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Septemberseptember 2005 SEPTEMBERSEPTEMBER 2005 www.asbmb.org Constituent Society of FASEB AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY ASBMB & JBC Annual Meeting & Centennial Celebration April 1-5, 2006 • San Francisco, CA Call for Abstracts The submission site is now open www.asbmb.org Abstract Submission Deadline: November 2, 2005 ASBMB Travel Award Application Deadline: October 21, 2005 Held in conjunction with EB2006 Celebrate the past & look to the future Join us for the ASBMB/JBC Centennial Celebration to honor a century of achievements and contributions of The American Society for Biochemistry and Molecular Biology (ASBMB) and The Journal of Biological Chemistry (JBC). This grand event will be held next year at the ASBMB 2006 Annual Meeting (April 1-5, 2006, San Francisco, CA, in conjunction with Experimental Biology 2006). k Special publications which tell the history of ASBMB and The JBC. A collection of Classics, Reflections, scientific landmarks, and the many contributions to science that have been made by ASBMB members. k Lectures and commentary by scientific luminaries. k Displays and demonstrations of both historic instruments and current state-of-the-art instrumentation. Join us in 2006 for this special ASBMB/JBC centennial celebration! www.asbmb.org AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY SEPTEMBER 2005, Volume 4, Issue 6 features 4 ASBMB Takes Issue with Bush 5 Stem Cell Vote on Hold 6 Molecular Models Fight Malaria 8 NIH Reauthorization Bill Surfaces 9 Scissor-Like Enzyme Causes Cancer 22 10 Dennis Vance to Get Avanti Award ON THE COVER: 12 Macromolecular Structure and Dynamics Call for Abstracts, Travel Award 16 RNA: Structure, Function, and Regulation Application Deadline 18 Signaling in Growth and Development 20 ASBMB Members Share FASEB Award 21 Could DNA Methylation be the Key? 22 Proteome of Human Cornea AWARDS OF EXCELLENCE: MOST IMPROVED MAGAZINE 23 Genes to Help Treat Obesity COLUMNS & EDITORIALS DESIGN & LAYOUT 6 departments 3 From the Desk of the President 4 News From the Hill 8 NIH News 26 Biotech Business 28 Calendar BRONZE AWARD WINNER 2003 LETTERS ASBMB Council Officers Judith S. Bond President Bettie Sue Masters Past-President Peggy J. Farnham Secretary Kenneth E. Neet Treasurer ‘Intelligent Design’ Does Not Council Members William R. Brinkley Councilor Joan W. Conaway Councilor Belong in the Science Classroom Robert A. Copeland Councilor Lila M. Gierasch Councilor resident George W. Bush com- arise through recombination and reas- Frederick P. Guengerich Councilor William J. Lennarz Councilor mented on August 3, 2005, sortment to produce new configura- Peter J. Parker Councilor P that he believes that “intelli- tions of genes, or existing genes may William S. Sly Councilor gent design” should be taught in be modified by mutation. Moreover, William L. Smith Councilor American science classrooms alongside genes can be transferred from one Ex-Officio Members evolution as competing theories. species to another. Not all mutations George M. Carman Chair, Meetings Committee Injecting un-testable beliefs about the result in a detectable change in Cecile Rochette-Egly origin of species, especially Homo sapi- appearance or function of a cell or Dennis R. Voelker Co-chairs, 2005 Program Committee ens, into science classrooms confuses organism. Moto Kimura argued that J. Ellis Bell the distinction between theology and these neutral mutations could play a Chair, Education and Professional Development Committee science, to the detriment of both. Sci- role in evolution. The issue that scien- Juliette Bell entists need to define clearly their tists disagree about is not the “what” Chair, Minority Affairs Committee William R. Brinkley goals in understanding the “what and of evolution, but the “how” of evolu- Chair, Public Affairs Advisory Committee how” of natural phenomena, and rec- tion, that is, the relative importance of Christopher K. Mathews Chair, Publications Committee ognize that science does not address various sources of genetic variation Herbert Tabor the spiritual or mystical “why” of natu- and the driving factors. Editor, JBC ral phenomena. The scientific process does not Ralph A. Bradshaw Editor, MCP Russel Wallace and Charles Darwin address the “why” of evolution or the Edward A. Dennis in the 19th century described continu- “why” of any other natural phenome- Editor, JLR ous changes and adaptations of plants Continued on page 7 ASBMB Today and animals to better fit a particular is a monthly publication of The American Society for niche or environment. There are Biochemistry and Molecular Biology numerous examples of changes in the Tell Us What Editorial Advisory Board flora and fauna, including extinction You Think Irwin Fridovich of species, after natural disasters and Richard W. Hanson introduction of new species that over- Bettie Sue Masters whelm an endogenous species. The J. Evan Sadler We appreciate receiving letters Robert D. Wells “what” of evolution is based upon that are suitable