ERC Advanced Grant 2008 Project Acronym Title Principal Investigator Host Institution Host Country 226037 NSYS Nonlinear System
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Nature Medicine Essay
COMMENTARY LASKER BASIC MEDICAL RESEARCH AWARD Of maize and men, or peas and people: case histories to justify plants and other model systems David Baulcombe One of the byproducts of molecular biology cork is altogether filled with air, and that air is has been support for the ‘model system’ con- perfectly enclosed in little boxes or cells distinct cept. All living organisms are based on the same from one another.”)2 (Fig. 1). Two hundred fifty genetic code, they have similar subcellular years later, Beijerinck discovered a contagium structures and they use homologous metabolic vivum fluidum in extracts of diseased tobacco pathways. So, mechanisms can be investigated plants that he later referred to as a virus3. using organisms other than those in which In contemporary science, a green alga— the knowledge will be exploited for practical Chlamydomonas reinhardtii—is a useful model benefit. Model systems are particularly use- in the analysis of kidney disease4. However, ful in the early discovery phase of a scientific in this article, I refer to the contribution of endeavor, and recent progress in biomedical plant biology to a family of mechanisms that I science has fully vindicated their use. Jacques refer to as RNA silencing. This topic has been Monod, for example, famously justified his reviewed comprehensively elsewhere5,6, so here work on a bacterial model system by stating I focus on personal experience and my view of that “what is true for Escherichia coli is also future potential from this work. true for elephants.” My fellow laureates, Victor Ambros and Gary Ruvkun, can defend the use The early history of RNA silencing in of the worm Caenorhabditis elegans as a good plants model system and so I will focus on plants. -
3718 Issue63july2010 1.Pdf
Issue 63.qxd:Genetic Society News 1/10/10 14:41 Page 1 JULYJULLYY 2010 | ISSUEISSUE 63 GENETICSGENNETICSS SOCIETYSOCIEETY NENEWSEWS In this issue The Genetics Society NewsNewws is edited by U Genetics Society PresidentPresident Honoured Honoured ProfProf David Hosken and items ittems for future future issues can be sent to thee editor,editor, preferably preferably U Mouse Genetics Meeting by email to [email protected],D.J.Hosken@@exeter.ac.uk, or U SponsoredSponsored Meetings Meetings hardhard copy to Chair in Evolutionary Evoolutionary Biology, Biology, UniversityUniversity of Exeter,Exeter, Cornwall Cornnwall Campus, U The JBS Haldane LectureLecture Tremough,Tremough, Penryn, TR10 0 9EZ UK.UK. The U Schools Evolutionn ConferenceConference Newsletter is published twicet a year,year, with copy dates of 1st June andand 26th November.November. U TaxiTaxi Drivers The British YeastYeaste Group Group descend on Oxford Oxford for their 2010 meeting: m see the reportreport on page 35. 3 Image © Georgina McLoughlin Issue 63.qxd:Genetic Society News 1/10/10 14:41 Page 2 A WORD FROM THE EDITOR A word from the editor Welcome to issue 63. In this issue we announce a UK is recognised with the award of a CBE in the new Genetics Society Prize to Queen’s Birthday Honours, tells us about one of Welcome to my last issue as join the medals and lectures we her favourite papers by Susan Lindquist, the 2010 editor of the Genetics Society award. The JBS Haldane Mendel Lecturer. Somewhat unusually we have a News, after 3 years in the hot Lecture will be awarded couple of Taxi Drivers in this issue – Brian and seat and a total of 8 years on annually to recognise Deborah Charlesworth are not so happy about the committee it is time to excellence in communicating the way that the print media deals with some move on before I really outstay aspects of genetics research to scientific issues and Chris Ponting bemoans the my welcome! It has been a the public. -
Fire Departments of Pathology and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Room L235, Stanford, CA 94305-5324, USA
