International Society for 2019 Newsletter Biomedical Research Volume 9, June 2019 on

586 Members, 39 Countries, 1 Mission 2019 Newsletter

Inside

Note from the President

Current Officers, Board of Directors, and Committee Members

Help Support ISBRA

Call for ISBRA Members to Serve on New Communications Committee

ISBRA Official Relations with the World Health Organization (WHO): ISRBA’s Contribution to Gaming Disorder in ICD 11

ISBRA 2018 Congress in ,

RSA/ISBRA 2020 Joint Scientific Meeting

ISBRA Early Career Investigator Award

Asia-Pacific Society for and Addiction Research (APSAAR)

European Society for Biomedical Research on Alcoholism (ESBRA): Past and Future Congresses

Japanese Medical Society of Alcohol and Addiction Studies (JMSAAS): The Japanese Alcohol, Nicotine & Drug Addiction Conference

Latin America Society for Biomedical Research on Alcoholism (LASBRA): Past and Future Congresses

In Memoriam of Dr. Ting-Kai Li

ISBRA Member Publications from January 1, 2018 – March 31, 2019 Provided for the 2019 Newsletter

On the Cover: The International Society for Biomedical Research on Alcoholism has a wide representation of members from throught the world. The logo on the cover is a celebration of this and the flags represent the 39 countries from which our 586 members reside.

2 Note from the President Please take note of the 2019 meetings of our affiliate It has been a busy several months since my Presiden- societies. Information regarding each affiliate society is cy officially began at the end of the September 9-13, 2018 described in the newsletter in separate articles. I will be ISBRA meeting in Kyoto, Japan, which was co-hosted by attending the meeting of our affiliate society, the Re- the Japanese Medical Society for Alcohol and Addiction search Society on Alcoholism (RSA), in late June in Min- Studies (JMSAAS). Due to the impact of Typhoon Jebi, neapolis, Minnesota, USA. The venue for the upcoming which hit western Japan on September 4th, ISBRA Presi- European Society for Biomedical Research on Alcoholism dent Dr. Rainer Spanagel was unfortunately unable to (ESBRA) meeting to be held September 21-24, 2019 will attend the 2018 meeting and as Senior Vice President, be Lille, 21-24, 2019, and an ESBRA-JMSAAS joint I was honored to assume his duties. Typhoon Jebi was symposium will be a feature. The Latin American Society the strongest such storm to come ashore in 25 years and for Biomedical Research on Alcoholism (LASBRA) will be it caused power outages and flooding that halted trains holding a meeting this year in Córdoba, Argentina No- and led to an airport closure impacting the travel plans vember 7-9, 2019. JMSAAS is also planning to collaborate of several who planned to attend. Our local host, Dr. with the APSAAR meeting to be held in Kuala Lumpur in Susumu Higuchi, describes these events and the meeting November, 2019. I hope that many of you can attend the in greater detail in his article in this issue of the ISBRA meetings of our affiliate societies. Newsletter. He and all members of the local To highlight the research accomplishments of organizing committee and staff exerted heroic our members, we have initiated a call for new efforts to put on a highly successful and sci- publication citations. We have included a list of entifically stimulating meeting, despite the the citations received at the end of the cur- difficult circumstances, for which all who rent ISBRA Newsletter and plan to continue attended were extremely grateful. this practice each year, as well as posting the In recent months, we have worked to citations on the ISBRA website. The citations populate our ISBRA standing and advisory here are for the period of January 1, 2018 committees, taking the initiative to solicit – March 31, 2019, and your citations for the interest and engagement in committee in- period of January 1, 2019 – March 31, 2020 are volvement from the ISBRA membership. I was now invited and should be emailed to isbra@ pleased to see a large number of members ex- isbra.com. Included can be on-line publications dur- pressing an interest in serving the society in this capac- ing that period. ity. The committees have developed proposed activities The world continues to experience tumultuous times. and are working toward several accomplishments, includ- It is important to treat each other with dignity and ing increasing our membership. I encourage EACH OF respect. ISBRA is united by a common interest, and we YOU to identify just one individual at any career level to continue to make significant progress toward identify- join ISBRA. If each of us added just 1 new member to the ing risk factors for alcohol use disorders and treatments roster, there would be a vast improvement in our finan- that must be considered on a person-by-person basis. cial viability and the collaborative mission of our society The global status report on 2018, by would be strengthened – ISBRA’s mission is to promote the World Health Organization (WHO) indicates that the excellence internationally in all aspects of biomedical harmful use of alcohol has a significant role in 27% of research on alcoholism and alcohol-related biomedical traffic injuries, 18% of interpersonal violence episodes, phenomena. I believe that many investigators who have large percentages of multiple cancers and some other more recently joined the field of alcohol research or are diseases, and 18% of suicides. There is much yet to be in early stages of their careers are unfamiliar with ISBRA. done, not only on the scientific front, but in regulation, Our society members are deeply committed to educat- implementation of treatment, and community awareness ing and assisting our new and early stage investigators. and action. Creativity and innovation abound across all Please take the time to introduce them to ISBRA and areas of science and offer us new tools and methods to encourage their membership. AND, if you are reading incorporate into our own research, with the possibility of this and are not a member, please join! Here is the link: more rapid advancements in the field. https://isbra.com/membership/ . Finally, we have begun The ISBRA Board is beginning deliberations for the se- the establishment of a Communications Committee to lection of the 2022 meeting venue. A European location is increase our social media presence. A call for committee favored, based on the rotation of locations across years. I members was distributed by email and is repeated here- look forward to a productive year for all and safe travels, in. We need the help of our social media-savvy members wherever your destination. to make this a success! Tamara J. Phillips, PhD, President, ISBRA 3 Current Officers Executive Committee Chair: Tamara Phillips, USA President Rosana Camarini, Brazil Tamara Phillips, USA Kenichi Ikejima, Japan Immediate Past President Sung-Gon Kim, South Korea Harbans Lal, USA Rainer Spanagel, Ricardo Pautassi, Argentina Senior Vice-President Rainer Spanagel, Germany Rosana Camarini, Brazil Jennifer Thomas, USA Junior Vice-President Sung-Gon Kim, South Korea Finance Committee Chair: Helmut Seitz, Germany Secretary Paula Hoffman,USA Jennifer Thomas, USA Kusum Kharbanda, USA Treasurer Karl Mann, Germany Paula Hoffman, USA Tamara Phillips, USA

