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(12) Patent Application Publication (10) Pub. No.: US 2007/0104805 A1 Udel (43) Pub

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(12) Patent Application Publication (10) Pub. No.: US 2007/0104805 A1 Udel (43) Pub US 20070 104805A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2007/0104805 A1 Udel (43) Pub. Date: May 10, 2007 (54) COMPOSITIONS OF HOODIA GORDONII Related U.S. Application Data AND PINOLENIC ACID DERVATIVES (60) Provisional application No. 60/732,440, filed on Nov. (76) Inventor: Ronald G. Udell, Beverly Hills, CA 1, 2005. (US) Publication Classification Correspondence Address: DORSEY & WHITNEY LLP (51) Int. Cl. INTELLECTUAL PROPERTY DEPARTMENT A6IR 36/3 (2006.01) SUTE 15OO A6II 3 L/704 (2006.01) SO SOUTH SIXTH STREET A6IR 36/85 (2006.01) MINNEAPOLIS, MN 55402-1498 (US) (52) U.S. Cl. ............................. 424/725; 424/770; 514/26 (57) ABSTRACT (21) Appl. No.: 11/554,982 The present invention is directed to compositions containing a pine nut oil and an extract from the genus Hoodia or (22) Filed: Oct. 31, 2006 Trichocaulon and methods of treatment for weight loss. US 2007/0104805 A1 May 10, 2007 COMPOSITIONS OF HOODA GORDON AND maintain a healthy weight. Weight gain is often a combina PNOLENIC ACID DERVATIVES tion of reduced metabolism of glucose, the individuals inability to block carbohydrate absorption from the diet CROSS-REFERENCE TO RELATED and/or the inability to reduce body fat. A solution to one or APPLICATION(S) more of these problems is sought by many people, young and old alike 0001) This application claims the benefit of U.S. Provi sional Application No. 60/732,440, filed Nov. 1, 2005, the 0009. There is a need in the art for a nutritional supple entire contents of which is incorporated herein by reference. ment that counteracts one or more of the afore-mentioned weight related afflictions. FIELD OF THE INVENTION BRIEF SUMMARY OF THE INVENTION 0002 The present invention relates to formulations, including soft gelatin capsules, that contain a combination of 0010. The present invention pertains to compositions for an extract from the genus Trichocaulon, including Tri appetite suppression, for the reduction of body fat, for chocaulon officinale or Trichocaulon piliferum, or from the reduction of caloric intake, to increase the feeling of satia genus Hoodia, including Hoodia currorii, Hoodia gordonii tion, to increase the release of cholecystokinin (CCK), to or Hoodia lugardii and an extract from the genus Pinus increase glucose metabolism, for inhibiting absorption of containing pinolenic acid and/or derivatives thereof. carbohydrates, and/or for weight loss. The invention also pertains to methods to accomplish one or more of these BACKGROUND OF THE INVENTION goals. The invention further pertains to packaged nutraceu tical formulations to treat such conditions. 0003 Over the past several decades the world’s popula tion, in general, has been becoming overweight. In many 0011. In one aspect, the present invention surprisingly instances, excessive weight gain increases the risk of dia provides that a combination extracts from the genus Pinus, betes, hypertension, cardiac diseases or kidney disease i.e., Pinus koraiensis, which contain pinolenic acid (and among other diseases or conditions related to obesity. It is derivatives thereof, such as esters including but not limited not just an affliction of the elderly; in fact, many recent to mono-, di-, or triglycerides thereof) and an extract from studies show that increasing numbers of juveniles and the genus Trichocaulon, including Trichocaulon officinale or teenagers are developing weight related afflictions. Trichocaulon piliferum, or from the genus Hoodia, includ ing Hoodia currorii, Hoodia gordonii or Hoodia lugardii 0004 Today’s sedentary lifestyle unfortunately helps to and/or derivatives thereof can improve one or more of the promote excessive weight gain in individuals. One of the afore-mentioned health issues. problems with the Western diet during the last fifty years has been excessive consumption of linoleic acid, due to the 0012. In certain embodiments, the compositions of the introduction of margarine, seed oils such as corn oil and invention can further include abanaba leaf extract or deriva safflower oil, and the modern artificial feeding methods of tives thereof, conjugated linoleic acid (CLA) or derivatives cattle that have raised the linoleic acid content of meat. At thereof, and/or a starch blocker. More specifically, the com the same time, the consumption of beneficial fatty acids Such positions can further include corosolic acid. polyunsaturated fatty acids (PUFAs) including omega-3 0013 The compositions of the invention can be ingested fatty acids from food sources such as fish and seeds have in the form of a tablet, pill, lozenge, Soft gel capsule, in a decreased. health food Snack, in a drink, etc. The recommended daily 0005 There are many treatments and diet programs avail amount can be taken in one or more portions. able to help promote a healthy lifestyle and weight loss. Most diet programs consist of reducing caloric intake, 