Activity of Dietary Fatty Acids on FFA1 and FFA4 and Characterisation of Pinolenic Acid As a Dual FFA1/FFA4 Agonist with Potential Effect Against Metabolic Diseases
British Journal of Nutrition, page 1 of 12 doi:10.1017/S000711451500118X q The Authors 2015 Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases Elisabeth Christiansen1, Kenneth R. Watterson2, Claire J. Stocker3, Elena Sokol4, Laura Jenkins2, Katharina Simon5, Manuel Grundmann5, Rasmus K. Petersen6, Edward T. Wargent3, Brian D. Hudson2, Evi Kostenis5, Christer S. Ejsing4, Michael A. Cawthorne3, Graeme Milligan2 and Trond Ulven1* 1Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark 2Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK 3Buckingham Institute of Translational Medicine, University of Buckingham, Hunter Street, Buckingham MK18 1EG, UK 4Department of Biochemistry and Molecular Biology, Villum Center for Bioanalytical Sciences, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark 5Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53115 Bonn, Germany 6Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, DK-2200, Copenhagen N, Denmark (Submitted 14 January 2015 – Final revision received 11 March 2015 – Accepted 16 March 2015) Abstract Various foods are associated with effects against metabolic diseases such as insulin resistance and type 2 diabetes; however, their mech-
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