Volume 2 / Suppl. 2 / 2017
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Universidade Feevale Uma Metodologia De Gestão
UNIVERSIDADE FEEVALE UMA METODOLOGIA DE GESTÃO SOCIOAMBIENTAL PARA O SOCIOECOSSISTEMA BACIA HIDROGRÁFICA RIO DOS SINOS Programa de Pós-graduação em Qualidade Ambiental Doutorado em Qualidade Ambiental Rodolfo González Ortega Linha de pesquisa: Tecnologia e Intervenção Ambiental Orientador: Dr. João Alcione Sganderla Figueiredo Novo Hamburgo 2019 Universidade Feevale Programa de Pós-Graduação em Qualidade Ambiental Doutorado em Qualidade Ambiental RODOLFO GONZÁLEZ ORTEGA UMA METODOLOGIA DE GESTÃO SOCIOAMBIENTAL PARA O SOCIOECOSSISTEMA BACIA HIDROGRÁFICA RIO DOS SINOS Tese apresentada ao Programa de Pós-graduação em Qualidade Ambiental como requisito para a obtenção do título de Doutor em Qualidade Ambiental. Orientador: Dr. João Alcione Sganderla Figueiredo Novo Hamburgo 2019 Universidade Feevale Programa de Pós-Graduação em Qualidade Ambiental Doutorado em Qualidade Ambiental Rodolfo González Ortega UMA METODOLOGIA DE GESTÃO SOCIOAMBIENTAL PARA O SOCIOECOSSISTEMA BACIA HIDROGRÁFICA RIO DOS SINOS Componentes da Banca Examinadora: Prof. Dr. João Alcione Sganderla Figueiredo (Orientador) Universidade FEEVALE Prof. Dr. Dusan Schreiber Universidade FEEVALE Prof. Dr. Claus Haetinger Universidade do Vale do Taquarí - UNIVATES Prof. Dr. Maikel Leyva Vázquez Universidad de Guayaquil Dedicatória A minha família pela sua dedicação, seu sacrifício e pela incomensurável saudade nestes quatro longos anos. Agradecimentos Ao povo Brasileiro que com seus impostos, por meio do financiamento da CAPES e do programa PEC-PG, me permitiram ter esta experiência. À CAPES pelo financiamento da bolsa de estudos para o desenvolvimento desta pesquisa. A meu amigo e irmão, o Dr Maikel Leyva, pela sua ajuda incondicional e seus sábios conselhos. A minha estimada Olguita, pela sua confiança em mim. À FEEVALE e seu staff de professores e pessoal de serviço que fizeram mais leve a estadia. -
Rediscovery of Fexinidazole
New Drugs against Trypanosomatid Parasites: Rediscovery of Fexinidazole INAUGURALDISSERTATION zur Erlangung der Würde eines Doktors der Philosophie vorgelegt der Philosophisch-Naturwissenschaftlichen Fakultät der Universität Basel von Marcel Kaiser aus Obermumpf, Aargau Basel, 2014 Originaldokument gespeichert auf dem Dokumentenserver der Universität Basel edoc.unibas.ch Dieses Werk ist unter dem Vertrag „Creative Commons Namensnennung-Keine kommerzielle Nutzung-Keine Bearbeitung 3.0 Schweiz“ (CC BY-NC-ND 3.0 CH) lizenziert. Die vollständige Lizenz kann unter creativecommons.org/licenses/by-nc-nd/3.0/ch/ eingesehen werden. 1 Genehmigt von der Philosophisch-Naturwissenschaftlichen Fakultät der Universität Basel auf Antrag von Prof. Reto Brun, Prof. Simon Croft Basel, den 10. Dezember 2013 Prof. Dr. Jörg Schibler, Dekan 2 3 Table of Contents Acknowledgement .............................................................................................. 5 Summary ............................................................................................................ 6 Zusammenfassung .............................................................................................. 8 CHAPTER 1: General introduction ................................................................. 10 CHAPTER 2: Fexinidazole - A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness ........ 26 CHAPTER 3: Anti-trypanosomal activity of Fexinidazole – A New Oral Nitroimidazole Drug Candidate for the Treatment -
