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Presentation. Pine Nut Effects of pinus radiata pine seed oil consumption on murine model: Evidence of a new functional alimentary additive for the control of diabetes Gonzalez, Ja., Becerra, Jb., Perez, Cb., Hernández, Vb., Duran, Dc., Diaz, Pd., Silva, Jd., Fuentealba, Cd. a Biotechnology Center, University of Concepcion. Barrio Universitario s/n b Faculty of Natural and Oceanographic Sciences, University of Concepcion. Barrio Universitario s/n c Faculty of Pharmacy, University of Concepcion. Edmundo Larenas 64 d Technological Development Unit, University of Concepcion. Av. Cordillera Nº 2634, Coronel ¿Have you hear about the metabolic syndrome? Heart Intestine Circulatory Skin disorders Pancreas Stomach Liver ¿Do you know how many people have it only in Chile? It affects 32% of the Chilean inhabitants older than 17 years. That is to say, almost 4 million people suffer from it! Source: La Tercera, 2017 ¿How much annually spend a person with metabolic syndrome? The average annual cost is 2.100 USD/person and increases by 24% for each risk factor Source: Boudreau et al, 2009. ¿How much does a person consume in natural and / or complementary alternatives? 7% captive market looking for new alternatives! Source: Laboratorios Knop, 2017. Bringing all of the 112 MUSD of above to market captive market 15,7 MUSD in oils numbers in Chile (alimentary supplements) But the most impressive is that it is estimated a growth of 15.3% in value and 3.8% in volume for the next few years! Source: IMS Health, 2017. UM Comtrade, 2018 ¿What alternatives are there to solve this problem? There are plants and seeds that contain natural chemical compounds that are beneficial for health Chia Nuts Almonds They contain chain polyunsaturated fatty acids > C14 ¿What about the pine nuts?. That little products… ¿Pine nuts? ü Pines and other pinaceae, species of the pinaceae family, are classified within conifers that produce pine nuts contained in cone-shaped structures called strobilus, pineapples or cones. ü Worldwide there are about 30 species of pine that produce edible pine nuts, but only some have commercial relevance. ü The most important being Pinus gerardiana, which produces the so called Pakistani or Indian pine nut; Pinus koraiensis, the Chinese pine nut; Pinus sibirica, the Russian pine nut; and Pinus pinea, the Mediterranean pine nut. ü The rest of the edible pine nuts are relevant mainly at the local level, where they are in general a traditional food particularly used by aboriginal cultures or "First Nations" (GRAS-FDA, 2010). Brief Technical State of art ü The pine nuts, in comparison to other fruits or seeds, corresponds essentially to the significantly higher presence of C18 and C20 polyunsaturated fatty acid with unsaturations positioned in the form of omega-3, omega-4 and omega-6. ü Specifically, in this type of plant sources, a high content of linolenic acid, pinolenic acid (PNLA), taxoleic acid and sciadonic acid, among others, is usually found in a unique manner. ü Of these, one of the most studied corresponds to PNLA representing 14-19% of the total fatty acids present in the pine nuts. ü The consumption of PNLA has been associated with positive effects in the reduction of inflammation, immune function, appetite and body weight, blood lipids, insulin sensitivity and cancer metastasis (Xie et al 2016). Brief Commercial State of art Price Excellent Quantity ¿What we found with our proposal? Pine nuts from radiata pine: Pine present in Chile in 1,4 million hectares We discovered the following in obese mice model (strain C57BL/6) Food consumption Consumed food (g) food Consumed Days under treatment The strange thing is that they ate the same ... Mice when consuming our oil And the effect was enhanced stopped gaining weight! by mixing it with another kind Source: Chilean patent. 2015-03182 of oils But not only that… A B 120 Suplemento A 6 Suplemento B Suplemento C 100 Suplemento D 4 3 80 AOC x10 AOC 2 % Glicemia basal % Glicemia 60 Basal Glycemia (mg/dL) BasalGlycemia 0 20 40 60 80 100 120 TiempoTime (min) (min) Decreased insulin resistance, that is, caused an insulin sensitization Source: Chilean patent. 2015-03182 20 Suplemento A And also… 16 12 8 4 A B 500 Suplemento A 50 20 Suplemento B 450 Suplemento B 16 Suplemento C 40 12 ) 400 Suplemento D dL 8 350 3 30 4 300 C x10 20 20 250 AU Suplemento C 16 Glicemia (mg/ Glicemia 200 Glycemia (mg/dL) 10 Food/day % 12 % alimento / dìa % alimento 150 8 4 0 20 40 60 80 100 120 Tiempo (min) Time (min) 20 Suplemento D Modulated the appetite, that is, 16 12 encourages eating in an orderly 8 manner during the day 4 0 5 10 15 20 25 Source: Chilean patent. 2015-03182 TimeHoras (hours) Therefore, our offer corresponds to provide a new nutraceutical oil This type of oil can go from 100-140 USD / Liter, depending on different market segments ¿What is our idea of market penetration? Enter step by step: Producto tipo aceite Product type table oil: de mesa: pure pine seed oil aceite de premium character Supplier of pine seed 4 oil for pharmaceutical Supplier of pine sector = New seed oil for food pharmaceutical 3 benefits sector = New 2 benefits in food 1 Product type table oil: olive oil supplemented with pine seed oil 5 minuts for questions.
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