Stereoselective Synthesis of 2-Deoxyoligosaccharides New
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Annual Report 2013-2014
ANNUAL REPORT 2013 – 14 One Hundred and Fifth Year Indian Institute of Science Bangalore - 560 012 i ii Contents Page No Page No Preface 5.3 Departmental Seminars and IISc at a glance Colloquia 120 5.4 Visitors 120 1. The Institute 1-3 5.5 Faculty: Other Professional 1.1 Court 1 Services 121 1.2 Council 2 5.6 Outreach 121 1.3 Finance Committee 3 5.7 International Relations Cell 121 1.4 Senate 3 1.5 Faculties 3 6. Continuing Education 123-124 2. Staff 4-18 7. Sponsored Research, Scientific & 2.1 Listing 4 Industrial Consultancy 125-164 2.2 Changes 12 7.1 Centre for Sponsored Schemes 2.3 Awards/Distinctions 12 & Projects 125 7.2 Centre for Scientific & Industrial 3. Students 19-25 Consultancy 155 3.1 Admissions & On Roll 19 7.3 Intellectual Property Cell 162 3.2 SC/ST Students 19 7.4 Society for Innovation & 3.3 Scholarships/Fellowships 19 Development 163 3.4 Assistance Programme 19 7.5 Advanced Bio-residue Energy 3.5 Students Council 19 Technologies Society 164 3.6 Hostels 19 3.7 Award of Medals 19 8. Central Facilities 165-168 3.8 Placement 21 8.1 Infrastructure - Buildings 165 8.2 Activities 166 4. Research and Teaching 26-116 8.2.1 Official Language Unit 166 4.1 Research Highlights 26 8.2.2 SC/ST Cell 166 4.1.1 Biological Sciences 26 8.2.3 Counselling and Support Centre 167 4.1.2 Chemical Sciences 35 8.3 Women’s Cell 167 4.1.3 Electrical Sciences 46 8.4 Public Information Office 167 4.1.4 Mechanical Sciences 57 8.5 Alumni Association 167 4.1.5 Physical & Mathematical Sciences 75 8.6 Professional Societies 168 4.1.6 Centres under Director 91 4.2. -
Ditellurides
Molecules 2010, 15, 1466-1472; doi:10.3390/molecules15031466 OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Article Novel Oxidative Ring Opening Reaction of 1H-Isotelluro- chromenes to Bis(o-formylstyryl) Ditellurides Haruki Sashida 1,*, Hirohito Satoh 1, Kazuo Ohyanagi 2 and Mamoru Kaname 1 1 Faculty of Pharmaceutical Sciences, Hokuriku University, Kanagawa-machi, Kanazawa 920-1181, Japan; E-Mail: [email protected] (M.K.) 2 Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan; E-Mail: [email protected] (K.O.) * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +81-76-229-6211; Fax: +81-76-229-2781. Received: 5 January 2010; in revised form: 2 February 2010 / Accepted: 5 March 2010 / Published: 9 March 2010 Abstract: The oxidation of 1-unsubstituted or 1-phenyl-1H-isotellurochromenes with m-chloroperbenzoic acid (mCPBA) in CHCl3 resulted in a ring opening reaction to produce as the sole products the corresponding o-formyl or benzoyl distyryl ditellurides, which were also produced by the hydrolysis of the 2-benzotelluropyrylium salts readily prepared from the parent isotellurochromene. Keywords: isotellurochromene; mCPBA oxidation; 2-benzotelluropyrylium salt; distyryl ditelluride 1. Introduction The preparation and investigation of the reactions of new tellurium-containing heterocycles have lately attracted increasing interest in the fields of both heterocyclic [1–3] and organotellurium chemistry [4–8]. We have been studying the syntheses and reactions of the novel tellurium- or selenium-containing heterocyclic compounds over the past twenty years. -
Durham E-Theses
Durham E-Theses A spectroscopic study of some halogeno-complexes of tellurium (IV) Gorrell, Ian Barnes How to cite: Gorrell, Ian Barnes (1983) A spectroscopic study of some halogeno-complexes of tellurium (IV), Durham theses, Durham University. Available at Durham E-Theses Online: http://etheses.dur.ac.uk/7890/ Use policy The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that: • a full bibliographic reference is made to the original source • a link is made to the metadata record in Durham E-Theses • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders. Please consult the full Durham E-Theses policy for further details. Academic Support Oce, Durham University, University Oce, Old Elvet, Durham DH1 3HP e-mail: [email protected] Tel: +44 0191 334 6107 http://etheses.dur.ac.uk A SPECTROSCOPIC STUDY OF SOME HALOGENO- COMPLEXES OF TELLURIUM (IV) by Ian Barnes Gorrell A thesis submitted in part fulfilment of the requirements for the degree of Master of Science in the University of Durham. The copyright of this thesis rests with the author. April 19 8 3 No quotation from it should be published without his prior written consent and information derived from it should be acknowledged. -5. OFC. 1983 TO MY MOTHER and MY FATHER1 S MEMORY' iii ACKNOWLEDGMENTS I wish to express my gratitude towards the late Professor T.C. -
