The Female Reproductive System Part 2

Total Page:16

File Type:pdf, Size:1020Kb

The Female Reproductive System Part 2 The Reproductive System The Female Reproductive System Part 2 Female Reproductive System Ovaries Produce female gametes (ova) Secrete female sex hormones Estrogen and progesterone Accessory ducts include Uterine tubes (oviducts, fallopian tubes) Uterus Maintains zygote development Vagina Receives male gametes Suspensory ligament of ovary Infundibulum Uterine tube Ovary Fimbriae Peritoneum Uterus Uterosacral Round ligament ligament Vesicouterine Perimetrium pouch Rectouterine pouch Urinary bladder Pubic symphysis Rectum Mons pubis Posterior fornix Cervix Urethra Anterior fornix Clitoris Vagina External urethral Anus orifice Urogenital diaphragm Hymen Greater vestibular Labium minus (Bartholin’s) gland Labium majus Copyright © 2010 Pearson Education, Inc. Figure 27.10 Ovaries Each about twice as large as an almond Retroperitoneal Ovarian ligaments Suspensory ligament of ovary Uterine (fallopian) tube Uterine Ovarian blood Fundus Lumen (cavity) tube vessels of uterus of uterus Ampulla Mesosalpinx Ovary Isthmus Mesovarium Infundibulum Broad Fimbriae ligament Mesometrium Round ligament of uterus Ovarian ligament Body of uterus Endometrium Ureter Myometrium Wall of uterus Uterine blood vessels Perimetrium Isthmus Internal os Uterosacral ligament Cervical canal Lateral cervical External os (cardinal) ligament Vagina Lateral fornix Cervix (a) Copyright © 2010 Pearson Education, Inc. Figure 27.12a Ovaries Follicles About 400,000 present at birth Some develop into mature ova at sexual maturity Maturation of a follicle occurs about every 28 days Ovulation Tunica albuginea Oocyte Granulosa cells Late secondary follicle Degenerating corpus Cortex Mesovarium and luteum (corpus blood vessels albicans) Germinal Vesicular epithelium (Graafian) Primary follicle follicles Antrum Oocyte Ovarian Zona ligament pellucida Theca Medulla folliculi Ovulated oocyte Corpus luteum Developing Corona corpus luteum radiata (a) Diagrammatic view of an ovary sectioned to reveal the follicles in its interior Figure 27.11a Female Duct System Uterine tubes Uterus Vagina Suspensory ligament of ovary Uterine (fallopian) tube Uterine Ovarian blood Fundus Lumen (cavity) tube vessels of uterus of uterus Ampulla Mesosalpinx Ovary Isthmus Mesovarium Infundibulum Broad Fimbriae ligament Mesometrium Round ligament of uterus Ovarian ligament Body of uterus Endometrium Ureter Myometrium Wall of uterus Uterine blood vessels Perimetrium Isthmus Internal os Uterosacral ligament Cervical canal Lateral cervical External os (cardinal) ligament Vagina Lateral fornix Cervix (a) Figure 27.12a Uterine (Fallopian) Tubes Extend from uterus to near ovary End in infundibulum Post-ovulation Cilia create currents, move ovum into uterine tube Fertilization normally takes place within tube Ectopic pregnancy Pelvic Inflammatory Disease Uterus Structure Body Main region Fundus Rounded superior region Isthmus Narrowed inferior region Layers Serosa Myometrium Endometrium Suspensory ligament of ovary Uterine (fallopian) tube Uterine Ovarian blood Fundus Lumen (cavity) tube vessels of uterus of uterus Ampulla Mesosalpinx Ovary Isthmus Mesovarium Infundibulum Broad Fimbriae ligament Mesometrium Round ligament of uterus Ovarian ligament Body of uterus Endometrium Ureter Myometrium Wall of uterus Uterine blood vessels Serosa Isthmus Internal os Uterosacral ligament Cervical canal Lateral cervical External os (cardinal) ligament Vagina Lateral fornix Cervix (a) Figure 27.12a Lumen of uterus