L'académie Des Sciences Dans La Presse En 2011
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2013 Annual Report
2013 ANNUAL REPORT PETER WALL INSTITUTE FOR ADVANCED STUDIES The Institute is committed foremost to excellence in research; its goal is to stimulate collaborative, creative, innovative interdisciplinary research that makes important advances in knowledge. A guiding principle is that excellence and truly innovative research are achieved in a highly collaborative international research environment at the University of British Columbia, where UBC scholars have sustained opportunity to exchange ideas with national and international scholars, to work together on innovative research, develop new thinking that is beyond disciplinary boundaries, and engage in intellectual risk-taking. The Institute respects diversity of perspectives and backgrounds, research embedded in the community and integration of multimodal and expressive arts as an important component of research across all disciplines. The Institute is committed to wise stewardship of its resources in continuing to build on its significant research accomplishments. TABLE OF CONTENTS 04 Message from the Director 06 UBIAS Conference INTERNATIONAL PROGRAMS 10 International Visiting Research Scholar 14 UBC Visiting Scholar Abroad 18 International Research Roundtables 28 International Distinguished Visiting Professors 32 International Partnerships 36 Major Thematic Grant 39 French Lecture Series 40 Exploratory Workshops NATIONAL PROGRAMS 44 Peter Wall Distinguished Professor 48 Distinguished Scholars in Residence 54 Early Career Scholars 64 The Wall Exchange 66 The Wall Hour 70 Associate Research Fora 74 Theme Development Workshop 76 Research Mentoring Program 78 Colloquia 79 Special Events PETER WALL SOLUTIONS INITIATIVE 80 Program Review and Highlights ABOUT THE INSTITUTE 84 Funding and Governance 86 Committies 88 The Institute 90 Director and Staff Director’s Message Excellence in research is the Institute’s primary goal, creating the environment for collaborative, creative, interdisciplinary research that makes important advances in knowledge. -
Mapping of Shigella Flexneri's Tissue Distribution and Type III Secretion Apparatus Activity During Infection of the Large I
Mapping of Shigella flexneri’s tissue distribution and type III secretion apparatus activity during infection of the large intestine of guinea pigs Giulia Nigro, Ellen Arena, Martin Sachse, Maryse Moya-Nilges, Benoit Marteyn, Philippe Sansonetti, F-X Campbell-Valois To cite this version: Giulia Nigro, Ellen Arena, Martin Sachse, Maryse Moya-Nilges, Benoit Marteyn, et al.. Mapping of Shigella flexneri’s tissue distribution and type III secretion apparatus activity during infection of the large intestine of guinea pigs. Pathogens and Disease, Oxford University Press, 2019, 77 (7), pp.ftz054,. 10.1093/femspd/ftz054. hal-02429855 HAL Id: hal-02429855 https://hal.archives-ouvertes.fr/hal-02429855 Submitted on 13 Jan 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution - NonCommercial| 4.0 International License Pathogens and Disease, 77, 2019, ftz054 doi: 10.1093/femspd/ftz054 Advance Access Publication Date: 3 October 2019 Research Article RESEARCH ARTICLE Mapping of Shigella flexneri’s tissue distribution and type III secretion apparatus activity during infection of the large intestine of guinea pigs Giulia Nigro1, Ellen T. Arena1,2, Martin Sachse3, Maryse Moya-Nilges3, Benoit S. -
Science & Policy Meeting Jennifer Lippincott-Schwartz Science in The
SUMMER 2014 ISSUE 27 encounters page 9 Science in the desert EMBO | EMBL Anniversary Science & Policy Meeting pageS 2 – 3 ANNIVERSARY TH page 8 Interview Jennifer E M B O 50 Lippincott-Schwartz H ©NI Membership expansion EMBO News New funding for senior postdoctoral In perspective Georgina Ferry’s enlarges its membership into evolution, researchers. EMBO Advanced Fellowships book tells the story of the growth and ecology and neurosciences on the offer an additional two years of financial expansion of EMBO since 1964. occasion of its 50th anniversary. support to former and current EMBO Fellows. PAGES 4 – 6 PAGE 11 PAGES 16 www.embo.org HIGHLIGHTS FROM THE EMBO|EMBL ANNIVERSARY SCIENCE AND POLICY MEETING transmissible