DOCSLIB.ORG

WO 2018/029705 Al 15 February 2018 (15.02.2018) W !P O PCT

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
WO 2018/029705 Al 15 February 2018 (15.02.2018) W !P O PCT (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2018/029705 Al 15 February 2018 (15.02.2018) W !P O PCT (51) International Patent Classification: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, C12N 9/00 (2006 .0 1) C12N 9/04 (2006 .01) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (21) International Application Number: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY,TH, TJ, TM, TN, PCT/IN2017/050332 TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 08 August 2017 (08.08.2017) kind of regional protection available): ARIPO (BW, GH, (25) Filing Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (26) Publication Language: English TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (30) Priority Data: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 201621027241 09 August 2016 (09.08.2016) IN MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, PCT/IN20 17/000084 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 17 April 2017 (17.04.2017) IN KM, ML, MR, NE, SN, TD, TG). (71) Applicant: CHAUHAN, Mahesh [IN/IN]; 503, Delight. Declarations under Rule 4.17: Plot 81, RSC-48. Gorai-2. Borivali (west), Mumbai 400091 — as to applicant's entitlement to apply for and be granted a (IN). patent (Rule 4.1 7(H)) (72) Inventors; and — as to the applicant's entitlement to claim the priority of the (71) Applicants: KASARLE, Sharad Krishnaji [IN/IN]; B earlier application (Rule 4.17(Hi)) 107, Kamdhenu Society, Satya Nagar, Borivali (West), — of inventorship (Rule 4.1 7(iv)) Mumbai 400092 (IN). KASARLE, Divya Sharad [IN/IN]; Published: B 107, Kamdhenu Society, Satya Nagar, Borivali (West), — with international search report (Art. 21(3)) Mumbai 400092 (IN). (74) Agent: KHARKAR, Pallavi et al; IPRAM Intellectual Property Services, 716, Swastik Disa Corporate Park, L.B.S Marg, Ghatkopar (W), Mumbai 400086 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (54) Title: NOVEL GLUCOSE OXIDASE COMPOSITIONS (57) Abstract: The invention relates to glucose oxidase compositions and further compositions prepared from glucose oxidase com positions. The glucose oxidase compositions comprise of glucose oxidase and at least one ingredient selected from one or more of carbohydrate, polyol or sugar alcohol. Carbohydrate is selected from a dietary fibre or saccharide. Further compositions are sweetener compositions, food compositions, compositions for fortification of food, nutraceutical compositions and pharmaceutical compositions. The glucose oxidase compositions and further compositions incorporate low glycemic index nutritive compound of glycemic index less than 70, preferably less than 50. The glucose oxidase compositions and further compositions are in the form of powder compositions, granule compositions, crystalline compositions, flour compositions, pill, tablet, hard and soft capsule compositions, pellet compositions, powder for oral suspensions, gels, liquid solutions and suspensions and sterile preparations. The glucose oxidase compositions and further compositions regulate one or more of hyperglycemia, hypoglycemia, weight management challenges, obesity, oxidative stress, hyperuricemia, ketoacidosis, non-ketotic hyperosmolar coma, cardiovascular disease, heart stroke, nephropathy, microalbuminuria, in sulin resistance, amyloid foot ulcers, diabetic retinopathy, non-proliferative diabetic retinopathy, proliferative diabetic retinopathy, di © abetic macular edema, cataract, glaucoma, High blood cholesterol (HDL) and LDL, triglycerides, atherosclerosis, hypertension, meta bolic disorders, constipation, inflammatory bowel disease, ulcerative colitis, Crohn's disease, diverticulitis, neuropathy, coeliac disease, hypothyroidism, hyperthyroidism, polycystic ovarian syndrome, diabetes insipidus, necrobiosis lipoidica diabeticorum, mastopathy, © limited joint mobility, frozen shoulder, dupuytren's contracture, trigger finger, carpal tunnel syndrome, gingivitis, periodontitis, dental 00 caries, xerostomia, oral thrush, cognitive dysfunction, Alzheimer's and Parkinson's disease. o o NOVEL GLUCOSE OXIDASE COMPOSITIONS FIELD OF THE INVENTION The