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Leitlinienreport S3-Leitlinie Prostatakarzinom | Version 5.0 | April 2018 3 1 1 1 1 Leitlinienreport Interdisziplinäre Leitlinie der Qualität S3 zur Früherkennung, Diagnose und Therapie der verschie- denen Stadien des Prostatakarzinoms Version 5.0 – April 2018 AWMF-Registernummer: 043/022OL © Leitlinienprogramm Onkologie | Leitlinienreport zur S3-Leitlinie Prostatakarzinom | für Version 2.2 Konsulta- tionsfassung, 2. Aktualisierung 2014 2 Inhaltsverzeichnis 1. Informationen zum Leitlinienreport ................................................................. 6 1.1. Autoren des Leitlinienreports ................................................................................................... 6 1.2. Herausgeber ............................................................................................................................ 6 1.3. Federführende Fachgesellschaft ............................................................................................... 6 1.4. Finanzierung der Leitlinie ........................................................................................................ 6 1.5. Kontakt .................................................................................................................................... 6 1.6. Zitierweise des Leitlinienreports .............................................................................................. 7 1.7. Weitere Dokumente zur Leitlinie .............................................................................................. 7 1.8. Abkürzungsverzeichnis ............................................................................................................ 8 2. Geltungsbereich und Zweck der Leitlinie ................................................... 10 2.1. Adressaten ............................................................................................................................ 10 2.2. Zielsetzung ............................................................................................................................ 10 3. Zusammensetzung der Leitliniengruppe .................................................... 11 3.1. Steuergruppe der Leitlinie ...................................................................................................... 11 3.2. Beteiligte Autoren und Mitglieder der Leitliniengruppe .......................................................... 11 3.3. Andere Institutionen .............................................................................................................. 14 3.4. Patientenbeteiligung .............................................................................................................. 15 4. Fragestellungen und Gliederung ..................................................................... 16 5. Methodik ...................................................................................................................... 17 5.1. Evidenzbasierung .................................................................................................................. 17 5.1.1.Erstellung der Leitlinie 2006-2009 .......................................................................................... 17 5.1.2.Erstellung der ersten modularen Aktualisierung 2011 ............................................................. 22 5.1.3.Erstellung der zweiten modularen Aktualisierung 2014 ........................................................... 24 5.1.4.Erstellung der dritten modularen Aktualisierung 2016 ............................................................ 27 5.1.5.Erstellung der vierten modularen Aktualisierung 2017 ............................................................ 28 5.2. Formulierung der Empfehlung und formale Konsensusfindung .............................................. 29 5.2.1.Themenbezogene Gruppenarbeit ............................................................................................ 32 5.2.2.Plenumssitzung mit endgültiger Verabschiedung der Empfehlungen ...................................... 33 5.2.3.Empfehlungen und deren Graduierung .................................................................................... 34 5.2.4.Statements .............................................................................................................................. 34 5.2.5.Expertenkonsens (EK) .............................................................................................................. 34 6. Qualitätsindikatoren ............................................................................................. 35 6.1. 1. Aktualisierung 2011 .......................................................................................................... 35 © Leitlinienprogramm Onkologie | Leitlinienreport S3-Leitlinie Prostatakarzinom | Version 5.0 | April 2018 3 6.2. 2. Aktualisierung 2014 .......................................................................................................... 35 6.3. 3. Aktualisierung 2017 .......................................................................................................... 38 7. Externe Begutachtung und Verabschiedung ............................................. 42 7.1. Erstellung der Leitlinie 2006-2009 ......................................................................................... 42 7.2. 1. Aktualisierung 2011 .......................................................................................................... 42 7.3. 2. Aktualisierung 2014 .......................................................................................................... 42 7.4. 3. Aktualisierung 2016 .......................................................................................................... 42 7.5. 4. Aktualisierung 2017 .......................................................................................................... 43 8. Redaktionelle Unabhängigkeit und Umgang mit Interessenkonflikten ............................................................................................ 44 9. Verbreitung und Implementierung ................................................................ 45 10. Gültigkeitsdauer der Leitlinie ........................................................................... 46 11. Tabellenverzeichnis ............................................................................................... 46 12. Anhänge ....................................................................................................................... 47 12.1. Schlüsselfragen und Autoren 2009/2011/2014/2016/2017 ................................................. 47 12.2. Methodik und Ergebnisse der Recherchen zur Erstellung der Leitlinie 2009 ........................... 55 12.2.1.Recherche zum Thema Epidemiologie, Risikofaktoren, Prävention und Ernährung ................ 55 12.2.2.Recherche zum Thema Früherkennung und Biopsie .............................................................. 56 12.2.3.Recherche zum Thema Diagnostik und Stadieneinteilung ...................................................... 57 12.2.4.Recherche zum Thema Therapie des nichtmetastasierten Prostatakarzinoms ........................ 60 12.2.5.Recherche zum Thema Lokale Therapie des lokal begrenzten Prostatakarzinoms ................. 61 12.2.6.Recherche zum Thema Lokale Therapie des lokal fortgeschrittenen Prostatakarzinoms ........ 63 12.2.7.Recherche zum Thema Diagnostik und Therapie des rezidivierten oder metastasierten Prostatakarzinoms ....................................................................................................... 66 12.2.8.Recherche zum Thema Rehabilitation und Nachsorge ........................................................... 68 12.2.9.Recherche zum Thema Psychosoziale Aspekte und Lebensqualität ....................................... 68 12.3. Methodik und Ergebnisse der Recherchen zur 1. Aktualisierung 2011 ................................... 69 12.3.1.Recherche zum Thema Stellenwert der Früherkennung/Screening ......................................... 69 12.3.2.Recherche zu den Fragestellungen im Kapitel Diagnostik und Stadieneinteilung ................... 74 12.3.3.Recherche zu Active Surveillance bei lokal begrenztem Prostatakarzinom ............................. 97 12.3.4.Recherche zum Thema Radikale Prostatektomie bei Patienten mit hohem Risikoprofil ........ 110 12.3.5.Recherche zum Thema LDR-Brachytherapie ......................................................................... 118 12.3.6.Recherchen zum Thema perkutane Strahlentherapie ........................................................... 127 12.3.7.Recherchen zum Thema perkutane Strahlentherapie ........................................................... 137 12.3.8.Recherchen zum Thema Protonentherapie .......................................................................... 147 12.3.9.Recherchen zum Thema HIFU .............................................................................................. 152 12.3.10.Recherchen zum Thema Therapie von Knochenmetastasen ............................................... 158 12.3.11.Recherche zum Thema Behandlung des kastrationsresistenten Prostatakarzinoms ........... 164 © Leitlinienprogramm Onkologie | Leitlinienreport S3-Leitlinie Prostatakarzinom | Version 5.0 | April 2018 4 12.4. Methodik und Ergebnisse der Recherchen zur 2. Aktualisierung 2014 ................................. 171 12.4.1.Recherche zum Thema Früherkennung/Screening (Kapitel 3.1 der Leitlinie) ........................ 171 12.4.2.Recherche zum Thema PET-CT/MRT beim PSA-Rezidiv (Empfehlung 3.19 der Leitlinie) ....... 185 12.4.3.Recherche zum Thema
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