Annual Report 2001
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POLISH ACADEMY OF SCIENCES MEDICAL RESEARCH CENTRE ANNUAL REPORT 2001 WARSZAWA - 2002 http://rcin.org.pl Editors: Halina Weinrauder Wanda Dziedzic Katarzyna Radwańska Scientific Consultants: Jan Albrecht Krystyna Cedro-Ceremużyńska Mieczysław Pokorski Polish Academy of Sciences Medical Research Centre (MRC) 5 Pawinskiego St., 02-106 Warsaw, Poland Telephones: [+48 22] 668 52 50; 668 52 64; 608 65 50 Fax [+48 22] 668 55 32 http://rcin.org.pl CONTENTS Page MRC SCIENTIFIC COUNCIL 4 EXECUTIVE BOARD 5 STAFF LIST 6 RESEARCH REPORTS 21 Department of Neurophysiology 21 Laboratory of Respiration Physiology 27 Laboratory of Experimental Pharmacology 29 Department of Neurochemistry 34 Laboratory of Pharmaconeurochemistry 34 Laboratory of Pathobiochemistry of the Central Nervous System 41 Laboratory of Molecular Neuropathology 43 Molecular Biology Unit 50 Department of Cellular Signalling 52 Department of Neurotoxicology 61 Department of Neuropathology 67 Laboratory of Experimental Nuclear Medicine 76 Department of Neurodegenerative Disorders 79 Department of Developmental Neuropathology 83 Laboratory of Cell Ultrastructure 87 Department of Neurosurgery 92 Neuromuscular Unit 98 Neuroimmunological Unit 105 Department of Applied Physiology 110 Laboratory of Renal and Body Fluid Physiology 119 Cardiovascular Laboratory 123 Department of Surgical Research and Transplantology 125 Neuropeptide Laboratory 136 Department of Endocrinology 139 Laboratory of Molecular and Cellular Nephrology 147 PROMOTIONS 151 ORGANIZATION OF SYMPOSIA AND CONFERENCES 152 GUEST LECTURES 154 3 http://rcin.org.pl MRC SCIENTIFIC COUNCIL Chairman: Bohdan Lewartowski Vice-Chairman: Janusz Nauman Secretary: Barbara Gajkowska Members: Jan Albrecht Mirosław J. Mossakowski Maria Barcikowska Olgierd Narkiewicz Włodzimierz Bicz Krystyna Nazar Krystyna Cedro-Ceremużyńska Adam Nowosławski (Honorary Zbigniew Czernicki Chairman) Maria Dąmbska Barbara Oderfeld-Nowak Krystyna Domańska-Janik Waldemar L. Olszewski Jan Górski Kazimierz Ostrowski Irena Hausmanowa-Petrusewicz Tadeusz Popiela Wojciech Hilgier Edmund Przegaliński Włodzimierz Januszewicz Czesław Radzikowski Hanna Kaciuba-Uściłko Urszula Rafałowska Leszek Kaczmarek Janusz Sadowski Józef Kałuża Joanna Strosznajder Andrzej Kapuściński Ewa Szczepańska-Sadowska Witold Karczewski Małgorzata Szereda- Wojciech Kostowski -Przestaszewska Ewa Koźniewska-Kołodziejska Andrzej Szutowicz Andrzej W. Lipkowski Andrzej Trzebski Jerzy W. Łazarewicz Jerzy Vetulani Barbara Łukomska Mieczysław Wender Jerzy Maj Barbara Zabłocka Witold Mazurowski Andrzej Ziemba 4 http://rcin.org.pl EXECUTIVE BOARD Director:________________________________________________ Professor Mirosław J. Mossakowski, M.D., Ph.D., D.Sci., D.h.c. Member of Polish Academy of Sciences Scientific Directors: Professor Jan Albrecht, M.Biol., Ph.D., D.Sci. Professor Jerzy W. Łazarewcz, M.D., Ph.D., D.Sci. Managing Director: Eugeniusz Kaczmarczyk, M.C.L. 5 http://rcin.org.pl STAFF LIST DEPARTMENT OF NEUROPHYSIOLOGY Head: Professor Mieczysław Pokorski Scientific Staff Krystyna Budzińska, M. Pharm., Ph.D., D.Sci. Leszek Czerwosz, M.Phys., Ph.D. Aneta