Moderate Levels of Glyphosate and Its Formulations Vary in Their Cytotoxicity
3 Biotech (2018) 8:438 https://doi.org/10.1007/s13205-018-1464-z ORIGINAL ARTICLE Moderate levels of glyphosate and its formulations vary in their cytotoxicity and genotoxicity in a whole blood model and in human cell lines with different estrogen receptor status L. K. S. De Almeida1 · B. I. Pletschke1 · C. L. Frost2 Received: 22 December 2017 / Accepted: 26 September 2018 © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Abstract In vitro studies were conducted to determine the short-term cytotoxic and genotoxic effects of pure glyphosate and two glyphosate formulations (Roundup ® and Wipeout ®) at concentrations relevant to human exposure using whole blood (cyto- toxicity) and various cancer cell lines (cytotoxicity and genotoxicity). Pure glyphosate (pure glyph) and Roundup® (Ro) showed similar non-monotonic toxicological profiles at low dose exposure (from 10 µg/ml), whereas Wipeout® (Wo) dem- onstrated a monotonic reduction in cell viability from a threshold concentration of 50 µg/ml, when tested in whole blood. We evaluated whether using various cancer cells (the estrogen-E2-responsive HEC1A, MCF7 and the estrogen-insensitive MDA-MB-231) exposed to moderate doses (75–500 µg/ml) would indicate varied toxicity and results indicated significant effects in the HEC1A cancer cells. A non-monotonic reduction in cell viability was observed in HEC1A exposed to pure glyph (75–500 µg/ml) and proliferative effects were observed after exposure to Wo (75, 125 and 250 µg/ml). Genotoxicity assessment (test concentration 500 µg/ml) demonstrated DNA damage in the HEC1A and MDA-MB-231 cells. Adjuvants and/or glyphosate impurities were potential contributing factors of toxicity based on the differential toxicities displayed by Ro and Wo in human whole blood and the HEC1A cells. -
Avaliação Do Potencial Carcinogênico Do Megazol, Agente Anti-Chagásico, E Obtenção De Nanopartículas De Poli(Ε- Caprolactona) Contendo Megazol
MARTA LOPES LIMA Avaliação do potencial carcinogênico do Megazol, agente anti-chagásico, e obtenção de nanopartículas de poli(ε- caprolactona) contendo Megazol Dissertação apresentada ao Programa de Pós-Graduação Interunidades em Biotecnologia USP/Instituto Butantan/IPT, para obtenção do Título de Mestre em Biotecnologia. São Paulo 2011 1 MARTA LOPES LIMA Avaliação do potencial carcinogênico do Megazol, agente anti-chagásico, e obtenção de nanopartículas de poli(ε- caprolactona) contendo Megazol Dissertação para o exame de qualificação apresentada ao Programa de Pós-Graduação Interunidades em Biotecnologia USP/Instituto Butantan/ IPT, para obtenção do Título de Mestre em Biotecnologia. Área de Concentração: Biotecnologia Orientadora: Drª. Cristina Northfleet de Albuquerque Versão original São Paulo 2011 2 3 4 A mulher que em nenhum momento mediu esforços para a realização dos meus sonhos, ao meu exemplo de caráter, dedicação e fé Obrigada Mãe!!! 5 Agradecimentos Ao Laboratório de Química, Bioquímica e Biologia Molecular de Alimentos da Faculdade de Ciências Farmacêuticas, em especial para a Pós-Doutora Claudinéia Aparecida Soares, sem seu auxílio esta pesquisa não teria sido finalizada. Obrigada, pelas horas perdidas de discussões e trabalho árduo, especialmente finais de semana. A Pós-Doutora Nádia Araci Bou-Chacra e graduanda Juliana Conte pelo auxílio no preparo das nanopartículas. Ao Laboratório de Planejamento e Síntese de Quimioterápicos Potencialmente Ativos em Doenças Negligenciadas da Faculdade de Ciências Farmacêuticas, pelo uso dos equipamentos. Ao laboratório de Farmacotécnica da Faculdade de Ciências Farmacêuticas, em especial a Drª Vladi Olga Consiglieri e Dr. Guilherme Tavares pelo auxílio no desenvolvimento do método analítico aqui empregado. A toda família Zucchi pelo apoio, incentivo e hospitalidade. -
