VITEK® MS Microbiology Powered by Mass Spectrometry DELIVER ACTIONABLE RESULTS TO CLINICIANS TO SUPPORT INFORMED TREATMENT DECISIONS.

Fast and actionable organism identification provides clinicians with valuable diagnostic information that helps them tailor antimicrobial therapy. Incorporating fast identification and AST* with stewardship interventions has been shown to reduce time to appropriate therapy and to reduce hospital length of stay.1 • Safe and effective inactivation and extraction protocols offer excellent performance for identification of pathogenic microorganisms • Easy workflow with convenient, prepackaged reagent kits • In-lab solution to save time and costs compared to sending out tests or using other methods

*Antimicrobial Susceptibility Testing

TRULY INTEGRATED ID & AST SETUP Simple, step-by-step guided slide preparation for ID and connection with AST using the on-screen VITEK MS Prep Station.

SIMPLE SPOTTING Easy sample preparation step of spotting organism onto slide and applying sample matrix for bacteria or matrix plus formic acid for yeasts.

FLEXIBLE SAMPLE LOADING VITEK MS carrier can be loaded with up to four prepared slides and introduced into the instrument. With 48 sample spots per target slide, 192 isolates can be tested per run.

References

1. Cavalieri SJ, Kwon S, Vivekanandan R, et al. Effect of antimicrobial stewardship with rapid MALDI-TOF identification and VITEK 4. Dunne WMJ, Doing K, Miller E, et al. Rapid Inactivation of Mycobacterium and Nocardia species before identification using 2 antimicrobial susceptibility testing on hospitalization outcome. Diagn Microbiol Infec Dis. 2019. http://doi.org/10.1016/j. Matrix-Assisted Laser Desorption Ionization-Time of Flight mass spectrometry. J Clin Microbiol. 2014;52:3654-3659. diagmicrobio.2019.05.020. Available online June 6, 2019. 5. U.S. Food & Drug Administration. 510(k) substantial equivalence determination decision summary. https://www.accessdata.fda.gov/ 2. Dunne Jr. WM, Doing K, Miller E, et al. Rapid Inactivation of Mycobacterium and Nocardia Species before Identification Using cdrh_docs/reviews/K181412.pdf. Accessed March 20, 2019. Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry. J Clin Microbiol. 2014;52 (10) 3654-3659. 3. Totty H, Miller E, Moreno E, Dunne WM, Deol P. Comparison of Mechanical Disruption Techniques for Rapid Inactivation of Mycobacterium and Nocardia Species before Identification Using Matrix-Assisted Laser Desorption Ionization–Time of Flight (MALDI-TOF) Mass Spectrometry. J Clin Microbiol. 2016;54 (10) 2626-2627. ROBUST DATABASE With more than 15,000 strains and an average of 12 strains per species, the VITEK MS provides highly accurate results.

SPECTRUM FDA 510(k) cleared for 401 organisms — 1,316 total organisms in database The first FDA cleared database for Mycobacteria,Nocardia and molds A spectra from a sample is carefully digitized using Advanced Spectra Classifier and Weighted Bin Matrix.

Mycobacteria Nocardia Molds Bacteria Yeast DETECTOR Structural proteins are Now including Brucella species, Candida auris, and detected to create a Elizabethkingia anophelis! spectrum that • 39 Mycobacteria • 43 Streptococcus species represents the protein makeup of each sample. • 16 Nocardia species • 36 Staphylococcus species • 207 Molds & Yeast • 17 Burkholderia species • 19 Legionella species • 12 Yersinia species TIME-OF-FLIGHT Refer to the VITEK MS V3.2 Knowledge Base for the full list of claimed Proteins travel up the and unclaimed organisms. flight tube beforehitting the detector. A long flight SAFE EXTRACTION PROCEDURE tube helps deliver high resolution spectra for • No extractions required for routine bacteria and yeast identifications increased accuracy. • Simple and reliable inactivation for Mycobacteria, Nocardia and molds2,3 • Studies show no viable organisms after performing inactivation steps4 • Post-inactivation processing steps may be performed in BSL2 lab RING ELECTRODE Protein “cloud” is released HIGH PERFORMANCE and accelerated by an • 95.4% Total Combined Correct Identification Results electric charge. • Mycobacteria – 96.5% correct single choice IDs from patient cultures • Molds – 92.7% accurate single choice IDs with challenge strains5