Dymecka, M.Sci. Lidia Faff, M.Pharm., Ph.D. (until July, 2001) Bożena Kowalska, M.Biol., (until March, 2001) Jacek Kunicki, M.D. (until September, 2001) Magdalena Marczak, M.D. Mieczysław Pokorski, M.D., Ph.D., D.Sci., Professor of Medical Sciences Beata Sokołowska, M.Phys. Robert Strosznajder, M.Zoot., Ph.D. Lidia Zarębska, M.Biol. (until December, 2001) Technical Staff Anna Lendzion-Radajewska, Ewa Wielechowska Administrative Staff Ludmiła Haczyńska, secretary Laboratory of Respiration Physiology Head: Assoc. Professor Małgorzata Szereda-Przestaszewska Scientific Staff Katarzyna Kaczyńska, M.Biol. Beata Kopczyńska, M.Biol. 6 http://rcin.org.pl Małgorzata Szereda-Przestaszewska, M.D., Ph., D., D.Sci., Assoc. Prof. of Medical Sciences Technical Staff Teresa Warnawin LABORATORY OF EXPERIMENTAL PHARMACOLOGY Head: Assoc. Professor Paweł Grieb Scientific Staff Stanisław Chrapusta, M.Sci. Chem., Ph.D. Bronisław Głód, M.Chem., Ph.D., D.Sci., Assoc. Prof. of Chemical Sciences Paweł Grieb, M.Biol. Ph.D., D.Sci., Assoc. Prof. of Natural Sciences Wiktor Janczewski, M.Sci. Eng., Ph.D. Tomasz Kryczka, M.D. Mirosław Ryba, M.D., Ph.D., D.Sci., Assoc. Prof. of Medical Sciences Ewa Wojtal, M.D., Ph.D. (since November, 2001) Technical Staff Monika Janisz DEPARTMENT OF NEUROCHEMISTRY Head: Professor Jerzy Łazarewicz Laboratory of Pharmaconeurochemistry Head: Professor Jerzy Łazarewicz Scientific Staff Adam Filip, M.Biol. Wanda Gordon-Krajcer, M.Pharm., Ph.D. http://rcin.org.pl 7 Jerzy W. Łazarewicz, M.D., Ph.D., D.Sci., Professor of Medical Sciences Dorota Makarewicz, M.Biol. Elżbieta Salińska, M.Biol., Ph.D. Aleksandra Stafiej, M.Chem. Elżbieta Ziemińska, M.Biol. Technical Staff Halina Nowińska, Anna Sobczuk, Apolonia Ziembowicz Laboratory of Pathobiochemistry of the Central Nervous System Head: Professor Urszula Rafałowska Scientific Staff Irena Bubko, M.Biol., Ph.D. (until October, 2001) Beata Dąbrowska-Bouta, M.Biol. Urszula Rafałowska, M.Biol., Ph.D., D.Sci., Professor of Natural Sciences Lidia Strużyńska, M.Med.Anal., Ph.D. Grzegorz Sulkowski, M.Biol. Jolanta Waśkiewicz, M.Biol., Ph.D. Technical Staff Aleksandra Lenkiewicz Laboratory of Molecular Neuropathology Head: Professor Krystyna Domanska-Janik Scientific Staff Agnieszka Bronisz, M.Biol., Ph.D. Leonora Buzahska, M.Biol., Ph.D. 8 http://rcin.org.pl Krystyna Domańska-Janik, M.D., Ph.D., D.Sci., Professor of Medical Sciences Agnieszka Kobel-Borysiuk, M.D. (since October, 2001) Małgorzata Nałęcz, M.Biol. Anna Sarnowska, M.Biol. Joanna Sypecka, M.Biol., Ph.D. Teresa Zalewska, M.Pharm., Ph.D., D.Sci., Assoc. Prof. of Medical Sciences Technical Staff [Teresa Czechmańska,Halina Zając Administrative Staff of the Department Maria Izak, secretary MOLECULAR BIOLOGY UNIT Head: Dr. Barbara Zabłocka Scientific Staff Joanna Dłużniewska, M.Biol. (since February, 2001) Anna Kulińska, M.Biol. Barbara Zabłocka, M.Biol., Ph.D. DEPARTMENT OF NEUROTOXICOLOGY Head: Professor Jan Albrecht Scientific Staff Jan Albrecht, M.Biol., Ph.D., D.Sci., Professor of Medical Sciences Monika Dolińska, M.Sci. Anna Dybel, M.Biol. Wojciech Hilgier, M. Pharm., Ph.D. Hanna Klinowska, M.Agr.Sci. Magdalena Zielińska, M.Sci.Eng. 9 http://rcin.org.pl Technical Staff Małgorzata