CONICYT Ranking Por Disciplina > Sub-Área OECD (Académicas) Comisión Nacional De Investigación 1
CONICYT Ranking por Disciplina > Sub-área OECD (Académicas) Comisión Nacional de Investigación 1. Ciencias Naturales > 1.2 Computación y Ciencias de la Científica y Tecnológica Informática PAÍS INSTITUCIÓN RANKING PUNTAJE USA Carnegie Mellon University 1 5,000 CHINA Tsinghua University 2 5,000 USA University of California Berkeley 3 5,000 USA Massachusetts Institute of Technology (MIT) 4 5,000 Nanyang Technological University & National Institute of Education SINGAPORE 5 5,000 (NIE) Singapore USA Stanford University 6 5,000 SWITZERLAND ETH Zurich 7 5,000 HONG KONG Chinese University of Hong Kong 8 5,000 FRANCE Universite Paris Saclay (ComUE) 9 5,000 INDIA Indian Institute of Technology System (IIT System) 10 5,000 SINGAPORE National University of Singapore 11 5,000 USA University of Michigan 12 5,000 USA University of Illinois Urbana-Champaign 13 5,000 GERMANY Technical University of Munich 14 5,000 CHINA Harbin Institute of Technology 15 5,000 CHINA Shanghai Jiao Tong University 16 5,000 USA Georgia Institute of Technology 17 5,000 UNITED KINGDOM University of Oxford 18 5,000 UNITED KINGDOM Imperial College London 19 5,000 CHINA Peking University 20 5,000 USA University of Southern California 21 5,000 USA University of Maryland College Park 22 5,000 CHINA Zhejiang University 23 5,000 USA University of Texas Austin 24 5,000 USA University of Washington Seattle 25 5,000 CHINA Huazhong University of Science & Technology 26 5,000 USA University of California San Diego 27 5,000 USA University of North Carolina Chapel Hill 28 5,000 HONG KONG -
Are We Underestimating Benthic Cyanotoxins? Extensive Sampling Results from Spain
toxins Article Are We Underestimating Benthic Cyanotoxins? Extensive Sampling Results from Spain Enrique A. Cantoral Uriza 1, Antonia D. Asencio 2 and Marina Aboal 3,* 1 Unidad Multidisciplinaria de Docencia e Investigación (UMDI), Facultad de Ciencias, Universidad Nacional Autónoma de México, Campus Juriquilla, C.P. Querétaro 76230, Mexico; [email protected] 2 Departamento de Biología Aplicada (Botánica), Facultad de Ciencias Experimentales, Universidad Miguel Hernández, Campus de Elche, E-03202 Alicante, Spain; [email protected] 3 Laboratorio de Algología, Departamento de Biología Vegetal, Facultad de Biología, Universidad de Murcia, Campus de Espinardo, E-30100 Murcia, Spain * Correspondence: [email protected]; Tel.: +34-868-884-940 Academic Editor: Luis M. Botana Received: 29 August 2017; Accepted: 23 November 2017; Published: 28 November 2017 Abstract: Microcystins (MCs) are potent hepatotoxins, and their presence in water bodies poses a threat to wildlife and human populations. Most of the available information refers to plankton, and much less is known about microcystins in other habitats. To broaden our understanding of the presence and environmental distribution of this group of toxins, we conducted extensive sampling throughout Spain, under a range of conditions and in distinct aquatic and terrestrial habitats. More than half of the tested strains were toxic; concentrations of the hepatotoxin were low compared with planktic communities, and the number of toxic variants identified in each sample of the Spanish strains ranged from 1–3. The presence of microcystins LF and LY (MC-LF and MC-LY) in the tested samples was significant, and ranged from 21.4% to 100% of the total microcystins per strain. -
