Giovanni Berlucchi
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The Epistemology of Evidence in Cognitive Neuroscience1
To appear in In R. Skipper Jr., C. Allen, R. A. Ankeny, C. F. Craver, L. Darden, G. Mikkelson, and R. Richardson (eds.), Philosophy and the Life Sciences: A Reader. Cambridge, MA: MIT Press. The Epistemology of Evidence in Cognitive Neuroscience1 William Bechtel Department of Philosophy and Science Studies University of California, San Diego 1. The Epistemology of Evidence It is no secret that scientists argue. They argue about theories. But even more, they argue about the evidence for theories. Is the evidence itself trustworthy? This is a bit surprising from the perspective of traditional empiricist accounts of scientific methodology according to which the evidence for scientific theories stems from observation, especially observation with the naked eye. These accounts portray the testing of scientific theories as a matter of comparing the predictions of the theory with the data generated by these observations, which are taken to provide an objective link to reality. One lesson philosophers of science have learned in the last 40 years is that even observation with the naked eye is not as epistemically straightforward as was once assumed. What one is able to see depends upon one’s training: a novice looking through a microscope may fail to recognize the neuron and its processes (Hanson, 1958; Kuhn, 1962/1970).2 But a second lesson is only beginning to be appreciated: evidence in science is often not procured through simple observations with the naked eye, but observations mediated by complex instruments and sophisticated research techniques. What is most important, epistemically, about these techniques is that they often radically alter the phenomena under investigation. -
Outlook Magazine, Autumn 2018
Washington University School of Medicine Digital Commons@Becker Outlook Magazine Washington University Publications 2018 Outlook Magazine, Autumn 2018 Follow this and additional works at: https://digitalcommons.wustl.edu/outlook Recommended Citation Outlook Magazine, Autumn 2018. Central Administration, Medical Public Affairs. Bernard Becker Medical Library Archives. Washington University School of Medicine, Saint Louis, Missouri. https://digitalcommons.wustl.edu/outlook/188 This Article is brought to you for free and open access by the Washington University Publications at Digital Commons@Becker. It has been accepted for inclusion in Outlook Magazine by an authorized administrator of Digital Commons@Becker. For more information, please contact [email protected]. AUTUMN 2018 Elevating performance BERNARD BECKER MEDICAL LIBRARY BECKER BERNARD outlook.wustl.edu Outlook 3 Atop the Karakoram Mountains, neurologist Marcus Raichle, MD, (center) displays a Mallinckrodt Institute of Radiology banner he created. In 1987, he and other members of a British expedition climbed 18,000 feet above sea level — and then injected radioactive xenon to see how it diffused through their brains. Raichle, 81, has been a central force for decades in the history and science of brain imaging. See page 7. FEATURES MATT MILLER MATT 7 Mysteries explored Pioneering neurologist Marcus Raichle, MD, opened up the human brain to scientific investigation. 14 Growing up transgender The Washington University Transgender Center helps families navigate the complex world of gender identity. COVER Scott Brandon, who sustained a spinal cord injury 16 years ago, said he is 21 Building independence grateful to the Program in Occupational For 100 years, the Program in Occupational Therapy has Therapy for helping him build physical and helped people engage mind and body. -
FALL 2018 MSK Takes a Lead Role in Interventional Oncology FSFOCAL
