Online Submissions: http://www.journaltcm.com J Tradit Chin Med 2016 August 15; 36(4): 464-470
[email protected] ISSN 0255-2922 © 2016 JTCM. All rights reserved. EXPERIMENTAL STUDYTOPIC Yiguanjian cataplasm attenuates opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome Gao Shuai, Gao Hong, Fan Yuchen, Zhang Guanghua, Sun Fengkai, Zhao Jing, Li Feng, Yang Yang, Wang Kai aa Gao Shuai, Sun Fengkai, Zhao Jing, Li Feng, Yang Yang, morphine administration on day 3 and subsequent- Department of Hepatology, Qilu Hospital of Shandong Uni- ly removed at the end day 5. On day 6, naloxone (8 versity, jinan 250012, China mg/kg) was intraperitoneally injected to precipi- Gao Hong, Zhang Guanghua, Research Center for Material tate opioid withdrawal syndrome. Behavioral obser- Evidence Identification, Shandong Public Security Bureau, ji- vation was performed in two 30-min phases imme- nan 250012, China Fan Yuchen, Wang Kai, Department of Hepatology, Qilu diately after naloxone injection. Hospital of Shandong University, Jinan 250012, China and Institute of Hepatology, Shandong University, jinan 250012, RESULTS: The YGJ cataplasm significantly and China dose-dependently attenuated morphine-nalox- Supported by Shandong Foundation for Development of one-induced experimental opioid withdrawal, in Science and Technology, China (Research and Development terms of withdrawal severity score and the frequen- of Umbilical Treatment Cataplasm for Drug Rehabilitation, cies of jumping, rearing, forepaw licking, and cir- No. 2009GG10008007) cling behaviors. However, YGJ cataplasm treatment Correspondence to: Prof. Wang Kai, Department of Hepa- did not alter the acute analgesic effect of morphine. tology, Qilu Hospital of Shandong University, Jinan 250012, China; Institute of Hepatology, Shandong University, Jinan CONCLUSION: YGJ cataplasm could attenuate opi- 250012, China.