CONTROL of Bowling Green December 1978
ZINC PHOSPHIDE DEVELOPMENT FOR RODENT CONTROL Kasem Tongtavee A Dissertation Submitted to the Graduate College of Bowling Green State University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY December 1978 14 © 1979 KASEM TONGTAVEE ALL RIGHTS RESERVED ii ABSTRACT Adult lab and wild rats (Rattus norvégiens) were maintained under laboratory conditions for the investigation of the bait shyness phenomena, the evaluation of modified forms of zinc phosphide, and the efficacy testing of various bait formulations. One zinc phosphide formulation was selected for a field trial. Wild rats, but not lab rats, developed bait shyness specific to zinc phosphide following ingestion of sub-lethal doses, but not to the bait material. Some wild, bait-shy rats retained memory for zinc phos phide for at least 60 days. In food preference studies the rats were given the choice of EPA- standard food and a test food. Only red pepper (at 0.16%) increased palatability of EPA-standard food for both lab and wild rats. Bait combinations A (consisting of ground barley and rolled oats), B (consist ing of ground wheat and rolled oats), and E (consisting of ground barley, ground corn, and rolled oats) were preferred to EPA-standard food by lab but not by wild rats. Experimental forms of Zn3P2 were mixed with EPA-standard food at 1% and tested on individual lab and wild rats in choice and non-choice regimens. The addition of buffering substances to Zn3P2 did not signifi cantly improve the toxic bait consumption. Most of the special formula tions provided 100% mortality to lab rats in choice and non-choice feeding situations, but only one formulation gave 100% mortality to wild rats. -
ASP NEWSLETTER VOLUME 52, ISSUE 4 PAGE 2 Historic Gift by Brady Estate to ASP Foundation
The American Society Discovering Nature’s of Molecular Potential PharmacognosyThe ASP Newsletter: Volume 52, Issue 4 Historic Gift by Brady Estate to ASP Foundation By Drs. John Cardellina and Robert Krueger he ASP Foundation (ASPF) has received its largest single Board members are deeply moved by this enormous and con- donation ever from the estate of the late Dr. Lynn R. Brady siderate gift. and his wife Geraldine, known as Geri. Dr. Brady died in ASP President Cindy Angerhofer reacted to this historic dona- 1992 and Mrs. Brady in 2015. This current bequest of tion, Dr. Brady was exemplary in science and service to the field Tabout $300,000 comes from the final settlement of the Brady es- of pharmacognosy as well as to the Society. He has tate. Dr. Brady was a long-time devoted member of the ASP, and generously provided an endowment that funds trav- served as the Society’s 11th president (1970- el grants for graduate students to attend ASP an- 1971) as well as being an Honorary Mem- nual meetings. With this additional monetary gift ber (1991) and a member of the Journal from his estate, he has further strengthened his of Natural Products Editorial Advisory enduring legacy and helped to enable the contin- Board for nearly two decades. ued success and vision of the ASP. This extraordinary ASPF contribu- Dr. Brady possessed an unswerv- tion was unexpected, because Dr. ing commitment to educating and Brady had so generously given supporting future pharmacists to the ASP during his life- and researchers. After his time, and Mrs. -
