The Alien Hand Syndrome: Classification of Forms Reported and Discussion of a New Condition
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Alien Limb in the Corticobasal Syndrome: Phenomenological Characteristics and Relationship to Apraxia
Journal of Neurology https://doi.org/10.1007/s00415-019-09672-8 ORIGINAL COMMUNICATION Alien limb in the corticobasal syndrome: phenomenological characteristics and relationship to apraxia David J. Lewis‑Smith1,2,3 · Noham Wolpe1,4 · Boyd C. P. Ghosh1,5 · James B. Rowe1,4,6 Received: 13 September 2019 / Revised: 8 December 2019 / Accepted: 9 December 2019 © The Author(s) 2020 Abstract Alien limb refers to movements that seem purposeful but are independent of patients’ reported intentions. Alien limb often co-occurs with apraxia in the corticobasal syndrome, and anatomical and phenomenological comparisons have led to the suggestion that alien limb and apraxia may be causally related as failures of goal-directed movements. Here, we characterised the nature of alien limb symptoms in patients with the corticobasal syndrome (n = 30) and their relationship to limb apraxia. Twenty-fve patients with progressive supranuclear palsy Richardson syndrome served as a disease control group. Structured examinations of praxis, motor function, cognition and alien limb were undertaken in patients attending a regional specialist clinic. Twenty-eight patients with corticobasal syndrome (93%) demonstrated signifcant apraxia and this was often asym- metrical, with the left hand preferentially afected in 23/30 (77%) patients. Moreover, 25/30 (83%) patients reported one or more symptoms consistent with alien limb. The range of these phenomena was broad, including changes in the sense of ownership and control as well as unwanted movements. Regression analyses showed no signifcant association between the severity of limb apraxia and either the occurrence of an alien limb or the number of alien limb phenomena reported. -
THE CLINICAL ASSESSMENT of the PATIENT with EARLY DEMENTIA S Cooper, J D W Greene V15
J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.2005.081133 on 16 November 2005. Downloaded from THE CLINICAL ASSESSMENT OF THE PATIENT WITH EARLY DEMENTIA S Cooper, J D W Greene v15 J Neurol Neurosurg Psychiatry 2005;76(Suppl V):v15–v24. doi: 10.1136/jnnp.2005.081133 ementia is a clinical state characterised by a loss of function in at least two cognitive domains. When making a diagnosis of dementia, features to look for include memory Dimpairment and at least one of the following: aphasia, apraxia, agnosia and/or disturbances in executive functioning. To be significant the impairments should be severe enough to cause problems with social and occupational functioning and the decline must have occurred from a previously higher level. It is important to exclude delirium when considering such a diagnosis. When approaching the patient with a possible dementia, taking a careful history is paramount. Clues to the nature and aetiology of the disorder are often found following careful consultation with the patient and carer. A focused cognitive and physical examination is useful and the presence of specific features may aid in diagnosis. Certain investigations are mandatory and additional tests are recommended if the history and examination indicate particular aetiologies. It is useful when assessing a patient with cognitive impairment in the clinic to consider the following straightforward questions: c Is the patient demented? c If so, does the loss of function conform to a characteristic pattern? c Does the pattern of dementia conform to a particular pattern? c What is the likely disease process responsible for the dementia? An understanding of cognitive function and its anatomical correlates is necessary in order to ascertain which brain areas are affected. -
Association of Ideomotor Apraxia with Frontal Gray Matter Volume Loss in Corticobasal Syndrome
