In Endometrial Cancer Progression and Dissemination Laura Devis J

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In Endometrial Cancer Progression and Dissemination Laura Devis J ADVERTIMENT. Lʼaccés als continguts dʼaquesta tesi queda condicionat a lʼacceptació de les condicions dʼús establertes per la següent llicència Creative Commons: http://cat.creativecommons.org/?page_id=184 ADVERTENCIA. El acceso a los contenidos de esta tesis queda condicionado a la aceptación de las condiciones de uso establecidas por la siguiente licencia Creative Commons: http://es.creativecommons.org/blog/licencias/ WARNING. The access to the contents of this doctoral thesis it is limited to the acceptance of the use conditions set by the following Creative Commons license: https://creativecommons.org/licenses/?lang=en The role of activated leukocyte cell adhesion molecule (ALCAM) in endometrial cancer progression and dissemination Laura Devis Jauregui The role of activated leukocyte cell adhesion molecule (ALCAM) in endometrial cancer progression and dissemination Memoria presentada por Laura Devis Jauregui para optar al grado de Doctora por la Universitat Autònoma de Barcelona (UAB) Tesis doctoral realizada en el Grup de Recerca Biomèdica en Ginecologia del Institut de Recerca de l’Hospital Universitari de la Vall d’Hebron, bajo la dirección del Dr. Jaume Reventós, Dra. Eva Colás y Dr. Antonio Gil. Tesis adscrita al departamento de Biología Celular, Fisiología e Inmunología de la Facultad de Medicina de la UAB, en el programa de doctorado de Biología Celular, bajo la coordinación y tutoría de la Dra. Joaquima Navarro. Universitat Autònoma de Barcelona, 1 de Marzo de 2017 Dr. Jaume Reventós (director) Dra. Eva Colás (directora) Dr. Antonio Gil (director) Dra. Joaquima Navarro (tutora) Laura Devis Jauregui (estudiante) A mi ama A mi padre A Angel Agradecimientos/Acknowledges Parece que se cierra una etapa, una etapa de aprendizaje y crecimiento personal, una etapa de frustraciones pero también de éxitos y buenos momentos. Con el cambio de aire, llega también la ilusión por lo que está a punto de empezar pero no sin antes echar la vista atrás y agradecer a todas las personas que me han ayudado durante el proceso, en muchas facetas distintas. Estas líneas pretenden reflejar la inmensa gratitud que siento hacia todas ellas, gratitud que sin duda no puede expresarse con palabras. A mis directores de tesis, el Dr. Jaume Reventós, la Dra. Eva Colás y el Dr. Antonio Gil. A Jaume por sus consejos, por ser la primera persona que confió en mí, por brindarme la oportunidad de dar mis primeros pasos en el mundo de la investigación y hacerme un sitio en su laboratorio. A Eva, por confiar también en mí, querer que hiciese la tesis en el laboratorio desde el primer momento, por su apoyo constante a lo largo de todo el proceso y hasta el final, por el camino recorrido juntas. A Antonio, por su buena voluntad y disposición constante, su cercanía y su compromiso. A todos los coautores de los artículos que forman la base de esta tesis. Quisiera hacer una mención especial a la Dra. Sylvie Dufour y a la Dra. Françoise Brochard, así como a todo su equipo, por los buenos momentos que he vivido con ellos y por participar activamente en el desarrollo de los artículos, por su ayuda durante mi estancia de investigación en sus laboratorios (URM 144 y 168, Institut Curie, Paris), por la confianza depositada en mí y su cálida acogida en su equipo. “Merci Sylvie et Françoise pour votre accueil chaleureux au sein de vos laboratoires, pour votre participation active pendant le séjour et par la suite dans la réalisation des articles de cette thèse. Merci Vasilica et Bill, pour votre aide et les bons moments ensemble”. A mis compañeros de “Endometrio”, Irene, Elena, Cristian y Tati. A Irene y Elena por compartir estos años, por los ánimos y por la terapia de grupo. Porque parecía que no, pero al final parece que si, porque será verdad que todo llega y que ya estamos las tres en la línea de meta. Y porque he tenido la suerte de disfrutaros como compañeras y confidentes estos años. A Cristian por hacer más fácil la recta final, por estar siempre dispuesto a ayudar y a colaborar, por todos los ánimos y por el “asado”. A Tati por su fuerza y la energía que nos transmite y contagia. Al resto del equipo del Grup de Recerca Biomèdica en