Review www.cell-stress.com Fatty acids - from energy substrates to key regulators of cell survival, proliferation and effector function Danilo Cucchi1, Dolores Camacho-Muñoz2, Michelangelo Certo3, Valentina Pucino3, Anna Nicolaou2,4,* and Claudio Mauro3,5,6,* 1 Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. 2 Laboratory for Lipidomics and Lipid Biology, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, School of Health sciences, The University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT, UK. 3 Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Mindelsohn Way, Birming- ham B15 2WB, UK. 4 Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT, UK. 5 Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Mindelsohn Way, Birming- ham B15 2WB, UK. 6 Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Mindelsohn Way, Birmingham B15 2WB, UK. * Corresponding Authors: Anna Nicolaou, Stopford Building, Oxford Road, Manchester M13 9PT, UK; E-mail:
[email protected]; Claudio Mauro, Queen Elizabeth Hospital, Mindelsohn Way, Birmingham B15 2WB, UK; E-mail:
[email protected] ABSTRACT Recent advances in immunology and cancer research doi: 10.15698/cst2020.01.209 show that fatty acids, their metabolism and their sensing have a cru- Received originally: 07.10.2019 cial role in the biology of many different cell types.