for publication Comments observed fact. The “how” of evolution regarding issues of importance or Please direct any comments or questions has been the focus of continuing concerning ASBMB Today to: study. Darwin proposed ‘Natural Selec- commenting on articles appear- ing in ASBMB Today. Letters John D. Thompson tion,’ with ‘survival of the fittest,’ as Editor, ASBMB Today the process for evolution. Sewell should be sent to the editor, John 9650 Rockville Pike Wright proposed an additional process Thompson, at the address found Bethesda, MD 20814-3996 Phone: 301-634-7145; Fax: 301-634-7126 for evolution within a species, genetic at left. Letters must be signed E-mail: [email protected] drift, in which the small population and must contain the writer’s For information on advertising that settles in a new location or sur- address and telephone number. contact FASEB AdNet at 800-433-2732 vives a disaster is not necessarily repre- The editor reserves the right to ext. 7157 or 301-634-7157, or edit all letters. email [email protected]. sentative of the parent population. Genetic variation in a population may 2 ASBMBToday SEPTEMBER 2005 From the Desk of the President: ‘Science is Fun’ at the FEBS/IUBMB 2005 meeting in Budapest Dr. Judith Bond he 30th Federation of Euro- and were readily recognized by their and I promoted the centennial and the pean Biochemical Societies yellow T-shirts. Another special feature April 2006 meeting in San Francisco. T (FEBS) Congress and the 9th of the meeting was Pub Tours that The IUBMB and the other ASBMB International Union of Biochemistry matched each of 20 speakers with 6 to (Australian Society for Biochemistry and Molecular Biology (IUBMB) Confer- 12 young scientists. and Molecular Biology) are celebrating ence was held 2 to 7 July in Budapest, There was a continuing infusion of their 50th anniversary, and the Argen- Hungary. There was a refreshing spirit the Arts throughout the meeting, with tine Society for Biochemistry and Mol- that ran through the meeting organized one day focusing on paintings, another ecular Biology (SAIB) is celebrating its by our Hungarian hosts (Péter Friedrich, on sculpture, and another on building 40th anniversary. President of the Congress, and Peter molecular models. Elena Kameneva The meeting successfully brought Csermely, Chair of the Organizing won the protein painting contest with colleagues together from all over the Committee) that emphasized that sci- her work “Angel of Immunology.” world, highlighted exciting new devel- ence is a creative enterprise, and that The protein sculpture contest was opments, welcomed trainees and other science is fun. won by the team making the “Drago- aspiring scientists and brought them The meeting, held on the grounds of some”, a proteasome-dragon consum- together with experienced, accom- Eötvös Loránd University, was attended ing an unfolded protein-like feature plished scientists in formal and infor- by 2,646 persons from 89 countries. with a poly-ubiquitin chain. Both works mal settings. Our Hungarian colleagues Students made up 34% of the partici- remain on display at the Museum of were wonderful hosts. The experience pants, 39% were women, and 13% were the Faculty of Science. The opening ses- brought to mind a poem written by from Asia. Although only 11% of the sion included an impressive display of one of our great American poets, Carl attendees were from America, they sand painting by Ferenc Cakó, a well- Sandburg, who wrote: made up 24% of the 321 speakers from known Hungarian artist, in which one 32 countries. The National Science representation was replaced by another Happiness Foundation provided funds for ten against a background of rousing music I asked professors who teach the meaning young U.S. investigators to participate depicting the evolution of life on earth. of life to tell me what is happiness. in the meeting. The scientific oral and Local artisans demonstrated contests And I went to famous executives who boss poster presentations were well attended. between armored knights of the Austro- the work of thousands of men. The science focused on the ‘The Protein Hungarian Empire along the banks of World,’ and spanned the full range of the Danube River. They all shook their heads and gave me biochemistry and molecular biology. The conference banquet was an a smile as though I was trying to fool Plenary lectures included protein mis- evening riverboat cruise up and down with them. folding and human disease, ribosome the Danube, under the many bridges And then one Sunday afternoon I structure, molecular mechanisms of connecting the city of Pest and the city wandered out along the Desplaines River bacterial swimming and tumbling, and of Buda. Along the banks were the Par- complex networks in metabolics and liament Building, a twin of the Parlia- And I saw a crowd of Hungarians under systems biology. ment Building in London, St. Stephen’s the trees with their women and children There were a number of unique fea- Cathredral, and much more.
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