GENE SILENCING BY DOUBLE STRANDED RNA Nobel Lecture, December 8, 2006 by Andrew Z. Fire Departments of Pathology and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Room L235, Stanford, CA 94305-5324, USA. I would like to thank the Nobel Assembly of the Karolinska Institutet for the opportunity to describe some recent work on RNA-triggered gene silencing. First a few disclaimers, however. Telling the full story of gene silencing would be a mammoth enterprise that would take me many years to write and would take you well into the night to read. So we’ll need to abbreviate the story more than a little. Second (and as you will see) we are only in the dawn of our knowledge; so consider the following to be primer... the best we could do as of December 8th, 2006. And third, please understand that the story that I am telling represents the work of several generations of biologists, chemists, and many shades in between. I’m pleased and proud that work from my labo- ratory has contributed to the field, and that this has led to my being chosen as one of the messengers to relay the story in this forum. At the same time, I hope that there will be no confusion of equating our modest contributions with those of the much grander RNAi enterprise. DOUBLE STRANDED RNA AS A BIOLOGICAL ALARM SIGNAL These disclaimers in hand, the story can now start with a biography of the first main character. Double stranded RNA is probably as old (or almost as old) as life on earth. -
Unfolding Plant Disease Resistance : the Involvement of HSP90 and Its Co- Chaperone PP5 in I-2-Mediated Signalling De La Fuente Van Bentem, S
UvA-DARE (Digital Academic Repository) Unfolding plant disease resistance : the involvement of HSP90 and its co- chaperone PP5 in I-2-mediated signalling de la Fuente van Bentem, S. Publication date 2005 Document Version Final published version Link to publication Citation for published version (APA): de la Fuente van Bentem, S. (2005). Unfolding plant disease resistance : the involvement of HSP90 and its co-chaperone PP5 in I-2-mediated signalling. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:05 Oct 2021 Unfolding plant disease resistance the involvement of HSP90 and its co-chaperone PP5 in I-2-mediated signalling ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam, op gezag van de Rector Magnificus prof. -
Summary Publication and Bibliometric Information: Total Number of Peer-Reviewed Publications: 15
CV Andreas Sebastian Marquardt Education: 16/7/2010 Ph. D. in Biological Sciences, University of East Anglia, Norwich, UK. 2005 Diplom (M. Sc.) in Biochemistry, Free University Berlin, Berlin, Germany. 2002-2005 Undergraduate studies in Biochemistry at Free University Berlin, Berlin, Germany. 1999-2002 Undergraduate studies in Biochemistry at University of Tübingen, Tübingen, Germany. Employment: Jan. 2018 – Tenured Associate Professor, University of Copenhagen, Copenhagen Plant Science Centre (CPSC), Denmark. Leader of non-coding transcription group. 2015 - 2017 Assistant Professor, University of Copenhagen, Copenhagen Plant Science Centre (CPSC), Denmark. Leader of non-coding transcription group. 2012 - 2014 Visiting Scientist at Whitehead Institute for Biomedical Research, MIT, Cambridge, USA. Topic: Arabidopsis epigenetics & Pol II kinetics, with Prof. Mary Gehring. 2010 - 2014 Postdoc at the Harvard Medical School (HMS), Boston, USA. Topic: chromatin-based lncRNA repression in budding yeast with Prof. Steve Buratowski. 2006 - 2009 Ph. D. thesis research with Prof. Caroline Dean at John Innes Centre (JIC), Norwich, UK. Topic: lncRNA-mediated chromatin regulation of Arabidopsis flowering. 2005-2006 Ph. D. rotation projects with: Prof. David Baulcombe, Dr. Sean Walsh and Prof. Caroline Dean. 2004-2005 Diplom thesis research with Prof. Arp Schnittger at Max-Planck Institute (MPI) for Plant Breeding Research, Cologne, Germany. Summary publication and bibliometric information: Total number of peer-reviewed publications: 15. First author publications: 6 (e.g. Science, Cell, Mol. Cell). Corresponding author publications: 5 (e.g. Nat. Commun, eLife, PLoS Gen). Last author publications: 5 (e.g. Nat. Commun, eLife, PLoS Gen). Citations: 1309 source, H-index: 21: https://scholar.google.com/citations?user=_miZw7oAAAAJ&hl=en ). -
