mass Spectrometry DELIVER ACTIONABLE RESULTS TO CLINICIANS TO SUPPORT INFORMED TREATMENT DECISIONS. Fast and actionable organism identification provides clinicians with valuable diagnostic information that helps them tailor antimicrobial therapy. Incorporating fast identification and AST* with stewardship interventions has been shown to reduce time to appropriate therapy and to reduce hospital length of stay.1 • Safe and effective inactivation and extraction protocols offer excellent performance for identification of pathogenic microorganisms • Easy workflow with convenient, prepackaged reagent kits • In-lab solution to save time and costs compared to sending out tests or using other methods *Antimicrobial Susceptibility Testing TRULY INTEGRATED ID & AST SETUP Simple, step-by-step guided slide preparation for ID and connection with AST using the on-screen VITEK MS Prep Station. SIMPLE SPOTTING Easy sample preparation step of spotting organism onto slide and applying sample matrix for bacteria or matrix plus formic acid for yeasts. FLEXIBLE SAMPLE LOADING VITEK MS carrier can be loaded with up to four prepared slides and introduced into the instrument. With 48 sample spots per target slide, 192 isolates can be tested per run. References 1. Cavalieri SJ, Kwon S, Vivekanandan R, et al. Effect of antimicrobial stewardship with rapid MALDI-TOF identification and VITEK 4. Dunne WMJ, Doing K, Miller E, et al. Rapid Inactivation of Mycobacterium and Nocardia species before identification using 2 antimicrobial susceptibility testing on hospitalization outcome. Diagn Microbiol Infec Dis. 2019. http://doi.org/10.1016/j. Matrix-Assisted Laser Desorption Ionization-Time of Flight mass spectrometry. J Clin Microbiol. 2014;52:3654-3659. diagmicrobio.2019.05.020. Available online June 6, 2019. 5. U.S. Food & Drug Administration. 510(k) substantial equivalence determination decision summary. https://www.accessdata.fda.gov/ 2. Dunne Jr. WM, Doing K, Miller E, et al. Rapid Inactivation of Mycobacterium and Nocardia Species before Identification Using cdrh_docs/reviews/K181412.pdf. Accessed March 20, 2019. Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry. J Clin Microbiol. 2014;52 (10) 3654-3659. 3. Totty H, Miller E, Moreno E, Dunne WM, Deol P. Comparison of Mechanical Disruption Techniques for Rapid Inactivation of Mycobacterium and Nocardia Species before Identification Using Matrix-Assisted Laser Desorption Ionization–Time of Flight (MALDI-TOF) Mass Spectrometry. J Clin Microbiol. 2016;54 (10) 2626-2627. ROBUST DATABASE With more than 15,000 strains and an average of 12 strains per species, the VITEK MS provides highly accurate results. SPECTRUM FDA 510(k) cleared for 401 organisms — 1,316 total organisms in database The first FDA cleared database for Mycobacteria, Nocardia and molds A spectra from a sample is carefully digitized using Advanced Spectra Classifier and Weighted Bin Matrix. Mycobacteria Nocardia Molds Bacteria Yeast DETECTOR Structural proteins are Now including Brucella species, Candida auris, and detected to create a Elizabethkingia anophelis! spectrum that • 39 Mycobacteria • 43 Streptococcus species represents the protein makeup of each sample. • 16 Nocardia species • 36 Staphylococcus species • 207 Molds & Yeast • 17 Burkholderia species • 19 Legionella species • 12 Yersinia species TIME-OF-FLIGHT Refer to the VITEK MS V3.2 Knowledge Base for the full list of claimed Proteins travel up the and unclaimed organisms. flight tube before hitting the detector. A long flight SAFE EXTRACTION PROCEDURE tube helps deliver high resolution spectra for • No extractions required for routine bacteria and yeast identifications increased accuracy. • Simple and reliable inactivation for Mycobacteria, Nocardia and molds2,3 • Studies show no viable organisms after performing inactivation steps4 • Post-inactivation processing steps may be performed in BSL2 lab RING ELECTRODE Protein “cloud” is released HIGH PERFORMANCE and accelerated by an • 95.4% Total Combined Correct Identification Results electric charge. • Mycobacteria – 96.5% correct single choice IDs from patient cultures • Molds – 92.7% accurate single choice IDs with challenge strains5 LASER Ionizes the sample. VITEK MS provides identifications in minutes using an innovative mass spectrometry technology — Matrix Assisted Laser Desorption Ionization Time-of-Flight, or MALDI-TOF. n Mobiluncus curtisii n Leclercia adecarboxylata n Moraxella osloensis * n Paeniclostridium sordellii * n Lelliottia amnigena * n Neisseria cinerea VITEK® MS n Paraclostridium bifermentans * n Morganella morganii n Neisseria gonorrhoeae n Parvimonas micra n Pantoea agglomerans n Neisseria meningitidis Organism List n Peptoniphilus asaccharolyticus n Pantoea dispersa * n Neisseria mucosa / sicca