Bogacińska, Inez Fręśko, Mirosława Poławska DEPARTMENT OF CELLULAR SIGNALLING Head: Professor Joanna Strosznajder Scientific Staff Małgorzata Chalimoniuk, M.Chem., Ph.D. Grzegorz Czapski, M.Biol. Jolanta Dziewulska, M.A. candidate Henryk Jęśko, M.Biol. Joanna Strosznajder, M.D., Ph.D., D.Sci., Professor of Medical Sciences Agata Zambrzycka, M.Biol. Technical Staff Danuta Kacprzak, Monika Kamińska, Dorota Kopczuk Administrative Staff Beata Łuczyńska, secretary LABORATORY OF EXPERIMENTAL NUCLEAR MEDICINE Head: Professor Andrzej Kapuściński Scientific Staff Andrzej Kapuściński, M.D., Ph.D., D.Sci., Professor of Medical Sciences Ewa Koźniewska-Kołodziejska, M.Phys., Ph.D., D.Sci., Assoc. Prof. of Medical Sciences Robert P. Ostrowski, M.D., Ph.D. 10 http://rcin.org.pl Technical Staff Sławomir Januszewski, Zdzisława Kowalska, Lidia Radomska DEPARTMENT OF NEUROPATHOLOGY Head: Professor Janina Rafałowska Scientific Staff Jolanta Baraniecka, M.Chem.Eng. Dorota Dziewulska, M.D., Ph.D. Roman Gadamski, M.Vet., Ph.D. Ewa Matyja, M.D., Ph.D., D.Sci., Assoc. Prof. of Medical Sciences ¡Mirosław J. Mossakowski), M.D., Ph.D., D.Sci., Professor of Medical Sciences Ewa Nagańska, M.D. Piotr Piotrowski, M.D. Ryszard Pluta, M.D., Ph.D., D.Sci., Assoc. Prof. of Medical Sciences Janina Rafałowska, M.D., Ph.D., D.Sci., Professor of Medical Sciences Grażyna Szumańska, M.Biol., Ph.D. Mieczysław Śmiałek, M.D., Ph.D., D.Sci., Assoc. Prof. of Medical Sciences Anna Taraszewska, M.D., Ph.D. Irmina B. Zelman, M.D., Ph.D., D.Sci., Assoc. Prof. of Medical Sciences Technical Staff Hanna Chrzanowska, Joanna Derda, Jolanta Gębarowska, Elżbieta Grzywaczewska, Sławomir Januszewski, Jadwiga Kędzierska (until October, 2001), Małgorzata Kobryś, Jolanta Krzywicka, Wanda Ogonowska, Krystyna Wierzbicka, Renata Wojda, Maria Zielińska Administrative Staff Teresa Miodowska, secretary li http://rcin.org.pl DEPARTMENT OF NEURODEGENERATIVE DISORDERS Head: Professor Maria Barcikowska Scientific Staff Maria Barcikowska, M.D., Ph.D., D.Sci., Professor of Medical Sciences Tomasz Gabryelewicz, M.D., Ph.D. Marek Gołębiowski, M.D., Ph.D., D.Sci. Beata Pepłońska, M.Sci. (since April, 2001) Anna Pfeffer-Baczuk, M.D., Ph.D. Jarosław Pniewski, M.D., Ph.D. Dorota Religa, M.D. Maria Styczyńska, M.D. Bogusław Wasiak, M.Psych., Ph.D. Technical Staff Izabela Przekop DEPARTMENT OF DEVELOPMENTAL NEUROPATHOLOGY Head: Assoc. Professor Danuta Maślińska Scientific Staff Maria Dąmbska, M.D., Ph.D., D.Sci., Professor of Medical Sciences Agnieszka Kaliszek, M.D. Milena Laure-Kamionowska, M.D., Ph.D. Danuta Maślińska, M.D., Ph.D., D.Sci., Assoc. Prof. of Medical Sciences Technical Staff Jolanta Opertowska, Barbara Raczkowska, Jolanta Toborowicz, Elżbieta Wanacka, Hanna Winiarska Administrative Staff Lidia Wąsowska, secretary 12 http://rcin.org.pl LABORATORY OF THE CELL ULTRASTRUCTURE Head: Professor Barbara Gajkowska Scientific Staff Małgorzata Frontczak-Baniewicz, M.Biol., Ph.D. Barbara Gajkowska, M.Biol., Ph.D., D.Sci., Professor of Medical Sciences Hanna Olszewska-Bądarczuk, M.D. Michał Walski, M.D., Ph.D., D.Sci., Assoc. Prof. of Medical Sciences Urszula Wojewódzka, M.Vet. (since March, 2001) Technical Staff Henryk Bilski, Joanna Gajda,