Epigenetics and Transgenerational Inheritance Emilie Brasset, S
Epigenetics and transgenerational inheritance Emilie Brasset, S. Chambeyron To cite this version: Emilie Brasset, S. Chambeyron. Epigenetics and transgenerational inheritance. Genome Biology, BioMed Central, 2013, 14 (5), pp.306. 10.1186/gb-2013-14-5-306. hal-00852741 HAL Id: hal-00852741 https://hal.archives-ouvertes.fr/hal-00852741 Submitted on 3 Jun 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Brasset and Chambeyron Genome Biology 2013, 14:306 http://genomebiology.com/2013/14/5/306 MEETING REPORT Epigenetics and transgenerational inheritance Emilie Brasset1* and Séverine Chambeyron2* piRNAs are produced by two mechanisms: the primary Abstract processing pathway and secondary biogenesis, which is A report on the ‘Non-coding RNA, epigenetics and also called the ping-pong amplifi cation loop. Primary transgenerational inheritance’ meeting, Churchill piRNAs are likely processed from single-stranded College, Cambridge, UK, 11-12 April 2013. precursor transcripts that are encoded by heterochro- matic loci called piRNA clusters. Secondary piRNAs result from the processing of transposon mRNAs and Th e discovery of RNA interference in 1998 by Andrew piRNA clusters by an effi cient feed-forward amplifi cation Fire and Craig Mello revealed the complexity of gene loop. -
Science and the Sustainable Intensification of Global Agriculture
Reaping the benefits Science and the sustainable intensification of global agriculture October 2009 Cover image: From an illustration of a push-pull system for pest control, courtesy of The Gatsby Charitable Foundation. The Quiet Revolution: Push-Pull Technology and the African Farmer. Gatsby Charitable Foundation 2005. Reaping the benefi ts: science and the sustainable intensifi cation of global agriculture RS Policy document 11/09 Issued: October 2009 RS1608 ISBN: 978-0-85403-784-1 © The Royal Society, 2009 Requests to reproduce all or part of this document should be submitted to: The Royal Society Science Policy 6–9 Carlton House Terrace London SW1Y 5AG Tel +44 (0)20 7451 2500 Email [email protected] Web royalsociety.org Design by Franziska Hinz, Royal Society, London Copyedited and Typeset by Techset Composition Limited Reaping the benefi ts: science and the sustainable intensifi cation of global agriculture Contents Foreword v Membership of working group vii Summary ix 1 Introduction 1 1.1 An urgent challenge 1 1.2 Trends in food crop production 2 1.3 Science in context 5 1.4 The need for sustainable intensifi cation 6 1.5 Agricultural sustainability 7 1.6 Agriculture and sustainable economic development 7 1.7 Other major studies 8 1.8 Further UK work 9 1.9 About this report 9 1.10 Conduct of the study 10 2 Constraints on future food crop production 11 2.1 Climate change 11 2.2 Water 11 2.3 Temperature 12 2.4 Ozone 13 2.5 Soil factors 13 2.6 Crop nutrition 15 2.7 Pests, diseases and weed competition 16 2.8 Energy and greenhouse -
David Baulcombe
David Baulcombe Date of Birth 7 April 1952 Place Solihull, UK Nomination 18 August 2020 Field Genetics, Botany, Virology Title Emeritus Regius Professor of Botany, Cambridge University Most important awards, prizes and academies National Honour: Knight Bachelor, (Queens Birthday Honours list 2009). Awards: Sir Hans Krebs Medal and Lecture (2021) Federation of European Biochemical Societies; Mendel Medal (2017) Genetics Society; Prize Medal Lecture (2015) Society for General Microbiology; The McClintock Prize for Plant Genetics and Genome Studies (2014) Maize Genetics Executive Committee; Gruber Genetics Prize (2014) Gruber Foundation USA (shared with Ambros and Ruvkun); Balzan Prize (2012) (for epigenetics) Balzan Foundation, Rome; Wolf Prize for