invention relates to compositions which include glucose oxidase enzyme as a primary ingredient, hereinafter referred as glucose oxidase compositions. These glucose oxidase compositions can further produce various other further compositions such as food compositions, compositions for fortification of food, sweetener compositions, nutraceutical compositions, pharmaceutical compositions etc. hereinafter referred as 'Turther compositions". BACKGROND OF THE INVENTION Glucose oxidase compositions have several health benefits for healthy individuals and also individuals suffering from one or more of following: hyperglycemia, hypoglycemia, weight management challenges, obesity, oxidative stress, hyperuricemia, ketoacidosis, non-ketotic hyperosmolar coma, cardiovascular disease, heart stroke, nephropathy, microalbuminuria, insulin resistance, amyloid foot ulcers, diabetic retinopathy, non-proliferative diabetic retinopathy, proliferative diabetic retinopathy, diabetic macular edema, cataract, glaucoma, High blood cholesterol (HDL) and LDL, triglycerides, atherosclerosis, hypertension, metabolic disorders, constipation, inflammatory bowel disease, ulcerative colitis, Crohn's disease, diverticulitis, neuropathy, coeliac disease, hypothyroidism, hyperthyroidism, polycystic ovarian syndrome, diabetes insipidus, necrobiosis lipoidica diabeticorum, mastopathy, limited joint mobility, frozen shoulder, dupuytren's contracture, trigger finger, carpal tunnel syndrome, gingivitis, periodontitis, dental caries, xerostomia, oral thrush, cognitive dysfunction, Alzheimer's and Parkinson's disease. Glucose oxidase compositions may have from 0.01 95 % of glucose oxidase and an additional ingredient in an amount of at least 5 %. Preferably the additional ingredient is a carbohydrate. Most preferably carbohydrate is a dietary fibre. Carbohydrate may also include arides. The dietary fibre includes one or more ingredients from dietary fibres such as one or more of non-starch polysaccharides, methylcellulose, β-glucans, mucilage, waxes, cyclodextrins, celluloses, hemicelluloses, starches, dextrins, inulins, lignins, chitins, pectins, beta-glucans (from oat bran, whole oats, oatrim or rolled oats, whole grain or dry-milled barley), fibres extracted from legumes, Chitosan, natural gums, xanthan gum, guar gum, gellan gum, tara gum, gum acacia, gum arabic, beta-mannan, locust bean gum (carob), psylium seed husk gum, galactomannan (including fenumannans), glucomannan or konjac, karaya, tragacanth, hexoses, pentoses, resistant starch, plant waxes, alginic acids(alginates), natriumalginat, kaliumalginat, ammoniumalginat, calciumalginat, propylenglycolalginat, (PGA), agar, carrageen, raffinose, xylose, polydextrose, lactulose, vegetable gums, polysaccharide, heterosaccharides, agar-agar, alginate, oligosaccharides, arabinoxylan (a hemicellulose), fructooligosaccharides (FOS, oligofructose), galacto- oligosaccharides (GOS), human milk oligosaccharides (HMO), isomalto- oligosaccharides (IMO), lactosucrose, mannan-oligosaccharides (MOS), raffinose, stachyose, verbascose and derivatives thereof. Glucose oxidase compositions are incorporated to prepare further sweetener, food, nutraceutical or pharmaceutical compositions prepared and they are in the form of one or more of the following: Powder compositions, granule compositions, crystalline compositions, flour compositions, pill, tablet, hard and soft capsule compositions, pellet compositions, powder for oral suspensions, liquid solutions and suspensions and sterile preparations etc, The sweetener composition, a further composition prepared from glucose oxidase composition includes a low glycemic index nutritive ingredient wherein such compositions can be used in place of sugar or artificial / natural sweetener. A low glycemic index nutritive ingredient in such compositions contains at least one ingredient which tastes sweet and hereinafter referred as a sweetening agent. A low glycemic index nutritive ingredient selected from at least one low glycemic index compound with a glycemic index of less than 70. More particularly, the invention relates to a sweetener composition comprising Glucose oxidase (GOD) enzyme in a concentration range of 0.1% - 99.99% by weight of the total composition and at least one low glycemic index nutritive ingredient including one or more of polyols and saccharides. Furthermore, the invention relates to modified sugar, an article of food, a nutraceutical composition, a pharmaceutical composition comprising the Glucose oxidase (GOD) enzyme compositions DESCRIPTION OF THE RELATED ART: Nutraceutical sweetener compositions are widely known in the art. Several compositions have been developed for modifying the taste; appearance and mouth feel profile of consumables that contain these sweeteners. Natural caloric sugars, such