2018-2022 Board of Directors Liaison Committee Ina Bergheim, Germany Chair: Susumu Higuchi, Japan Sawitri Assanangkornchai, Thailand Rosana Camarini, Brazil Tatiana Balachova,USA Paula Hoffman (ex officio), USA Rosana Camarini, Brazil Kenichi Ikejima, Japan Tatsuya Fujimiya, Japan Sung-Gon Kim, Korea Mary Larimer, USA Andrew Lawrence, Australia Sebastian Mueller, Germany Ricardo Pautassi, Argentina Ricardo Pautassi, Argentina Tamara Phillips, USA Rainer Spanagel, Germany Marisa Roberto, Italy/USA Robert Swift, USA Helmut Seitz, Germany Membership Committee Rainer Spanagel, Germany Chair: Katie Witkiewitz,USA Jennifer Thomas, USA Onyemaechi Azu, Katie Witkiewitz, USA Eric Claus, USA Sun-Gon Kim, South Korea Committee Chairs and Members Penelope Lind, Australia Education Committee Julianne Price, USA Chair: Marisa Roberto, Italy/USA Ayumi Takano, Japan Ina Bergheim, Germany Publication Committee Heiner Brinnel, France Chair: Andrew Lawrence, Australia Rita Cervera-Juanes, USA Sawitri Assanangkornchai, Thailand Helmut Seitz, Germany Katerina Burina, Russia Kristy Donald, South Africa Joydip Das, USA Sean Farris, USA Natalia Osna, USA Carolina Haass-Koffler, USA Karl Mann, Germany Christian Hendershot, Canada Andrey Ryabinin, USA Vijay Ramchandani, USA 2020 Joint Congress Organizing Committee Communication Committee: Initial members Co-Chair: Terrence Deak, USA Chair: Robert Leeman, USA Co-Chair: Christian Hendershot,Canada Rosana Camarini, Brazil Co-Chair: Amy Lasek, USA Ricardo Pautassi, Argentina 2022 - 2026 Board Nominations Committee Vatsalya Vatsalya, USA TBD 4 Help Support ISBRA Call for ISBRA Members to Serve on New Communications Committee Dear ISBRA Member, One of the greatest health challenges of the present The International Society for Biomedical Research on and the future is successfully fighting alcohol use disor- Alcoholism (ISBRA) is seeking members for a new Com- ders and alcohol related diseases. To face this challenge, munications Committee, chaired by Dr. Robert Leeman. the International Society for Biomedical Research on This committee will serve as an advisory committee to Alcoholism (ISBRA) was founded in 1982. Over more than the Board of Directors. As a society, we need to enhance three decades, ISBRA scientists have continuously contrib- ISBRA’s online presence through the use of social media uted much to the understanding of the pathophysiology platforms. and to the improvement of diagnostics and treatment We wish to engage ISBRA members in this new en- possibilities for this ubiquitous disease. Unquestionably, deavor, which will involve activities such as posting infor- this has saved lives, has reduced the burden of disease, mation intended to promote ISBRA and ISBRA activities and importantly, has saved money for health systems and on social media sites (e.g., Facebook, Twitter, Instagram, societies. ISBRA meetings have contributed to these suc- LinkedIn, etc.) and monitoring those sites. For example, we cesses through face-to-face dissemination of important can post photos of the biennial international congresses, findings, leading to critical and insightful discussions that announcements of upcoming events, publication citations have launched important new initiatives. Without the of our members, announcements from affiliated societies financial support of many granting agencies and of many and funding organizations, etc. We can also use these sites of you, this could not have been achieved. To continue to solicit donations for the Early Career Investigator Award to achieve excellence internationally in all aspects of and other awards. The ISBRA website has been updated biomedical research on alcoholism and alcohol-related and can be used toward this endeavor; e.g., the Twitter biomedical phenomena, which is the mission of ISBRA, we feed can be embedded into the website, to encourage need your further financial support. We all know people, more involvement. We are hoping to attract creative vol- relatives, friends and acquaintances who suffer from al- unteers for this committee who are willing to interact with cohol-related problems, and we all want to help them. To the Board of Directors and other ISBRA members to keep do so, every cent you donate to ISBRA is of great benefit. the site(s) up to date, and to monitor and reply to posts ISBRA, with more than 570 members from 39 countries of from members and others. all 5 continents, has and will use science to provide clinical This is a great opportunity to be an involved ISBRA options and practical guidance to help people with alco- member and reach out to others across the world. Please reply to Michelyn Lintz ([email protected]) if you have an hol-related disease. Do not hesitate, do it now, the future interest in serving on this committee. has just started. Sincerely, Sincerely, Tamara J. Phillips, PhD, USA Helmut K. Seitz, MD, AGAF, Germany President, ISBRA ISBRA Board of Directors Chair, ISBRA Executive Committee Chair, ISBRA Finance Committee ISBRA Finance Committee ISBRA Education Committee

5 ISBRA Official Relations with the World Health As of now, we are still awaiting official approval of the Organization (WHO): ISBRA’s Contribution to inclusion of gaming disorder in ICD-11. However, I am op- Gaming Disorder in ICD-11 timistic of a positive result. Notwithstanding the eventual outcome, the contribution of ISBRA in this process has

been significant and greatly appreciated. Health, social, and familial problems associated with excessive playing of digital games, especially among Susumu Higuchi, MD, PhD, Japan young people, are global concerns and are expected to Chair, ISBRA Liaison Committee grow significantly worse. Reflecting the global situation, the DSM-5 included diagnostic criteria of Internet Gaming Disorder. However, these are preliminary criteria, located in Section III, which comprise conditions for further study. A definition of gaming disorder (GD) was included in the draft of the 11th revision of WHO’s International Clas- sification of Diseases (ICD-11). This was based on a careful review of the existing literature and intensive worldwide discussion by experts in the fields of addiction. The draft was released by WHO on June 18, 2018 and the inclu- sion of GD will be officially approved at the World Health Assembly, which will be held in late May 2019. However, the inclusion of a GD definition in ICD-11 may be at risk, due to possible opposition from some WHO member states. Interests from the gaming industry, including IT giants, have strongly opposed the inclusion of GD and ISBRA 2018 Congress in Kyoto, Japan this may influence the decision of some member states. I explained this situation at the Board of Directors meeting The 19th World Congress of ISBRA was held between held during the ISBRA meeting in Kyoto and the inclusion September 9 and 13, 2018 at Kyoto International Confer- of GD definition in ICD-11 was supported. ence Center in Kyoto, Japan. The congress was co-hosted Following that meeting, a group of international -ex by the Japanese Medical Society for Alcohol and Addic- perts in the field of behavioral addictions lent their sup- tion Studies (JMSAAS), one of ISBRA’s affiliated societies. port for the inclusion of GD in a joint letter, and invited This event was also jointly held by JMSAAS, the Japanese many scientific societies and organizations to be part of Society of Alcohol-Related Problems (JSARP), and the the initiative. ISBRA has an official relationship with WHO International Symposium on Alcohol Liver and Pancreatic and this unique position enabled us to take the lead in Diseases ALPD and (ISALPD/C). The annual meet- collecting supporting letters and signatories from a wide ings of the two Japanese societies were held between range of stakeholders. September 8 and 10 at the same venue, and more than Just before the WHO Executive Board (EB) meeting 1,000 participants attended the meeting. in January 2019, 14 international societies, including our society, and more than 60 national societies lent their support to the inclusion of GD in ICD-11. As chair of the liaison committee of our society, I forwarded these sup- porting letters and details of signatories to the Director- General of WHO prior to the meeting. An additional benefit of our society’s privileged posi- tion with WHO was that I was able to participate in the WHO EB meeting itself, as a representative of ISBRA, and delivered a statement to attendees. No EB members opposed the inclusion, with the exception of USA. I was pleased to observe that all other member states were supportive and there were also non-governmental orga- nizations, such as the World Federation of Mental Health, which made supportive statements at the meeting.

6 The lead-up to the congress was marked by calami- many of the region’s developing nations, which is likely tous weather, when a powerful typhoon struck the Kansai to lead to a further rise in alcohol-related harm in those area, including Kyoto, on September 4th. This caused the areas. closure of Kansai International Airport, a major airport for international visitors to Kyoto, and the subsequent can- cellation of many overseas flights. It was extremely chal- lenging for international participants to reschedule flights and secure transportation to get to Kyoto. Two days later, on September 6th, the situation was exacerbated when a major earthquake struck the prefecture of Hokkaido, which includes the city of , the venue for the 2012 ISBRA congress.

In the face of such adversity, we were delighted and humbled to welcome more than 550 participants from Japan and all over the world. Approximately 50 delegates, who had registered for the congress, were unfortunately unable to come to Kyoto, mainly due to these two natural disasters.