LASER Ionizes the sample. VITEK MS provides identifications in minutes using an innovative mass spectrometry technology — Matrix Assisted Laser Desorption Ionization Time-of-Flight, or MALDI-TOF. n Mobiluncus curtisii n Leclercia adecarboxylata n Moraxella osloensis * n Paeniclostridium sordellii * n Lelliottia amnigena * n Neisseria cinerea VITEK® MS n Paraclostridium bifermentans * n Morganella morganii n Neisseria gonorrhoeae n Parvimonas micra n Pantoea agglomerans n Neisseria meningitidis Organism List n Peptoniphilus asaccharolyticus n Pantoea dispersa * n Neisseria mucosa / sicca n Peptostreptococcus anaerobius n Plesiomonas shigelloides * n Oligella ureolytica n Porphyromonas asaccharolytica / n Pluralibacter gergoviae n Oligella urethralis uenonis * n Proteus mirabilis n Porphyromonas gingivalis * n Proteus penneri GRAM-NEGATIVE n Prevotella bivia n Proteus vulgaris NON-ENTEROBACTERIACEAE n Prevotella buccae n Providencia alcalifaciens * n Prevotella denticola n Providencia rettgeri ANAEROBES n Achromobacter denitrificans n Prevotella intermedia n Providencia rustigianii * n Achromobacter xylosoxidans n Prevotella loescheii * n Providencia stuartii n Acinetobacter baumannii * n Acidipropionibacterium n Prevotella melaninogenica n Pseudescherichia (Escherichia) n Acinetobacter calcoaceticus * (Propionibacterium) acidipropionici * n Prevotella oralis * vulneris * n Acinetobacter haemolyticus n Actinomyces bovis * n Prevotella oris * n Raoultella ornithinolytica n Acinetobacter johnsonii * n Actinomyces israelii * n Propionibacterium acnes n Raoultella planticola n Acinetobacter junii n Actinomyces meyeri n Pseudopropionibacterium n Raoultella terrigena * n Acinetobacter lwoffii n Actinomyces naeslundii * (Propionibacterium) propionicum * n Salmonella enterica ssp enterica n Acinetobacter nosocomialis * n Actinomyces neuii n Tannerella forsythia * n Serratia ficaria * n Acinetobacter pittii * n Actinomyces odontolyticus n Veillonella dispar * n Serratia fonticola n Aeromonas hydrophila n Actinotignum schaalii * n Serratia grimesii * n Aeromonas jandaei * n Bacteroides caccae GRAM-NEGATIVE n Serratia liquefaciens n Aeromonas punctata (caviae) n Bacteroides eggerthii * ENTEROBACTERIACEAE n Serratia marcescens n Aeromonas sobria n Bacteroides fragilis n Serratia odorifera n Alcaligenes faecalis ssp faecalis n Bacteroides ovatus / xylanisolvens n Serratia plymuthica * n Cedecea davisae * n Bordetella avium * n Bacteroides pyogenes * n Serratia proteamaculans * n Cedecea lapagei * n Bordetella bronchiseptica * n Bacteroides stercoris * n Serratia quinivorans * n Bordetella parapertussis n Bacteroides thetaiotaomicron n Cedecea neteri * n Serratia rubidaea * n Bordetella pertussis n Bacteroides uniformis n Citrobacter amalonaticus n Yersinia aldovae * n Brevundimonas diminuta n Bacteroides vulgatus n Citrobacter braakii n Yersinia enterocolitica n Brevundimonas vesicularis * n Bifidobacterium spp * n Citrobacter farmeri * n Yersinia frederiksenii n Burkholderia cenocepacia * n Bilophila wadsworthia * n Citrobacter freundii n Yersinia intermedia n Burkholderia cepacia * n Clostridium baratii * n Citrobacter koseri n Yersinia kristensenii n Burkholderia contaminans * n Clostridium beijerinckii * n Citrobacter youngae n Yersinia pseudotuberculosis n Cronobacter muytjensii * n Burkholderia gladioli * n Clostridium butyricum * n Yersinia ruckeri * n Burkholderia multivorans n Clostridium cadaveris * n Cronobacter sakazakii n Burkholderia vietnamiensis * n Clostridium clostridioforme n Cronobacter turicensis * GRAM-NEGATIVE FASTIDIOUS n Chryseobacterium gleum * n Clostridioides (Clostridium) difficile n