ORIGINAL CONTRIBUTION Association of Ideomotor Apraxia With Frontal Gray Matter Volume Loss in Corticobasal Syndrome Edward D. Huey, MD; Matteo Pardini, MD; Alyson Cavanagh, BS; Eric M. Wassermann, MD; Dimitrios Kapogiannis, MD; Salvatore Spina, MD; Bernardino Ghetti, MD; Jordan Grafman, PhD Objective: To determine the brain areas associated with matter volume in the left supplemental motor area, pre- specific components of ideomotor apraxia (IMA) in cor- motor cortex, and caudate nucleus of patients with CBS. ticobasal syndrome (CBS). The overall degree of apraxia was independent of the side of motor impairment. Praxis to imitation (vs command) Design: Case-control and cross-sectional study. was particularly impaired in the patients with CBS. Pa- tients demonstrated equal impairment in transitive and Participants: Forty-eight patients with CBS and 14 con- intransitive praxis. trol subjects. Conclusions: In patients with CBS, IMA is associated with Intervention: Administration of the Test of Oral and left posterior frontal cortical and subcortical volume loss. Limb Apraxia. Despite showing left frontal volume loss associated with IMA, patients with CBS have particularly impaired imita- Main Outcome Measures: Differences between pa- tion of gestures. These findings suggest either that the IMA tients with CBS and healthy controls and associations be- of CBS affects a route of praxis that bypasses motor en- tween areas of gray matter volume and IMA determined grams or that motor engrams are affected but that they ex- by voxel-based morphometry -
Alien Hand Syndrome: a Neurological Disorder of Will
Review article Alien hand syndrome: a neurological disorder of will Leonardo Saccoa,Pasquale Calabreseb, c, d a Reparto di Neurologia, Azienda Ospedaliera Sant’Anna, Como, Italia b Neurologische Klinik, Kantonsspital Basel, Switzerland c Neurocentro(EOC) della Svizzera Italiana, Ospedale Civico, Lugano, Switzerland d Abteilung f. allgemeine Psychologie und Methodologie, Universität Basel, Switzerland No conflict of interest to declare. Summary Introduction Sacco L, Calabrese P. Alien hand syndrome: a neurological disorder of will. Schweiz Alien hand syndrome (AHS) is a neurological disorder in Arch Neurol Psychiatr. 2010;161(2):60–3. which movement is performed without awareness or con- Alien hand syndrome (AHS) is a neurological disorder in which move- scious will. The phenomena of awareness or consciousness ments are performed without awareness or conscious will. Phenomena like is still poorly studied in physiology and has only become awareness or consciousness are still poorly studied in physiology and have a crucial topic for neuroscience in the last few years [1]. only become a crucial topic in neuroscience in the last few years. Pertinent There are two principal theories about consciousness. While experiments in which the volitional control of a movement was studied dualistic views think that the brain and mind are separate unanimously, demonstrate that movements are initiated before conscious- entities, the monistic perspective supports the idea that there ness occurs. By doing so, the brain adopts internal anticipatory models of is only one ultimate substance or principle governing our voluntary action. Several studies suggest that the parietal cortex is important mind, assuming the latter to be a product of the brain. -
Apraxia Neurology, Neuropsychology and Rehabilitation
Apraxia Neurology, Neuropsychology and Rehabilitation Jon Marsden Professor of Rehabilitation School of Health Professions Tool Use D. Stout, T. Chaminade / Neuropsychologia 45 (2007) 1091–1100 http://www.bradshawfoundation.com/origins/oldowan_stone_tools.php Action Steams in the Brain Apraxia Definitions, Prevalence and Impact Ideomotor Ideational Apraxia Apraxia Rehabilitation and Recovery of Apraxia Action Streams in the Brain What and How in the Visual System Posterior Parietal Cortex Dorsal stream Primary /Secondary Retina LGNd Visual Cortex Ventral stream Inferotemporal cortex Goodale et al (1996) In Hand and Brain. Visuomotor Control REACHING GRASPING PE-F2 AIP-F5 Directional Transforming visual Coding to objects intrinsic In extra-personal Object attributes into Space Motor commands Superior Longitudinal Fasciculus Rizzolatti and Luppino TOOL MANPULATION (2001), Neuron 31 889-901 VIP-F4 Bimodal receptive fields Sensorimotor Transformation RF altered by tool use in Parieto-Frontal Circuits Modification of Body Schema by Tools Visual receptive Field Somatosensory Receptive Field Inter-parietal Neurons Maravita and Iriki 204 TICS 79-86 Action Streams in the brain Bilateral Dorso-dorsal system “Grasp” (actions to visual targets) X2 action systems Vs ventral and Left lateralised Ventrodorsal dorsal stream system Interaction “Use” devoted to skilled functional Adapted from Liepmann 1920 Binkofski et al 2013 Brain and Language 127 22-229 object use What Is Apraxia Definitions, Prevalence and Impact What is Apraxia? A disorder of skilled -