In light of this trend of rising alcohol consumption, it was both timely and meaningful to host the ISBRA Con- gress in Kyoto last year. The main theme was “Global Alcohol Research - Expanding Our Knowledge, Supporting Across the globe, alcohol is raising serious health and Our Members” and attendees were presented with cutting- social concerns. According to the WHO Global Status Re- edge scientific information on alcohol-related harm in port on Alcohol and Health in 2018, the harmful use of al- biomedical, behavioral, and psychosocial areas. In addition, cohol is a component cause of more than 200 disease and the ISBRA 2018 program also included joint training ses- injury conditions. In 2016, around 3 million deaths, or 5.3% sions with WHO for young investigators, particularly focus- of all global deaths, were attributable to alcohol consump- ing on those from developing countries. This ISBRA-WHO tion. In Asia, alcohol consumption has been increasing in workshop comprised of six sessions and there were active 7 contributions from many of the delegates, evidenced by portunity to experience firsthand, elements of authentic the awarding of certificates of participation. We are- ex Japanese culture - magnificent ancient buildings, the arts, tremely grateful to those senior investigators who played and unique cuisine during their stay in Kyoto. the role of workshop facilitators.

Furthermore, I would like to extend my heartfelt Prior to the event, we had encouraged both members appreciation to all participants for their dedication and and non-members of ISBRA to submit symposium propos- contribution to the 2018 ISBRA congress. I also wish to als and abstracts for poster presentations. I am delighted thank the members of the Local Organizing Committee to report a total of 72 symposia, including ALDP symposia, and the International Program Committee, who provided and 170 poster presentations - a reflection of the contribu- great assistance, both intellectually and technically, for the tors’ keen interest and dedication to the pursuit of scien- congress preparations. Finally, I would like to extend my tific progress. In addition, we were proud to welcome six sincere gratitude to my colleagues, friends, and especially world-renowned scholars from diverse fields, who broad- my family for their continued dedication and support. ened our understanding of areas such as basic and clinical I very much look forward to the next ISBRA meeting. studies, and policy development and implementation. They Let’s see all of you again in June 2020 in New Orleans, USA. were, in alphabetical order: Prof. Markus Heilig, Dr. Vladi- mir Poznyak, Dr. Vijay Ramchandani, Prof. Jurgen Rehm, Susumu Higuchi, MD, PhD, Japan Prof. Yoshiyuki Takei, and Prof. Reinout Wiers. These excel- President, ISBRA 2018 Congress lent presentations facilitated the exchange of information Chair, ISBRA Liaison Committee and undoubtedly increased the collective knowledge of participants. Perhaps this will also lead to future collabora- tions. Kyoto was chosen as the congress site in 2018, due to its status as one of the most historic and well-known cities in Japan and its preeminence as a global tourist destina- tion. In addition to an innovative and exciting scientific congress program, I believe many participants had an op- 8 RSA/ISBRA 2020 Joint Scientific Meeting Initial meeting information (program proposals and abstract submissions, plus additional details) will be posted June 20-24, 2020 October 15, 2019 at www.rsoa.org. The second set of New Orleans, Louisiana, USA meeting materials (program outline, poster session details, registration, lodging, plus additional details) will be posted The RSA/ISBRA Joint Scientific Meeting will be held March 10, 2020. The ISBRA website will have a direct link at the Hyatt Regency New Orleans, Louisiana. Over 1600 to the RSA Conference pages. attendees are expected from around the world. The 3 The Hyatt Regency New Orleans is centrally located appointed Chairs of the program committee, Amy Lasek, within 10 minutes by foot from beautiful Lafayette Square Terrence Deak and Christian Hendershot, will select mem- and 1.1 km from the Contemporary Arts Center. Lafayette bers from across the globe and from both RSA and ISBRA Square is one of the numerous parks of New Orleans that to jointly develop the program. There will be opportunities you may enjoy visiting, during your free time. However, to attend plenary lectures, and to propose and attend sym- for those more interested in the lively New Orleans scene, posia and workshops. Scientific posters will be featured at visit the French Quarter, where you can hear live music and multiple sessions. The joint meeting stimulates internation- enjoy jambalaya and other local specialties. al connections and the sharing of perspectives and ideas that benefit all fields of alcohol research and addresses the Robert Swift, MD, PhD issues associated with alcohol-related problems. Vice President, RSA ISBRA Liaison Committee & Tamara J. Phillips, PhD President, ISBRA

The RSA/ISBRA Joint Scientific Meeting welcomes trainees (students and post-docs) and hosts special events including a student lunch, a post-doc dinner, and special poster awards to recognize trainees and to facilitate net- working with scientists from around the world. ISBRA Early Career Investigator Award

In 2010, ISBRA established an award for young ISBRA members in the field of alcoholism. Twenty-eight awards have been given to individuals in 12 countries. The ISBRA Early Career Investigator Award acknowledges stellar con- tributions by graduate students and post- doctoral fellows to the advancement of knowledge in the alcohol/alcohol- ism field. Through an application process, the potential recipients’ abstracts and posters or talks are judged by the Education Committee during each biennial congress. Each recipient receives a partial cash award to travel to the bien- nial congress and a commemorative plaque. We encourage young investigators to apply for the Early Career Investigators Award for the 2020 joint ISBRA/ RSA Congress, in New Orleans, Louisiana, USA, June 20-24, 9 2020. The 2020 application process will be announced and Asia-Pacific Society for Alcohol and Addiction posted early 2020. Research (APSAAR)

The Asia-Pacific Society for Alcohol and Addiction Research (APSAAR), affiliated as a regional Society of the ISBRA was established in October 2007 in Kyoto, Japan, and officially began operations on January 1, 2008. The