Edwardsiella hoshinae n Chryseobacterium indologenes n Clostridium innocuum * n Edwardsiella tarda n Comamonas testosteroni * n Clostridium novyi * n Enterobacter aerogenes n Aggregatibacter n Delftia acidovorans * n Clostridium perfringens n Enterobacter asburiae actinomycetemcomitans n Elizabethkingia anophelis * n Clostridium ramosum n Enterobacter cancerogenus n Aggregatibacter aphrophilus n Elizabethkingia meningoseptica n Clostridium septicum * n Enterobacter cloacae n Aggregatibacter segnis n Elizabethkingia miricola * n Clostridium sporogenes * n Enterobacter hormaechei * n Brucella spp * n Mannheimia haemolytica * n Clostridium tertium * n Enterobacter kobei * n Campylobacter coli n Myroides spp * n Clostridium tetani * n Enterobacter ludwigii * n Campylobacter jejuni n Ochrobactrum anthropi n Cutibacterium acnes n Escherichia coli n Campylobacter rectus * n Pasteurella aerogenes * n Cutibacterium (Propionibacterium) n Escherichia fergusonii n Eikenella corrodens n Pasteurella multocida avidum * n Escherichia hermannii n Haemophilus influenzae n Pseudomonas aeruginosa n Cutibacterium (Propionibacterium) n Ewingella americana n Haemophilus parahaemolyticus n Pseudomonas alcaligenes * granulosum * n Hafnia alvei n Haemophilus parainfluenzae n Pseudomonas fluorescens n Finegoldia magna n Klebsiella oxytoca n Kingella denitrificans n Pseudomonas luteola * n Fusobacterium mortiferum * n Klebsiella pneumoniae n Kingella kingae n Pseudomonas mendocina * n Fusobacterium necrophorum n Klebsiella variicola * n Legionella pneumophila n Pseudomonas oryzihabitans * n Fusobacterium nucleatum n Kluyvera ascorbata * n Moraxella catarrhalis n Pseudomonas putida n Fusobacterium periodonticum * n Kluyvera cryocrescens * n Moraxella lacunata * n Pseudomonas stutzeri n Hathewaya histolytica * n Kluyvera intermedia * n Moraxella nonliquefaciens * n Ralstonia pickettii n Rhizobium radiobacter n Staphylococcus simulans n Curvularia hawaiiensis NOCARDIA n Shewanella putrefaciens * n Staphylococcus warneri n Curvularia spicifera n Sphingobacterium multivorum n Staphylococcus xylosus * n Epidermophyton floccosum n Nocardia abscessus n Sphingobacterium spiritivorum n Streptococcus agalactiae n Exophiala dermatitidis n Nocardia africana / nova n Sphingomonas paucimobilis n Streptococcus alactolyticus * n Exophiala xenobiotica n Nocardia asteroides n Stenotrophomonas maltophilia n Streptococcus anginosus n Exserohilum rostratum n Nocardia brasiliensis n Vibrio alginolyticus * n Streptococcus canis * n Fusarium oxysporum complex n Nocardia cyriacigeorgica n Vibrio cholerae n Streptococcus constellatus n Fusarium proliferatum n Nocardia farcinica n Vibrio fluvialis * n Streptococcus cristatus * n Fusarium solani complex n Nocardia otitidiscaviarum n Vibrio metschnikovii * n Streptococcus dysgalactiae ssp n Histoplasma capsulatum n Nocardia paucivorans n Vibrio mimicus * dysgalactiae n Lecythophora hoffmannii n Nocardia pseudobrasiliensis n Vibrio parahaemolyticus n Streptococcus dysgalactiae ssp n Lichtheimia corymbifera n Nocardia transvalensis n Vibrio vulnificus equisimilis n Microsporum audouinii n Nocardia veterana n Streptococcus equi ssp equi * n Microsporum canis n Nocardia wallacei GRAM-POSITIVE n Streptococcus equi ssp n Microsporum gypseum zooepidemicus * n Mucor racemosus complex YEAST n Streptococcus equinus * n Paecilomyces variotii complex n Abiotrophia defectiva n Streptococcus gallolyticus ssp n Penicillium chrysogenum n Aerococcus viridans gallolyticus n Pseudallescheria boydii n Candida albicans n Corynebacterium jeikeium n Streptococcus gallolyticus ssp n Purpureocillium lilacinum n Candida auris * n