Epithelium Capillaries Uterine glands Venous sinusoids Lamina propria of connective tissue Spiral (coiled) artery Straight artery Endometrial vein Smooth muscle fibers Radial artery Arcuate artery Uterine artery (b) Figure 27.13b Uterus Cervix Narrow neck, or outlet Projects into the vagina Common site for cancer Vagina Muscular tube from uterus (cervix) to outside the body Birth canal Organ of copulation Pathway for menstrual flow Lined by mucous membrane Acidic secretions retard bacterial growth Immune cells Suspensory ligament of ovary Uterine (fallopian) tube Uterine Ovarian blood Fundus Lumen (cavity) tube vessels of uterus of uterus Ampulla Mesosalpinx Ovary Isthmus Mesovarium Infundibulum Broad Fimbriae ligament Mesometrium Round ligament of uterus Ovarian ligament Body of uterus Endometrium Ureter Myometrium Wall of uterus Uterine blood vessels Perimetrium Isthmus Internal os Uterosacral ligament Cervical canal Lateral cervical External os (cardinal) ligament Vagina Lateral fornix Cervix (a) Figure 27.12a Hormonal Function of Ovaries Endocrine function Estrogen and progesterone production Development of reproductive organs Secondary sexual characteristics Affect protein anabolism Affect fluid and electrolyte balance Hormonal Function of Ovaries FSH and LH Produced by pituitary gland Human chorionic gonadotropin Produced by placenta More on these later…. External Genitalia Vulva Skin folds surrounding vaginal orifice Clitoris Erectile tissue Homologous to male penis Sexual arousal Accessory Organ Mammary glands Present in both males and females Modified sweat glands Glandular alveoli capable of hormone stimulated milk production Accessory Organ Mammary glands Breast cancer .
Recommended publications
  • Te2, Part Iii
    TERMINOLOGIA EMBRYOLOGICA Second Edition International Embryological Terminology FIPAT The Federative International Programme for Anatomical Terminology A programme of the International Federation of Associations of Anatomists (IFAA) TE2, PART III Contents Caput V: Organogenesis Chapter 5: Organogenesis (continued) Systema respiratorium Respiratory system Systema urinarium Urinary system Systemata genitalia Genital systems Coeloma Coelom Glandulae endocrinae Endocrine glands Systema cardiovasculare Cardiovascular system Systema lymphoideum Lymphoid system Bibliographic Reference Citation: FIPAT. Terminologia Embryologica. 2nd ed. FIPAT.library.dal.ca. Federative International Programme for Anatomical Terminology, February 2017 Published pending approval by the General Assembly at the next Congress of IFAA (2019) Creative Commons License: The publication of Terminologia Embryologica is under a Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) license The individual terms in this terminology are within the public domain. Statements about terms being part of this international standard terminology should use the above bibliographic reference to cite this terminology. The unaltered PDF files of this terminology may be freely copied and distributed by users. IFAA member societies are authorized to publish translations of this terminology. Authors of other works that might be considered derivative should write to the Chair of FIPAT for permission to publish a derivative work. Caput V: ORGANOGENESIS Chapter 5: ORGANOGENESIS
    [Show full text]
  • Laparoscopic Extraperitoneal Salpingo-Oophorectomy in Women with Suspicious Ovarian Mass, a Way to Reduce the Risk of Spillage