Load more

Recommended publications
  • Postulated Physiological Roles of the Seven-Carbon Sugars, Mannoheptulose, and Perseitol in Avocado
    J. AMER. SOC. HORT. SCI. 127(1):108–114. 2002. Postulated Physiological Roles of the Seven-carbon Sugars, Mannoheptulose, and Perseitol in Avocado Xuan Liu,1 James Sievert, Mary Lu Arpaia, and Monica A. Madore2 Department of Botany and Plant Sciences, University of California, Riverside, CA 92521 ADDITIONAL INDEX WORDS. ‘Hass’ avocado on ‘Duke 7’ rootstock, phloem transport, ripening, Lauraceae ABSTRACT. Avocado (Persea americana Mill.) tissues contain high levels of the seven-carbon (C7) ketosugar mannoheptulose and its polyol form, perseitol. Radiolabeling of intact leaves of ‘Hass’ avocado on ‘Duke 7’ rootstock indicated that both perseitol and mannoheptulose are not only primary products of photosynthetic CO2 fixation but are also exported in the phloem. In cell-free extracts from mature source leaves, formation of the C7 backbone occurred by condensation of a three-carbon metabolite (dihydroxyacetone-P) with a four-carbon metabolite (erythrose-4-P) to form sedoheptulose-1,7- bis-P, followed by isomerization to a phosphorylated D-mannoheptulose derivative. A transketolase reaction was also observed which converted five-carbon metabolites (ribose-5-P and xylulose-5-P) to form the C7 metabolite, sedoheptu- lose-7-P, but this compound was not metabolized further to mannoheptulose. This suggests that C7 sugars are formed from the Calvin Cycle, not oxidative pentose phosphate pathway, reactions in avocado leaves. In avocado fruit, C7 sugars were present in substantial quantities and the normal ripening processes (fruit softening, ethylene production, and climacteric respiration rise), which occurs several days after the fruit is picked, did not occur until levels of C7 sugars dropped below an apparent threshold concentration of ≈20 mg·g–1 fresh weight.
    [Show full text]
  • United States Patent 1191 Lll] 3,983,266 Bahls [451 Sept
    United States Patent 1191 lll] 3,983,266 Bahls [451 Sept. 28, 1976 [54] METHOD FOR APPLYING METALLIC 3.776.740 [2/1973 Sivcrz ct al. .......................... .. l06/l SILVER TO A SUBSTRATE OTHER PUBLICATIONS [75] Inventor: Harry Bahls, Wayne, Pa. lvanov et al., Chem. Abs. 43:2548c, I949, [73] Assignee: Peacock Laboratories, Inc., Philadelphia, Pa. Primary Examiner-Ralph S. Kendall [22] Filed: Oct. 9, I974 I 57] ABSTRACT [2!] ,Appl. No.: 513,417 High efficiency deposition of silver on the surface of a substrate is obtained by providing a solution contain [52] [1.8. CI ............................... .. 427/164; 427/165; ing reducible dissolved silver in the presence of an al 427/168; 427/424; 427/426; l06/l kali metal hydroxide and ammonia, all of which are [51] Int. CLZ. ......................................... .. C23C 3/02 applied to the substrate in the presence of an aqueous [58] Field of Search .............. .. l06/l; 427/l68. I69, solution of a moderating reducer containing :1 poly 427/165, I64, 426, 304, 125, 425 hydric alcohol of the formula CH2OH(CHOH),,C H,OH, where n is an integer from 1 to 6. Preferably [56] References Cited the polyhydric alcohol is sorbitol, and in a preferred UNITED STATES PATENTS embodiment a moderator is the form of a thio glycerol is present. 2,996,406 8/l96l Weinrich ........... ............ .. 427/168 3,772,078 ll/l973 Polichcttc ct al ................. .. l06/l X l5 Claims, No Drawings 3,983,266 1 Other objects and advantages of this invention, in METHOD FOR APPLYING METALLIC SILVER TO cluding the economy of the same, and the case with A SUBSTRATE which it may be applied to existing silver coating equip ment and apparatus, will further become apparent BRIEF SUMMARY OF THE INVENTION 5 hereinafter.
