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Self-Guided Online Cognitive Behavioral Strategies for Chemotherapy-Induced Peripheral

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Self-Guided Online Cognitive Behavioral Strategies for Chemotherapy-Induced Peripheral Self-Guided Online Cognitive Behavioral Strategies for Chemotherapy-Induced Peripheral Neuropathy: A Multicenter, Randomized, Wait-List Controlled Trial by Robert J. Knoerl A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy (Nursing) in the University of Michigan 2017 Dissertation Committee: Associate Professor Ellen Lavoie Smith, Chair Professor Debra L. Barton Professor Janean E. Holden Professor David A. Williams Associate Research Scientist, James J. Yang Robert J. Knoerl [email protected] OCRID iD: 0000-0002-6996-5068 DEDICATION This dissertation is dedicated to my parents and sister for their love and support throughout my baccalaureate and doctoral education. I’d also like to dedicate this dissertation to the many friends I’ve made at the University of Michigan over the past seven years. Without them, I would not have had such a fantastic experience. This is Mich. iii ACKNOWLEDGEMENTS I would like to acknowledge Lynn Henry, MD, PhD for her work in developing the PROSPECT modules. In addition, I would like to acknowledge Mikele Garrett MBA, BBA and Celia Bridges BA, BSN, RN for their assistance in designing and editing the CIPN PROSPECT module, Cesar Figueras RN and Bethany LaVasseur RN, MS for their assistance in the implementation of the study procedures, and Zach Chornoby, Olivia Merrit, and Madison Vanallsburg for their assistance with data collection. I would like to acknowledge Philip Stella, MD, John C. Krauss, MD, Christine Veenstra, MD, and Grace Chen, MD for their assistance in identifying patients at the study locations. Funding for this study was provided by the University of Michigan School of Nursing New Investigator Award. Creation of the PROSPECT website was supported by the Damon Runyon Cancer Research Foundation (#CI-53-10) to NLH. PROSPECT was adapted from the website, Fibroguide, which was developed with support from Grant numbers R01-AR050044 (NIAMS/ NIH), and DAMD 17-00-2-0018 (Department of Defense). iv Table of Contents DEDICATION ............................................................................................................................. iii ACKNOWLEDGEMENTS ........................................................................................................ iv LIST OF TABLES ...................................................................................................................... vii LIST OF FIGURES ................................................................................................................... viii LIST OF APPENDICES .............................................................................................................. x ABSTRACT .................................................................................................................................. xi CHAPTER I: INTRODUCTION ................................................................................................ 1 Statement of the Problem ......................................................................................................... 2 Purpose....................................................................................................................................... 3 Specific Aims and Hypotheses ................................................................................................. 3 Theoretical Approach ............................................................................................................... 5 Results ...................................................................................................................................... 14 References ................................................................................................................................ 16 CHAPTER II: TREATMENT OF CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY AND ASSOCIATED PAIN ........................................................................... 23 Chronic Neuropathic Pain ..................................................................................................... 23 Pathophysiology of Neuropathic Pain ................................................................................... 23 Cancer Treatment Related Neuropathic Pain ...................................................................... 28 Chemotherapy-Induced Peripheral Neuropathy ................................................................. 29 Incidence, Pathophysiology, Symptoms, and Risk Factors of Chemotherapy-Induced Peripheral Neuropathy .......................................................................................................... 29 Treatment of Chemotherapy-Induced Peripheral Neuropathy .............................................. 35 References ................................................................................................................................ 47 CHAPTER III: CHRONIC PAIN AND COGNITIVE BEHAVIORAL THERAPY: AN INTEGRATIVE REVIEW ........................................................................................................ 59 Abstract .................................................................................................................................... 59 Background ............................................................................................................................. 59 Methods .................................................................................................................................... 65 Results ...................................................................................................................................... 68 Discussion ................................................................................................................................ 72 References ................................................................................................................................ 88 CHAPTER IV: SELF-GUIDED ONLINE COGNITIVE BEHAVIORAL STRATEGIES FOR CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY: A MULTICENTER, RANDOMIZED, WAIT-LIST CONTROLLED TRIAL ....................... 97 Abstract .................................................................................................................................... 97 Background ............................................................................................................................. 98 Methods .................................................................................................................................. 100 Results .................................................................................................................................... 106 v Discussion .............................................................................................................................. 109 References .............................................................................................................................. 131 CHAPTER V: MEDIATORS OF CHRONIC PAINFUL CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY IMPROVEMENT FOLLOWING AN EIGHT-WEEK SELF-GUIDED COGNITIVE AND BEHAVIORALLY-BASED PAIN MANAGEMENT INTERVENTION ..................................................................................................................... 138 Abstract .................................................................................................................................. 138 Background ........................................................................................................................... 139 Methods .................................................................................................................................. 144 Results .................................................................................................................................... 149 Discussion .............................................................................................................................. 151 References .............................................................................................................................. 175 CHAPTERV VI: SUMMARY ................................................................................................. 184 Results .................................................................................................................................... 185 Limitations ............................................................................................................................. 195 Recommendations for Future Research ............................................................................. 197 Recommendations for Clinical Practice .............................................................................. 200 Conclusions ............................................................................................................................ 201 References .............................................................................................................................. 202 APPENDICES ........................................................................................................................... 208 vi LIST OF TABLES Table 1: Search Terms 82 Table 2: Populations Testing Cognitive Behavioral Pain Management Interventions 83 Table 3: Cognitive Behavioral Pain Management Intervention Characteristics 84 Table 4: IMMPACT Variables Measured 85 Table 5: Frequency of Types of Pain Intensity Measures 86 Table 6: Summary of Proactive Self-Management
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