    5 Surgical Technique Page 1 of 5 Laparoscopic extraperitoneal salpingo-oophorectomy in women with suspicious ovarian mass, a way to reduce the risk of spillage Giulio Sozzi, Giulia Zaccaria, Mariano Catello Di Donna, Giuseppina Lo Balbo, Stefania Cannarozzo, Vito Chiantera Department of Gynecologic Oncology, University of Palermo, Piazza Nicola Leotta, Palermo, Italy Correspondence to: Giulio Sozzi, MD. Department of Gynecologic Oncology, University of Palermo, Piazza Nicola Leotta 4, 90127 Palermo, Italy. Email: [email protected]. Abstract: The objective of the present paper is to provide a step by step description of the laparoscopic extraperitoneal salpingo-oophorectomy, a surgical technique useful to reduce the risk of spillage in women with suspected ovarian masses. The patient was a 52-year-old woman with sonographic diagnosis of a multilocular, 5 cm lesion, with Color Score 3 at right ovary. Computed tomography (CT) scan excluded any other localization of disease. Tumor markers were negative, except for Ca 19.9 that was 85 IU/mL. Preliminary diagnostic laparoscopy was performed and peritoneal carcinomatosis was excluded. In order to obtain a histological diagnosis, an extraperitoneal right salpingo-oophorectomy was performed. At frozen section analysis it was diagnosed an ovarian adenocarcinoma. Therefore, a laparoscopic complete surgical staging including total hysterectomy, controlateral salpingo-oophorectomy, infracolic omentectomy, multiple peritoneal biopsies, and pelvic and para-aortic lymphadenectomy, was performed. Operative time was 240 minutes and estimated blood loss was about 50 mL. No intra or post-operative complications were observed, and the patient was discharged 3 days after surgery. Final histology showed the presence of clear cell high grade carcinoma in both ovaries without fallopian tubes infiltration.
    [Show full text]
  • Ovarian Cancer and Cervical Cancer
    What Every Woman Should Know About Gynecologic Cancer R. Kevin Reynolds, MD The George W. Morley Professor & Chief, Division of Gyn Oncology University of Michigan Ann Arbor, MI What is gynecologic cancer? Cancer is a disease where cells grow and spread without control. Gynecologic cancers begin in the female reproductive organs. The most common gynecologic cancers are endometrial cancer, ovarian cancer and cervical cancer. Less common gynecologic cancers involve vulva, Fallopian tube, uterine wall (sarcoma), vagina, and placenta (pregnancy tissue: molar pregnancy). Ovary Uterus Endometrium Cervix Vagina Vulva What causes endometrial cancer? Endometrial cancer is the most common gynecologic cancer: one out of every 40 women will develop endometrial cancer. It is caused by too much estrogen, a hormone normally present in women. The most common cause of the excess estrogen is being overweight: fat cells actually produce estrogen. Another cause of excess estrogen is medication such as tamoxifen (often prescribed for breast cancer treatment) or some forms of prescribed estrogen hormone therapy (unopposed estrogen). How is endometrial cancer detected? Almost all endometrial cancer is detected when a woman notices vaginal bleeding after her menopause or irregular bleeding before her menopause. If bleeding occurs, a woman should contact her doctor so that appropriate testing can be performed. This usually includes an endometrial biopsy, a brief, slightly crampy test, performed in the office. Fortunately, most endometrial cancers are detected before spread to other parts of the body occurs Is endometrial cancer treatable? Yes! Most women with endometrial cancer will undergo surgery including hysterectomy (removal of the uterus) in addition to removal of ovaries and lymph nodes.