FOCAL SPOT FS FALL 2018 MSK Takes a Lead Role in Interventional Oncology MALLINCKRODT INSTITUTE OF RADIOLOGY // WASHINGTON UNIVERSITY // ST. LOUIS CONTENTS 10 A look at 10 MIR professors RAD who are helping lead the way for women in radiology. (From left: Geetika Khanna, MD, Pamela K. WOMEN Woodard, MD, and Farrokh Dehdashti, MD) 6 16 20 LIFE-ALTERING MYSTERIES MIR ALUMNI TREATMENT EXPLAINED WEEKEND MSK imaging chief Jack Jennings, Thirty years later, Marcus E. Raichle, Old friends, new stories and a sweet MD, provides quality-of-life improving MD, remains a central figure in the serenade from Ronald G. Evens, MD. procedures for patients with cancer. science of brain imaging. Inside MIR’s first reunion. Cover Photo: Metastatic melanoma patient Chris Plummer still works his farm every day, thanks to treatment resulting in unprecedented control of his tumors. 2 SPOT NEWS 24 ALUMNI SPOTLIGHT FOCAL SPOT MAGAZINE FALL 2018 Editor: Marie Spadoni Photography: Mickey Wynn, Daniel Drier Design: Kim Kania YI F A LOOK BACK ©2018 Mallinckrodt Institute of Radiology 26 28 mir.wustl.edu FOCAL SPOT MAGAZINE // 1 SPOT NEWS David H. Ballard, MD, a TOP-TIER participant, uses 3D printing in his translational imaging work. Training the Next Generation of Imaging Scientists by Kristin Rattini For young scientists eager to make their way to the forefront in clinical translational imaging research and bringing of translational research and precision imaging, Mallinckrodt innovation to the practice of medicine. The interdisciplinary Institute of Radiology (MIR) offers a clear path. A leader in grant provides two training slots per year in years one NIH funding, MIR is home to premier training programs and and two, and three slots in years three through five. -
Cholinergic Cells and Pathways
2 Cholinergic Cells and Pathways A. History of Methodological Feldberg was struck with the uneven distribu- Development Needed to tion of ACh, sites of ACh release and synthesis, Defi ne the Cholinergic and activities of ChEs in the CNS; these fi ndings Neuron, Explain led him to postulate that “the central nervous system is built of cholinergic and noncholinergic Acetylcholine Release, neurones,” distributed in an alternative fashion and Establish Central (Feldberg, 1945). This was the fi rst step toward Cholinergic Pathways the notion of a transmitter, including ACh CNS pathways; in fact, Feldberg (1945) was perhaps 1. What Led to Establishing the fi rst investigator to employ the term “central Cholinergic Pathways? pathway” to denote “transmission . through the mediation of acetylcholine across a number a. Sir Henry Dale and Sir William of . central . synapses.” The evidence in Feldberg and the Existence of question was obtained via the use of several Cholinergic Pathways extraction methods and bioassays for extracted ACh, although occasionally chemical identifi ca- The central presence of cholinergic trans- tion was attempted (Stedman and Stedman, 1937). mission was fi rst hypothesized by Sir Henry Also, collecting released ACh whether from the Dale (1937). The Stedmans, Paul Mann, John cerebrospinal fl uid or via perfusion of appropriate Quastel, and Maurice Tennenbaum, Dale’s spinal or brain sites was helpful with formulating associate William (now Sir William) Feldberg, Feldberg’s notion (Feldberg, 1945; Bulbring and and his coworkers, including Martha Vogt and Burn, 1941). Catherine Hebb, and Josiah Burn and Edith A digression is warranted. Although Zenon Bulbring provided additional evidence for Dale’s Bacq had already employed chemical identifi ca- hypothesis; this evidence included the demon- tion of endogenous ACh in 1935, his method was stration of the central nervous system (CNS) pre- complex and impracticable. -
Reviewers [PDF]
The Journal of Neuroscience, January 2013, 33(1) Acknowledgement For Reviewers 2012 The Editors depend heavily on outside reviewers in forming opinions about papers submitted to the Journal and would like to formally thank the following individuals for their help during the past year. Kjersti Aagaard Frederic Ambroggi Craig Atencio Izhar Bar-Gad Esther Aarts Céline Amiez Coleen Atkins Jose Bargas Michelle Aarts Bagrat Amirikian Lauren Atlas Steven Barger Lawrence Abbott Nurith Amitai David Attwell Cornelia Bargmann Brandon Abbs Yael Amitai Etienne Audinat Michael Barish Keiko Abe Martine Ammasari-Teule Anthony Auger Philip Barker Nobuhito Abe Katrin Amunts Vanessa Auld Neal Barmack Ted Abel Costas Anastassiou Jesús Avila Gilad Barnea Ute Abraham Beau Ances Karen Avraham Carol