cancer: the Tasmanian devil facial Science meets policy and politics tumour disease and the canine transmissible venereal tumour. After a ceremony to unveil the 2014 marks the 50th anniversary of EMBO, the 45th anniversary of the ScienceTree (see box), an oak tree planted in soil European Molecular Biology Conference (EMBC), the organization of obtained from countries throughout the European member states who fund EMBO, and the 40th anniversary of the European Union to symbolize the importance of European integration, representatives from the govern- Molecular Biology Laboratory (EMBL). EMBO, EMBC, and EMBL recently ments of France, Luxembourg, Malta, Spain combined their efforts to put together a joint event at the EMBL Advanced and Switzerland took part in a panel discussion Training Centre in Heidelberg, Germany, on 2 and 3 July 2014. The moderated by Marja Makarow, Vice President for Research of the Academy of Finland. -
2009 Paris, France the Movement Disorder Society’S 13Th International Congress of Parkinson’S Disease and Movement Disorders
FINAL PROGRAM The Movement Disorder Society’s 13th International Congress OF PARKINSon’S DISEASE AND MOVEMENT DISORDERS JUNE 7-11, 2009 Paris, France The Movement Disorder Society’s 13th International Congress of Parkinson’s Disease and Movement Disorders Claiming CME Credit To claim CME credit for your participation in the MDS 13th International Congress of Parkinson’s Disease and Movement Disorders, International Congress participants must complete and submit an online CME Request Form. This Form will be available beginning June 10. Instructions for claiming credit: • After June 10, visit www.movementdisorders.org/congress/congress09/cme • Log in following the instructions on the page. You will need your International Congress Reference Number, located on the upper right of the Confirmation Sheet found in your registration packet. • Follow the on-screen instructions to claim CME Credit for the sessions you attended. • You may print your certificate from your home or office, or save it as a PDF for your records. Continuing Medical Education The Movement Disorder Society is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Credit Designation The Movement Disorder Society designates this educational activity for a maximum of 30.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity. Non-CME Certificates of Attendance were included with your on- site registration packet. If you did not receive one, please e-mail [email protected] to request one. The Movement Disorder Society has sought accreditation from the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists. -
2012 Annual Report
2012 ANNUAL REPORT PETER WALL INSTITUTE FOR ADVANCED STUDIES Providing resources for capable and committed individuals to follow their instincts leads to the best of all discoveries, the totally surprising, the most unexpected, and the most useful ones. “Dr. Michael Smith, Nobel Laureate, Peter Wall Institute Distinguished Professor 1995-2000 TABLE OF CONTENTS 04 Message from the Director INTERNATIONAL PROGRAMS 06 International Visiting Research Scholar 10 UBC Visiting Scholar Abroad Program 12 International Roundtable Discussion Program 16 International Distinguished Visiting Professor 18 International Partnerships 22 Major Thematic Grant 26 French Lecture Series 28 Exploratory Workshops NATIONAL PROGRAMS 34 Peter Wall Distinguished Professors 38 Distinguished Scholars in Residence 42 Early Career Scholars 50 The Wall Exchange 52 Arts-based Initiatives Program 56 The Wall Hour 58 Faculty Associate Forums 62 Wall Scholars Café 64 Theme Development Workshop 68 Colloquia PETER WALL SOLUTIONS INITIATIVE 70 Solutions Projects ABOUT THE INSTITUTE 76 Funding and Governance 78 Committies 80 The Institute 82 Director and Staff Director’s Message It has been an extraordinary year of innovative research, exciting collaborations and new program initiatives, all aimed at the Institute’s core objective of creating and supporting innovative research that will lead to important advances in knowledge. The Peter Wall Institute for Advanced Studies hosted sixteen International Visiting Research Scholars under a new program that partners with UBC faculties and research centres to bring outstanding scholars to UBC to work collaboratively with UBC faculty members on ground-breaking research. The Institute also launched a new initiative to host six International Roundtable Discussions each year for scholars from the international community and Canada to come together in the pursuit of knowledge in an interdisciplinary environment. -