National Implementation Plan (Nip) 2010 – 2025
NATIONAL IMPLEMENTATION PLAN OF THE STOCKHOLM CONVENTION ON PERSISTENT ORGANIC POLLUTANTS. GUATEMALA 2009. NATIONAL IMPLEMENTATION PLAN (NIP) 2010 – 2025 MINISTRY OF ENVIRONMENT AND NATURAL RESOURCES OFFICE OF ENVIRONMENT AND NATURAL RESOURCES VICE OFFICE OF ENVIRONMENT ENVIRONMENTALLY SOUND MANAGEMENT OF CHEMICALS AND HAZARDOUS WASTES COORDINATION UNIT [i] NATIONAL IMPLEMENTATION PLAN OF THE STOCKHOLM CONVENTION ON PERSISTENT ORGANIC POLLUTANTS. GUATEMALA 2009. NATIONAL IMPLEMENTATION PLAN (NIP) ON PERSISTENT ORGANIC POLLUTANTS 2010-2025 PROJECT No. GF/GUA/02/015 “TRAINING ACTIVITIES TO FACILITATE THE IMPLENTATION OF THE STOCKHOLM CONVENTION ON PERSISTENT ORGANIC POLLUTANTS” NATIONAL AUTHORITIES Ministry of Environment and Natural Resources - MARN Minister Dr. Luis Alberto Ferraté Felice Ministry of Foreign Affairs – MINEX - Minister Dr. Roger Haroldo Rodas Melgar Ministry of Public Health and Social Assistance – MSPAS Minister Dr. Ludwig Werner Ovalle Cabrera Ministry of Agriculture, Livestock and Food – MAGA Minister Ing. Juan Alfonso de León Ministry of Energy and Mines – MEM Minister Ing. Alfredo Américo Pokus Yaquián Ministry of National Defense - MINDEF Minister General of Division Abraham Valenzuela González Ministry of Education – MINEDUC Minister Lic. Denis Alonso Mazariegos Ministry of Economy - MINECO Minister Lic. Erick Haroldo Coyoy Echeverría Ministry of Labour and Social Security - MINTRAB Minister Lic. Mario Roberto Illescas Aguirre Ministry of Public Finances – MINFIN Minister Lic. Alfredo Rolando del Cid Pinillos Ministry of Communication, Infraestructure and Housing - MICIVI Minister Lic. Jesús Insua Ramazzinni [ii] NATIONAL IMPLEMENTATION PLAN OF THE STOCKHOLM CONVENTION ON PERSISTENT ORGANIC POLLUTANTS. GUATEMALA 2009. NATIONAL PROJECT COORDINATOR Ing. Agr. Ana Dolores Arévalo Morales NATIONAL COORDINATION UNIT CONSULTING TEAM Ing. Ruth Portillo, Ing. Wendy Pineda Dra. Olga Pinto, Msc. -
Toxicity of Metal Containing Micro- and Nanoparticles
From THE DEPARTMENT OF BIOSCIENCES AND NUTRITION Karolinska Institutet, Stockholm, Sweden TOXICITY OF METAL CONTAINING MICRO- AND NANOPARTICLES - Studies from an inhalation perspective Johanna Kain Stockholm 2013 All previously published papers were reproduced with permission from the publisher. Cover photo: SEM picture of stainless steel particles 316L (investigated in study IV), taken by the colleagues at the Division for Surface and Corrosion Science at the Royal Institute of Technology (KTH) in Stockholm, Sweden. Published by Karolinska Institutet. © Johanna Kain, 2013 ISBN 978-91-7549-240-7 Printed by 2013 Gårdsvägen 4, 169 70 Solna To those who are closest to my heart; To my lovely family and dearest friends Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less. /Marie Curie* * Marie Curie (1867 – 1934), Scientist and the first woman to be awarded a Nobel Prize (1903, in Physics). She was also the first person ever to get the award a second time (1911, in Chemistry). ABSTRACT Particles in urban environments have for a long time been associated with different health problems and diseases, such as worsening of asthma and chronic obstructive pulmonary disease as well as cancer and cardiovascular diseases. In addition, metal containing particles present in occupational settings and industries, particularly particles produced during welding, have been linked to several adverse health effects. In recent years it has also become obvious that humans get exposed to metal containing particles in subway systems although possible health effects of such exposure is unknown. Furthermore, engineered nanoparticles (often containing metals) are increasingly being used within various applications including consumer products, thus constituting a risk for human exposure. -