    [Show full text]
  • Reports of the Scientific Committee for Food
    Commission of the European Communities food - science and techniques Reports of the Scientific Committee for Food (Sixteenth series) Commission of the European Communities food - science and techniques Reports of the Scientific Committee for Food (Sixteenth series) Directorate-General Internal Market and Industrial Affairs 1985 EUR 10210 EN Published by the COMMISSION OF THE EUROPEAN COMMUNITIES Directorate-General Information Market and Innovation Bâtiment Jean Monnet LUXEMBOURG LEGAL NOTICE Neither the Commission of the European Communities nor any person acting on behalf of the Commission is responsible for the use which might be made of the following information This publication is also available in the following languages : DA ISBN 92-825-5770-7 DE ISBN 92-825-5771-5 GR ISBN 92-825-5772-3 FR ISBN 92-825-5774-X IT ISBN 92-825-5775-8 NL ISBN 92-825-5776-6 Cataloguing data can be found at the end of this publication Luxembourg, Office for Official Publications of the European Communities, 1985 ISBN 92-825-5773-1 Catalogue number: © ECSC-EEC-EAEC, Brussels · Luxembourg, 1985 Printed in Luxembourg CONTENTS Page Reports of the Scientific Committee for Food concerning - Sweeteners (Opinion expressed 14 September 1984) III Composition of the Scientific Committee for Food P.S. Elias A.G. Hildebrandt (vice-chairman) F. Hill A. Hubbard A. Lafontaine Mne B.H. MacGibbon A. Mariani-Costantini K.J. Netter E. Poulsen (chairman) J. Rey V. Silano (vice-chairman) Mne A. Trichopoulou R. Truhaut G.J. Van Esch R. Wemig IV REPORT OF THE SCIENTIFIC COMMITTEE FOR FOOD ON SWEETENERS (Opinion expressed 14 September 1984) TERMS OF REFERENCE To review the safety in use of certain sweeteners.
    [Show full text]
  • Sugar Alcohols a Sugar Alcohol Is a Kind of Alcohol Prepared from Sugars
    Sweeteners, Good, Bad, or Something even Worse. (Part 8) These are Low calorie sweeteners - not non-calorie sweeteners Sugar Alcohols A sugar alcohol is a kind of alcohol prepared from sugars. These organic compounds are a class of polyols, also called polyhydric alcohol, polyalcohol, or glycitol. They are white, water-soluble solids that occur naturally and are used widely in the food industry as thickeners and sweeteners. In commercial foodstuffs, sugar alcohols are commonly used in place of table sugar (sucrose), often in combination with high intensity artificial sweeteners to counter the low sweetness of the sugar alcohols. Unlike sugars, sugar alcohols do not contribute to the formation of tooth cavities. Common Sugar Alcohols Arabitol, Erythritol, Ethylene glycol, Fucitol, Galactitol, Glycerol, Hydrogenated Starch – Hydrolysate (HSH), Iditol, Inositol, Isomalt, Lactitol, Maltitol, Maltotetraitol, Maltotriitol, Mannitol, Methanol, Polyglycitol, Polydextrose, Ribitol, Sorbitol, Threitol, Volemitol, Xylitol, Of these, xylitol is perhaps the most popular due to its similarity to sucrose in visual appearance and sweetness. Sugar alcohols do not contribute to tooth decay. However, consumption of sugar alcohols does affect blood sugar levels, although less than that of "regular" sugar (sucrose). Sugar alcohols may also cause bloating and diarrhea when consumed in excessive amounts. Erythritol Also labeled as: Sugar alcohol Zerose ZSweet Erythritol is a sugar alcohol (or polyol) that has been approved for use as a food additive in the United States and throughout much of the world. It was discovered in 1848 by British chemist John Stenhouse. It occurs naturally in some fruits and fermented foods. At the industrial level, it is produced from glucose by fermentation with a yeast, Moniliella pollinis.