WO 2016/034942 Al 10 March 2016 (10.03.2016) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/034942 Al 10 March 2016 (10.03.2016) P O P C T (51) International Patent Classification: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, C07H 1/08 (2006.01) A23L 1/22 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, C07H 15/256 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (21) International Application Number: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PCT/IB20 15/00 1879 PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (22) International Filing Date: SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 27 August 2015 (27.08.2015) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (30) Priority Data: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 62/044,626 2 September 2014 (02.09.2014) US TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 62/059,562 3 October 2014 (03. 10.2014) US DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 62/061,363 8 October 2014 (08. -
(12) Patent Application Publication (10) Pub. No.: US 2007/0104805 A1 Udel (43) Pub
US 20070 104805A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2007/0104805 A1 Udel (43) Pub. Date: May 10, 2007 (54) COMPOSITIONS OF HOODIA GORDONII Related U.S. Application Data AND PINOLENIC ACID DERVATIVES (60) Provisional application No. 60/732,440, filed on Nov. (76) Inventor: Ronald G. Udell, Beverly Hills, CA 1, 2005. (US) Publication Classification Correspondence Address: DORSEY & WHITNEY LLP (51) Int. Cl. INTELLECTUAL PROPERTY DEPARTMENT A6IR 36/3 (2006.01) SUTE 15OO A6II 3 L/704 (2006.01) SO SOUTH SIXTH STREET A6IR 36/85 (2006.01) MINNEAPOLIS, MN 55402-1498 (US) (52) U.S. Cl. ............................. 424/725; 424/770; 514/26 (57) ABSTRACT (21) Appl. No.: 11/554,982 The present invention is directed to compositions containing a pine nut oil and an extract from the genus Hoodia or (22) Filed: Oct. 31, 2006 Trichocaulon and methods of treatment for weight loss. US 2007/0104805 A1 May 10, 2007 COMPOSITIONS OF HOODA GORDON AND maintain a healthy weight. Weight gain is often a combina PNOLENIC ACID DERVATIVES tion of reduced metabolism of glucose, the individuals inability to block carbohydrate absorption from the diet CROSS-REFERENCE TO RELATED and/or the inability to reduce body fat. A solution to one or APPLICATION(S) more of these problems is sought by many people, young and old alike 0001) This application claims the benefit of U.S. Provi sional Application No. 60/732,440, filed Nov. 1, 2005, the 0009. There is a need in the art for a nutritional supple entire contents of which is incorporated herein by reference. -
Molecular Matchmaking Between the Popular Weight-Loss Herb Hoodia Gordonii and GPR119, a Potential Drug Target for Metabolic Disorder
Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder Shuyong Zhanga,b,1, Yuyong Mac,1, Jing Lib, Junjun Mac, Biao Yuc,2, and Xin Xiea,b,2 aShanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-Based Bio-Medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; bChinese Academy of Sciences Key Laboratory of Receptor Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; and cState Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China Edited by Robert J. Lefkowitz, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, and approved August 19, 2014 (received for review December 29, 2013) African cactiform Hoodia gordonii (Asclepiadaceae) has been used The plant is rich in pregnane glycosides containing 6-deoxy- for thousands of years by Xhomani Bushmen as an anorexant and 2,6-dideoxy-sugars. To date, P57AS3 (P57) is the only bi- during hunting trips and has been proposed as a new agent for ologically active constituent from H. gordonii that has been the management of body weight. However, its in vivo targets and reported to have anorexigenic activity (5). There is no evidence molecular mechanisms remain elusive. GPR119, a G protein-cou- of P57 binding to or altering activity of known receptors or pled receptor highly expressed in pancreatic β cells and intestinal proteins, but intracerebroventricular injections of P57 in rats has L cells, has been demonstrated to facilitate glucose-stimulated in- been reported to increase ATP content in the hypothalamus, sulin secretion (GSIS) and represents a novel and attractive target which might represent a signal of satiety and suppress appetitive for the therapy of metabolic disorders. -