Barnes Wickliffe Abraham Richard Andersen Gautam Awatramani Steven Barnes Andrey Abramov Søren Andersen Edward Awh Sue Barnett Hermann Ackermann Adam Anderson Cenk Ayata Michael Barnett-Cowan David Adams Anne Anderson Anthony Azevedo Kevin Barnham Nii Addy Clare Anderson Rony Azouz Scott Barnham Arash Afraz Lucy Anderson Hiroko Baba Colin J. Barnstable Ariel Agmon Matthew Anderson Luiz Baccalá Scott Barnum Adan Aguirre Susan Anderson Stephen Baccus Ralf Baron Geoffrey Aguirre Anuska Andjelkovic Stephen A. Back Pascal Barone Ehud Ahissar Rodrigo Andrade Lars Bäckman Maureen Barr Alaa Ahmed Ole Andreassen Aldo Badiani Luis Barros James Aimone Michael Andres David Badre Andreas Bartels Cheryl Aine Michael Andresen Wolfgang Baehr David Bartés-Fas Michael Aitken Stephen Andrews Mathias Bähr Alison Barth Elias Aizenman Thomas Andrillon Bahador Bahrami Markus Barth Katerina Akassoglou Victor Anggono Richard Baines Simon Barthelme Schahram Akbarian Fabrice Ango Jaideep Bains Edward Bartlett Colin Akerman María Cecilia Angulo Wyeth Bair Timothy Bartness Huda Akil Laurent Aniksztejn Victoria Bajo-Lorenzana Marisa Bartolomei Michael Akins Lucio Annunziato David Baker Marlene Bartos Emre Aksay Daniel Ansari Harriet Baker Jason Bartz Kaat Alaerts Mark S. -
ESRS 40Th Anniversary Book
European Sleep Research Society 1972 – 2012 40th Anniversary of the ESRS Editor: Claudio L. Bassetti Co-Editors: Brigitte Knobl, Hartmut Schulz European Sleep Research Society 1972 – 2012 40th Anniversary of the ESRS Editor: Claudio L. Bassetti Co-Editors: Brigitte Knobl, Hartmut Schulz Imprint Editor Publisher and Layout Claudio L. Bassetti Wecom Gesellschaft für Kommunikation mbH & Co. KG Co-Editors Hildesheim / Germany Brigitte Knobl, Hartmut Schulz www.wecom.org © European Sleep Research Society (ESRS), Regensburg, Bern, 2012 For amendments there can be given no limit or warranty by editor and publisher. Table of Contents Presidential Foreword . 5 Future Perspectives The Future of Sleep Research and Sleep Medicine in Europe: A Need for Academic Multidisciplinary Sleep Centres C. L. Bassetti, D.-J. Dijk, Z. Dogas, P. Levy, L. L. Nobili, P. Peigneux, T. Pollmächer, D. Riemann and D. J. Skene . 7 Historical Review of the ESRS General History of the ESRS H. Schulz, P. Salzarulo . 9 The Presidents of the ESRS (1972 – 2012) T. Pollmächer . 13 ESRS Congresses M. Billiard . 15 History of the Journal of Sleep Research (JSR) J. Horne, P. Lavie, D.-J. Dijk . 17 Pictures of the Past and Present of Sleep Research and Sleep Medicine in Europe J. Horne, H. Schulz . 19 Past – Present – Future Sleep and Neuroscience R. Amici, A. Borbély, P. L. Parmeggiani, P. Peigneux . 23 Sleep and Neurology C. L. Bassetti, L. Ferini-Strambi, J. Santamaria . 27 Psychiatric Sleep Research T. Pollmächer . 31 Sleep and Psychology D. Riemann, C. Espie . 33 Sleep and Sleep Disordered Breathing P. Levy, J. Hedner . 35 Sleep and Chronobiology A. -
Donald B. Lindsley Papers Biomed.0423
http://oac.cdlib.org/findaid/ark:/13030/kt1p3036g6 No online items Finding Aid for the Donald B. Lindsley Papers Biomed.0423 Finding aid prepared by Jason Richard Miller, 2010. The processing of this collection was generously supported by Arcadia funds. UCLA Library Special Collections Online finding aid last updated 2020 November 18. Room A1713, Charles E. Young Research Library Box 951575 Los Angeles, CA 90095-1575 [email protected] URL: https://www.library.ucla.edu/special-collections Finding Aid for the Donald B. Lindsley Biomed.0423 1 Papers Biomed.0423 Contributing Institution: UCLA Library Special Collections Title: Donald B. Lindsley papers Identifier/Call Number: Biomed.0423 Physical Description: 58.5 Linear Feet(97 boxes, 4 half document boxes, 4 shoe boxes, 2 flat oversize boxes, 1 magazine box, 3 LP boxes) Date (inclusive): 1866-2001 Abstract: Donald B. Lindsley was an early pioneer of the electroencephalogram (EEG) and an internationally recognized psychologist and brain scientist. Originally from Ohio, Lindsley worked throughout the United States and spent the last half of his career at UCLA where he was instrumental in founding UCLA's Brain Research Institute. Nearly half of this collection is constituted by Lindsley's correspondence spanning over 70 years. The remainder of the collection consists of reprints, typescripts of papers and talks, research notes, research and technical data, audiovisual material, and autobiographical ephemera that date from the late nineteenth century to the beginning of the twenty-first century. Stored off-site. All requests to access special collections material must be made in advance using the request button located on this page. -