Functional Brain Imaging in Apraxia
OBSERVATION Functional Brain Imaging in Apraxia David A. Kareken, PhD; Frederick Unverzagt, PhD; Karen Caldemeyer, MD; Martin R. Farlow, MD; Gary D. Hutchins, PhD Background: An extensive literature describes struc- sults of the neurological examination were normal. There tural lesions in apraxia, but few studies have used func- was ideomotor apraxia of both hands (command, imita- tional neuroimaging. We used positron emission tomog- tion, and object) and buccofacial apraxia. The patient raphy (PET) to characterize relative cerebral glucose could recognize meaningful gestures performed by the metabolism in a 65-year-old, right-handed woman with examiner and discriminate between his accurate and awk- progressive decline in ability to manipulate objects, write, ward pantomime. The magnetic resonance image showed and articulate speech. moderate generalized atrophy and mild ischemic changes. Positron emission tomographic scans showed abnormal Objective: To characterize functional brain organiza- fludeoxyglucose F 18 uptake in the posterior frontal, tion in apraxia. supplementary motor, and parietal regions, the left af- fected more than the right. Focal metabolic deficit was Design and Methods: The patient underwent a neu- present in the angular gyrus, an area hypothesized to store rological examination, neuropsychological testing, mag- conceptual knowledge of skilled movement. netic resonance imaging, and fludeoxyglucose F 18 PET. The patient’s magnetic resonance image was coregis- Conclusions: Greater parietal than frontal physiologi- tered to her PET image, which was compared with the cal dysfunction and preserved gesture recognition are not PET images of 7 right-handed, healthy controls. Hemi- consistent with the theory that knowledge of limb praxis spheric regions of interest were normalized by calcrine is stored in the dominant parietal cortex. -
A Model Based Approach to Apraxia in Parkinson's Disease
A Model Based Approach to Apraxia in Parkinson’s Disease by Lauren King A thesis presented to the University of Waterloo in fulfillment of the thesis requirement for the degree of Master of Science in Kinesiology Waterloo, Ontario, Canada, 2010 © Lauren King 2010 AUTHOR'S DECLARATION I hereby declare that I am the sole author of this thesis. This is a true copy of the thesis, including any required final revisions, as accepted by my examiners. I understand that my thesis may be made electronically available to the public. ii ABSTRACT This thesis provides new insight into how learned skilled movements are affected in a disease with basal ganglia damage, within what task demands these deficits can be detected, and how this detection can occur within the constraints of primary motor symptoms. Hence the purpose of this thesis was threefold. Firstly, the aim was to take a model-based approach to apraxia in PD, in order to determine the nature of the errors in reference to other populations that experience apraxia. Apraxia by definition cannot be the product of primary motor deficits, weakness, sensory loss, or lack of comprehension, therefore the second objective of the study was to detect apraxia while remaining true to these prerequisites. The third objective was to extend the examination of apraxia beyond the upper limbs, and investigate the relationship between upper limb and lower limb apraxia, as well as the relationship between freezing (which shares similarities with gait apraxia) and upper limb and lower apraxia. Overall, the most common pattern of apraxia identified in this PD group was impairment at both pantomime and imitation, suggesting issues with executive function. -
The Nature of Apraxia in Corticobasal Degeneration