n Peptostreptococcus anaerobius n Plesiomonas shigelloides * n Oligella ureolytica n Porphyromonas asaccharolytica / n Pluralibacter gergoviae n Oligella urethralis uenonis * n Proteus mirabilis n Porphyromonas gingivalis * n Proteus penneri GRAM-NEGATIVE n Prevotella bivia n Proteus vulgaris NON-ENTEROBACTERIACEAE n Prevotella buccae n Providencia alcalifaciens * n Prevotella denticola n Providencia rettgeri ANAEROBES n Achromobacter denitrificans n Prevotella intermedia n Providencia rustigianii * n Achromobacter xylosoxidans n Prevotella loescheii * n Providencia stuartii n Acinetobacter baumannii * n Acidipropionibacterium n Prevotella melaninogenica n Pseudescherichia (Escherichia) n Acinetobacter calcoaceticus * (Propionibacterium) acidipropionici * n Prevotella oralis * vulneris * n Acinetobacter haemolyticus n Actinomyces bovis * n Prevotella oris * n Raoultella ornithinolytica n Acinetobacter johnsonii * n Actinomyces israelii * n Propionibacterium acnes n Raoultella planticola n Acinetobacter junii n Actinomyces meyeri n Pseudopropionibacterium n Raoultella terrigena * n Acinetobacter lwoffii n Actinomyces naeslundii * (Propionibacterium) propionicum * n Salmonella enterica ssp enterica n Acinetobacter nosocomialis * n Actinomyces neuii n Tannerella forsythia * n Serratia ficaria * n Acinetobacter pittii * n Actinomyces odontolyticus n Veillonella dispar * n Serratia fonticola n Aeromonas hydrophila n Actinotignum schaalii * n Serratia grimesii * n Aeromonas jandaei * n Bacteroides caccae GRAM-NEGATIVE n Serratia liquefaciens n Aeromonas punctata (caviae) n Bacteroides eggerthii * ENTEROBACTERIACEAE n Serratia marcescens n Aeromonas sobria n Bacteroides fragilis n Serratia odorifera n Alcaligenes faecalis ssp faecalis n Bacteroides ovatus / xylanisolvens n Serratia plymuthica * n Cedecea davisae * n Bordetella avium * n Bacteroides pyogenes * n Serratia proteamaculans * n Cedecea lapagei * n Bordetella bronchiseptica * n Bacteroides stercoris * n Serratia quinivorans * n Bordetella parapertussis n Bacteroides thetaiotaomicron n Cedecea neteri * n Serratia rubidaea * n Bordetella pertussis n Bacteroides uniformis n Citrobacter amalonaticus n Yersinia aldovae * n Brevundimonas diminuta n Bacteroides vulgatus n Citrobacter braakii n Yersinia enterocolitica n Brevundimonas vesicularis * n Bifidobacterium spp * n Citrobacter farmeri * n Yersinia frederiksenii n Burkholderia cenocepacia * n Bilophila wadsworthia * n Citrobacter freundii n Yersinia intermedia n Burkholderia cepacia * n Clostridium baratii * n Citrobacter koseri n Yersinia kristensenii n Burkholderia contaminans * n Clostridium beijerinckii * n Citrobacter youngae n Yersinia pseudotuberculosis n Cronobacter muytjensii * n Burkholderia gladioli * n Clostridium butyricum * n Yersinia ruckeri * n Burkholderia multivorans n Clostridium cadaveris * n Cronobacter sakazakii n Burkholderia vietnamiensis * n Clostridium clostridioforme n Cronobacter turicensis * GRAM-NEGATIVE FASTIDIOUS n Chryseobacterium gleum * n Clostridioides (Clostridium) difficile n Edwardsiella hoshinae n Chryseobacterium indologenes n Clostridium innocuum * n Edwardsiella tarda n Comamonas testosteroni * n Clostridium novyi * n Enterobacter aerogenes n Aggregatibacter n Delftia acidovorans * n Clostridium perfringens n Enterobacter asburiae actinomycetemcomitans n Elizabethkingia anophelis * n Clostridium ramosum n Enterobacter cancerogenus n Aggregatibacter aphrophilus n Elizabethkingia meningoseptica n Clostridium septicum * n Enterobacter cloacae n Aggregatibacter segnis n Elizabethkingia miricola * n Clostridium sporogenes * n Enterobacter hormaechei * n Brucella spp * n Mannheimia haemolytica * n Clostridium tertium * n Enterobacter kobei * n Campylobacter coli n Myroides spp * n Clostridium tetani * n Enterobacter ludwigii * n Campylobacter jejuni n Ochrobactrum anthropi n Cutibacterium acnes n Escherichia coli n Campylobacter rectus * n Pasteurella aerogenes * n Cutibacterium (Propionibacterium) n Escherichia fergusonii n Eikenella corrodens n Pasteurella multocida avidum * n Escherichia hermannii n Haemophilus influenzae n Pseudomonas aeruginosa n Cutibacterium (Propionibacterium) n Ewingella americana n Haemophilus parahaemolyticus n Pseudomonas alcaligenes * granulosum * n Hafnia alvei n Haemophilus parainfluenzae n Pseudomonas fluorescens n Finegoldia magna n Klebsiella oxytoca n Kingella denitrificans n Pseudomonas luteola * n Fusobacterium mortiferum * n Klebsiella pneumoniae n Kingella kingae n Pseudomonas mendocina * n Fusobacterium necrophorum n Klebsiella variicola * n Legionella pneumophila n Pseudomonas oryzihabitans * n Fusobacterium nucleatum n Kluyvera ascorbata * n Moraxella catarrhalis n Pseudomonas
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