CONICYT Ranking Por Disciplina > Sub-Área OECD (Académicas) Comisión Nacional De Investigación 1
CONICYT Ranking por Disciplina > Sub-área OECD (Académicas) Comisión Nacional de Investigación 1. Ciencias Naturales > 1.6 Ciencias Biológicas Científica y Tecnológica PAÍS INSTITUCIÓN RANKING PUNTAJE USA Harvard University 1 5,000 USA Massachusetts Institute of Technology (MIT) 2 5,000 UNITED KINGDOM University of Oxford 3 5,000 USA Stanford University 4 5,000 UNITED KINGDOM University of Cambridge 5 5,000 USA Johns Hopkins University 6 5,000 USA University of California San Francisco 7 5,000 USA University of Washington Seattle 8 5,000 UNITED KINGDOM University College London 9 5,000 USA Cornell University 10 5,000 CANADA University of Toronto 11 5,000 USA University of Pennsylvania 12 5,000 USA University of California San Diego 13 5,000 DENMARK University of Copenhagen 14 5,000 USA University of Michigan 15 5,000 USA University of California Berkeley 16 5,000 USA University of California Los Angeles 17 5,000 USA Duke University 18 5,000 USA University of California Davis 19 5,000 UNITED KINGDOM Imperial College London 20 5,000 USA Columbia University 21 5,000 USA Yale University 22 5,000 USA University of Minnesota Twin Cities 23 5,000 FRANCE Universite Paris Saclay (ComUE) 24 5,000 USA University of North Carolina Chapel Hill 25 5,000 AUSTRALIA University of Queensland 26 5,000 AUSTRALIA University of Melbourne 27 5,000 USA Washington University (WUSTL) 28 5,000 NETHERLANDS Utrecht University 29 5,000 USA University of Wisconsin Madison 30 5,000 FRANCE Sorbonne Universite 31 5,000 SWEDEN Karolinska Institutet 32 5,000 USA University -
CONICYT Ranking Por Disciplina > Sub-Área OECD (Académicas) Comisión Nacional De Investigación 2
CONICYT Ranking por Disciplina > Sub-área OECD (Académicas) Comisión Nacional de Investigación 2. Ingeniería y Tecnología > 2.11 Otras Ingenierías y Tecnologías Científica y Tecnológica PAÍS INSTITUCIÓN RANKING PUNTAJE INDIA Indian Institute of Technology System (IIT System) 1 5,000 CHINA Harbin Institute of Technology 2 5,000 FRANCE Universite Paris Saclay (ComUE) 3 5,000 CHINA Tsinghua University 4 5,000 GERMANY Technical University of Munich 5 5,000 CHINA Zhejiang University 6 5,000 CHINA Shanghai Jiao Tong University 7 5,000 CHINA Beihang University 8 5,000 SINGAPORE Nanyang Technological University & National Institute of Education 9 5,000 CHINA Huazhong University of Science & Technology 10 5,000 SWITZERLAND ETH Zurich 11 5,000 USA University of California Berkeley 12 5,000 USA Massachusetts Institute of Technology (MIT) 13 5,000 ITALY Polytechnic University of Milan 14 5,000 ITALY University of Naples Federico II 15 5,000 USA University of Maryland College Park 16 5,000 IRAN Islamic Azad University 17 5,000 CHINA South China University of Technology 18 5,000 USA Stanford University 19 5,000 ITALY University of Bologna 20 5,000 SINGAPORE National University of Singapore 21 5,000 USA University of Wisconsin Madison 22 5,000 CHINA Jiangnan University 23 5,000 USA California Institute of Technology 24 5,000 USA Purdue University 25 5,000 BELGIUM Ghent University 26 5,000 USA University of Michigan 27 5,000 NETHERLANDS Wageningen University & Research 28 5,000 GERMANY RWTH Aachen University 29 5,000 BELGIUM KU Leuven 30 5,000 CHINA Wuhan