Shigella Impairs T Lymphocyte Dynamics in Vivo
impairs T lymphocyte dynamics in vivo Shigella INAUGURAL ARTICLE Wilmara Salgado-Pabóna,b,1, Susanna Cellic, Ellen T. Arenaa,b, Katharina Nothelfera,b, Pascal Rouxd, Gernot Sellgea,b,2, Elisabetta Frigimelicaa,b,3, Philippe Boussoc, Philippe J. Sansonettia,b,4, and Armelle Phalipona,b aMolecular Microbial Pathogenesis Unit, Department Cell Biology and Infection, bInstitut National de la Santé et de la Recherche Médicale U786, dPlatform for Dynamic Imaging Studies, and cDynamics of Immune Responses Unit, Department of Immunology, Institut Pasteur, 75724 Paris Cedex 15, France This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected in 2012. Contributed by Philippe J. Sansonetti, January 17, 2013 (sent for review September 12, 2012) The Gram-negative enteroinvasive bacterium Shigella flexneri is infection (12). Information is also scant regarding Shigella’s ca- responsible for the endemic form of bacillary dysentery, an acute pacity to subvert the host acquired immune responses by directly rectocolitis in humans. S. flexneri uses a type III secretion system to interacting with T or B lymphocytes. Such interactions may take inject effector proteins into host cells, thus diverting cellular func- place in the colonic lymphoid follicles after Shigella’s crossing of tions to its own benefit. Protective immunity to reinfection requires the intestinal barrier via M cells located within the follicle-as- several rounds of infection to be elicited and is short-lasting, sociated epithelium, in the lamina propria, or the mesenteric suggesting that S. flexneri interferes with the priming of specific lymph nodes (LNs) (5). immunity. Considering the key role played by T-lymphocyte traf- We recently demonstrated that Shigella invades activated, but + ficking in priming of adaptive immunity, we investigated the im- not resting, human CD4 T cells in vitro, leading to cell migra- pact of S. -
Pnas11052ackreviewers 5098..5136
Acknowledgment of Reviewers, 2013 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2013. Their generous contribution is deeply appreciated. A Harald Ade Takaaki Akaike Heather Allen Ariel Amir Scott Aaronson Karen Adelman Katerina Akassoglou Icarus Allen Ido Amit Stuart Aaronson Zach Adelman Arne Akbar John Allen Angelika Amon Adam Abate Pia Adelroth Erol Akcay Karen Allen Hubert Amrein Abul Abbas David Adelson Mark Akeson Lisa Allen Serge Amselem Tarek Abbas Alan Aderem Anna Akhmanova Nicola Allen Derk Amsen Jonathan Abbatt Neil Adger Shizuo Akira Paul Allen Esther Amstad Shahal Abbo Noam Adir Ramesh Akkina Philip Allen I. Jonathan Amster Patrick Abbot Jess Adkins Klaus Aktories Toby Allen Ronald Amundson Albert Abbott Elizabeth Adkins-Regan Muhammad Alam James Allison Katrin Amunts Geoff Abbott Roee Admon Eric Alani Mead Allison Myron Amusia Larry Abbott Walter Adriani Pietro Alano Isabel Allona Gynheung An Nicholas Abbott Ruedi Aebersold Cedric Alaux Robin Allshire Zhiqiang An Rasha Abdel Rahman Ueli Aebi Maher Alayyoubi Abigail Allwood Ranjit Anand Zalfa Abdel-Malek Martin Aeschlimann Richard Alba Julian Allwood Beau Ances Minori Abe Ruslan Afasizhev Salim Al-Babili Eric Alm David Andelman Kathryn Abel Markus Affolter Salvatore Albani Benjamin Alman John Anderies Asa Abeliovich Dritan Agalliu Silas Alben Steven Almo Gregor Anderluh John Aber David Agard Mark Alber Douglas Almond Bogi Andersen Geoff Abers Aneel Aggarwal Reka Albert Genevieve Almouzni George Andersen Rohan Abeyaratne Anurag Agrawal R. Craig Albertson Noga Alon Gregers Andersen Susan Abmayr Arun Agrawal Roy Alcalay Uri Alon Ken Andersen Ehab Abouheif Paul Agris Antonio Alcami Claudio Alonso Olaf Andersen Soman Abraham H. -
Development of Vaccines at the Time of COVID-19 Jeffrey Almond1,Jorg¨ Hacker2, Colin Harwood3,†, Mariagrazia Pizza4, Rino Rappuoli4, Eliora Z