WO 2014/151206 Al 25 September 2014 (25.09.2014) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/151206 Al 25 September 2014 (25.09.2014) P O P C T (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C07K 7/08 (2006.01) A61P 1/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, A61K 38/10 (2006.01) A61P 29/00 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (21) International Application Number: KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, PCT/US20 14/025207 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (22) International Filing Date: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 13 March 2014 (13.03.2014) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (25) Filing Language: English ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 61/790,266 15 March 2013 (15.03.2013) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, 61/826,749 23 May 2013 (23.05.2013) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (71) Applicant: SYNERGY PHARMACEUTICALS INC. -
A Systematic Review of the European Rapid Alert System for Food and Feed: Tendencies in Illegal Food Supplements for Weight Loss
SYSTEMATIC REVIEW published: 26 January 2021 doi: 10.3389/fphar.2020.611361 A Systematic Review of the European Rapid Alert System for Food and Feed: Tendencies in Illegal Food Supplements for Weight Loss Dorottya Koncz 1, Barbara Tóth 1,2, Orsolya Roza 1,2 and Dezso} Csupor 1,2* 1Department of Pharmacognosy, University of Szeged, Szeged, Hungary, 2Medical School, Institute for Translational Medicine, University of Pécs, Pécs, Hungary Background: Slimming products represent a dynamically growing group of food supplements worldwide. The efficacy of safely usable natural ingredients is usually below consumers’ expectations. Certain manufacturers add unauthorized or prohibited ingredients to weight loss supplements in order to increase their efficacy. Hence, many of these products are adulterated and may pose a risk to the consumers’ health. Aims: The aim of our work was to give an overview on natural ingredients used in slimming products, to summarize the frequently used synthetic adulterants and also to assess the Edited by: trends of adulterated and illegal food supplements in the European Union based on the Michał Tomczyk, Medical University of Bialystok, Poland warnings of the Rapid Alert System for Food and Feed (RASFF) in the time period of – Reviewed by: 1988 2019. Eric Deconinck, – Sciensano, Belgium Methods: Reports between 1988 2019 were extracted from the RASFF portal on Jakub Dorozy˙ nski, ´ January 1, 2020. Each entry was individually reviewed. Department of Family Medicine, Medical University of Lodz, Poland Results: 2,559 records of food supplements with quality problems were identified in the *Correspondence: RASFF, several of which [319 (12,5%)] were marketed to facilitate weight loss. -
Research Article Sympathomimetic Activity of a Hoodia Gordonii Product: a Possible Mechanism of Cardiovascular Side Effects
Hindawi Publishing Corporation BioMed Research International Volume 2013, Article ID 171059, 6 pages http://dx.doi.org/10.1155/2013/171059 Research Article Sympathomimetic Activity of a Hoodia gordonii Product: A Possible Mechanism of Cardiovascular Side Effects Orsolya Roza,1 Norbert Lovász,2 István Zupkó,2 Judit Hohmann,1 and Dezsy Csupor1 1 Department of Pharmacognosy, University of Szeged, Eotv¨ os¨ u. 6, Szeged 6720, Hungary 2 Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eotv¨ os¨ u. 6, Szeged 6720, Hungary Correspondence should be addressed to Dezso˝ Csupor; [email protected] Received 12 April 2013; Revised 30 August 2013; Accepted 2 October 2013 Academic Editor: Gail B. Mahady Copyright © 2013 Orsolya Roza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hoodia gordonii, a popular appetite suppressant, is widely used as an ingredient in many food supplements despite the fact that supporting scientific evidence is scarce. Recently alarming side effects of H. gordonii products (increased blood pressure and elevated pulse rate) have been reported. The aim of our study was to elucidate the underlying mechanism of these symptoms. A H. gordonii- containing product was tested for sympathomimetic activity. Isolated organ experiments on rat uterine rings revealed smooth muscle relaxant effect with a substantial component mediated through -adrenergic receptors. Chromatographic comparison of the analyzed product and authentic plant material confirmed that the herbal product contained Hoodia spp. extract, and its cardi- ovascular effects may be linked to the compounds of the plant. -
