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Gram-Negative Bacterial Toe Web Intertrigo extensive use of closed shoes for professional and colonisation, with Afghanistan-based personnel GRAM-NEGATIVE BACTERIAL TOE WEB INTERTRIGO extraprofessional reasons or during the practice of showing a 5.5-fold higher prevalence in respect *Laura Atzori, Michela Lai, Myriam Zucca, Monica Pau sports.1,6-13 A US military survey for Gram-negative to other US military.14 The high frequency of bacteria colonisation in healthy asymptomatic asymptomatic carriers and diffusion of MDR Department of Dermatology, University of Cagliari, Cagliari, Italy personnel showed that toe web spaces were bacteria in the community are critical points, *Correspondence to [email protected] Gram-negative colonised in 35% of cases.14 The suggesting a possible increase of the infection cases, study also documented a relevant community unresponsive to common treatment, especially in Disclosure: No potential conflict of interest. onset of multidrug-resistant (MDR) Escherichia coli precarious healthy conditions. Received: 28.04.14 Accepted: 22.08.14 Citation: EMJ Dermatol. 2014;2: - . Table 1: Clinical differential features of toe web infections and other frequent inflammatory conditions. ABSTRACT Disease Clinical presentation Symptoms Gram-negative infection of the toe web space is less frequent than dermatophytes and yeasts, but it is Simple intertrigo Mild erythema on each side of the skin Warming sensation more challenging, especially with the involvement of Pseudomonas aeruginosa in relation to antibiotic fold, almost in a mirror image, more resistance and the increased risk of potentially lethal complications. Many conditions, other than infections, evident on convexity than on bottom. might initially present with the same clinical features, recognising the common initial damage (intertrigo), Gram-positive Well-demarcated bright red erosions, Burning sensation due to skin-on-skin rubbing in a moist environment with air entrapment, which is typical of interdigital intertrigo with abundant weeping and crusting, spaces. Conditions such as contact eczema, atopic dermatitis, and inverse psoriasis, frequently predispose foul odour. No satellite lesions. to, and are maintained by, the intertrigo, triggering a vicious circle. The dermatologist is in a lead position to Candida intertrigo Mild-to-moderate erythema and Moderate itching address the correct assessment and management. A careful screening for predisposing factors is necessary: maceration, with a central fissure, and overweight, diabetic, but also athletes or people attending swimming pools, gyms, public showers/dressing typical satellite papules and small size rooms, and thermal baths are also at an increased risk of intertrigo of the toe web spaces. Occupational white pustules. activities other than recreational might be relevant, such as the use of safety shoes or working in wet warm Tinea pedis Mild erythema, mainly under a scaling Mild itching, often asymptomatic conditions. Incongruous therapy for tinea pedis or contact dermatitis, frequently auto-prescribed, might be macerated surface, more evident in the among promoting factors altering the microbial ecosystem balance. The aim of this review is to evaluate fold bottom, which might present a superficial erosion. the main epidemiologic and clinical features of Gram-negative bacteria intertrigo, the role of promoting factors, and the measures taken to treat and prevent this disorder. Appropriate treatment and patient Gram-negative Intense erythema, erosions, and Burning and pain, possible education are crucial to prevent further infection and relapses. intertrigo maceration, with profuse oozing or functional disability purulent discharge, crusting, typically Keywords: Toe web intertrigo, skin and soft tissue infections, Gram-negative infection, multidrug resistance. malodorous. A green discolouration of the lesion borders is highly evocative of P. aeruginosa isolate. Oedema and severe erythema of surrounding tissues in severe forms. INTRODUCTION to severe acute exudative, macerating, painful inflammatory forms, causing discrete functional Scabies Mild erythematous scaling lesions, linear Itching more severe than The term ‘intertrigo’, from the Latin roots ‘inter impotence. Gram-negative prevalence over other or isolated papules. expected from visible lesions, night worsening (between) + terere (to rub)’, medically groups bacteria, dermatophytes, and Candida spp. usually different conditions involving the flexural areas of cause a sudden aggravation of the lesions.5-7 This Inverse psoriasis Smooth erythematous well-demarcated the body, where the opposing surfaces produce review aims to outline the main clinical aspects of vulgaris lesions, with compact scaling at the periphery. Plantar hyperkeratosis, and/ friction and promote inflammation and thereby Gram-negative foot intertrigo, causative organisms, or typical psoriasis lesions on other skin modification of the cutaneous ecosystem, which promoting factors, and the most common areas, nail changes. is habitually colonised by polymicrobial flora, therapeutic actions. Contact dermatitis Erythema, maceration, severe weeping, More intense itching; positive precariously balanced by biologic interference Epidemiology and crusting. Sometimes visible vesicles patch tests distinguish allergic mechanisms.1-3 Interdigital toe folds are frequently at the periphery. from simple irritant dermatitis affected,4 and differentiation from major dermatitis Current literature on interdigital Gram-negative Atopic dermatitis Eczematous variable manifestations. Intense itching on a clinical basis is sometimes a challenge (Table 1), infections is limited, and an incidence rate cannot Coexisting atopic disease or positive especially from contact eczema, atopic dermatitis, be extrapolated from such a small case series,4,7-11 family history. and inverse psoriasis, which are frequently but daily practice suggests the disease is more Dyshidrotic eczema Itching and/or burning predisposed to, and are maintained by the intertrigo, common and probably underestimated, because Clear, deep blisters, more visible on the side of the inter-digital surfaces. Mild triggering a vicious cycle. Presentation is also of empirical diagnosis and treatment. Any race, erythema and flexural fissures on the variable, from mild erythematous-scaling forms, age, or sex is affected. The sharp prevalence of fold. more or less asymptomatic with a chronic trend, male gender, with 4:1 ratio7 is justified by the more AETIOLOGY AND PATHOGENESIS but healthy individuals might also be affected throughout life, especially athletes or people Gram-negative bacteria are ubiquitous, sometimes attending to swimming pools, gyms, public showers/ present as part of the normal human flora, dressing rooms, and thermal baths.7,11,20 but potentially very aggressive,5,6 and the fine mechanisms turning from bacterial colonisation to Promoting factors are also topical medications with active proliferation, invasion, and tissue damage antifungal, mixed antibiotic, and cortisone creams (infection phase) are complex and variable. Toe which are commonly used for other conditions, web spaces provide a hospital niche for several such as tinea pedis or contact dermatitis.7,16 These microorganisms, with warm and moistening air treatments are rarely based on diagnostic support, entrapment. The most common isolates that have are auto prescribed, and often inadequate or too been reported include: Pseudomonas, Moraxella, prolonged. Besides, a confirmed allergic contact Alcaligenes, Acinetobacter, Proteus, and Erwinia dermatitis might be a frequent condition, which species.7,10-15 Pathogens determinant of virulence was reported in 20% of patients in our published Figure 1: A mild erythematous scaling form of intertrigo, involving the third and fourth interdigital fold. are crucial for subsequent tissue infection, but host experience.7 Sensitisation further reduces the choice From this clinical presentation it is impossible to further diagnose the type of microorganism, as defence impairment for local, as well as general of medications, cosmetic products, clothes, and dermatophyte, yeasts, as well as Gram-positive bacteria might cause it. predisposing conditions, is necessary to lose the shoes. Some of our patients underwent aggravation natural ability to counteract infections. In intertrigo after a footbath with potassium salts, and patch tests process, first, integumental alteration depends on revealed potassium dichromate sensitisation, alone mechanical chafing, as the skin-on-skin rubbing or combined with cobalt chloride, balsam of Peru, causes an initial corneal damage favouring bacterial leather, rubber, and fragrance sensitisations.7 Other or fungal invasion.16 Clothes, especially tight-fitting than recreational activities, occupational activities shoes, but also climate variables, such as increased might be a determinant, such as the use of safety temperature and relative humidity, as well as shoes or working in wet, warm conditions.7,8,13,19 pH modification, cause over-hydration of the stratum corneum and favour surface concentration CLINICAL MANIFESTATIONS AND 17,18 of Gram-negative bacteria. Primary or secondary EVOLUTION hyperhidrosis and poor hygiene further collaborate to produce a fertile breeding ground for Gram-negative intertrigo is characterised by dark several microorganisms. red oedema and erythema, varying from mild to A previously unrecognised interdigital dermatophyte very severe forms. Initial, mild manifestations (Figure infection (tinea pedis) might be
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