    [Show full text]
  • Chapter 28 *Lecture Powepoint
    Chapter 28 *Lecture PowePoint The Female Reproductive System *See separate FlexArt PowerPoint slides for all figures and tables preinserted into PowerPoint without notes. Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Introduction • The female reproductive system is more complex than the male system because it serves more purposes – Produces and delivers gametes – Provides nutrition and safe harbor for fetal development – Gives birth – Nourishes infant • Female system is more cyclic, and the hormones are secreted in a more complex sequence than the relatively steady secretion in the male 28-2 Sexual Differentiation • The two sexes indistinguishable for first 8 to 10 weeks of development • Female reproductive tract develops from the paramesonephric ducts – Not because of the positive action of any hormone – Because of the absence of testosterone and müllerian-inhibiting factor (MIF) 28-3 Reproductive Anatomy • Expected Learning Outcomes – Describe the structure of the ovary – Trace the female reproductive tract and describe the gross anatomy and histology of each organ – Identify the ligaments that support the female reproductive organs – Describe the blood supply to the female reproductive tract – Identify the external genitalia of the female – Describe the structure of the nonlactating breast 28-4 Sexual Differentiation • Without testosterone: – Causes mesonephric ducts to degenerate – Genital tubercle becomes the glans clitoris – Urogenital folds become the labia minora – Labioscrotal folds
    [Show full text]
  • Reproductive System, Day 2 Grades 4-6, Lesson #12
    Family Life and Sexual Health, Grades 4, 5 and 6, Lesson 12 F.L.A.S.H. Reproductive System, day 2 Grades 4-6, Lesson #12 Time Needed 40-50 minutes Student Learning Objectives To be able to... 1. Distinguish reproductive system facts from myths. 2. Distinguish among definitions of: ovulation, ejaculation, intercourse, fertilization, implantation, conception, circumcision, genitals, and semen. 3. Explain the process of the menstrual cycle and sperm production/ejaculation. Agenda 1. Explain lesson’s purpose. 2. Use transparencies or your own drawing skills to explain the processes of the male and female reproductive systems and to answer “Anonymous Question Box” questions. 3. Use Reproductive System Worksheets #3 and/or #4 to reinforce new terminology. 4. Use Reproductive System Worksheet #5 as a large group exercise to reinforce understanding of the reproductive process. 5. Use Reproductive System Worksheet #6 to further reinforce Activity #2, above. This lesson was most recently edited August, 2009. Public Health - Seattle & King County • Family Planning Program • © 1986 • revised 2009 • www.kingcounty.gov/health/flash 12 - 1 Family Life and Sexual Health, Grades 4, 5 and 6, Lesson 12 F.L.A.S.H. Materials Needed Classroom Materials: OPTIONAL: Reproductive System Transparency/Worksheets #1 – 2, as 4 transparencies (if you prefer not to draw) OPTIONAL: Overhead projector Student Materials: (for each student) Reproductive System Worksheets 3-6 (Which to use depends upon your class’ skill level. Each requires slightly higher level thinking.) Public Health - Seattle & King County • Family Planning Program • © 1986 • revised 2009 • www.kingcounty.gov/health/flash 12 - 2 Family Life and Sexual Health, Grades 4, 5 and 6, Lesson 12 F.L.A.S.H.
    [Show full text]
  • Chapter 24 Primary Sex Organs = Gonads Produce Gametes Secrete Hormones That Control Reproduction Secondary Sex Organs = Accessory Structures
    Anatomy Lecture Notes Chapter 24 primary sex organs = gonads produce gametes secrete hormones that control reproduction secondary sex organs = accessory structures Development and Differentiation A. gonads develop from mesoderm starting at week 5 gonadal ridges medial to kidneys germ cells migrate to gonadal ridges from yolk sac at week 7, if an XY embryo secretes SRY protein, the gonadal ridges begin developing into testes with seminiferous tubules the testes secrete androgens, which cause the mesonephric ducts to develop the testes secrete a hormone that causes the paramesonephric ducts to regress by week 8, in any fetus (XX or XY), if SRY protein has not been produced, the gondal ridges begin to develop into ovaries with ovarian follicles the lack of androgens causes the paramesonephric ducts to develop and the mesonephric ducts to regress B. accessory organs develop from embryonic duct systems mesonephric ducts / Wolffian ducts eventually become male accessory organs: epididymis, ductus deferens, ejaculatory duct paramesonephric ducts / Mullerian ducts eventually become female accessory organs: oviducts, uterus, superior vagina C. external genitalia are indeterminate until week 8 male female genital tubercle penis (glans, corpora cavernosa, clitoris (glans, corpora corpus spongiosum) cavernosa), vestibular bulb) urethral folds fuse to form penile urethra labia minora labioscrotal swellings fuse to form scrotum labia majora urogenital sinus urinary bladder, urethra, prostate, urinary bladder, urethra, seminal vesicles, bulbourethral inferior vagina, vestibular glands glands Strong/Fall 2008 Anatomy Lecture Notes Chapter 24 Male A. gonads = testes (singular = testis) located in scrotum 1. outer coverings a. tunica vaginalis =double layer of serous membrane that partially surrounds each testis; (figure 24.29) b.
