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Research Review 2010

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Research Review 2010 UCL Institute of Child Health Street Ormond and Great Hospital NHS Trust Children for Design Manager UCL Institute Great Ormond Street Hospital Fourth fl oor of Child Health 40 Bernard Street 30 Guilford Street London WC1N 1LE London WC1N 1EH E [email protected] 020 7242 9789 www.ucl.ac.uk/ich Great Ormond Street Bengali Hospital for Children NHS Trust Great Ormond Street English London WC1N 3JH Translations, large print, Braille or audio versions of this report are available upon 020 7405 9200 request from the address above. www.gosh.nhs.uk French Traductions disponibles sur demande à l’adresse ci-dessus. Des versions en gros caractères, en braille ou audio sont également disponibles sur demande. Polish Tłumaczenia są do uzyskania na żądanie pod podanym powyżej adresem. Dokumenty w formacie dużym drukiem, brajlem lub audio są także do uzyskania na żądanie. Punjabi Somali Turjubaan ayaa cinwaanka kor ku qoran Designed and produced by Great laga heli karaa markii la soo codsado. Ormond Street Hospital Marketing Daabacad far waa-wayn, farta indhoolaha and Communications. Braille ama hab la dhegaysto ayaa xittaa la heli karaa markii la soo codsado. Photography by Richard Learoyd, Adam Laycock and Candice-Joelle Wordley. Tamil Printed by The Colourhouse, utilising vegetable-based inks on Heaven 42. Thank you to everyone who was interviewed for, or gave permission for their picture to be used in this review, as well as the many members of the UCL Institute of Child Health and Great Ormond Street Hospital staff who helped during its production. Turkish Please visit www.ucl.ac.uk/ich/ Talep edilirse yukarıdaki adresten research-ich/research-and-development çevirileri tedarik edilebilir. Talep edilirse, 2010 Research Review or www.gosh.nhs.uk for an online version iri harfl erle, Braille (görme engelliler için) of this review. veya sesli şekilde de tedarik edilebilir. Urdu Research ReviewTh e child fi rst 2010 and always Zoe, age 17, suffers from hydrocephalus, also known as ‘water on the brain’. Today she is in hospital to have some fluid drained and will hopefully only be in for a few days. She loves her cheeky monkey pyjama bottoms and doing her hair and make-up. Contents 03 Director’s report 07 Chief Executive’s report 09 Research and Development report Research 13 15 16 19 Research on children, In search of targeted Refusing to be beaten Let the right sun in for children cancer therapies Dr Hannah Mitchison Dr Elina Hyppönen Professor Terence Stephenson Professor Kathy Pritchard-Jones 21 22 25 27 Relearning how to learn Healthy lifestyles Kidney cures from cancer Personalising children’s Professor Faraneh Ms Julie Lanigan and drugs to citrus fruit treatments for arthritis Vargha-Khadem Professor Atul Singhal Dr David Long Professor Lucy Wedderburn People 30 Awards, honours and prizes 2010 33 Grants and donations 2010 36 Senior academic staff 2010 42 Administration 2010 44 Working with UCL Business PLC Cover: Rosie is 10 months old and has been in hospital for nine of those months due to a gastro-intestinal problem. Her family are very used to hospital life now, and Rosie’s older sister loves the playroom. Research Review 2010 01 Director’s report The UCL Institute of Child Health (ICH) is Europe’s largest academic centre for research and education in children’s health and disease. A highlight of 2010 was the establishment of several new research centres which significantly extend the Institute’s paediatric research profile. The Louis Dundas Centre for Children’s Members of the Institute continued to Palliative Care became the first unit in the attract significant grant funding from UK devoted to research and education in external bodies, with new grants totalling children’s terminal illness. Myra Bluebond- more than £25 million during the year. Langner was appointed the first True Those leading successful bids in excess Colours Chair in Palliative Care for Children of £1 million were: Professor Andrew Taylor, and Young People, and she set about Dr Silvia Schievano and Dr Tain-Yen Hsia establishing a team to deliver high quality, for Multi-scale modelling of single ventricle collaborative studies to inform practice hearts for clinical decision support and policy in this important, but previously (Fondation Leducq); Professor Russell neglected area of paediatrics. In addition Viner for Improving the assessment and to the Dundas family and True Colours Trust, management of obesity in UK children and the new centre benefits from generous adolescents (National Institute of Health donations from the Charles Wolfson Research [NIHR]); and Dr David Osrin for Charitable Trust, Marie Curie Cancer Care, Community resource centres to improve and the Raisa Gorbachev Foundation. the health of women and children in Mumbai slums: a cluster randomized The ICH’s Nuffield Professor of Child controlled trial of a complex intervention Health, Professor Terence Stephenson, (Wellcome Trust). was awarded £4.6 million over five years by the Department of Health to establish More than 300 new research papers were a Policy Research Unit (PRU) for the Health published during the year. Highlights include of Children, Young People and Families. the identification of genetic factors regulating Senior colleagues who will lead work brain tumour types (Dr Tom Jacques and streams within the unit include Professor Professor Sebastian Brandner in The Ruth Gilbert, Professor Catherine Law, Dr EMBO Journal), new methods for isolating Miranda Wolpert, Professor Helen Roberts photoreceptors allowing transplant to the and Professor Russell Viner. The PRU’s diseased retina (Dr Jorn Lakowski and aim is to provide evidence for policy Professor Jane Sowden in Human Molecular and practice, so as to promote the Genetics), identification of a lymphocyte health and wellbeing of children, class with key function in autoimmune young people and families. arthritis (Dr Kiran Nistala and Professor Lucy Wedderburn in Proceedings of the Professor Faraneh Vargha-Khadem National Academy of Sciences) and received pump-priming support from identification of long-lasting lung disorders the Provost of UCL to develop a Centre in children born extremely premature (Dr for Developmental Cognitive Neuroscience Sooky Lum and Professor Janet Stocks (CDCN). The CDCN brings together in the American Journal of Respiratory cognitive neuroscience, neurology, and Critical Care Medicine). neuro-imaging and neurophysiology as applied to children’s brain studies, and During the year, several staff received also links with collaborators in mathematics, honours. Professor Anthony Costello engineering and computer science. UCL was elected Fellow of the Academy of is one of the UK’s largest universities, with Medical Sciences for his achievements in a myriad of departments, institutes and research and education for global health; divisions, and it is crucial that we are able Professor Catherine Law was appointed Hope is eight and suffers from to collaborate with those who share interests to the NIHR College of Senior Investigators a lot of allergies. She is here for an outpatient appointment on Kingfisher and have complementary skills. The CDCN for achievements in child health policy Ward so that her doctors can try to is an important step in this direction. find out why she is always so tired. Director’s report Research Review 2010 03 Director’s report continued research; and Dr Margaret Mayston was Lucy Wedderburn became Professor named Australian Woman of the Year in of Paediatric Rheumatology for research the UK for her work on the physiotherapy into the development of autoimmunity, of disabled children. We were delighted to with particular reference to juvenile arthritis hear of the knighthood for Hugh Stevenson and dermatomyositis. Lucy is leading work in the Queen’s Birthday Honours List. Hugh to identify biomarkers for predicting the and his wife Catherine are long-standing course of autoimmune disease and for benefactors of the Institute, and the Hugh monitoring response to treatment. and Catherine Stevenson Chair of Paediatric Oncology was conferred on Professor Jonathan Wells became Professor of Kathy Pritchard-Jones during 2010. Anthropology and Paediatric Nutrition for research, combining detailed measurement A sad loss this year was the death of of body composition and energetics, with Professor Otto Wolff, former Dean of the the application of anthropological and ICH. A talented paediatrician and academic evolutionary concepts to nutrition. His in metabolic medicine, Otto was a great book, Evolutionary Biology of Human supporter of the ICH right up to the months Body Fatness, is a seminal contribution before his death at the age of 90. The in the modern epidemic of obesity. Institute’s main lecture series is named in his honour, and we greatly miss his Staff promoted to Reader were Dr John attendance and participation (always Anderson for research into immunotherapy with a penetrating question) at his as a treatment for malignancy, Dr Chris eponymous lectures. Clark for research into development of new methods for magnetic resonance imaging A number of Institute members gained of the brain, Dr David Osrin for research academic promotion at UCL in 2010. Persis involving randomised trials to improve Amrolia became Professor of Transplantation newborn care in resource poor countries, Immunology for research in developing and Dr Arturo Sala for research into the clinical protocols to harness the power role of oncogenes in development and of lymphocytes to fight both leukaemia treatment of childhood tumours. progression and viral infection after bone marrow transplant and immunosuppression. These protocols are now widely used to treat seriously ill children for whom few alternative options exist. Professor Andrew Copp Jugnoo Rahi became Professor of Director Ophthalmic Epidemiology for research UCL Institute of Child Health which takes a life-course, epidemiological Zarrar (above) is 10 months old and he and genetic approach to visual impairment. has come into hospital for an overnight As the first Director of the Ulverscroft Vision stay. His body does not produce enough salt, and so his doctor wants to make Research Group, Jugnoo has enabled sure that his medication is correct.
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