Journal ofNeurology, Neurosurgery, and Psychiatry 1994;57:455-459 455 The nature of apraxia in corticobasal J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.57.4.455 on 1 April 1994. Downloaded from degeneration R Leiguarda, A J Lees, M Merello, S Starkstein, C D Marsden Abstract shows a combination of parietal and frontal Although apraxia is one of the most fre- hypometabolism and an asymmetrical quent signs in corticobasal degeneration, decrease of fluorodopa uptake in the striatum the phenomenology of this disorder has and medial frontal cortex.378 not been formally examined. Hence 10 When fully developed, the disorder has a patients with corticobasal degeneration distinctive clinical picture, but the initial were studied with a standardised evalua- manifestations of basal ganglia dysfunction tion for different types of apraxia. To may be confused with other akinetic-rigid minimise the confounding effects of the syndromes. Therefore, findings such as primary motor disorder, apraxia was apraxia are essential for the clinical assessed in the least affected limb. diagnosis.' 57 Whereas none of the patients showed The pathological process in corticobasal buccofacial apraxia, seven showed degeneration affects many brain structures deficits on tests ofideomotor apraxia and involved in praxic functions (parietal and movement imitation, four on tests of non-primary motor cortex). Apraxia has been sequential arm movements (all of whom described in about 80% of patients, but the had ideomotor apraxia), and three on nature of this deficit has not been systemati- tests of ideational apraxia (all of whom cally examined.'- We have tested 10 patients had ideomotor apraxia). Ideomotor with corticobasal degeneration for the pres- apraxia significantly correlated with ence of buccofacial apraxia, ideomotor deficit in both the mini mental state apraxia, and ideational apraxia, and have cor- examination and in a task sensitive to related these phenomena with other cardinal frontal lobe dysfunction (picture features of the disorder. -
Supernumerary Phantom Limbs in Spinal Cord Injury
Spinal Cord (2011) 49, 588–595 & 2011 International Spinal Cord Society All rights reserved 1362-4393/11 $32.00 www.nature.com/sc REVIEW Supernumerary phantom limbs in spinal cord injury A Curt1, C Ngo Yengue1, LM Hilti2 and P Brugger2 1Spinal Cord Injury Centre, University Hospital Balgrist, University of Zu¨rich, Zurich, Switzerland and 2Department of Neurology, University Hospital, Zurich, Switzerland Study design and objectives: Case report and review of supernumerary phantom limbs in patients suffering from spinal cord injury (SCI). Setting: SCI rehabilitation centre. Case report: After a ski accident, a 71-year-old man suffered an incomplete SCI (level C3; AIS C, central cord syndrome), with a C3/C4 dislocation fracture. From the first week after injury, he experienced a phantom duplication of both upper limbs that lasted for 7 months. The supernumerary limbs were only occasionally related to painful sensation, specifically when they were perceived as crossed on his trunk. Although the painful sensations were responsive to pain medication, the presence of the illusory limb sensations were persistent. During neurological recovery, the supernumerary limbs gradually disappeared. A rubber hand illusion paradigm was used twice during recovery to monitor the patient’s ability to integrate visual, tactile and proprioceptive stimuli. Conclusion: Overall, the clinical relevance of supernumerary phantom limbs is not clear, specific treatment protocols have not yet been developed, and the underlying neural mechanisms are not fully understood. Supernumerary phantom limbs have been previously reported in patients with (sub)cortical lesions, but might be rather undocumented in patients suffering from traumatic SCI. For the appropriate diagnosis and treatment after SCI, supernumerary phantoms should be distinguished from other phantom sensations and pain syndromes after SCI. -
Video Abstracts Arm Levitation As Initial Manifestation of Creutzfeldt–Jakob Disease: Case Report and Review of the Literature