    [Show full text]
  • List of Spectra /Compound Names
    IS NIR Spectra Complete collection (6049 spectra) This collection includes all NIR spectra collected within this project. Those are organic and inorganic chemicals, pharmaceutical excipients, drugs, polymers, additives, coatings, dyes, pigments, toxic substances, hazardous substances like explosives, agrochemicals and other types of materials. This collection should be chosen by customers with broad range of analytical applications. The near infrared spectral library „IS NIR Spectra“ is a unique collection of 6049 NIR (near infrared) digital spectra. The spectra have been collected in range 4200-10000 cm-1 (=2.4 – 1 micrometers). „IS NIR Spectra“ is the biggest and newest NIR library available on the market. This spectral library has been designed for users who use their NIR spectrometer not only for quantitative and chemometric analysis, but also want to identify unknown samples or just want to use the library as reference spectra database. ra t IS means “Intergrating Sphere” and at the same time “Identify Samplec”. e Technical parameters: p The „IS NIR Spectra“ were collected using the FT-NIR Spectrometer equipped with Integrating Sphere Accessory. Resolution: standard 4cm-1 IR Customized resolution: upon special request the speNctra can be delivered in customized resolution to reach better correspondence with spectr a collected by customer NIR instrument Spectral range in wavenumbers units: 4200-1000I0S cm-1 Spectral range in wavelength units: 2.4 – 1 micr ometers Only one spectrum/compound covering the mentioned spectral range Typical text information about the sample inmcludes (when available): Compound name including synonyms o CAS number .c Chemical formula a Molecular weight tr Additional information about thec sample like manufacturer and comments.
    [Show full text]
  • Bbm:978-3-642-64955-4/1.Pdf
    Sachverzeichnis. (deutsch.engliscb) Wegen allgemeiner Stichworte wie Extraktion, Abtrennnng, Reinigung usw. der einzelnen Stoffgruppen vergleiche man auch das InhaltBverzeichnis am Anfang dieses Bandes. cis-, trans-, no, D-, L- und ii.hnliche IBOmere sind unter dem Anfangsbuchstaben der Ver­ bindung und nicht unter dem Prifix eingeordnet. AIle iBO-Verbindungen finden sich unter Iso-. A, n, t)' sind wie A~, Oe, Ue eingereiht. Aca.cipetalin, aC4CipetaZin 310. L-Apfelsaure, L-malic acid 504-509. Acetaldehyd, acetaldehyde 422, 429, 434. Apfelsii.ure, Nachweis, malic acid, detection Acetalphosphatide, acetal ph08phoZipids 364. 554. Acetessigsii.ure, acetoacetic acid 533, 576. -, RrWert, Rf value 546, 550, 557, 558. Acetoin, acetoin 424, 436. -, Sii.ulenchromatogr., column chromatogr. Aceton, acet<me 423, 429, 436. 567-573. -, RrWert, Rf value 576. L-Apfelsii.ure, Vorkommen, L-malic acid, Acetophenon, acetophenone 436. occurrence 508. Acetoveratron, acetoveratrone 436. Aesculin, ae8culin 301,587. Acetylencarbonsii.uren, fatty acids, acetylenic Athana.l (s. auch Acetaldehyd), ethanal 323. (B. aLBo acetaldehyde) 434. Acetylglucosamin, acetylglUCOBamine 272. Athansii.ure (= Essigsaure), ethanoic acid Acetylgruppen, acetyl group.! 213. (= acetic acid) 445. Acetylierung, acetylation 146. Athylalkohol, ethanol 416. Acetylpektin, acetyl pectin 229, 230. Aktivierungsana.lyse auf Phosphor, activation Acetylphellonsii.ure, acetylphellcmic acid 398. analYMB for ph08ph0ru8 116. Acetylzahl, acetyl value 341. Alanin, RrWert, alanine, Rf value 550, 558. Aciditii.t, acidity 479. /I-Alanin, RrWert, /I-alanine, Rf value 558. -, aktuelle, actual 479. Alantolacton, alantolact<me 587. -, titrimetrische, titrimetric 479, 484. Aldehydderivate, Papierchromatogr., Aconitase, aconitase 520. aldehyde derivative8, paper chromatogr. 428, cis-Aconitsaure, cis-aconitic acid 517, 518, 429. 546,550. -, Siiulenchromatogr., column chromatogr. AconitBii.ure, cis-trans-Formen, aconitic acid, 427.