Curtobacterium flaccumfaciens * pasteurianus * n Rasamsonia argillacea complex n Candida dubliniensis n Enterococcus avium n Streptococcus gordonii * n Rhizopus arrhizus complex n Candida duobushaemulonii * n Enterococcus casseliflavus n Streptococcus infantarius ssp coli n Rhizopus microsporus complex n Candida famata n Enterococcus durans (Str.lutetiensis) n Sarocladium kiliense n Candida glabrata n Enterococcus faecalis n Streptococcus infantarius ssp n Scedosporium apiospermum n Candida guilliermondii n Enterococcus faecium infantarius n Scedosporium prolificans n Candida haemulonii n Enterococcus gallinarum n Streptococcus intermedius n Sporothrix schenckii complex n Candida inconspicua n Enterococcus hirae * n Streptococcus mitis / Streptococcus n Trichophyton interdigitale n Candida intermedia n Gardnerella vaginalis oralis n Trichophyton rubrum n Candida kefyr n Gemella haemolysans n Streptococcus mutans n Trichophyton tonsurans n Candida krusei n Gemella morbillorum n Streptococcus parasanguinis * n Trichophyton verrucosum n Candida lambica n Granulicatella adiacens n Streptococcus pneumoniae n Trichophyton violaceum n Candida lipolytica n Kocuria rhizophila * n Streptococcus pseudoporcinus * n Candida lusitaniae n Lactococcus garvieae n Streptococcus pyogenes MYCOBACTERIUM n Candida metapsilosis * n Lactococcus lactis n Streptococcus salivarius ssp salivarius n Candida norvegensis n Leuconostoc mesenteroides n Streptococcus sanguinis n Candida orthopsilosis * n Leuconostoc pseudomesenteroides n Mycobacterium abscessus n Streptococcus sobrinus * n Candida parapsilosis n Listeria monocytogenes n Mycobacterium avium n Streptococcus suis * n Candida pelliculosa n Micrococcus luteus n Mycobacterium chelonae n Streptococcus uberis * n Candida rugosa n Pediococcus acidilactici n Mycobacterium fortuitum group n Streptococcus vestibularis * n Candida tropicalis n Rothia mucilaginosa n Mycobacterium gordonae n Candida utilis n Staphylococcus aureus n Mycobacterium haemophilum MOLDS n Candida zeylanoides n Staphylococcus auricularis * n Mycobacterium immunogenum n Cryptococcus gattii * n Staphylococcus capitis n Mycobacterium intracellulare n Cryptococcus neoformans n Staphylococcus chromogenes * n Acremonium sclerotigenum n Mycobacterium kansasii n Kodamaea ohmeri n Staphylococcus cohnii ssp cohnii n Alternaria alternata n Mycobacterium lentiflavum n Malassezia furfur n Staphylococcus cohnii ssp urealyticus n Aspergillus brasiliensis n Mycobacterium malmoense n Malassezia pachydermatis n Staphylococcus epidermidis n Aspergillus calidoustus / ustus n Mycobacterium marinum n Rhodotorula mucilaginosa n Staphylococcus haemolyticus n Aspergillus flavus / oryzae n Mycobacterium mucogenicum n Saccharomyces cerevisiae n Staphylococcus hominis n Aspergillus fumigatus n Mycobacterium scrofulaceum n Saprochaete capitata n Staphylococcus hyicus * n Aspergillus lentulus n Mycobacterium simiae n Trichosporon asahii n Staphylococcus intermedius * n Aspergillus nidulans n Mycobacterium smegmatis n Trichosporon dermatis n Staphylococcus kloosii * n Aspergillus niger complex n Mycobacterium szulgai / mucoides * n Staphylococcus lentus * n Aspergillus sydowii n Mycobacterium tuberculosis complex n Trichosporon inkin n Staphylococcus lugdunensis n Aspergillus terreus complex n Mycobacterium xenopi n Staphylococcus pseudintermedius * n Aspergillus versicolor n Staphylococcus saprophyticus n Blastomyces dermatitidis n Staphylococcus schleiferi n Cladophialophora bantiana n Staphylococcus sciuri n Coccidioides immitis / posadasii * Added in V3.2 database update ENHANCE MICROBIOLOGY WORKFLOW WITH VITEK® MS V3.1 SYSTEM SOFTWARE

