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Avançons Pour Et Avec Les PATIENTS DOCUMENT DE RÉFÉRENCE 2016 Avançons pour et avec les PATIENTS DOCUMENT DE RÉFÉRENCE 2016 SOMMAIRE REMARQUES GÉNÉRALES 2 3 INFORMATIONS SOCIALES ET ENVIRONNEMENTALES DE L’ACTIVITÉ 135 INTRODUCTION : PRÉSENTATION GÉNÉRALE 3 3.1 Ressources humaines 136 3.1.1 Les effectifs au sein du Groupe 136 1 PRÉSENTATION D’IPSEN ET DE SON ACTIVITÉ 5 3.1.2 La politique de Ressources Humaines du Groupe 138 3.2 Environnement, Santé et Sécurité 140 1.1 Présentation générale du Groupe et de sa stratégie 6 3.2.1 Les enjeux réglementaires 140 1.1.1 Historique et évolution de la Société 6 3.2.2 Politique EHS 141 1.1.2 Stratégie du Groupe 8 3.2.3 La performance EHS 2016 142 1.2 Activité et organisation du Groupe 9 3.2.4 Ressources internes 151 1.2.1 Produits du Groupe 9 3.2.5 2016 – Communication d’Ipsen sur le Pacte Mondial des Nations unies 151 1.2.2 Principaux partenariats 13 3.3 Informations sociales et sociétales 154 1.2.3 Recherche et Développement 17 3.3.1 Relations sociales 154 1.2.4 Propriété intellectuelle 23 3.3.2 Information sociétale 155 1.2.5 Principaux marchés 25 1.2.6 Réglementation 26 4 GOUVERNEMENT D’ENTREPRISE ET INFORMATIONS JURIDIQUES 165 1.2.7 Structure juridique du Groupe 27 4.1 Gouvernement d’entreprise 166 1.2.8 Facteurs de risques 29 4.1.1 Présentation du Conseil d’administration et de la Direction générale 166 2 INFORMATIONS FINANCIÈRES DE LA SOCIÉTÉ 39 4.1.2 Rapports du Président et des Commissaires aux comptes 186 2.1 Rapport de gestion de l’exercice 40 4.1.3 Rémunérations des mandataires sociaux 203 2.1.1 Événements significatifs survenus au cours de l’exercice 40 4.1.4 Conventions conclues par le Groupe 2.1.2 Analyse du résultat 41 avec ses dirigeants et principaux actionnaires 2.1.3 Trésorerie nette et financement 47 et rapport des Commissaires aux comptes 221 4.2 Renseignements concernant la Société et son capital 225 2.1.4 Annexes 50 4.2.1 Description des principales dispositions statutaires 225 2.1.5 Événements postérieurs à la clôture 56 4.2.2 Capital social 227 2.1.6 Perspectives du Groupe 56 4.2.3 Actionnariat 234 2.2 Comptes consolidés 2016 57 2.2.1 Compte de résultat consolidé 57 5 ANNEXES 239 2.2.2 Bilan consolidé - avant affectation du résultat 59 5.1 Personnes responsables 240 2.2.3 Tableau des flux de trésorerie consolidé 60 5.1.1 Responsable du document de référence et attestation 240 2.2.4 Variation des capitaux propres consolidés 61 5.1.2 Responsable de l’information financière 240 2.2.5 Notes annexes 63 5.1.3 Responsables du contrôle des comptes et honoraires 240 5.2 Déclarations provenant de tiers, déclarations 2.2.6 Rapport des Commissaires aux comptes d’experts et déclaration d’intérêts 241 sur les comptes consolidés 114 5.3 Documents accessibles au public 241 2.3 Comptes sociaux 2016 116 5.4 Tables de concordance du document de référence, 2.3.1 Documents de synthèse 116 du rapport financier annuel et du rapport de gestion 241 2.3.2 Annexe aux comptes annuels 118 5.4.1 Table de concordance du rapport financier annuel 241 2.3.3 Rapport des Commissaires aux comptes 5.4.2 Table de concordance du document de référence 242 sur les comptes annuels 131 2.3.4 Informations relatives à l’activité de Ipsen 132 6 INDEX 247 Le présent document de référence (chapitres 1 à 6) a été établi conformément à l’annexe 1 du réglement européen de la commission n° 809/2004 du 29 avril 2004. Société anonyme au capital de 83 580 494 euros Siège social : 65 quai Georges Gorse – 92650 Boulogne-Billancourt 419 838 529 R.C.S. Nanterre DOCUMENT DE RÉFÉRENCE 2016 Le présent document de référence a été déposé auprès de l’Autorité des marchés financiers le 27 mars 2017, sous le numéro D.17-0231 conformément à l’article 212-13 de son règlement général. Il pourra être utilisé à l’appui d’une opération financière s’il est complété par une note d’opération visée par l’AMF. Ce document a été établi par l’émetteur et engage la responsabilité de ses signataires. Incorporation par référence : Conformément aux dispositions de l’article 28 du règlement européen n° 809/2004 du 29 avril 2004, le lecteur est renvoyé au document de référence de la société Ipsen enregistré par l’Autorité des marchés financiers, le 29 mars 2016 sous le numéro D.16-0216 relatif à l’exercice 2015 et le 27 mars 2015 sous le numéro D.15-0221 relatif à l’exercice 2014 pour les informations financières établies selon le référentiel IFRS (International Financial Reporting Standard) : rapport de gestion et comptes consolidés historiques (incluant les rapports des Commissaires aux comptes). REMARQUES GÉNÉRALES Dans le présent document de référence, sauf indication Les investisseurs sont invités à examiner attentivement chacun contraire, les termes « Société » et « Ipsen » renvoient à la des