    [Show full text]
  • List of Spectra /Compound Names
    IS NIR Spectra Pharma, Drugs (1340 spectra) The NIR sublibrary “IS NIR Spectra Pharma, Drugs (1340 spectra)” has been designed for QC or R&D laboratories of pharmaceutical industry, for laboratories studying drugs and forensic laboratories. It includes NIR spectra of pharnaceutical excipients, drugs or active substances and other supporting chemicals used in pharma industry. The near infrared spectral library „IS NIR Spectra“ is a unique collection of NIR (near infrared) digital spectra. The spectra have been collected in range 4200-10000 cm-1 (=2.4 – 1 micrometers). „IS NIR Spectra“ is the biggest and newest NIR library available on the market. This spectral library has been designed for users who use their NIR spectrometer not only for quantitative and chemometric analysis, but also want to identify unknown samples or just want to use the library as reference spectra database. ra IS means “Intergrating Sphere” and at the same time “Identify Sample”.t c Technical parameters: e The „IS NIR Spectra“ were collected using the FT-NIR Spepctrometer equipped with Integrating Sphere Accessory. S Resolution: standard 4cm-1 Customized resolution: upon special request the spectrIaR can be delivered in customized resolution to reach better correspondence with spectraN collected by customer NIR instrument Spectral range in wavenumbers units: 4200-10000 cm -1 Spectral range in wavelength units: 2.4 – 1 micromISeters Only one spectrum/compound covering the men tioned spectral range Typical text information about the sample includes (when available): Compound name including synonyms m CAS number o Chemical formula .c Molecular weight a Additional information about the starmple like manufacturer and comments.
    [Show full text]
  • Thom Ulovlulitu
    THOMULOVLULITU US009737386B2 (12 ) United States Patent ( 10 ) Patent No. : US 9 ,737 , 386 B2 Weyer ( 45) Date of Patent: Aug . 22 , 2017 ( 54 ) DOSAGE PROJECTILE FOR REMOTELY F42B 12 /46 (2006 .01 ) TREATING AN ANIMAL A61K 9 / 00 ( 2006 . 01 ) A61K 9 /48 (2006 .01 ) (71 ) Applicant : SmartVet Pty Ltd , Fig Tree Pocket, (52 ) U . S . CI. Queensland ( AU ) ??? . .. .. .. .. A610 7700 ( 2013 . 01 ) ; A61K 8 /0241 (2013 .01 ) ; A61K 8 / 062 ( 2013 .01 ) ; A61K 8 / 585 ( 72 ) Inventor : Grant Weyer , Noosa Heads (AU ) ( 2013 .01 ) ; A61K 8 /8152 ( 2013 .01 ) ; A61K 8 / 895 ( 2013 . 01 ) ; A610 19 /00 ( 2013 .01 ) ; F42B ( 73 ) Assignee : SmartVet Pty Ltd , Brisbane , 12 / 40 (2013 .01 ) ; F42B 12 / 46 ( 2013 .01 ) ; A61K Queensland (AU ) 9 /0017 ( 2013 .01 ) ; A61K 9 / 4858 ( 2013 . 01 ) ; A61K 2800 / 412 ( 2013 .01 ) ; A61K 2800 /49 ( * ) Notice : Subject to any disclaimer , the term of this ( 2013 .01 ) patent is extended or adjusted under 35 (58 ) Field of Classification Search U . S . C . 154 (b ) by 0 days. CPC . .. .. A61K 2800 /49 ; A61K 8 / 064 ; A61K 2800 /596 ; A61K 8 /0241 ; A61K 8 /895 ; (21 ) Appl. No. : 14 /890 ,230 A61K 2800 / 412 ; A61K 8 / 891; A61K 8 /8152 ; A61K 8 / 585 ; A61K 8 / 062 ; A610 ( 22 ) PCT Filed : May 8 , 2014 19 / 00 See application file for complete search history . ( 86 ) PCT No. : PCT/ AU2014 / 000501 $ 371 ( c ) ( 1 ) , ( 56 ) References Cited ( 2 ) Date : Nov. 10 , 2015 U . S . PATENT DOCUMENTS 6 ,524 , 286 B1 2 /2003 Helms et al . (87 ) PCT Pub . No .: WO2014 /179831 2010 /0203122 AL 8 / 2010 Weyer et al.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2015/0209377 A1 Lin Et Al