Agriculture (2010) Wolf Foundation Israel; Harvey Prize in Science and Technology (2009) Technion Israel Institute of Technology; Benjamin Franklin Medal in Life Science (2008) Franklin Institute, Philadelphia (joint with Ambros and Ruvkun); Special Achievement Award (2008) Miami Winter Symposium; Albert Lasker Award for Basic Medical Research (2008) Lasker Foundation (shared with Ambros and Ruvkun); Royal Medal (2006) The Royal Society; Massry Prize (2005) Massry Foundation – University of Southern California (shared with Fire and Mello); M.W. Beijerinck Virology Prize (2004) Royal Netherlands Academy of Arts and Sciences; Wiley Prize in Biomedical Science (2003) (Wiley Foundation – Rockefeller University – shared with Fire, Mello and Tuschl); Ruth Allen Award, American Phytopathology Society -
BTI 2000 Final
Boyce Thompson Institute for Plant Research BTI2000 The 77th Annual Report Boyce Thompson Institute for Plant Research The Boyce Thompson Institute conducts research to expand the frontiers of plant biology and related areas of science while continuing a tradition of using science and technology to protect the environment and improve human health and well-being. BTI2000 1 President’s Report 4 Outreach 8 History and Philosophy 9 Research 22 Publications 26 Staff 28 National Agricultural Biotechnology Council 29 Board of Directors 29 Committees 30 Gift Report 31 Finance and Investments The past year has brought many changes to the Boyce Thompson Institute for Plant President’s Research (BTI). On September 1, 2000, I took over the responsibilities of president and CEO from Charles J. Arntzen. Under his able leadership, the BTI made great Report strides toward streamlining its operations and enhancing its research programs; during Arntzen’s five-year tenure, sponsored research funding more than doubled to $6 million per year. With the addition of several new faculty members, research in the areas of plant development, plant pathology, and plants for human health was significantly enhanced. In October 2000, Charles Arntzen assumed an endowed chair and distinguished professorship at Arizona State University; he remains, however, a project leader at the BTI where he continues to direct an active research group with Hugh Mason. Their pioneering work with plant-based edible vaccines brings hope to millions of people in developing countries who do not have access to traditional vaccines that could protect them against several deadly diseases. The work of this innovative research group receives increasing attention in print and broadcast media. -
A Single Modular Serine Protease Integrates Signals from Pattern-Recognition Receptors Upstream of the Drosophila Toll Pathway
A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway Nicolas Buchona,1, Mickael Poidevinb,1, Hyun-Mi Kwonc, Aure´ lien Guilloua, Valentin Sottasa, Bok-Luel Leec, and Bruno Lemaitrea,b,2 aGlobal Health Institute, Ecole Polytechnique Fe´de´ rale de Lausanne, 1015 Lausanne, Switzerland; bCentre de Ge´ne´ tique Mole´culaire (CGM), Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France; and cNational Research Laboratory of Defense Proteins, College of Pharmacy, Pusan National University, Kumjeong Ku, Busan 609-735, Korea Edited by Frederick M. Ausubel, Harvard Medical School, Boston, MA, and approved June 1, 2009 (received for review February 23, 2009) The Drosophila Toll receptor does not interact directly with microbial extended to the sensing of proteases produced by various bacteria determinants, but is instead activated by a cleaved form of the (11). Surprisingly, tracheal melanization in mutant larvae lacking cytokine-like molecule Spa¨tzle. During the immune response, Spa¨tzle the serpin Spn77Ba also activates the Toll pathway in a Psh- is processed by complex cascades of serine proteases, which are dependent manner (12). This suggests that Psh-dependent Toll activated by secreted pattern-recognition receptors. Here, we dem- pathway activation is induced by a host factor derived from mela- onstrate the essential role of ModSP, a modular serine protease, in the nization. This also points to a possible cross-talk between the activation of the Toll pathway by Gram-positive bacteria and fungi. proteolytic cascades that regulate the Toll pathway and those Our analysis shows that ModSP integrates signals originating from regulating the melanization reaction. -