VU Research Portal
VU Research Portal The Role of Selenium in Glutathione Peroxidase Bortoli, M. 2019 document version Publisher's PDF, also known as Version of record Link to publication in VU Research Portal citation for published version (APA) Bortoli, M. (2019). The Role of Selenium in Glutathione Peroxidase: Insights from Molecular Modeling. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. E-mail address: [email protected] Download date: 23. Sep. 2021 VRIJE UNIVERSITEIT UNIVERSITÀ DEGLI STUDI DI PADOVA THE ROLE OF SELENIUM IN GLUTATHIONE PEROXIDASE: INSIGHTS FROM MOLECULAR MODELING ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad Doctor of Philosophy aan de Vrije Universiteit Amsterdam, op gezag van de rector magnificus prof.dr. V. Subramaniam en Dottore di Ricerca aan de Università degli Studi di Padova op gezag van de rector magnificus prof.dr. Rosario Rizzuto, in het openbaar te verdedigen ten overstaan van de promotiecommissie van de Faculteit der Bètawetenschappen op woensdag 17 april 2019 om 11.45 uur in de aula van de universiteit, De Boelelaan 1105 door Marco Bortoli geboren te Marostica, Italië promotoren: prof.dr. -
The Effectof Stwcturalmodificationson the Adrenaluptakeof Steroidslabeled in the Sidechainwith Tellurium-123M
TheEffectof StwcturalModificationson the AdrenalUptakeof SteroidsLabeled in the SideChainwithTellurium-123m FurnF.Knapp,Jr., KathleenP.Ambrose,andAlvinP.Callahan Oak Ridge National Laboratory, Oak Ridge, Tennessee A seriesof structurallymodifiedsteroidslabeledinthe sidechainwithTe-123m have been preparedandtested in ratsto determinethe criticalstructuralfeatures required for maximal adrenal uptake of this new class of potential adrenal-imaging agents.The Te-123m steroidsinvestigatedcontainedstructuralmodificationsof both the nucleus and side chain. Tissue distribution experiments and rectilinear scansindicatedthat 23-(isopropylteliuro)-24-nor-5a-choian-3@9-oI(saturatednu cleus), and 24-(isopropylteIIuro)-chol-5-en-3@9-ol(nuclear doublebond)showed pronouncedadrenaluptake after 1 day, with adrenal-to-liverratiosof 41 and 27, respectively.Theseresultsindicatethat a combinationof structuralfeaturesis re quiredfor significantadrenaluptakeof steroidslabeledin the sidechainwfthTe 123m.Thestructuralrequirementsincludea transringstructure,an equatorialC-S hydroxylgroup,anda 17$ sidechainof moderatelength. J Nuci Med 21:258—263, 1980 The pioneering studies of Beierwaltes and coworkers use (2,13,14). have demonstrated that steroids labeled with gamma From an analysis of structure-activity data, however, emitting nuclides can be used to image the adrenal it is difficult to predict the effect of steroid structure on glands (1,2). Iodine-l3l-labeled 19-iodocholesterol was the relative tissue distribution and potential adrenal the first agent available -
Abbreviations and Symbols
University of Szeged Faculty of Pharmacy Department of Pharmacognosy PROMISING ASSETS OF SOUTHERN AFRICA? CYCLOPIA GENISTOIDES AND HOODIA GORDONII Ph.D. Thesis Orsolya Roza Pharm.D. Supervisors: Prof. Judit Hohmann DSc. Dezső Csupor PhD. Szeged, Hungary 2016 LIST OF PUBLICATIONS RELATED TO THE THESIS I. Roza O, Lovász N, Zupkó I, Hohmann J, Csupor D Sympathomimetic activity of a Hoodia gordonii product: a possible mechanism of cardiovascular side effects Biomed Research International 2013; Article ID 171059: 6 pages II. Roza O, Lai W-C, Zupkó I, Hohmann J, Eloff JN, Chang F-R, Csupor D Bioactivity-guided isolation of phytoestrogenic compounds from Cyclopia genistoides by pER8:GUS reporter system South African Journal of Botany 2016; In Press. III. Roza O, Martins A, Hohmann J, Lai W-C, Eloff JN, Chang F-R, Csupor D Flavonoids from Cyclopia genistoides and their xanthine oxidase inhibitory activity Planta Medica 2016; 82: 1274-1278. TABLE OF CONTENTS ABBREVIATIONS ........................................................................................................................ 1 1. INTRODUCTION ..................................................................................................................... 2 2. AIMS OF THE STUDY ............................................................................................................. 3 3. LITERATURE OVERVIEW ...................................................................................................... 3 3.1. Botany of the Cyclopia and Hoodia genus and the investigated