facteurs de risques décrits aux paragraphes 1.2.8.1 ; société Ipsen S.A. et le terme « Groupe » renvoie à Ipsen 1.2.8.2 ; 1.2.8.3 ; 1.2.8.4 ; 1.2.8.5 ; 1.2.8.6 du présent document et ses filiales et participations. de référence avant de prendre leur décision d’investissement. La réalisation de tout ou partie de ces risques est susceptible Le présent document de référence contient des indications d’avoir un effet négatif sur les activités, la situation, les résultats sur les objectifs du Groupe, notamment dans le chapitre 2.1.4. financiers du Groupe ou ses objectifs et prévisions. En outre, Ces indications sont parfois identifiées par l’utilisation du d’autres risques, non encore actuellement identifiés ou futur, du conditionnel et de termes à caractère prospectif considérés comme non significatifs par le Groupe, pourraient tels que « penser », « avoir pour objectif », « s’attendre à », avoir le même effet négatif et les investisseurs pourraient « entend », « devrait », « ambitionner », « estimer », « croire », perdre tout ou partie de leur investissement. « souhaite », « pourrait », etc. Ces informations sont fondées Le présent document de référence contient par ailleurs des sur des données, hypothèses et estimations considérées informations relatives aux marchés sur lesquels le Groupe comme raisonnables par la Société. Elles sont susceptibles est présent. Ces informations proviennent notamment d’évoluer ou d’être modifiées en raison des incertitudes d’études réalisées par des sources extérieures. Compte liées notamment aux aléas de toute activité de Recherche tenu des changements très rapides qui marquent le secteur et Développement ainsi qu’à l’environnement économique, pharmaceutique en France et dans le monde, il est possible financier, concurrentiel, réglementaire et climatique. En outre, que ces informations s’avèrent erronées ou ne soient plus à jour. la matérialisation de certains risques décrits au chapitre 1.2.8. « Facteurs de risques » du présent document de référence est Les déclarations prospectives et les objectifs figurant dans susceptible d’avoir un impact sur les activités du Groupe et le présent document de référence peuvent être affectés sa capacité à réaliser ses objectifs. Par ailleurs, la réalisation par des risques connus et inconnus, des incertitudes et des objectifs suppose le succès de la stratégie présentée au d’autres facteurs qui pourraient faire en sorte que les résultats paragraphe 1.1.2 du chapitre 1 « Stratégie du Groupe » du futurs, les performances et les réalisations du Groupe soient présent document de référence. significativement différents des objectifs formulés ou suggérés. Ces facteurs peuvent inclure les évolutions de la conjoncture La Société ne prend aucun engagement ni ne donne aucune économique et commerciale, de la réglementation, ainsi que garantie sur la réalisation des objectifs et prévisions figurant les facteurs exposés dans le chapitre 1.2.8 « Facteurs de dans le présent document de référence. risques » du présent document de référence. 2 Ipsen Document de référence 2016 INTRODUCTION : PRÉSENTATION GÉNÉRALE Chiffre d’affaires 2016 par domaine thérapeutique Chiffre d’affaires 2016 par zone géographique Médecine Principaux de spécialité Oncologie pays d’Europe Autres 80,3 % 57,1 % de l’Ouest pays 36,1 % d’Europe 22,0 % Endocrinologie 5,1 % Neurosciences 18,1 % Médecine générale Amérique du Nord Reste du Monde 19,7 % 17,2 % 24,7 % Résultat opérationnel des activités (en millions d’euros)(1) Résultat net consolidé des activités (en millions d’euros)(1) 364 328 264 234 2015 2016 2015 2016 Répartition du capital au 31 décembre 2016 Dividende par action versé au titre de l’exercice (en euros) FCPE 0,85 0,85 Salariés Mayroy SA 0,2 % 56,6 % Autodétention 1,4 % Autres actionnaires nominatifs 0,9 % Administrateurs Public (hors Mayroy SA) 40,7 % 0,2 % 2015 2016 (1) Exclut les amortissements des immobilisations incorporelles (hors logiciels), les plus ou moins-values de cession d’immobilisations, les coûts liés à des restructurations, les pertes de valeur ainsi que d’autres éléments non directement liés à l’activité. Ipsen Document de référence 2016 3 INTRODUCTION : PRÉSENTATION GÉNÉRALE Évolution du cours de l’action en Bourse Les titres de la Société sont admis au Système à Règlement Les actions de la Société sont négociées sur le marché Eurolist Différé (« SRD ») depuis le 28 mars 2007. by Euronext™ (Compartiment A) depuis le 7 décembre 2005, Ipsen a mis en place un programme d’American Depositary avec un prix d’introduction de 22,20 euros par action. Receipt (ADR) sponsorisé de niveau I. Depuis le 24 décembre 2007, l’action de la Société est entrée Les ADR d’Ipsen se négocient de gré à gré aux États-Unis dans l’indice de référence SBF 120.
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