goal of APSAAR is to improve the quality of life of people in

the Asia-Pacific region through extensive and constructive

research on alcohol and addiction problems. APSAAR cur-

rently has members from about 20 countries and territo-

ries and is constantly aiming to expand its base. Members Below is the history of the recipients of the ISBRA Early reside in countries in our region, or have interests or links Career Investigator Awards: to the Asia Pacific whilst working elsewhere. This diversity 2010 Congress, Paris FRANCE: Rebecca (Reba) J. How- of membership is one of our great strengths and we work ard, Ph.D., USA; Ricardo Marcos Pautassi, Ph.D., ARGEN- hard to maintain and expand it. TINA; Wataru Ukai, Ph.D., JAPAN; Daya Perkins, Ph.D., USA; and, Dmitri Govorko, M.D., USA 2012 Congress, Sapporo, JAPAN: Jin-Seok Byun, D.D.S., KOREA; Robert J. Lipinski, Ph.D., USA; Kristen Pleil, Ph.D., USA; William Giardino, B.S. USA; and, Angela Renee Oz- burn, Ph.D. USA 2014 Congress, Seattle, USA: Laura Broccoli, M.S., GER- MANY 2016 Congress, Berlin, GERMANY: Leon G. Coleman Jr, Leon, M.D., Pre-doctoral Student, USA; Olli Kärkkäinen, Ph.D., FINLAND; Alexander Glahn, Pre-doctoral -medical Student, GERMANY; Lucia Marit-Prats, Ph.D., Spain; Sean Farris, Ph.D., USA; Esi Domi, Ph.D., SWEDEN; Maria Vrettou, Pre-doctoral Student, SWEDEN; Daviel Vallöf, Pre-doctoral Student, SWEDEN; Michael E. Price, Pre-doctoral Student, USA; Oren Even-Chen, Pre-doctoral Student, ISRAEL 2018 Congress, Kyoto, JAPAN: Erin Campbell, Ph.D., AUSTRALIA; Esi Domi, Ph.D., SWEDEN; Sheila Engi, Ph.D., BRAZIL; Emily Petruccelli, Ph.D., USA; Ayumi Takano, Ph.D., JAPAN; Som Bohora, M.S., NEPAL; Zachary Gursky, B.S., The APSAAR conferences are held biennially in the USA years between ISBRA congresses to facilitate and promote interactions and collaborations among our members we Marisa Roberto, PhD, Italy/USA hold. Past conferences have been in Seoul, Korea, 2009; Chair, ISBRA Education Committee Bangkok, Thailand, 2012 (postponed from 2011); Shang- ISBRA Board of Directors hai, China, 2014 (postponed from 2013); Sydney, Australia, 2015 and Taipei, Taiwan 2017. The 2019 meeting will be in Kuala Lumpur, Malaysia on 27-29 November 2019. The Congress venue is Bangi Resort Hotel, Putrajaya, Malaysia. http://www.bangiresorthotel. com/en-us/home. This hotel has free daily shuttle service from the hotel to KL central and is about 35 mins away from Kuala Lumpur International Airport. 10 Some plenary talks include Development of treatment European Society for Biomedical Research on and services for online gaming disorder (Susumau Higu- Alcoholism (ESBRA): Past and Future Congresses chi, Japan), Challenges in managing HIV in people who use drugs (Adeeba Kamarulzaman, Malaysia), Expansion of ESBRA-Nordmann Award Meeting 2018 opioid pharmacotherapy treatment throughout China (Min From 11.-12. October 2018 the ESBRA-Nordmann Zhoa, China) and Alcohol finding in NHMS 2015: What are Award Meeting was successfully organized in Louvain-la- the gaps? (Chris Bullen, New Zealand). More detailed infor- Neuve, , by Prof. Roberta Ward (Belgium) and Prof. mation on the APSAAR Meeting in Kuala Lumpur. Henriette Walter (Austria). The topic “Alcohol and the Immune System” addressed the important role of alcohol interactions with the immune system in the gut, liver and brain. Participants where from Europe and the USA. Outstanding keynote lectures were given by Prof. Gyongyi Szabo from the Univ.Massa- chusetts Medical School, USA on the “The immune system in alcoholic liver disease” Prof. Lorenzo Leggio from the NIAAA, USA and one of the Chief editors of Alcohol & Alcoholism on “Gut-liver-brain axis in alcohol use dis- order: Peptides, Bugs and Lan- cets”. The 2018 Nordmann Award was given to Dr. Olli Kärkkäinen from Finland for his pioneering work on metabo- lomics and alco- Sawitri Assanagkornchai, MD, PhD, Thailand hol consumption. APSAAR President Finally, and besides ISBRA Liaison Committee a very intensive ISBRA Publications Committee meeting, six young investigators received a YOUNG INVESTIGATOR award (see picture). The symposium finished with a highly educative and interactive trip to the ancient battle field of Waterloo and a visit to the newly opened museum.

11 will be end of June 2019 and a separate call will be send out in April and available on the ESBRA webpage. The next ESBRA Nordmann award meeting 2020 will be held in Madrid, Spain in October 2020.Local Organiz- ing Committee will be guided by Prof. Jose Antonio López Moreno, Universidad Complutense de Madrid, Prof. Maria Pascual, Universitat de Valencia and Prof. Joaquim Fernán- dez-Solà, Universitat de Barcelona. More details about topic and exact date will be communicated soon per email and at the ESBRA webpage.

Sebastian Mueller, PhD, Germany ESBRA President JMSAAS-ESBRA joint meeting at ISBRA 2018 in Kyoto ISBRA Liaison Committee On 10.9. 2018, the now already traditional JMSAAS- ESBRA joint meeting was organized within ISBRA 2019 by Prof. Saito and Prof. Mueller. Topic was “Alcohol-induced organ damage” that was broadly covered by speakers from both from Japan and Europe (see picture). The symposium generated several highly interesting discussions on the various types of cell death in the alcohol-exposed liver including the role of iron. Prof. Mueller also welcomed Prof. Tatsuya Fujimiya, the newly elected JMSAAS President from Yamaguchi University and all participants agreed to continue these series of symposia at the next ESBRA 2019 in Lille.

Japanese Medical Society of Alcohol and Addic- tion Studies (JMSAAS): The Japanese Alcohol, Nicotine & Drug Addiction Conference

The Japanese Medical Society of Alcohol and Addic- tion Studies (JMSAAS) became an academic corporation in August 2018. At this occasion, Dr. Toshikazu Saito, the 1st president of JMSAAS retired, and Prof. Tatsuya Fujimiya was elected as the 2nd president. Prof. Fujimiya will try to stabilize the management of the academic corporation systems smoothly and promote the activities of the young Future ESBRA meetings and female scientists in related fields. He is a forensic pa- ESBRA 2019 in Lille/France thologist and interested in the pharmacokinetics and legal The upcoming biannual congress of the European aspects of the alcohol-related problems. Society for Biomedical Research on Alcoholism (ESBRA) The Japanese Alcohol, Nicotine & Drug Addiction Con- will be held in Lille from September 21-24, 2019 (www. ference 2018, which was joint meetings of JMSAAS and esbra2019.org). Congress president is Prof. Mickael Naas- The Japanese Society of Alcohol-Related Problems (JSARP), sila. This meeting will cover all aspects of alcohol-related were held at Kyoto, September 8-10, with ISBRA 2018. The diseases ranging from alcohol addiction to epidemiology congress presidents at the meeting were Prof. Yoshiyuki and alcoholic liver disease. At this meeting, Young investi- Takei of Mie University (JMSAAS) and Dr. Shiro Tsujimoto gator Awards will be given for scientists under 36 years and (JSARP). The principal themes were “The Addictions studies awardees will present their work at the two Young Investi- and new biomedical sciences” (JMSAAS) and “The hope of gator Symposia. In addition, the prestigious Manfred-Laut- recovery” (JSARP). enschläger-Award which will be also given. The deadline 12 JMSAAS has continuously facilitated international liai- son in cooperation with the ISBRA and other affiliated soci- eties. In the ISBRA-JMSAAS joint congress in Kyoto last Sep- tember, JMSAAS supported 5 joint symposia with ISBRA; “The current situation and treatment systems for drug addiction in Asia” chaired by Toshikazu Saito and Tomohiro Shirasaka, “The current situation and treatment systems for alcoholics in Pacific countries” chaired by Hisatsugu Mi- yata and Tomohiro Shirasaka, “How should we promote a strategy for healthy drinking?” chaired by Koshi Nakamura and Kohji Takada, “Alcohol and organ damage: bridging the gap between bench and bedside (Part I “Bench” & Part II “Translational”)” chaired by Kenichi Ikejima and Gavin E Arteel, and “The current situation of internet gaming ad- diction from the standpoint of young researchers” chaired as symposiasts. In addition, JMSAAS is also planning to col by Yoko Nishitani and Tomohiro Shirasaka. Further, a joint laborate with the APSAAR meeting to be held in Kuala symposium with ESBRA entitled “Alcohol-induced organ Lumpur in November 2019. damage” was held in collaboration with Prof. Sebastian The Japanese Alcohol, Nicotine & Drug Addiction Con- Mueller, the ESBRA President. JMSAAS also provided travel ference 2019 will be held at Sapporo, October 4-6, 2019. award to three foreign symposiasts; Ming-Chyi Huang (Tai- The congress presidents at the meeting are Dr. Tomonobu Shirasaka (JMSAAS) and Dr. Takeshi Ashizawa (JSARP). The principal theme is “Dependence and addiction problems as historical background”. Sapporo had ISBRA Congress 2012 and is a native city of Dr. T. Saito. It is known for its deli- cious food and its good natural fields and activities.

