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ERC Advanced Grant 2008 Project Acronym Title Principal Investigator Host Institution Host Country 226037 NSYS Nonlinear System
ERC Advanced Grant 2008 Project Acronym Title Principal Investigator Host Institution Host Country Nonlinear System Identification and Analysis in the Time, Prof. Stephen Alec 226037 NSYS THE UNIVERSITY OF SHEFFIELD UK Frequency, and Spatio-Temporal Domains Billings HOWTOCONT Search for mechanisms to control massless electrons in 226043 ROLGRAPHE Prof. Carlo Beenakker UNIVERSITEIT LEIDEN. NL graphene NE THE HEBREW UNIVERSITY OF 226135 EXPANDERS Expander Graphs in Pure and Applied Mathematics Prof. Alexander Lubotzky IL JERUSALEM. 226136 VISCHEM Visualizing Molecular Change Prof. Villy Sundström LUNDS UNIVERSITET SE Consistent computation of the chemistry-cloud THE CYPRUS RESEARCH AND 226144 C8 Prof. Johannes Lelieveld CY continuum and climate change in Cyprus EDUCATIONAL FOUNDATION Modern Approaches to Temperature Reconstructions in 226172 MATRICS Dr. Hubertus Fischer UNIVERSITAET BERN CH polar Ice Cores FUndamental studies and innovative appROaches of Prof. Roland Martin 226180 FURORE UNIVERSITAET HAMBURG DE REsearch on magnetism Wiesendanger EBERHARD KARLS 226187 SOCATHES Solid State/Cold Atom Hybrid Quantum Devices Prof. Reinhold Kleiner DE UNIVERSITAET TUEBINGEN KUNGLIGA TEKNISKA 226203 APPROXNP Approximation of NP-hard optimization problems Prof. Johan Håstad SE HOEGSKOLAN Patchy colloidal particles: a powerful arsenal for the PATCHYCOLL fabrication of tomorrow new super-molecules . A UNIVERSITA DEGLI STUDI DI 226207 Prof. Francesco Sciortino IT OIDS theoretical and numerical study of their assembly ROMA LA SAPIENZA processes. ERC Advanced Grant 2008 Analytic Techniques for Geometric and Functional UNIVERSITA DEGLI STUDI DI 226234 ANTEGEFI Prof. Nicola Fusco IT Inequalities NAPOLI FEDERICO II. Multiscale Models for Catalytic-Reaction-Coupled 226238 MMFCS Prof. Bengt Sundén LUNDS UNIVERSITET SE Transport Phenomena in Fuel Cells WEIZMANN INSTITUTE OF 226246 NANOSQUID Scanning Nano-SQUID on a Tip Prof. -
Macromolecular and Electrical Coupling Between Inner Hair Cells in the Rodent Cochlea
ARTICLE https://doi.org/10.1038/s41467-020-17003-z OPEN Macromolecular and electrical coupling between inner hair cells in the rodent cochlea Philippe Jean 1,2,3,4,14, Tommi Anttonen1,2,5,14, Susann Michanski2,6,7, Antonio M. G. de Diego8, Anna M. Steyer9,10, Andreas Neef11, David Oestreicher 12, Jana Kroll 2,4,6,7, Christos Nardis9,10, ✉ Tina Pangršič2,12, Wiebke Möbius 9,10, Jonathan Ashmore 8, Carolin Wichmann2,6,7,13 & ✉ Tobias Moser 1,2,3,5,10,13 1234567890():,; Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea and convey sound information to the brain via synapses with the auditory nerve. IHCs have been thought to be electrically and metabolically independent from each other. We report that, upon developmental maturation, in mice 30% of the IHCs are electrochemically coupled in ‘mini-syncytia’. This coupling permits transfer of fluorescently-labeled metabolites and macromolecular tracers. The membrane capacitance, Ca2+-current, and resting current increase with the number of dye-coupled IHCs. Dual voltage-clamp experiments substantiate low resistance electrical coupling. Pharmacology and tracer permeability rule out coupling by gap junctions and purinoceptors. 3D electron microscopy indicates instead that IHCs are coupled by membrane fusion sites. Consequently, depolarization of one IHC triggers pre- synaptic Ca2+-influx at active zones in the entire mini-syncytium. Based on our findings and modeling, we propose that IHC-mini-syncytia enhance sensitivity and reliability of cochlear sound encoding. 1 Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany. 2 Collaborative Research Center 889, University of Göttingen, Göttingen, Germany. -
Functional Effects Detailed Research Plan