The VITEK MS V3.1 System software enhances the microbiology workflow with features focusing on results management and FLEXPREPTM software.

• Increased Setup Efficiency VITEK FLEXPREP VITEK FLEXPREP VITEK FLEXPREP • Improved Traceability and Quality • User-Friendly to Maximize Your Time

MULTIPLE BENCH SETUP AND RESULTS REVIEW

SLIDE DATA

ID RESULTS

ACQUISITION STATION RESULTS MANAGEMENT COMPUTER

SHARE & IMPROVED TRACEABILITY, ENHANCED RUO MODIFY SLIDES QUALITY & REPORTING FUNCTIONALITY • Isolate information now saved by • QC Mapping: Create customized • One user-friendly application for IVD spot instead of acquisition group QC lists and RUO • Slides shared within acquisition • Reagent traceability: ability to • VITEK FLEXPREP is now used for RUO groups with full traceability track the lot number and expiration date target slide preparation for reagents and kits (customizable) • Ability to have multiple operators • Automatically send “no ID” results to per acquisition group • Operator traceability: track the SARAMIS® for analysis technician who sets up each spot and/ or slide (customizable) • New reports including QC, isolate, spot, and usage report FLEXPREP: THE NEW WAY TO SET UP TARGET SLIDES AND VITEK 2 CARDS • Simplified, browser-based setup from any computer connected to the same network as your VITEK Solution VITEK FLEXPREP • Easily switch between setup layouts (ID/AST) for optimal workflow • Reminder to add formic acid for yeast identifications • Ability to add a comment by spot

SLIDE DATA

ID RESULTS PATIENT DEMOGRAPHICS

PATIENT ID/AST RESULTS

LIS

RESULTS MYLA® CONNECTED MANAGEMENT MICROBIOLOGY FOR BLOOD • Auto release high confidence green results to the LIS CULTURE & ID/AST (customizable for E. coli) MYLA is the foundation of your VITEK Solution, providing • Review results by selection, batch, specimen, slide, or important connectivity and reporting functions. acquisition group MYLA software offers you a real-time, control-tower overview • Sort and filter results with customizable fields such as operator, of your bioMérieux instruments with flexible and easy-to- confidence level, bench name, accession number, or setup generate-reports. technician/operator • Display of new icons provides additional information during Put MYLA at the heart of your lab operations to transform result review, including a duplicate isolate alert results into smart data insights. ©2020 bioMérieux, Inc. • BIOMÉRIEUX and the BIOMÉRIEUX logo, ETEST, FLEXPREP, MYLA, SARAMIS, VILINK, and VITEK are used, pending, and/or registered trademarks belonging to bioMérieux, or one of its subsidiaries, or one of its companies • Patents: www.biomerieux-usa.com/patents • PRN 052706 02.A www.biomerieuxDIRECT.com Order reagents track and shipments: critical clinical situations. accuracy bioMérieux’s ID/AST solutions provide increase the insights selectionsupport of seamless integration solutions for infectious disease diagnostics. Together, VITEK MS, VITEK 2andETEST VITEK MSispart of bioMérieux’s ID/AST SOLUTIONS www.biomerieux-usa.com/vitek-ms F or moreor information visit usingMYLA — whether you are faced with routine diagnoses, unusualorresistant organisms, or value of every test result. appropriate antimicrobial treatment ® , bioMérieux’s easy-to-use middleware andinstrument manager, and and the flexibility comprehensive andcomplementary by Mass Spectrometry

confidence in reporting Microbiology Powered ensure test results thatimpact timely, appropriate therapy. identification andsusceptibility testing (ID/AST) solution lets you leverage your expertise to For all your testing needs—from the strengthen laboratory impact onpatient therapy. stop Innovation inmicrobiology must never stop —because your FOR WE ARE neededto . For more than50 years, bioMérieux hasshared your commitment to continually optimizelaboratory workflow . Turn data into results with ready to help you keep your lab runningsmoothly. support. 24 hours aday, 365 days a year, we’re provides rapid access to remote diagnostic and customer service experts. Our VILINK® solution than 300award winning application, engineering into your lab, you’ll besupported by ateam of more When you invest inbringing our instrumentation VITEK LEVERAGING EXPERTISE LAB range of ID/AST actionable speed and most routine to thetruly challenging ® andto provide laboratory challenges never ® MS —ourintegrated