Ginecologia del VHIR. A la Dra. Anna Santamaría por su activa participación e implicación en una parte de los artículos que conforman esta tesis. Anna, gracias por darme confianza, por ser tan justa y por tu cariño. A Blanca, por ser compañera de travesía, por entendernos muy bien y porque haya más “Manchesters” juntas en el futuro. A Lucía, por hacer el día a día más fácil, siempre con una sonrisa cariñosa. ¡Vosotras también estáis ya en la línea de meta campeonas! A Mireia, por sus ánimos y sus consejos, por aguantar que le quitase la tranquilidad del despacho en muchas ocasiones, por su cariño. A Eli, porque ella ya sabe que en el fondo está pluriempleada, y que nos ayuda a mantener la cordura, ¡aunque a veces te la hagamos perder a ti! A Júlia, por su alegría contagiosa y por hacerlo todo siempre más divertido. A Nuria, por tener otro trocito de la “terreta” cerca, por los ensayos a mil manos entre las dos y por su cariño. A Iolanda y a Marta, el otro trocito de “terreta”, y a Leire, por su cariño y ánimos durante los meses en que pude coincidir con vosotras. A Gabriel, por hacerme reír en muchas ocasiones, por tener palabras bonitas muchas veces de esas que sin querer ayudan a pasar los días mejor. A Alfonso, por su cariño, su empatía y por traerme chocolate a cultivos cuando mis ánimos lo necesitaban. A los que han empezado esta aventura, Berta, Manuel ¡Suerte¡ Y a todos vosotros¡nos vemos fuera! A mi amiga Laura Lobato, porque nuestras vidas siempre se entrecruzan. Porque tenía que vivir mi estancia en Paris contigo y porque increíblemente también tenía que vivir la de Buenos Aires. Porque tu eres la parte más esencial de “mí”/“nuestro” Buenos Aires y porque estemos preparadas para el resto de sorpresas que nos depara el futuro. A uno de los mejores regalos que directa o indirectamente me trajo Paris, poder disfrutar de la amistad de personas tan especiales, buenas y bonitas como Chema, Fer, Olalla, Marta y Aleix. Gracias por haberos convertido en parte fundamental de mi día a día y por hacerlo todo mejor. A Adri y Marina, por todos estos años juntos y por lo afortunada que soy por teneros a los dos, siempre. Por todos los buenos momentos con dos de las mejores personas que conozco y por todo lo que nos queda por venir. A mis grandes amigas, Bea, Ziggie, Amparo y Amanda por ser mi gran apoyo fuera del laboratorio, porque ya no se cuentan los años juntas, los momentos, las ciudades, las vivencias compartidas y las que nos quedan por vivir, por ser mis grandes confidentes y por hacerlo todo más bonito. ¡Os quiero chicas! A mi familia catalana-aragonesa: Roser, Angel, Miriam, Jose e Ingrid por su inmenso cariño y su apoyo desde el primer momento. En especial, a Ingrid que con su llegada nos llenó a todos de alegría e ilusión. A mi familia Portugaluja, a mis queridos y añorados tíos Imanol e Iñaki, a mis tías Mertxe, Lucía y Marina, por su enorme cariño y en especial a mis maravillosos primos Ane, Leire, Eneko y Jon con quienes tengo la suerte de mantener un vínculo tan especial. A mi tía y madrina Loli, por estar siempre ahí, por su cariño y por confiar continuamente en mi con más fuerza que yo misma. A todos vosotros, eskerrik asko. A mis abuelitos Lola y Manolo, a mi amama Vicen y mi aitite Iñaki porque sé que también hubiesen disfrutado de este momento y se hubiesen sentido orgullosos. A mi padre por recordarme siempre que crea en mi misma, por los descansos en el oasis de Oropesa, por el “arròs al forn” cuando lo he necesitado, por sus consejos, por intentar calmar mis ansias y neuras (sobre todo en la recta final!), por su cariño incondicional, por sus ánimos y su optimismo. Moltes gràcies papa, t’estime. A mi ama por ser la responsable de que hoy haya llegado hasta aquí. Por ser cariño, inspiración y admiración. Por enseñarme siempre los valores de la constancia, del tesón y la voluntad. Por recogerme y levantarme siempre que lo he necesitado, por recordarme siempre lo que es realmente importante, por hacerme reír a carcajadas, por darme siempre todo y quererme tan incondicionalmente. Por ser tú. Maite zaitut. A Angel, por ser mi compañero de viaje todos estos años. Por aguantar las frustraciones y también ser cómplice y responsable de los mejores momentos de mi vida, por hacerme sentir siempre tan querida. Per tot, t’estimo Angel. 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