GeCIP Detailed Research Plan Form Background The Genomics England Clinical Interpretation Partnership (GeCIP) brings together researchers, clinicians and trainees from both academia and the NHS to analyse, refine and make new discoveries from the data from the 100,000 Genomes Project. The aims of the partnerships are: 1. To optimise: • clinical data and sample collection • clinical reporting • data validation and interpretation. 2. To improve understanding of the implications of genomic findings and improve the accuracy and reliability of information fed back to patients. To add to knowledge of the genetic basis of disease. 3. To provide a sustainable thriving training environment. The initial wave of GeCIP domains was announced in June 2015 following a first round of applications in January 2015. On the 18th June 2015 we invited the inaugurated GeCIP domains to develop more detailed research plans working closely with Genomics England. These will be used to ensure that the plans are complimentary and add real value across the GeCIP portfolio and address the aims and objectives of the 100,000 Genomes Project. They will be shared with the MRC, Wellcome Trust, NIHR and Cancer Research UK as existing members of the GeCIP Board to give advance warning and manage funding requests to maximise the funds available to each domain. However, formal applications will then be required to be submitted to individual funders. They will allow Genomics England to plan shared core analyses and the required research and computing infrastructure to support the proposed research. They will also form the basis of assessment by the Project’s Access Review Committee, to permit access to data. -
Nature Medicine Essay
COMMENTARY LASKER BASIC MEDICAL RESEARCH AWARD Of maize and men, or peas and people: case histories to justify plants and other model systems David Baulcombe One of the byproducts of molecular biology cork is altogether filled with air, and that air is has been support for the ‘model system’ con- perfectly enclosed in little boxes or cells distinct cept. All living organisms are based on the same from one another.”)2 (Fig. 1). Two hundred fifty genetic code, they have similar subcellular years later, Beijerinck discovered a contagium structures and they use homologous metabolic vivum fluidum in extracts of diseased tobacco pathways. So, mechanisms can be investigated plants that he later referred to as a virus3. using organisms other than those in which In contemporary science, a green alga— the knowledge will be exploited for practical Chlamydomonas reinhardtii—is a useful model benefit. Model systems are particularly use- in the analysis of kidney disease4. However, ful in the early discovery phase of a scientific in this article, I refer to the contribution of endeavor, and recent progress in biomedical plant biology to a family of mechanisms that I science has fully vindicated their use. Jacques refer to as RNA silencing. This topic has been Monod, for example, famously justified his reviewed comprehensively elsewhere5,6, so here work on a bacterial model system by stating I focus on personal experience and my view of that “what is true for Escherichia coli is also future potential from this work. true for elephants.” My fellow laureates, Victor Ambros and Gary Ruvkun, can defend the use The early history of RNA silencing in of the worm Caenorhabditis elegans as a good plants model system and so I will focus on plants. -
Diversity Data Report 2019 Diversity Data Report 2019 Issued: November 2020 DES6507
Diversity data report 2019 Diversity data report 2019 Issued: November 2020 DES6507 The text of this work is licensed under the terms of the Creative Commons Attribution License which permits unrestricted use, provided the original author and source are credited. The license is available at: creativecommons.org/licenses/by/4.0 Images are not covered by this license. This report can be viewed online at: royalsociety.org/diversity Contents Introduction .....................................................4 The Fellowship ..................................................11 Committees, panels and working groups ..........................19 Research Fellowship Grants ......................................26 Scientific programmes ...........................................38 Public engagement .............................................50 Publishing ......................................................62 Schools engagement ............................................67 Royal Society staff ..............................................72 Gender pay gap .................................................75 Definitions .....................................................77 DIVERSITY DATA REPORT 2019 3 Introduction The Royal Society is a Fellowship of many of the world’s most eminent scientists and is the oldest scientific academy in continuous existence. The Society is committed to increasing sections of this report such as organisers, diversity in science, technology, engineering chairs and speakers at scientific meetings, and mathematics (‘STEM’) -
3718 Issue63july2010 1.Pdf
Issue 63.qxd:Genetic Society News 1/10/10 14:41 Page 1 JULYJULLYY 2010 | ISSUEISSUE 63 GENETICSGENNETICSS SOCIETYSOCIEETY NENEWSEWS In this issue The Genetics Society NewsNewws is edited by U Genetics Society PresidentPresident Honoured Honoured ProfProf David Hosken and items ittems for future future issues can be sent to thee editor,editor, preferably preferably U Mouse Genetics Meeting by email to [email protected],D.J.Hosken@@exeter.ac.uk, or U SponsoredSponsored Meetings Meetings hardhard copy to Chair in Evolutionary Evoolutionary Biology, Biology, UniversityUniversity of Exeter,Exeter, Cornwall Cornnwall Campus, U The JBS Haldane LectureLecture Tremough,Tremough, Penryn, TR10 0 9EZ UK.UK. The U Schools Evolutionn ConferenceConference Newsletter is published twicet a year,year, with copy dates of 1st June andand 26th November.November. U TaxiTaxi Drivers The British YeastYeaste Group Group descend on Oxford Oxford for their 2010 meeting: m see the reportreport on page 35. 3 Image © Georgina McLoughlin Issue 63.qxd:Genetic Society News 1/10/10 14:41 Page 2 A WORD FROM THE EDITOR A word from the editor Welcome to issue 63. In this issue we announce a UK is recognised with the award of a CBE in the new Genetics Society Prize to Queen’s Birthday Honours, tells us about one of Welcome to my last issue as join the medals and lectures we her favourite papers by Susan Lindquist, the 2010 editor of the Genetics Society award. The JBS Haldane Mendel Lecturer. Somewhat unusually we have a News, after 3 years in the hot Lecture will be awarded couple of Taxi Drivers in this issue – Brian and seat and a total of 8 years on annually to recognise Deborah Charlesworth are not so happy about the committee it is time to excellence in communicating the way that the print media deals with some move on before I really outstay aspects of genetics research to scientific issues and Chris Ponting bemoans the my welcome! It has been a the public. -
Fire Departments of Pathology and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Room L235, Stanford, CA 94305-5324, USA
GENE SILENCING BY DOUBLE STRANDED RNA Nobel Lecture, December 8, 2006 by Andrew Z. Fire Departments of Pathology and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Room L235, Stanford, CA 94305-5324, USA. I would like to thank the Nobel Assembly of the Karolinska Institutet for the opportunity to describe some recent work on RNA-triggered gene silencing. First a few disclaimers, however. Telling the full story of gene silencing would be a mammoth enterprise that would take me many years to write and would take you well into the night to read. So we’ll need to abbreviate the story more than a little. Second (and as you will see) we are only in the dawn of our knowledge; so consider the following to be primer... the best we could do as of December 8th, 2006. And third, please understand that the story that I am telling represents the work of several generations of biologists, chemists, and many shades in between. I’m pleased and proud that work from my labo- ratory has contributed to the field, and that this has led to my being chosen as one of the messengers to relay the story in this forum. At the same time, I hope that there will be no confusion of equating our modest contributions with those of the much grander RNAi enterprise. DOUBLE STRANDED RNA AS A BIOLOGICAL ALARM SIGNAL These disclaimers in hand, the story can now start with a biography of the first main character. Double stranded RNA is probably as old (or almost as old) as life on earth. -