    [Show full text]
  • Uterine Rupture During Subsequent
    ISSN: 2474-1353 Nishida et al. Int J Womens Health Wellness 2018, 4:070 DOI: 10.23937/2474-1353/1510070 Volume 4 | Issue 1 International Journal of Open Access Women’s Health and Wellness RESEARCH ARTICLE Uterine Rupture during Subsequent Pregnancy following Adeno- myomectomy - Report of Five Cases and Proposal for Prevention Masato Nishida1*, Yasuo Otsubo1, Yuko Arai1, Ryota Ichikawa1, Yuzuru Kondo2, Hiroya Itagaki1 and Miyako Sakanaka1 1Department of Obstetrics and Gynecology, National Hospital Organization, Kasumigaura Medical Center, Japan 2Department of Pathology, National Hospital Organization, Kasumigaura Medical Center, Tsuchiura, Japan *Corresponding author: Masato Nishida, Department of Obstetrics and Gynecology, National Hospital Organization, Kasumigaura Medical Center, 2-7-14 Shimotakatsu, Tsuchiura, Ibaraki, 300-8585, Japan, Check for Tel: +81-29-822-5050, Fax: +81-29-824-0494, E-mail: [email protected] updates Abstract taining the possibility of conception following surgery Purpose: The risk of uterine rupture is a major concern for [2,3]. Various perinatal complications are associated women who become pregnant after undergoing an adeno- with an adenomyomectomy [4], thus consensus for its myomectomy. The aim of this study was to investigate the indications among obstetricians has not been obtained. mechanism of uterine rupture and improve the surgical pro- Notably, uterine rupture is a lethal condition for both cedure used for prevention. mother and fetus [5]. Material and methods: Five patients who experienced uterine rupture during subsequent pregnancy after under- It is clinically important to investigate the mecha- going an adenomyomectomy performed with an open lapa- nism of uterine rupture in affected patients, and also rotomy were retrospectively investigated.
    [Show full text]
  • FEMALE REPRODUCTIVE SYSTEM Female ReproducVe System
    Human Anatomy Unit 3 FEMALE REPRODUCTIVE SYSTEM Female Reproducve System • Gonads = ovaries – almond shaped – flank the uterus on either side – aached to the uterus and body wall by ligaments • Gametes = oocytes – released from the ovary during ovulaon – Develop within ovarian follicles Ligaments • Broad ligament – Aaches to walls and floor of pelvic cavity – Connuous with parietal peritoneum • Round ligament – Perpendicular to broad ligament • Ovarian ligament – Lateral surface of uterus ‐ ‐> medial surface of ovary • Suspensory ligament – Lateral surface of ovary ‐ ‐> pelvic wall Ovarian Follicles • Layers of epithelial cells surrounding ova • Primordial follicle – most immature of follicles • Primary follicle – single layer of follicular (granulosa) cells • Secondary – more than one layer and growing cavies • Graafian – Fluid filled antrum – ovum supported by many layers of follicular cells – Ovum surrounded by corona radiata Ovarian Follicles Corpus Luteum • Ovulaon releases the oocyte with the corona radiata • Leaves behind the rest of the Graafian follicle • Follicle becomes corpus luteum • Connues to secrete hormones to support possible pregnancy unl placenta becomes secretory or no implantaon • Becomes corpus albicans when no longer funconal Corpus Luteum and Corpus Albicans Uterine (Fallopian) Tubes • Ciliated tubes – Passage of the ovum to the uterus and – Passage of sperm toward the ovum • Fimbriae – finger like projecons that cover the ovary and sway, drawing the ovum inside aer ovulaon The Uterus • Muscular, hollow organ – supports