Uva-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository) The space inside the skull : digital representations, brain mapping and cognitive neuroscience in the decade of the brain Beaulieu, J.A. Publication date 2000 Link to publication Citation for published version (APA): Beaulieu, J. A. (2000). The space inside the skull : digital representations, brain mapping and cognitive neuroscience in the decade of the brain. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:30 Sep 2021 Workss Cited Ahhot.. Allison 19922 Confusion about form and function clouds launch of EC's Decade of ihe Brain. Nature. 24 September.. 359: 260. Ackerman.. Sandra 19922 The Role of the Brain in Mental Illness. !n Discovering the Brain. 46-66. Washington. DC:: National Academy Press. -
7 Self and Self-Understanding* Lecture I: Some Origins of Self
7 Self and Self-Understanding* Lecture I: Some Origins of Self I will reflect on constitutive features of selves—especially a certain sort of self- understanding. This self-understanding is the main topic of these lectures. I ‘Self ’ is a technical term, refined from ordinary usage. Ordinary usage is, however, very close to what I want. A definition from the Oxford English Dictionary runs, ‘Self: a person’s essential being that distinguishes the person from others, especially considered as the object of introspection or reflexive action; a person’s particular nature.’ Kant characterized a person as ‘what is conscious of its numerical identity, of its self, in different times’.1 This * This essay is a revision, with some expansion, of the Dewey Lectures, given at Columbia University, December 2007. I am grateful to Christopher Peacocke for valuable criticisms in spring 2011 of the last section of Lecture I and all of Lecture III; and to Denis Bu¨hler for saving me from an error and prompting an argument in Lecture II. 1 Immanuel Kant, Critique of Pure Reason, A361; see also Metaphysics Mrongovius 29: 911 in Karl Ameriks and Steve Naragon (eds.), Lectures on Metaphysics (New York: Cambridge University Press, 1997), p. 276. Kant’s formulation in the Critique is not ideally specific and might qualify as ambiguous. It is clear from context that Kant means the consciousness to include consciousness at a given time of the self as it is at different times. It is also clear that Kant intends the consciousness to be noninferential, and in my terms de re. -
Focus on the REM Sleep Behavior Disorder (RBD)
Sleep phenotyping of the animal models of neurodegenerative diseases: Focus on the REM sleep behavior disorder (RBD) Pierre-Hervé Luppi, Team "Physiopathology of the neuronal network of the sleep-waking cycle” Centre of Neuroscience of Lyon UMR 5292 CNRS/U1028 INSERM , Lyon, France Michel Jouvet: the father of paradoxical (REM) sleep and RBD! 16 November 1925- 3 October 2017 CNRS Research Director (full time researcher) 2011- Head of the Team “Physiopathology of the neuronal network of the sleep-waking cycle" of the Center of Neuroscience of Lyon, UMR 5292 CNRS/U1028 INSERM, Université Claude Bernard Lyon 1, France. 2002-2010: Director of the CNRS laboratory UMR5167, University Claude Bernard Lyon I. 1999 – 2001 Director of Research (DR2), CNRS, INSERM U52, University Claude Bernard Lyon I. 1989 – 1999 CR1 CNRS, INSERM U52, University Claude Bernard Lyon I. 1984 – 1989 PhD in Neurosciences, University Claude Bernard Lyon I. Michel Jouvet, Advisor. 1990-911983 – 1984Visiting DEA (Master) scientist Neuroscience, (6 months in Universitytotal) at the Claude Department Bernard of Lyon I. MentalMichel Jouvet,Health Sciences,Advisor. Hahnemann University, Philadelphia, USA (Pr. ASTON-JONES), Study of the afferents to the locus coeruleus. 