microLife, 1, 2020, uqaa003 doi: 10.1093/femsml/uqaa003 Advance Access Publication Date: 17 December 2020 Short Review SHORT REVIEW Downloaded from https://academic.oup.com/microlife/article/1/1/uqaa003/6041022 by Robert Koch-Institut user on 29 December 2020 Development of vaccines at the time of COVID-19 Jeffrey Almond1,Jorg¨ Hacker2, Colin Harwood3,†, Mariagrazia Pizza4, Rino Rappuoli4, Eliora Z. Ron5,*,‡, Philippe Sansonetti6, Samantha Vanderslott7 and Lothar H. Wieler8 1The Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK, 2German National Academy of Science Leopoldina, Jagerberg¨ 1, 06108 Halle, Germany, 3Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Baddiley-Clark Building, Newcastle upon Tyne NE2 4AX, UK, 4GSK Vaccines, Via Fiorentina, 1, 53100 Siena SI, Italy, 5The Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, PO Box 39040, Tel Aviv 6997801, Israel, 6Institut Pasteur, 25-28 Rue du Dr Roux, 75015 Paris, France, 7Oxford Vaccine Group and Oxford Martin School, 34 Broad St, Oxford OX1 3BD, UK and 8Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany ∗Corresponding author: The Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel. E-mail: [email protected] One sentence summary: Development of vaccines in the times of COVID-19. †Colin Harwood, http://orcid.org/0000-0002-3624-0001 ‡Eliora Z. Ron, http://orcid.org/0000-0003-2615-8685 ABSTRACT In December 2019, a working group of the European Academy of Microbiology assembled to discuss various aspects of vaccines and vaccinations. -
Lasker Interactive Research Nom'18.Indd
THE 2018 LASKER MEDICAL RESEARCH AWARDS Nomination Packet albert and mary lasker foundation November 1, 2017 Greetings: On behalf of the Albert and Mary Lasker Foundation, I invite you to submit a nomination for the 2018 Lasker Medical Research Awards. Since 1945, the Lasker Awards have recognized the contributions of scientists, physicians, and public citizens who have made major advances in the understanding, diagnosis, treatment, cure, and prevention of disease. The Medical Research Awards will be offered in three categories in 2018: Basic Research, Clinical Research, and Special Achievement. The Lasker Foundation seeks nominations of outstanding scientists; nominations of women and minorities are encouraged. Nominations that have been made in previous years are not automatically reconsidered. Please see the Nomination Requirements section of this booklet for instructions on updating and resubmitting a nomination. The Foundation accepts electronic submissions. For information on submitting an electronic nomination, please visit www.laskerfoundation.org. Lasker Awards often presage future recognition of the Nobel committee, and they have become known popularly as “America’s Nobels.” Eighty-seven Lasker laureates have received the Nobel Prize, including 40 in the last three decades. Additional information on the Awards Program and on Lasker laureates can be found on our website, www.laskerfoundation.org. A distinguished panel of jurors will select the scientists to be honored with Lasker Medical Research Awards. The 2018 Awards will -
Ligne Du Temps
Mon père, ce robot ? Une chronologie forcément subjective … où il est question de l'histoire technologique de l'humanité, de créatures artificielles, de machinisme, d'informatique, d'eugénisme, d'intelligence artificielle Préhistoire - 2,5 millions d'années Les premiers hommes sont déjà des êtres techniques puisqu'ils façonnent et utilisent comme outils des éclats de silex. - 400 000 ans L'homme domestique le feu ! - 100 000 ans Premières sépultures au Proche-Orient, puis en Europe. L'existence sociale de l'individu se perpétue, à travers des offrandes, des objets rituels. Conscience de la mort, de la finitude… - 35 000 ans Premières traces de représentations anthropomorphes, telle la Vénus de Hohle Fels sculptée dans de l'ivoire de mammouth et considérée comme la première représentation humaine en trois dimensions. Haute Antiquité - 3500 invention de la roue en Mésopotamie (dans l'actuel Irak). - 3300 début de l'écriture Des chaouabti (statuettes funéraires) sont retrouvés dans les caveaux funéraires égyptiens Les Egyptiens pensaient que leur esprit pouvait s'y réincarner et reprendre ainsi un corps véritable. - 2000 av JC La longue quête initiatique de Gilgamesh, roi d'Uruk (Mésopotamie), en vue d'obtenir l'immortalité est l'un des premiers récits écrits connu. [Devrai-je donc mourir, moi aussi ? Ne me faudra-t-il pas ressembler à Enkidu ? L'angoisse m'est entrée au ventre ! C'est par peur de la mort que je cours la steppe. ] entre - 1500 et - 800 Écriture de la Genèse, le récit fondateur des origines de l'homme dans la religion juive (Torah) et chrétienne (Bible). Il y est écrit que le monde, toutes les créatures et donc l'homme et la femme ont été crée par Dieu à son image. -