    [Show full text]
  • The Morphology, Androgenic Function, Hyperplasia, and Tumors of the Human Ovarian Hilus Cells * William H
    THE MORPHOLOGY, ANDROGENIC FUNCTION, HYPERPLASIA, AND TUMORS OF THE HUMAN OVARIAN HILUS CELLS * WILLIAM H. STERNBERG, M.D. (From the Department of Pathology, School of Medicine, Tulane University of Louisiana and the Charity Hospital of Louisiana, New Orleans, La.) The hilus of the human ovary contains nests of cells morphologically identical with testicular Leydig cells, and which, in all probability, pro- duce androgens. Multiple sections through the ovarian hilus and meso- varium will reveal these small nests microscopically in at least 8o per cent of adult ovaries; probably in all adult ovaries if sufficient sections are made. Although they had been noted previously by a number of authors (Aichel,l Bucura,2 and von Winiwarter 3"4) who failed to recog- nize their significance, Berger,5-9 in 1922 and in subsequent years, pre- sented the first sound morphologic studies of the ovarian hilus cells. Nevertheless, there is comparatively little reference to these cells in the American medical literature, and they are not mentioned in stand- ard textbooks of histology, gynecologic pathology, nor in monographs on ovarian tumors (with the exception of Selye's recent "Atlas of Ovarian Tumors"10). The hilus cells are found in clusters along the length of the ovarian hilus and in the adjacent mesovarium. They are, almost without excep- tion, found in contiguity with the nonmyelinated nerves of the hilus, often in intimate relationship to the abundant vascular and lymphatic spaces in this area. Cytologically, a point for point correspondence with the testicular Leydig cells can be established in terms of nuclear and cyto- plasmic detail, lipids, lipochrome pigment, and crystalloids of Reinke.
    [Show full text]
  • Vocabulario De Morfoloxía, Anatomía E Citoloxía Veterinaria
    Vocabulario de Morfoloxía, anatomía e citoloxía veterinaria (galego-español-inglés) Servizo de Normalización Lingüística Universidade de Santiago de Compostela COLECCIÓN VOCABULARIOS TEMÁTICOS N.º 4 SERVIZO DE NORMALIZACIÓN LINGÜÍSTICA Vocabulario de Morfoloxía, anatomía e citoloxía veterinaria (galego-español-inglés) 2008 UNIVERSIDADE DE SANTIAGO DE COMPOSTELA VOCABULARIO de morfoloxía, anatomía e citoloxía veterinaria : (galego-español- inglés) / coordinador Xusto A. Rodríguez Río, Servizo de Normalización Lingüística ; autores Matilde Lombardero Fernández ... [et al.]. – Santiago de Compostela : Universidade de Santiago de Compostela, Servizo de Publicacións e Intercambio Científico, 2008. – 369 p. ; 21 cm. – (Vocabularios temáticos ; 4). - D.L. C 2458-2008. – ISBN 978-84-9887-018-3 1.Medicina �������������������������������������������������������������������������veterinaria-Diccionarios�������������������������������������������������. 2.Galego (Lingua)-Glosarios, vocabularios, etc. políglotas. I.Lombardero Fernández, Matilde. II.Rodríguez Rio, Xusto A. coord. III. Universidade de Santiago de Compostela. Servizo de Normalización Lingüística, coord. IV.Universidade de Santiago de Compostela. Servizo de Publicacións e Intercambio Científico, ed. V.Serie. 591.4(038)=699=60=20 Coordinador Xusto A. Rodríguez Río (Área de Terminoloxía. Servizo de Normalización Lingüística. Universidade de Santiago de Compostela) Autoras/res Matilde Lombardero Fernández (doutora en Veterinaria e profesora do Departamento de Anatomía e Produción Animal.