    US 20150209377A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2015/0209377 A1 Lin et al. (43) Pub. Date: Jul. 30, 2015 (54) USE OF NOVEL MONOSACCHARIDE-LIKE filed on Sep. 13, 2014, provisional application No. GLYCYLATED SUGAR ALCOHOL 62/054,981, filed on Sep. 25, 2014. COMPOSITIONS FOR DESIGNING AND DEVELOPNG ANT-DABETC DRUGS Publication Classification (71) Applicants: Shi-Lung Lin, Arcadia, CA (US); (51) Int. Cl. Samantha Chang-Lin, Arcadia, CA A613 L/702 (2006.01) (US); Yi-Wen Lin, Arcadia, CA (US); A63L/22 (2006.01) Donald Chang, Arcadia, CA (US) (52) U.S. Cl. CPC ........... A6 IK3I/7012 (2013.01); A61 K3I/221 (72) Inventors: Shi-Lung Lin, Arcadia, CA (US); (2013.01) Samantha Chang-Lin, Arcadia, CA (US); Yi-Wen Lin, Santa Fe Spring, CA (57) ABSTRACT (US); Donald Chang, Cerritos, CA (US) This invention is related to a novel Sugar-like chemical com position and its use for diabetes therapy. Particularly, the (73) Assignees: Shi-Lung Lin, Arcadia, CA (US); present invention teaches the use of monosaccharide-like gly Samantha Chang-Lin, Arcadia, CA cylated Sugar alcohol compounds to block or reduce Sugar (US); Yi-Wen Lin, Arcadia, CA (US); absorption in diabetes patients, so as to prevent the risk of Donald Chang, Arcadia, CA (US) hyperglycemia symptoms. Glycylation of Sugar alcohols is a totally novel reaction that has never been reported before. (21) Appl. No.: 14/585,978 Therefore, the novelty of the present invention is that for the first time glycylated Sugar alcohols not only was found but (22) Filed: Dec.
    [Show full text]
  • WO 2016/049278 Al 31 March 2016 (31.03.2016) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/049278 Al 31 March 2016 (31.03.2016) P O P C T (51) International Patent Classification: (74) Agent: BISSETT, Melanie D.; The Chemours Company, D06M 15/564 (2006.01) C08G 18/48 (2006.01) 1007 Market Street, Wilmington, Delaware 19801 (US). C14C 11/00 (2006.01) C08G 18/28 (2006.01) (81) Designated States (unless otherwise indicated, for every D21H 17/57 (2006.01) C08G 18/32 (2006.01) kind of national protection available): AE, AG, AL, AM, C09D 175/04 (2006.01) D06M 15/568 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/US20 15/05 1872 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 24 September 2015 (24.09.201 5) MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (25) Filing Language: English PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (26) Publication Language: English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/055,930 26 September 2014 (26.09.2014) US kind of regional protection available): ARIPO (BW, GH, (71) Applicant: THE CHEMOURS COMPANY FC, LLC GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, [US/US]; 1007 Market Street, D-7028, Wilmington, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Delaware 19801 (US).