Tatsuya Fujimiya, MD PhD JMSAAS President ISBRA Liaison Committee & Kenichi Ikejima, MD PhD ISBRA Board of Directors ISBRA Executive Committee

wan), Leo Yoshida (Ireland), and Visnja Banjac (Bosnia and Herzegovina). To this extent, the next ESBRA-JMSAAS joint sympo- sium will be held at the ESBRA Congress in Lille, France, up-coming September 2019. The proposed session is en- titled “Novel concepts in alcoholic liver disease” organized by Prof. Sebastian Mueller and Kenichi Ikejima, where four young investigators from Europe and Japan will be invited 13 Latin America Society for Biomedical Research 7th LASBRA Congress was another joint event, in this case on Alcoholism (LASBRA): Past and Future Con- in cooperation with the 15th ESBRA meeting at Valencia gresses (Spain). Subsequently, Dr. Aguayo organized the 8th (“Al- cohol and other Drugs of Abuse: from molecules to human disorders”) and 9th (“Neurobiological basis y of alcoholism: LASBRA (Latin American Society for Biomedical Re- from molecules to behavior”) LASBRA meetings in Chile, at search on Alcoholism, http://bit.ly/LASBRA123) is the Latin Concepcion (2013) and at the Chilean coastal city of Puerto American branch of ISBRA. It was founded in 1993 during Varas (2017), respectively. In the latter event, Dr. Pautassi a symposium supported by NIAAA and ISBRA, in Bethesda, (Argentina) and Dr. Cruz (Brazi) were designated president MD, USA. The 1st Executive committee was composed and vice-president of the society, respectively. by Dr. Maristela G. Monteiro (Brasil), Dr. Jorge Mardones LASBRA is currently organizing or co-organizing three (Chile), Dr Juan Carlos Molina (Argentina), Dr Raul Caetano events. The “Jornadas de investigación e intervención (USA), Dr Gina Struffaldi Morato (Brasil), Dr Harold Kalant sobre consumo de alcohol en Uruguay” will take place at (Canada), Dr Gloriza Canino (Porto Rico) and Dr Elvia Velas- Montevideo, Uruguay, on June 3-6; whereas the regular quez de Pabon (Colombia). LASBRA meeting will take place at Córdoba (Argentina) on The 1st LASBRA meeting was held in Santiago, Chile in November 7-9. A workshop will also take place in Brazil, in 1994, and it was organized by Dr. Jorge Mardones (Chile) a date to be announced. and Dr. Maristela Monteiro (Brazil). Speakers at the event were Dr. John Crabbe (USA), Dr. Adron Harris (USA); Dr. Ricardo Pautassi, PhD, Argentina Maristela Monteiro (Brazil); Dr. Juan Carlos Molina (Argen- LASBRA President tina); Dr. Lutske Tampier (Chile); Dr. Jorge Mardones (Chile). ISBRA Board of Directors Dr. Miguel Belascuain (Argentina); Dr. Raul Pacurucu (Ecua- ISBRA Communications Committee dor) and Dr. Alfredo Pemjean (Chile) also participated. ISBRA Executive Committee The 1996 meeting was organized as a satellite meeting of ISBRA Liaison Committee ISBRA, whereas the 3rd LASBRA meeting (Recife, Brazil, 1997) was as a satellite meeting of ABEAD (Associação Brasileira de Estudos do Álcool e outras Drogas). The 4th Meeting (1998) was organized by Dr. Juan Carlos Molina and Dr. Roberto Rovasio, at the events center of the Na- tional Academy of Sciences of Cordoba, Argentina. There were close to 150 attendees from Argentina, Chile and Brazil. After a period of quietness, the society was relaunched the in the symposium “Advances in Alcohol Research in Latin America”, at the 2008 RSA/ISBRA meeting in Wash- ington, DC, USA. A year later, during the 2009 RSA meeting at San Diego, CA (USA), Dr. Rosana Camarini from Brazil organized the symposium “Determinants of Con- sumption: From Genetic to Environmental Influences”. After the symposium, Latin-American researchers from Annual Meeting of the Research Society on Argentina, Brazil, Chile and elected an official Alcoholism LASBRA Board, with Dr. Rosana Camarini (Brazil) and Dr. Ri- cardo Pautassi (Argentina) as President and Vice-president, June 22-26, 2019 respectively. Dr. Camarini, along with Dr. Maria Lucia Olivei- Hyatt Regency Minneapolis ra de Souza Formigoni (Brazil), Dr. Roseli Boergnen-Lacerda Minneapolis, MN (Brazil) and Dr. Ricardo Pautassi (Argentina), organized the www.RSoA.org 5th LASBRA meeting, which was held in São Paulo, Brazil, in 2011, under the title “The Neuroscience of The 2019 Annual Meeting of the Research Society on and Alcoholism”. Alcoholism (RSA) will take place in Minneapolis, MN. The In 2012, the LASBRA meeting took place at Valparaiso 42nd Annual Meeting will begin on Saturday, with satellite (Chile) and was a joint event with the Latin-American sessions, the Fetal Alcohol Spectrum Disorder Study Group Research Network in Drug Addiction (LARNEDA). Dr. Luis and the RSA Opening Reception. On Sunday-Wednesday, Aguayo was then designated president of LASBRA. The there will be full days of plenary sessions, symposia, poster 14 sessions, special workshops and events, including the an- In Memoriam of Dr. Ting-Kai Li nual Student Networking Lunch, Post-Doc Dinner, Legisla- tive Workshop and Grantsmanship Workshop. The meeting It is with deep sadness that we note the passing of will end on Wednesday evening, with the Closing Ceremo- Ting-Kai (T-K) Li, MD, one of the founders of ISBRA, on ny – dinner, award presentations and slideshow. November 18, 2018. T-K’s wonderful and distinguished The research areas that will be covered include bio- academic and public service career spanned almost five medical/preclinical and psychosocial. The primary goal of decades. Born in Nanjing, China, T-K fled with his family the meeting is to provide a forum for alcohol researchers to South Africa during World War II. He began his col- - from all disciplines - to present their latest findings and legiate career at the University of the Witwatersrand in to learn about new research developments in an environ- South Africa but soon made his way to Chicago and North- ment that will promote interaction at both the professional western University where he obtained his undergraduate and personal level. Plenary Sessions will include Dr. Crystal degree. He graduated from Harvard Medical School and Hoyt on Sunday morning presenting “Mindsets Matter for completed his residency in internal medicine at the Peter Diversifying Scientific Leadership”, and a tribute to Dr. Ting- Bent Brigham Hospital (Boston). During residency he first Kai Li on Monday morning featuring several RSA members. became interested in the clinical disease of alcoholism. Things to do in and around Minneapolis: Families will Following his residency in Internal Medicine, TK conducted appreciate the Minnesota Zoo and Fort Snelling, while research at the Nobel Medical Research and Karolinska those interested in local culture can marvel at the distinct Institutes in Stockholm. He then served his country during design of the city’s hallmark buildings, such as the Walker the Viet Nam war and was stationed at the Walter Reed Art Center, or see a show at the Guthrie Theater. Those Army Institute of Research where he was Deputy Direc- who enjoy shopping can peruse the wide array of mer- tor of the Department of Biochemistry. In 1971 he joined chandise available in the Mall of America or in downtown’s the faculty at Indiana University as Professor of Medicine Nicollet Mall. Last but not least, the Chain of Lakes, a scenic and Biochemistry and later served as Associate Dean for byway located southwest of downtown, is popular among Research. Dr. Li held the school’s John B. Hickam Professor visitors who enjoy jogging or boating. If you still have more of Medicine and Professor of Biochemistry endowed chair; energy, hit the food spots on Nicollet Avenue for dinner, he was later named as a Distinguished Professor, IU’s high- and later, check out the bars and live music scene in Min- est rank. neapolis (First Avenue nightclub is highly recommended). As a physician scientist, T-K turned with a passion to Mark your calendars for these future RSA meetings alcohol research, focusing on different biological factors of June 20-24, 2020 New Orleans, LA (joint meeting with the disease, including its genetic bases. Using the alcohol ISBRA – our 6th collaboration) and June 19-23, 2021 San flushing response as a phenotype, he explored alcohol Antonio, TX. metabolism, including the role of acetaldehyde and the im- portant impact that variations in genes encoding alcohol- I look forward to seeing you in Minneapolis for RSA 2019!! and aldehyde-dehydrogenases have on alcoholism vulner- ability. In parallel, he worked on the development of the Mary Larimer, PhD, USA alcohol preferring / non-preferring rat as a model organism President, Research Society on Alcoholism to enable neurobiological studies of alcohol metabolism. ISBRA Liaison Committee Dr. Li was the founding director of the Indiana Alcohol Re- search Center (IARC) at the IU School of Medicine (1985), where he also was Associate Dean for Research. In 1989, Dr Li, along with Drs. Henri Begleiter and Theodore Reich, led the development of the Collaborative Study on the Genetics of Alcoholism (COGA). Dr. Li was a prolific scien- tist, incisive thinker, and a superb colleague. The author of more than 400 journal articles and book chapters, Dr. Li was also invited to deliver many major national and inter- national lectureships. Over his illustrious career, Dr. Li provided extensive service to the alcohol research field. His many contribu- tions included being a founding member, and later Presi- dent, of both the Research Society on Alcoholism (RSA) and the International Society of Biomedical Research on Alcoholism (ISBRA). In addition, he was instrumental in 15 founding the Asian Pacific Society on Alcohol and Addiction his mischievous smile, his sharp wit, and his warm friend- Research (APSAAR). His service to both RSA & ISBRA ship. In lieu of flowers, T-K’s family has asked that also included serving as editor of the societies’ donations in T-K’s name be made to either the journal, Alcoholism: Clinical and Experimen- Research Society on Alcoholism, the Ting tal Research. As an expert scientist, T-K Kai Li Lectureship [http://www.rsoa.org/ also served as a reviewer on numerous donations] or to the Indiana University NIH study sections and on NIAAA’s Foundation [https://www.myiu.org/ National Advisory Council. give-now]. T-K was frequently recognized by RSA for his many scientific and Victor Hesselbrock, PhD, USA service contributions, receiving & the society’s Lifetime Achieve- Michie Hesselbrock, PhD, USA ment Award, the Henri Begleiter Excellence in Research Award, and the Sexias Award for Service. Other scientific societies honored Dr Li for his work on alcoholism and he was the recipient of the Jellinek Award, the James B. Isaacson Award for Research in Chemical Depen- dency Diseases, the R. Brinkley Smithers Distinguished Science Award, and the Tharp Award for Research Excellence on Alcoholism. Elected to membership in the Institute of Medicine of ISBRA Member Publications from January 1, the National Academy of Sciences in 1999, Dr. Li was also an honorary fellow of the United Kingdom’s Society for the 2018 – March 31, 2019 Provided for the 2019 Study of Addiction. Newsletter Dr. Li was appointed as Director, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes This year we would like to celebrate and acknowldge of Health in November 2002, a position he held until 2008. the contributions made to the field of biomedical research As Director of NIAAA, Dr. Li was a staunch advocate for on alcoholism by the members of ISBRA. Below is a collec- both basic and clinical alcohol research science within the tion of published work from 41 members totaling 353 peer NIH and with the US Congress. As Director, he was a strong reviewed publications spanning January 1, 2018 - March advocate for international collaborations and established 31, 2019. These are member submitted publications from formal ties with countries in Europe and Asia. After retiring our recent call for publications and thus is a partial rep- from NIAAA, T-K took on another challenge, helping found resentation of the influence of ISBRA members on this the Duke-NUS Graduate Medical School, Singapore Neuro- important field of research. science and Behavioral Disorders. Dr. Li, “T-K” to his friends and colleagues, was a staunch Giovanni Addolorato advocate for the development of young investigators and de Beaurepaire R, Sinclair JMA, Heydtmann M, Addolorato worked to enhance the careers of countless investigators G, Aubin HJ, Beraha EM, Caputo F, Chick JD, de La Selle at all stages of their professional life. While he was well P, Franchitto N, Garbutt JC, Haber PS, Jaury P, Lingford- known to be scientifically critical, T-K was always approach- Hughes AR, Morley KC, Müller CA, Owens L, Pastor A, able and provided supportive guidance to both young and Paterson LM, Pélissier F, Rolland B, Stafford A, Thompson older scientists whenever asked. He was truly a monu- A, van den Brink W, Leggio L, Agabio R. The Use of Ba- mental figure in the field of alcohol research and leaves an clofen as a Treatment for Alcohol Use Disorder: A Clinical enormous legacy in the many lives he touched, personally Practice Perspective. Front Psychiatry. 2019 Jan 4;9:708. and professionally. doi: 10.3389/fpsyt.2018.00708. eCollection 2018. Review. Dr. Li was the devoted husband of Susan Li, proud – PubMed PMID: 30662411; PubMed some would say doting – father of Jennifer Li, MD and Central PMCID: PMC6328471. Karen Koide, MBA, and he took great delight in his grand- children. We fondly remember his tremendous intellect,