Unfolding Plant Disease Resistance : the Involvement of HSP90 and Its Co- Chaperone PP5 in I-2-Mediated Signalling De La Fuente Van Bentem, S
UvA-DARE (Digital Academic Repository) Unfolding plant disease resistance : the involvement of HSP90 and its co- chaperone PP5 in I-2-mediated signalling de la Fuente van Bentem, S. Publication date 2005 Document Version Final published version Link to publication Citation for published version (APA): de la Fuente van Bentem, S. (2005). Unfolding plant disease resistance : the involvement of HSP90 and its co-chaperone PP5 in I-2-mediated signalling. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:05 Oct 2021 Unfolding plant disease resistance the involvement of HSP90 and its co-chaperone PP5 in I-2-mediated signalling ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam, op gezag van de Rector Magnificus prof. -
Summary Publication and Bibliometric Information: Total Number of Peer-Reviewed Publications: 15
CV Andreas Sebastian Marquardt Education: 16/7/2010 Ph. D. in Biological Sciences, University of East Anglia, Norwich, UK. 2005 Diplom (M. Sc.) in Biochemistry, Free University Berlin, Berlin, Germany. 2002-2005 Undergraduate studies in Biochemistry at Free University Berlin, Berlin, Germany. 1999-2002 Undergraduate studies in Biochemistry at University of Tübingen, Tübingen, Germany. Employment: Jan. 2018 – Tenured Associate Professor, University of Copenhagen, Copenhagen Plant Science Centre (CPSC), Denmark. Leader of non-coding transcription group. 2015 - 2017 Assistant Professor, University of Copenhagen, Copenhagen Plant Science Centre (CPSC), Denmark. Leader of non-coding transcription group. 2012 - 2014 Visiting Scientist at Whitehead Institute for Biomedical Research, MIT, Cambridge, USA. Topic: Arabidopsis epigenetics & Pol II kinetics, with Prof. Mary Gehring. 2010 - 2014 Postdoc at the Harvard Medical School (HMS), Boston, USA. Topic: chromatin-based lncRNA repression in budding yeast with Prof. Steve Buratowski. 2006 - 2009 Ph. D. thesis research with Prof. Caroline Dean at John Innes Centre (JIC), Norwich, UK. Topic: lncRNA-mediated chromatin regulation of Arabidopsis flowering. 2005-2006 Ph. D. rotation projects with: Prof. David Baulcombe, Dr. Sean Walsh and Prof. Caroline Dean. 2004-2005 Diplom thesis research with Prof. Arp Schnittger at Max-Planck Institute (MPI) for Plant Breeding Research, Cologne, Germany. Summary publication and bibliometric information: Total number of peer-reviewed publications: 15. First author publications: 6 (e.g. Science, Cell, Mol. Cell). Corresponding author publications: 5 (e.g. Nat. Commun, eLife, PLoS Gen). Last author publications: 5 (e.g. Nat. Commun, eLife, PLoS Gen). Citations: 1309 source, H-index: 21: https://scholar.google.com/citations?user=_miZw7oAAAAJ&hl=en ). -
Autumn 2005 SCIENCE in PARLIAMENT
Autumn 2005 SCIENCE IN PARLIAMENT State of the Nation Plastic Waste Private Finance Initiative Visions of Science Airbus Launches the New A350 The Journal of the Parliamentary and Scientific Committee http://www.scienceinparliament.org.uk THE STATE OF THE NATION 2005 An assessment of the UK’s infrastructure by the Institution of Civil Engineers PUBLISHED 18 OCTOBER 2005 About the Institution of Civil Engineers About the report As a professional body, the The State of the Nation Report For more information on the Institution of Civil Engineers (ICE) is compiled each year by a panel background to the State of the is one of the most important of civil engineering experts. The Nation Report, contact ICE sources of professional expertise report’s aim is to stimulate debate External Relations: in road and rail transport, water and to highlight