0014. The combination of extracts from the genus Pinus reducing the amount of carbohydrates consumed, and appro and Hoodia or Trichocaulon provide a synergistic combi priate exercise. Surgical treatments are available and include nation (effect) relative to either of the extracts given alone. stomach stapling, gastric by-pass and liposuction 00.15 Banaba (Lagerstroemia Speciosa L.), also known as Queen's flower, pride of India, or queen's crape myrtle, 0006 Unfortunately, an individual will often lose weight belongs to the botanical family lythraceae and contains on a diet program but then later Succumb to old eating habits. corosolic acid and other beneficial phytochemicals. Coro Exercise often becomes a luxury due to life style constraints solic acid (2-O-hydroxyursolic acid, CAS #52213-27-1) is a and the individual lapses into a cycle of dieting, weight loss, triterpenoid with a molecular weight of 743.63 daltons and cessation of the diet and weight gain, only to repeat this is a lipophilic, polar compound that is extracted from the process over and over. leaves of Lagerstroemia Speciosa L. A Suitable commercial 0007 Surgical procedures can be quite expensive and source of corosolic acid is available from Soft Gel Tech inconvenient. Many procedures are not paid for by insurance nologies, Inc. of Los Angeles, Calif., USA, and is known by companies and the individual is forced with a decision to the trademark GLUCOTRIMTM (available as a 1% or 3% either pay for the procedure himself or herself or forgo the corosolic acid extract). Surgery. Additionally, Surgery can result in the person not 0016 Conjugated linoleic acid derivatives (CLA's) being ambulatory for a week or more and can be quite include any conjugated linoleic acid or octadecadienoic fatty painful. acid, including all positional and geometric isomers of 0008 Weight gain is a complex problem. The health linoleic acid with two conjugated carbon-carbon double conscious public is concerned about excessive weight gain, bonds at any position in the molecule. Additionally, the term but does not generally want to maintain strict diets to lose or includes salts and esters thereof, including triglycerides. US 2007/0104805 A1 May 10, 2007 0017 Starch blockers are known in the art and the term sport bars, sport drinks, mayonnaise, Salad dressing, bread is intended to include, but is not limited to, alpha amylase and any other fat or oil containing foods. As used herein, the inhibitors, alpha-glucoside inhibitors and glucosidase term “food product” refers to any substance fit for human or inhibitors. In particular, the present invention includes starch animal consumption. blockers based on derivatives from white kidney beans 0024. The compositions of the invention can be added to (Phaseolis vulgaris). Phaseolamin is a partially-purified various drinks, such as fruit juices, milkshakes, milk, etc. protein extract of white kidney beans that binds to alpha amylase enzymes, which are responsible for the digestive 0025 The compositions of the invention are intended not breakdown of starch. It has been proposed that phaseolamin only for weight loss, a method to increase glucose metabo inhibits the alpha-amylase breakdown of starch by non lism, a method to reduced body fat, and/or block carbohy competitively binding the enzyme to prevent the hydrolysis drate absorption from the diet, etc. but as nutritional Supple ments to maintain the results obtained from use of the of the alpha-1,4-glycosidic linkages in the starch molecule. composition(s). This is a life style change, wherein carbo 0018. The composition can include additional additives, hydrate intake is diminished such that one or more of the Such as antioxidants, stabilizers, fillers, carriers, etc. aforementioned goals is achieved. That is, once the indi vidual achieves the result(s) desired, the use of the compo 0.019 Suitable carriers for the ingredients include, for sitions of the invention to maintain that achievement is just example, wheat germ oil, rice bran oil, or yellow beeswax. as important and first reaching the goal. Therefore, the 0020 While multiple embodiments are disclosed, still compositions of the invention can be viewed as Supplements other embodiments of the present invention will become to help an individual prevent one or more of the afore apparent to those skilled in the art from the following mentioned conditions from reoccurring. detailed description, which shows and describes illustrative 0026. The preferred method of administration is oral. The embodiments of the invention. As will be realized, the compositions of the invention can be formulated with suit invention is capable of modifications in various obvious able carriers such as starch, Sucrose or lactose in tablets, aspects, all without departing from the spirit and scope of the capsules, solutions, syrups and emulsions. The tablet or present invention. Accordingly, the detailed description is to capsule of the present invention may be coated with an be regarded as illustrative in nature and not restrictive. enteric coating that dissolves at a pH of about 6.0 to 7.0.
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