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17 Onyemaechi Okpara Azu K Kouame, AI Peter, EN Akang, U Offor, R Moodley, K Ogedengbe OO, Naidu ECS and Azu OO (2018). Antiretro- Pruessner, Naidu ECS, OO Azu (2018). Effect of long-term viral therapy and alcohol interactions: X-raying testicular administration of Cinnamomum cassia silver nanoparticles and seminal parameters under the HAART era. Eur J Drug on organs (kidneys and liver) of Sprague Dawley rats. Turk- Metab Pharmacokinet 43(2): 121-135. http://doi:10.1007/ ish J Biol 42: 498 – 505 http://doi.org:10.3906/biy-1805-103 s13318-017-0438-6 Akang EN, Adana MY, Peter AI, Naidu ECS, Mackraj I, Azu MY Adana, EN Akang, AI Peter, AI Jegede, ECS Naidu, C OO (2019). Highly Active Antiretroviral Therapy (HAART): A Tiloke, AA Chuturgoon, OO Azu¬ (2018). Naringenin at- Plus or A Minus on Testicular 3β-HSD? Eur J Anat 23(1): 1-7. tenuates Highly Active Antiretroviral Therapy (HAART)- Induced Sperm DNA Fragmentations and Testicular-Toxicity Offor U, Naidu ECS, Ogedengbe OO, Jegede AI, Peter AI, in Sprague-Dawley rats. Andrology6(1): 166-175. http://doi. Azu OO (2018). Nephrotoxicity and highly active antiretro- org:10.1111/andr.12439 viral therapy: mitigating action of Momordica charantia. Toxicology Reports 5: 1153-1160 https://doi.org/10.1016/j. Ogedengbe OO, Jegede AI, Onanuga IO, Offor U, Peter AI, toxrep.2018.09.003 Akang EN, Naidu ECS and Azu OO (2018). Adjuvant poten- tial of virgin coconut oil extract on antiretroviral therapy- K Kouame, AI Peter, EN Akang, R Moodley, ECNS Naidu, OO induced testicular toxicity: an ultrastructural study. Andro- Azu (2018). Histologic and biochemical effects of Cinnamo- logia 50(3): 1 – 14. https://doi.org/10.1111/and.12930 mum cassia nanoparticles in kidneys of diabetic Sprague- Dawley rats. Manuscript ID3481. Bosnian Journal of Basic Ogedengbe OO, Naidu ECS, Akang EN, Offor U, Onanuga IO, Medical Sciences. https://www.bjbms.org ;https://blog. Peter AI, Jegede AI, and AZU OO (2018). Virgin coconut oil bjbms.org extract mitigates testicular-induced toxicity of alcohol use in antiretroviral therapy. Andrology 6: 1 – 11 http://dx.doi. Azu OO and Naidu ECS (2018). Vitamin E and testicular org/10.1111/andr.12490 damage protection in highly active antiretroviral drugs (HAART) in HIV/AIDs: In HIV/AIDS Oxidative Stress and Di- AI Peter, ECS Naidu, EN Akang, OO Ogedengbe, U Offor, S etary Antioxidants. Edited by: Victor R. Preedy and Ronald Rambharose, R Kalhapure, AA Chuturgoon, T Govender, OO Ross Watson. ISBN: 978-0-12-809853-0 Academy Press 6 Azu (2018). Investigating Organ Toxicity Profile of Tenofovir (1): 166 -175. http://doi.org:10.1016/b978-0-12-809853- and Tenofovir Nano Particle on the Liver and Kidney: Ex- 0.00019-5 perimental Animal Study.Toxicol Res 34(3): 221-229 http:// dx.doi.org/10.5487/TR.2018.34.3.221 Swati Joshi Barve Urinary acrolein metabolite levels in severe acute alcoholic Venant Tchokonte-Nana, Benjamin Longo-Mbenza, Azu OO hepatitis patients. Vatsalya V, Kong M, Gobejishvili L, Chen (2018). Synergistic effects of Arachis Hypogea and stem WY, Srivastava S, Barve S, McClain C, Joshi-Barve S. Am J cell factors on follicular maturation and implantation in Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G115- the superovulated rat. Transactions of the Royal Society of G122. doi: 10.1152/ajpgi.00209.2018. Epub 2018 Sep 20. South Africa 73(3): 270-276. https://doi.org/10.1080/00359 PMID: 30234998 19X.2018.1504833 Joyce Besheer Onanuga IO, Jegede AI, Offor U, Ogedengbe OO, Naidu ECS, Randall PA, Fortino B, Huynh YW, Thompson BM, Larsen Peter AI, Azu OO (2018). Histo-morphological & seminal CE, Callen MP, Barrett ST, Murray JE, Bevins RA, Besheer J evaluation of testicular parameters in diabetic rats under (2019). Effects of nicotine conditioning history on alcohol antiretroviral therapy (HAART): Interactions with Hy- and methamphetamine self-administration in rats. Pharma- poxis hemerocallidea. Iran J Basic Med Sci 21: 1322-1330 cology, biochemistry, and behavior. 179: 1-8. doi:10.22038/IJBMS.2018.25046.6213 Randall PA, Veterno RP, Makhijani VH, Crews FT, Besheer J Adana MY, Akang E, Naidu ECS, Peter AI, Ogedengbe OO, (2019) The Toll-like receptor 3 agonist poly(I:C) induces rap- Koffi K, Azu OO (2018). Testicular Microanatomical and -Hor id and lasting changes in gene expression related to gluta- monal alterations following use of Antiretroviral Therapy in matergic function and increases ethanol self-administration Sprague-Dawley rats: role of Naringenin. Andrologia 50(9): in rats. Alcoholism: Clinical and Experimental Research, 43: e13137 https://doi.org/10.1111/and.13137 48-60.