the actions that supply and treatment, flood ICE believes need to be taken to t +44 (0)20 7665 2151 management, waste and energy – improve the UK’s infrastructure. e [email protected] our infrastructure. Established in It has been produced since 2000. w www.uk-infrastructure.org.uk 1818, it has over 75,000 members This year, six regional versions throughout the world – including of the State of the Nation Report – over 60,000 in the UK. covering Northern Ireland, Scotland, Wales as well as the North West, South West and West Midlands of England – are being produced, in conjunction with the UK-wide publication. To read the complete report please visit www.uk-infrastructure.org.uk Registered Charity No. -
IEB at 50: a Scientific Timeline
IEB at 50: a scientific timeline Alcalá de Henares, 12 September 2013, Jonathan Ashmore When the Inner Ear Biochemistry Workshop started in 1964, we knew of giants who had given us some the key ideas. They included Alfonso Corti Robert Barany Georg von Bekesy Halliwell Davis and many others…… What science had happened be fore the workshop started? 1 Elsewhere we had seen the birth of molecular biology “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying method for the genetic material.” Elsewhere: we had seen the birth of cellular biophysics Alan Hodgkin and Andrew Huxley J. Physiol 1952 2 As Jochen Schact describes, Sigurd Rauch convened the first workshop to enable a research interface between clinicians and biochemists: Sigurd Rauch Invitation: 1st Workshop November 6 & 7, 1964 To be followed in 1965 by a 2nd Workshop on Inner Ear Biochemistry Topics Mucopolysaccharides in the inner ear Inner ear fluids: composition, secretion and absorption Membrane problems : electron microscopy and electrophysiology Ototoxicity: pharmacology and pathology 3 How the 1965 discussions were divided up Mucopolysaccharides Ototoxicity Electrophysiology and electron microscopy Inner ear fluids Timelines : 1964 1st Workshop on Inner Ear Biochemistry 1968 5th Workshop on Inner Ear Biology SfN 1971 ARO 1976 MoH 1980 MBHD 1992 2013 4 How has inner ear biology developed? Here are (some!) enabling technologies 1950s - Electron microscopy 1960s - Recording from nerves and cells (1976 – low noise patch -
The Role of Potassium Recirculation in Cochlear Amplification
The role of potassium recirculation in cochlear amplification Pavel Mistrika and Jonathan Ashmorea,b aUCL Ear Institute and bDepartment of Neuroscience, Purpose of review Physiology and Pharmacology, UCL, London, UK Normal cochlear function depends on maintaining the correct ionic environment for the Correspondence to Jonathan Ashmore, Department of sensory hair cells. Here we review recent literature on the cellular distribution of Neuroscience, Physiology and Pharmacology, UCL, Gower Street, London WC1E 6BT, UK potassium transport-related molecules in the cochlea. Tel: +44 20 7679 8937; fax: +44 20 7679 8990; Recent findings e-mail: [email protected] Transgenic animal models have identified novel molecules essential for normal hearing Current Opinion in Otolaryngology & Head and and support the idea that potassium is recycled in the cochlea. The findings indicate that Neck Surgery 2009, 17:394–399 extracellular potassium released by outer hair cells into the space of Nuel is taken up by supporting cells, that the gap junction system in the organ of Corti is involved in potassium handling in the cochlea, that the gap junction system in stria vascularis is essential for the generation of the endocochlear potential, and that computational models can assist in the interpretation of the systems biology of hearing and integrate the molecular, electrical, and mechanical networks of the cochlear partition. Such models suggest that outer hair cell electromotility can amplify over a much broader frequency range than expected from isolated cell studies. Summary These new findings clarify the role of endolymphatic potassium in normal cochlear function. They also help current understanding of the mechanisms of certain forms of hereditary hearing loss.