1992 Invited scientist (6 months), at the Brain Research Institute, UCLA, Los Angeles, USA. (Dr. MICHAEL CHASE), Study of the glycinergic neurons responsible for muscle atonia of paradoxical sleep. What is paradoxical (REM) sleep (PS)? Waking SWS or nonREM sleep EEG EEG EMG EMG EOG EOG Paradoxical (REM) sleep EEG EMG EOG total sleep 12h50 (SWS 10h50 min - PS2h00 min) Hypnogram of 24h PS SWS W 07h00 19h00 07h00 A paradoxical (REM) sleep (PS)-like state with muscle atonia is still present in ªpontine catsº: muscle atonia of PS is generated by a brainstem circuit Jouvet, 1962, Arch. -
Jeannerod and Jean Decety
Mental motor imagery: a window into the representational stages of action Marc Jeannerod and Jean Decety INSERM Unit6 94, Bron, France The physiological basis of mental states can be effectively studied by combining cognitive psychology with human neuroscience. Recent research has employed mental motor imagery in normal and brain-damaged subjects to decipher the content and the structure of covert processes preceding the execution of action. The mapping of brain activity during motor imagery discloses a pattern of activation similar to that of an executed action. Current Opinion in Neurobiology 1995, 5:727-732 Introduction: motor representations increases with respect to rest. When this is the case, elec- trornyographic (EMG) activity is limited to those muscles Most of our actions are driven indirectly by internally that participate in the simulated action, and tends to be reprsesented goals, rather than directly by the external proportional to the amount of imagined effort [lo]. The environment. Until recently, the existence and structure fact that muscular activity is only partially blocked during of such motor representations were inferred from the simulation of movement suggests that motoneurons are duration and timing of a reaction, or from the pattern of close to threshold. executed movements [l]. Now, however, a more direct approach has been adopted that exploits the unique In several other motor imagery experiments, however, ability of human subjects to image and simulate actions EMG is quiescent (e.g. [ll]). This does not necessarily consciously [P-4]. Motor imag,ery is a cognitive state that contradict the link between motor imagery and muscular can be experienced by virtually everyone with minimal activity, as it may merely reflect better inhibition of training. -
Toward an Ethnography of Experimental Psychology Emily Martin 1
UC Berkeley UC Berkeley Previously Published Works Title Plasticity and Pathology Permalink https://escholarship.org/uc/item/0vc9v8rj ISBN 9780823266135 Authors Bates, David Bassiri, Nima Publication Date 2015 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Plasticity and Pathology Berkeley Forum in the Humanities Plasticity and Pathology On the Formation of the Neural Subject Edited by David Bates and Nima Bassiri Townsend Center for the Humanities University of California, Berkeley Fordham University Press New York Copyright © 2016 The Regents of the University of California All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means—electronic, mechanical, photocopy, recording, or any other—except for brief quotations in printed reviews, without the prior permission of the publishers. The publishers have no responsibility for the persistence or accuracy of URLs for external or third-party Internet websites referred to in this publication and do not guarantee that any content on such websites is, or will remain, accurate or appropriate. The publishers also produce their books in a variety of electronic formats. Some content that appears in print may not be available in electronic books. Library of Congress Cataloging-in-Publication Data Plasticity and pathology : on the formation of the neural subject / edited by David Bates and Nima Bassiri. — First edition. p. cm. — (Berkeley forum in the humanities) The essays collected here were presented at the workshop Plasticity and Pathology: History and Theory of Neural Subjects at the Doreen B. Townsend Center for the Humanities at the University of California, Berkeley.