18 Schmidt KT, Makhijani VH, Boyt KM, Pati D, Pina M, Bravo but long-term consequences are age- and sex-dependent. IM, Besheer J, McElligott ZA (2019) Stress-induced altera- Frontiers in Behavioral Neuroscience, in press. tions of norepinephrine release in the bed nucleus of the stria terminalis of mice. ACS Chemical Neuroscience, 10: Kasten C, Zhang Y, Mackie K Boehm II SL (2018) Short-term 1908-1914. genetic selection for adolescent locomotor sedative sensi- tivity to Δ9-tetrahydrocannabinol (THC). Behavior Genetics, Yu W, Hwa LS, Makhijani VH, Besheer J, Kash TL (2018) 48:224-235. PMCID: PMC5935564. Chronic inflammatory pain drives alcohol drinking in a sex- dependent manner for C57BL/6J mice. Alcohol, 77: 135- Katerine Burina 145. Olga Yu. Shchelkova, Ekaterina B. Usmanova, Ekaterina A. Burina. Emotional and personal status in patients with Makhijani VH, Van Voorhies K, Besheer J (2018). The min- bone tumor. Bulgarian medicine, vol. 8 № 1/2018. P. 33-42. eralocorticoid receptor antagonist spironolactone reduces alcohol self-administration in female and male rats. Phar- Burina E.A., Kulieva A.K., Marianian A.Y. The risk of Fetal Al- macology Biochemistry and Behavior, 175: 10-18. cohol Syndrome in pregnant women and women planning pregnancy. Alcoholism: Clinical and Experimental Research. Jin C, Decker AM, Makhijani VH, Besheer J, Darcq E, Kieffer August 2018, vol. 42 – Suppl. 2, 42A. 19th World Congress BL, Maitra R (2018) Discovery of a Potent, Selective, and of International Society for Biomedical Research on Alco- Brain-Penetrant Small-Molecule that Activates the Orphan holism (ISBRA 2018), Kyoto, Japan, September 9–13, 2018. Receptor GPR88 and Reduces Alcohol Intake. Journal of Medicinal Chemistry, 61: 6748-6758. Kostromina S., Grishina N., Moskvicheva N., Zinovieva E., Burina E. Transmission of values and patterns of relations: Jaramillo AA, Van Voorhies K, Randall PA, Besheer J (2018) intergenerational studies. The European Proceedings of Silencing the insular-striatal circuit decreases alcohol self- Social & Behavioural Sciences Ep-SBS. Volume XLVII, P. 56- administration and increases sensitivity to alcohol. Behav- 66. 6th CPSYC 2018 – International Congress on Clinical and ioural Brain Research. 348: 74-81. Counselling Psychology, Portugal, July 4-6, 2018.