Science Strategy 2012 - 2017
Rothamsted Research where knowledge grows Science Strategy 2012 - 2017 Rothamsted Research where knowledge grows Contents Foreword 2 Rothamsted Research where knowledge grows: the vision 3 Putting the strategy in context 4 Strategic Theme 1: 20:20 Wheat 5 Strategic Theme 2: Cropping Carbon 6 Strategic Theme 3: Designing Seeds for Nutrition and Health 7 Strategic Theme 4: Delivering Sustainable Systems 8 National Resources to support our Strategy 9 Enablers: 10 Collaboration Delivering excellence and valuing diversity Public engagement 11 Being open and transparent Origins and legal status of Rothamsted Research 12 The Boards 13 Lawes Agricutural Trust Company Limited Board of Directors Rothamsted Research Board of Directors Further information 13 References 14 Science Strategy 2012 - 2017 1 Rothamsted Research where knowledge grows Professor Maurice Moloney Director of Rothamsted Research Foreword Rothamsted is almost certainly the oldest agricultural research centre in the world. Over its 168 year history, it has built an enviable international reputation as a centre of excellence and innovation for science in support of agricultural productivity, crop protection and soil science. Our strength lies in our ability to move with the times and embrace the evolving scientific challenges through creativity and ingenuity. Our history is one of excellence and our future will ensure that we deliver the highest quality science for maximal impact on agricultural practice. This is a testament to the foresight of our founders Sir John Lawes and Sir Henry Gilbert, as well as the influential scientists such as Ronald Fisher, Sir Edward John Russell, David Jenkinson and Michael Elliott, who helped build Rothamsted's name and reputation. -
Brexit and Research: 58 Life Science Good Bye EU Money Researchers Elected and Colleagues? PAGES 4 –5 PAGE 8
SUMMER 2016 ISSUE 33 EMBO | EMBL Symposium | Tubulin discovery’s 50th anniversary Moving on transient tracks PAGES 12 – 13 © Carsten Janke © Commentary EMBO Members Brexit and research: 58 life science Good bye EU money researchers elected and colleagues? PAGES 4 –5 PAGE 8 EMBO Gold Medal 2016 awarded to Sharing of preprint manuscripts From potential to policy Interview with Richard Benton and Ben Lehner Are biologists ready? Carlos Moedas, European Commissioner for Research, Science and Innovation PAGE 6 PAGE 7 PAGES 10 – 11 www.embo.org Table of contents The EMBO community welcomes Malta and Lithuania Page 2 New EMBO Members 2016 Page 4 Richard Benton and Ben Lehner awarded EMBO Gold Medal Page 6 Are biologists ready for preprints? How transparency in publishing is opening up research Page 7 Brexit and research: Good bye EU money and Editorial colleagues? Commentary ince the creation of EMBO and Page 8 Sits intergovernmental funding body EMBC, the European idea has probably never been questioned How objective can one be? Metrics in research more than in the last few months. assessment With the vote in the UK to leave the Page 9 European Union, European organi- zations will have an important From potential to policy role in showing the value of an a Interview with EU Commissioner Carlos Moedas common and open European space Page 10 – in general, but also for us a scien- © Marietta Schupp, EMBL Photolab Marietta Schupp, © tists in particular. On pages 8 and 9, we publish commentaries from Moving on transient tracks: 50th anniversary of two concerned scientists. EMBO will not directly the discovery of tubulin affected by the UK leaving Europe, as its funding Science story comes from an intergovernmental organization of Page 12 which the UK will remain a member.