Le Putéolien Michel Talagrand, Prix Shaw 2019 En Mathématiques
Talents de Puteaux SCienCes Le Putéolien Michel Talagrand, prix Shaw 2019 en mathématiques Ancien directeur de recherche au CNRS (Centre national de la recherche scientifique), Michel Talagrand a reçu, le 25 septembre dernier à Hong-Kong, le prix Shaw 2019 en mathématiques. « Cette récompense représente le travail d’une vie », réagit Michel Talagrand, ému, après l’annonce des lauréats. Considéré comme le « prix Nobel asiatique », le prix Shaw honore, chaque année depuis 2004, les plus grands scientifiques du monde dans trois domaines : l’astronomie, les sciences biologiques et médicales et enfin les mathématiques. « Bien sûr, quand on s’investit totalement dans ce que l’on fait, on peut espérer un jour être reconnu. Mais très franchement, je n’aurais jamais imaginé gagner ce prix », confie-t-il. Pour- Michel Talagrand reçoit le prix Shaw des mains de Carrie Lam, cheffe de l’executif hongkongais tant, Michel Talagrand collectionne les distinctions depuis son entrée au CNRS en 1974 : Prix Peccot en 1980, Prix Servant Le saviez-vous ? de l’Académie des sciences en 1985, Prix L’excellence française Michel Talagrand est le cinquième Loève en 1995, Prix Fermat en 1997… et C’est un fait indiscutable, la France est chercheur français à être distingué par donc le prix Shaw en 2019. une terre de mathématiques. René Des- le prix Shaw, après Maxim Kontsevich Abonné dès l’âge de 7 ans au magazine cartes, Blaise Pascal, Pierre de Fermat, (2011) et Claire Voisin (2017), tous Sciences et Avenir, le jeune mathématicien Evariste Galois, Henri Poincaré et plus deux récompensés par le prix Shaw de en herbe est devenu l’un des plus grands récemment Jean-Pierre Serre ou encore mathématiques, et les chercheurs Jules scientifiques au monde, distingué pour ses Alexandre Grothendieck ont accumulé les Hoffmann (2011) et Jean-Loup Puget travaux sur les inégalités de concentration, distinctions internationales : prix Shaw, (2018), lauréats en sciences biolo- les processus stochastiques ou encore pour prix Abel, médaille Fields.. -
Concentration on the Boolean Hypercube Via Pathwise Stochastic Analysis
Concentration on the Boolean hypercube via pathwise stochastic analysis Ronen Eldan∗ and Renan Grossy Abstract We develop a new technique for proving concentration inequalities which relate between the variance and influences of Boolean functions. Using this technique, we 1. Settle a conjecture of Talagrand [Tal97], proving that Z q 1 1=2 h (x)dµ ≥ C · Var (f) · log ; f P 2 {−1;1gn Infi (f) where hf (x) is the number of edges at x along which f changes its value, and Infi (f) is the influence of the i-th coordinate. 2. Strengthen several classical inequalities concerning the influences of a Boolean function, showing that near-maximizers must have large vertex boundaries. An inequality due to Talagrand states that for a Boolean function f, Var (f) ≤ C Pn Infi(f) . We give i=1 1+log(1=Infi(f)) a lower bound for the size of the vertex boundary of functions saturating this inequality. As a corollary, we show that for sets that satisfy the edge-isoperimetric inequality or the Kahn-Kalai-Linial inequality up to a constant, a constant proportion of the mass is in the inner vertex boundary. 3. Improve a quantitative relation between influences and noise stability given by Keller and Kindler. Our proofs rely on techniques based on stochastic calculus, and bypass the use of hypercontrac- tivity common to previous proofs. arXiv:1909.12067v3 [math.PR] 12 Mar 2020 ∗Weizmann Institute of Science. Incumbent of the Elaine Blond Career Development Chair. Supported by a European Research Council Starting Grant (ERC StG) and by an Israel Science Foundation grant no.