    [Show full text]
  • Study of Ef Fec Tive Atomic Num Bers and Elec Tron Den Si Ties, Kerma of Al Co Hols, Phan Tom and Human Or Gans, and Tis Sues Sub Sti Tutes
    V. P. Singh, et al.: Study of Ef fec tive Atomic Num bers and Electron Densi ties, ... Nuclear Technol ogy & Ra dia tion Pro tection: Year 2013, Vol. 28, No. 2, pp. 137-145 137 STUDY OF EF FEC TIVE ATOMIC NUM BERS AND ELEC TRON DEN SI TIES, KERMA OF AL CO HOLS, PHAN TOM AND HUMAN OR GANS, AND TIS SUES SUB STI TUTES by Vishwanath P. S I N G H * and Nagappa M. BADIGER De part ment of Phys ics, Karnatak Uni ver sity, Dharwad, Karnatak, India Sci en tific pa per DOI: 10.2298/NTRP1302137S Ef fec tive atomic num bers (ZPIeff) and elec tron den si ties of eigh teen al co hols such as wood al co - hol, CH3OH; grain al co hol, C2H5OH; rub bing al co hol, C3H7OH; butanol, C4H9OH; amyl al co hol, C5H11OH; cetyl al co hol, C16H33OH; eth yl ene gly col, C2H4(OH)2; glyc erin, C3H5(OH)3; PVA, C2H4O; erythritol, C4H6(OH)4; xylitol, C5H7(OH)5; sorbitol, C6H8(OH)6; volemitol, C7H9(OH)7; allyl al co hol, C3H5OH; geraniol, C10H17OH; propargyl al cohol, C3H3OH; inositol, C6H6(OH)6, and men thol, C10H19OH have been cal cu lated in the pho ton en ergy re gion of 1 keV-100 GeV. The es ti mated val ues have been com pared with ex per i- men tal val ues wher ever pos si ble. The com par i son of ZPIeff of the alco hols with water phan tom and PMMA phan tom in di cate that the eth yl ene gly col, glyc erin, and PVA are sub sti tute for PMMA phantom and PVA is sub sti tute of wa ter phan tom.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2016/0158121 A1 LEI Et Al
    US 2016O158121A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2016/0158121 A1 LEI et al. (43) Pub. Date: Jun. 9, 2016 (54) POLYUREA CAPSULE COMPOSITIONS Publication Classification (71) Applicant: INTERNATIONAL FLAVORS & (51) Int. Cl. FRAGRANCES INC., NEW YORK, A618/II (2006.01) NY (US) A68/73 (2006.01) A61O 13/00 (2006.01) (72) Inventors: Yabin LEI, Holmdel, NJ (US); Lewis A68/92 (2006.01) Michael POPPLEWELL, Morganville, A61O5/12 (2006.01) NJ (US); Li XU, Edison, NJ (US); John A618/8 (2006.01) BRAHMS, Morris Plains, NJ (US); A618/87 (2006.01) Xiang FENG, Edison, NJ (US) (52) U.S. Cl. CPC ................. A61K 8/11 (2013.01); A61 K8/81 17 (21) Appl. No.: 15/047,364 (2013.01); A61K 8/731 (2013.01); A61 K 8/8III (2013.01); A61K 8/87 (2013.01); A61 K (22) Filed: Feb. 18, 2016 8/922 (2013.01); A61O5/12 (2013.01); A61O Related U.S. Application Data 13/00 (2013.01) (63) Continuation-in-part of application No. 14/911,433, (57) ABSTRACT filed on Feb. 10, 2016, filed as application No. PCT/ US2014/051309 on Aug. 15, 2014, Continuation-in- A microcapsule composition useful in delivering an active part of application No. 13/968,862, filed on Aug. 16 material contains a first microcapsule and a second m1crocap 2013. Continuation-in-part O fapplication No. 13jo 69. Sule. The first microcapsule has a Zeta potential of 10 mV or O38 filed on Aug. 16, 2013, Continuation-in-part of greater, the second microcapsule has a Zeta potential of 5 mV l tion N i/967 8OO fil d on Aug.
    [Show full text]