    [Show full text]
  • The Reproductive System
    27 The Reproductive System PowerPoint® Lecture Presentations prepared by Steven Bassett Southeast Community College Lincoln, Nebraska © 2012 Pearson Education, Inc. Introduction • The reproductive system is designed to perpetuate the species • The male produces gametes called sperm cells • The female produces gametes called ova • The joining of a sperm cell and an ovum is fertilization • Fertilization results in the formation of a zygote © 2012 Pearson Education, Inc. Anatomy of the Male Reproductive System • Overview of the Male Reproductive System • Testis • Epididymis • Ductus deferens • Ejaculatory duct • Spongy urethra (penile urethra) • Seminal gland • Prostate gland • Bulbo-urethral gland © 2012 Pearson Education, Inc. Figure 27.1 The Male Reproductive System, Part I Pubic symphysis Ureter Urinary bladder Prostatic urethra Seminal gland Membranous urethra Rectum Corpus cavernosum Prostate gland Corpus spongiosum Spongy urethra Ejaculatory duct Ductus deferens Penis Bulbo-urethral gland Epididymis Anus Testis External urethral orifice Scrotum Sigmoid colon (cut) Rectum Internal urethral orifice Rectus abdominis Prostatic urethra Urinary bladder Prostate gland Pubic symphysis Bristle within ejaculatory duct Membranous urethra Penis Spongy urethra Spongy urethra within corpus spongiosum Bulbospongiosus muscle Corpus cavernosum Ductus deferens Epididymis Scrotum Testis © 2012 Pearson Education, Inc. Anatomy of the Male Reproductive System • The Testes • Testes hang inside a pouch called the scrotum, which is on the outside of the body
    [Show full text]
  • New Insights Into Human Female Reproductive Tract Development
    UCSF UC San Francisco Previously Published Works Title New insights into human female reproductive tract development. Permalink https://escholarship.org/uc/item/7pm5800b Journal Differentiation; research in biological diversity, 97 ISSN 0301-4681 Authors Robboy, Stanley J Kurita, Takeshi Baskin, Laurence et al. Publication Date 2017-09-01 DOI 10.1016/j.diff.2017.08.002 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Differentiation 97 (2017) xxx–xxx Contents lists available at ScienceDirect Differentiation journal homepage: www.elsevier.com/locate/diff New insights into human female reproductive tract development MARK ⁎ Stanley J. Robboya, , Takeshi Kuritab, Laurence Baskinc, Gerald R. Cunhac a Department of Pathology, Duke University, Davison Building, Box 3712, Durham, NC 27710, United States b Department of Cancer Biology and Genetics, The Comprehensive Cancer Center, Ohio State University, 460 W. 12th Avenue, 812 Biomedical Research Tower, Columbus, OH 43210, United States c Department of Urology, University of California, 400 Parnassus Avenue, San Francisco, CA 94143, United States ARTICLE INFO ABSTRACT Keywords: We present a detailed review of the embryonic and fetal development of the human female reproductive tract Human Müllerian duct utilizing specimens from the 5th through the 22nd gestational week. Hematoxylin and eosin (H & E) as well as Urogenital sinus immunohistochemical stains were used to study the development of the human uterine tube, endometrium, Uterovaginal canal myometrium, uterine cervix and vagina. Our study revisits and updates the classical reports of Koff (1933) and Uterus Bulmer (1957) and presents new data on development of human vaginal epithelium. Koff proposed that the Cervix upper 4/5ths of the vagina is derived from Müllerian epithelium and the lower 1/5th derived from urogenital Vagina sinus epithelium, while Bulmer proposed that vaginal epithelium derives solely from urogenital sinus epithelium.
    [Show full text]