Freely available online Video Abstracts Arm Levitation as Initial Manifestation of Creutzfeldt–Jakob Disease: Case Report and Review of the Literature 1 1,2 3 1,2* Vinı´cius Boaratti Ciarlariello , Orlando G. P. Barsottini , Alberto J. Espay & Jose´ Luiz Pedroso 1 Department of Neurology, Hospital Israelita Albert Einstein, Sa˜o Paulo, SP, BR, 2 Department of Neurology, Ataxia Unit, Universidade Federal de Sa˜o Paulo, Sa˜o Paulo, SP, BR, 3 Department of Neurology, University of Cincinnati, Cincinnati, OH, USA Abstract Background: Arm levitation is an involuntary elevation of the upper limb, a manifestation of the alien-limb phenomenon. It has rarely been reported in Creutzfeldt–Jakob disease (CJD), less so as an initial manifestation Case Report: We report a 56-year-old right-handed man with rapidly progressive gait ataxia and involuntary elevation of the left upper limb. During the next few weeks, the patient developed cognitive impairment, apraxia, visual hallucinations, and myoclonus. He met diagnostic criteria for CJD. We evaluated additional published cases of early-appearance of alien-limb phenomenon in the context of CJD; there were 22 such cases and alien-limb phenomenon was the first and exclusive manifestation in only five of them. Discussion: Arm levitation may be a distinct presentation of CJD, appearing earlier than other clinical features. Keywords: Arm levitation, alien-limb phenomenon, acute ataxia, Creutzfeldt–Jakob disease, movement disorders Citation: CiarlarielloVB,BarsottiniOGP,EspayAJ,PedrosoJL.Armlevitationasinitial manifestation of Creutzfeldt–Jakob disease: case report and review of the literature. Tremor Other Hyperkinet Mov. 2018; 8. doi: 10.7916/D80C6CGX * To whom correspondence should be addressed. -
Pathophysiology and Treatment of Alien Hand Syndrome
Freely available online Reviews Pathophysiology and Treatment of Alien Hand Syndrome 1* 2 3 Harini Sarva , Andres Deik & William Lawrence Severt 1 Department of Neurology, Maimonides Medical Center, New York, NY, USA, 2 Parkinson Disease and Movement Disorders Center, Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA, 3 Department of Neurology, Maimonides Medical Center, Brooklyn, NY, USA Abstract Background: Alien hand syndrome (AHS) is a disorder of involuntary, yet purposeful, hand movements that may be accompanied by agnosia, aphasia, weakness, or sensory loss. We herein review the most reported cases, current understanding of the pathophysiology, and treatments. Methods: We performed a PubMed search in July of 2014 using the phrases ‘‘alien hand syndrome,’’ ‘‘alien hand syndrome pathophysiology,’’ ‘‘alien hand syndrome treatment,’’ and ‘‘anarchic hand syndrome.’’ The search yielded 141 papers (reviews, case reports, case series, and clinical studies), of which we reviewed 109. Non-English reports without English abstracts were excluded. Results: Accumulating evidence indicates that there are three AHS variants: frontal, callosal, and posterior. Patients may demonstrate symptoms of multiple types; there is a lack of correlation between phenomenology and neuroimaging findings. Most pathologic and functional imaging studies suggest network disruption causing loss of inhibition as the likely cause. Successful interventions include botulinum toxin injections, clonazepam, visuospatial coaching techniques, distracting the affected hand, and cognitive behavioral therapy. Discussion: The available literature suggests that overlap between AHS subtypes is common. The evidence for effective treatments remains anecdotal, and, given the rarity of AHS, the possibility of performing randomized, placebo-controlled trials seems unlikely. As with many other interventions for movement disorders, identifying the specific functional impairments caused by AHS may provide the best guidance towards individualized supportive care. -
A Dictionary of Neurological Signs.Pdf
A DICTIONARY OF NEUROLOGICAL SIGNS THIRD EDITION A DICTIONARY OF NEUROLOGICAL SIGNS THIRD EDITION A.J. LARNER MA, MD, MRCP (UK), DHMSA Consultant Neurologist Walton Centre for Neurology and Neurosurgery, Liverpool Honorary Lecturer in Neuroscience, University of Liverpool Society of Apothecaries’ Honorary Lecturer in the History of Medicine, University of Liverpool Liverpool, U.K. 123 Andrew J. Larner MA MD MRCP (UK) DHMSA Walton Centre for Neurology & Neurosurgery Lower Lane L9 7LJ Liverpool, UK ISBN 978-1-4419-7094-7 e-ISBN 978-1-4419-7095-4 DOI 10.1007/978-1-4419-7095-4 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010937226 © Springer Science+Business Media, LLC 2001, 2006, 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made.