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Haass-Koffler CL, Swift RM, Leggio L. Noradrenergic targets Karl Mann for the treatment of alcohol use disorder. Psychopharma- Wölfling K, Müller KW, Dreier M, Ruckes C, Deuster O, cology (Berl). 2018 Jun;235(6):1625-1634. doi: 10.1007/ Batra A, Mann KF, Musalek M, Schuster A, Lemenager T, s00213-018-4843-6. Epub 2018 Feb 20. Review. PubMed Hanke S, Beutel ME (2019) Efficacy of short-term treatment PMID: 29460163; PubMed Central PMCID: PMC5995154. of Internet and Computer game addiction (STICA): A multi- center, randomized controlled trial. JAMA, (in press) Zallar LJ, Tunstall BJ, Richie CT, Zhang YJ, You ZB, Gardner EL, Heilig M, Pickel J, Koob GF, Vendruscolo LF, Harvey BK, Witkiewitz K, Falk D, Litten R, Mann K, O’Malley S (2019) Leggio L. Development and initial characterization of a Maintenance of World Health Organization Risk Drinking novel ghrelin receptor CRISPR/Cas9 knockout wistar rat Level Reductions and Post-Treatment functioning following model. Int J Obes (Lond). 2019 Feb;43(2):344-354. doi: a large alcohol use disorder clinical trial. Alc Clin Exp Res, in 10.1038/s41366-018-0013-5. Epub 2018 Jan 30. PubMed press PMID: 29453460; PubMed Central PMCID: PMC6066458. Bach P, Weil G, Pompili E, Hoffmann S, Hermann D, Voll- Haass-Koffler CL, Goodyear K, Loche A, Long VM, Lobina städt-Klein S, Mann K, Perez-Ramirez U, Moratal D, Canals C, Tran HH, Cacciaglia R, Swift RM, Colombo G, Leggio S, Dursun SM, Greenshaw AJ, Kirsch P, Kiefer F, Sommer L. Administration of the metabotropic glutamate recep- WH (2019) Incubation of neural alcohol cue reactivity after tor subtype 5 allosteric modulator GET 73 with alcohol: A withdrawal and its blockade by naltrexone. Addict Biol 1-11 translational study in rats and humans. J Psychopharmacol. (in print) 2018 Feb;32(2):163-173. doi: 10.1177/0269881117746904. Epub 2018 Jan 23. PubMed PMID: 29361897. Knox J, Wall MM, Scodes JM, Mann K, Anton R, Falk DE, Witkiewitz K, Kranzler H, Litten RE O'Malley S (2019) Litten RZ, Falk DE, Ryan ML, Fertig J, Leggio L. Ad- Reduction in non-abstinent WHO drinking risk levels and vances in Pharmacotherapy Development: Human epression/anxiety disorders: 3-year follow-up results in the Clinical Studies. Handb Exp Pharmacol. 2018 Jan 3. doi: US general population. Drug and Alc Dep. 197:228-235. 10.1007/164_2017_79. [Epub ahead of print] PubMed 27 Falk D, O’Malley S, Witkiewitz K, Anton R, Litten R, Slater 320. M, Kranzler H, Mann K, Hasin D, Johnson B, Meulien D, Ryan M, Fertig J (2019) Reductions in Drinking Risk Level Rumpf HJ,… Mann K,… Poznyak V (2018) Including gaming as Outcomes in Alcohol Pharmacotherapy Trials. JAMA disorder in the ICD-11: The need to do so from a clinical Psychiatry, (in press). Aubin HJ, Mann K (2019) Medication and public health perspective. Journal Behav Add 7: 556- development: reducing casualities in the valley of death 561. and providing support for survivors. Alcohol Clin Exp Res. 43: 22-25. Leménager T,… Mann K, Kiefer F (2018) The link between healthy, problematic, and addicted Internet use regard- Mann K, Roos CR, Hoffmann S, Nakovics H, Leménager T, ing comorbidities and self-concept-related characteristics. Heinz A, Witkiewitz K (2018) Precision Medicine in Alcohol Journal of Behavioral Addictions 7: 31-43. Dependence: A Controlled Trial Testing Pharmacotherapy Response among Reward and Relief Drinking Phenotypes. van den Brink W, Addolorato G, Aubin HJ, Benyamina Neuropsychopharmacology 43: 891-899. A, Caputa F, Dematteis M, Gual A, Lesch OM, Mann K, Maremmani I, NuttD, Paille F, Perney P, Rehm J, Reynaud Mann K F, Roos CR, Witkiewitz K (2018) Response to Let- M, Simon N, Söderpalm B, Sommer WH, Walter H, Spa- ter to Editor (Precision medicine in alcohol dependence: nagel R (2018) Efficacy and safety of sodium oxybate in evidence of efficacy and initial support for comparative alcohol-dependent patients with a very high drinking risk effectiveness). Neuropsychopharmacology 43: 1801-1802 level. Addic Biol. 23: 969-986.

Walters RK, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Bramness JG, Dom G, Gual A, Mann K, Wurst FM (2018) A Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen S, Survey on the Medical Use of Cannabis in Europe: A Posi- Clarke TK, Chou YL, Degenhardt F, Docherty AR, Fonanil- tion Paper. Eur Addict Res. 24: 201-205. las P, Foo J, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Paetz T, Frischknecht U, Bielmeier P, Dinter C, Reinhard I, Hodgkinson C, Hoffmann P, ...Mann K, ..Agrawal A (2018) Mann K, Kiefer F, Weber T (2018) Tabakentwöhnung mit Trans- ancestral GWAS of alcohol dependence reveals com- kognitiv-behavioraler Gruppentherapie während einer mon genetic underpinnings with psychiatric disorders. Nat dreiwöchigen, qualifizierten Alkoholentzugsbehandlung Neurosci. 21:1656-1669. – Effekte auf den Tabakkonsum. Verhaltenstherapie 28: 230-237. Khalili M, Rahimi-Movaghar A, Shadloo B, Mann K, Amin- Esmaeili M (2018) Global Scientific Production on Illicit Knox J, Wall M, Witkiewitz K, Kranzler HR, Falk D, Litten R, Drug Addiction: A Two-Decade Analysis. Europ Addict Res Mann K, O’Malley SS, Scodes J, Anton R, Hasin DS, ACTIVE 24: 60-70. (2018) Reduction in Nonabstinent WHO Drinking Risk Lev- els and Change in Risk for Liver Disease and Positve AUDIT- Preuss UW, Gouzoulis-Mayfrank E, Havemann-Reinecke C Scores: Prospective 3-Year Follow-Up Results in the U.S. U, Schäfer I, Beutel M, Hoch E, Mann KF (2018) Psychiatric General Population. Alcohol Clin Exp Res. 42: 2256-2265. comorbidity in alcohol use disorders: results from the Ger- man S3 guidelines. Eur Arch Psychiatry Clin Neurosci 268: Stein DJ, Billieux J, Bowden-Jones H, Grant JE, Fineberg 219-229. N, Higuchi S, Hao W, Mann K, Matsunaga H, Potenza MN, Rumpf HM, Veale D, Ray R, Saunders JB, Reed GM, Poznyak Zois E, Kiefer F, Vollstädt-Klein S, Lemenager T, Mann K, V (2018) Balancing validity, utility and public health consid- Fauth-Bühler M (2018) Amygdala grey matter volume erations in disorders due to addictive behaviours. World increase in gambling disorder with depression symptoms Psychiatry 17: 363-364. of clinical relevance: a voxel-based morphometry study, International Gambling Studies. 18, 259-268. Witkiewitz K, Kranzler HR, Hallgren KA, O’Malley SS, Falk DE, Hasin DS, Mann KF, Anton RF (2018) Drinking Risk Level Günthner A, Weissinger V, Fleischmann H, Veltrup C, Jäpel Reductions Associated with Improvements in Physical B, Längle G, Amann K, Hoch E, Mann K: Versorgungsorgan- Health and Quality of Life among Individuals with Alcohol isation – Die neue S3 LL Alkohol und ihre Bedeutung für die Use Disorder. Alcohol Clin Exp Res 42: 2453-2465. Versorgungspraxis [Health Care Organization – The New German S3-Guideline on Alcohol-Related Disorders and its King DL, Gaming Industry Response Consortium (2018) Relevance for Health Care]. Rehabilitation 2018; 57:314- Comment on the global gaming industry’s statement on 28 ICD-11 gaming disorder: a corporate strategy to disregard bardt, C. L. Czachowski, C. C. Lapish. eNeuro 12 October harm and deflect social responsibility? Addiction 113: 2145- 2018, 5 (5) ENEURO.0326-18.2018; DOI: 10.1523/ENEU- 2146. RO.0326-18.2018

Rosendahl J, … Mann K et al. and the members of the Robert Messing PanEuropean Working group on ACP (2018) Genome-wide Pomrenze MB, Tovar-Diaz J, Blasio A, Maiya R, Giovanetti association study identifies inversion in the CTRB1-CTRB2 SM, Lei K, Morikawa H, Hopf FW, Messing RO. A Cortico- locus to modify risk for alcoholic and non-alcoholic chronic tropin Releasing Factor Network in the Extended Amygdala . Gut 67: 1855-1863. for Anxiety. J Neurosci. 2019 Feb 6;39(6):1030-1043. doi: 10.1523/JNEUROSCI.2143-18.2018. Epub 2018 Dec 10. Ruggeri B, Macare C, Stopponi S, Jia T, Carvalho FM, Robert G, Banaschewski T, Bokde ALW, Bromberg U, Büchel C, Cat- Warden AS, Azzam M, DaCosta A, Mason S, Blednov YA, trell A, Conrod PJ, Desrivières S, Flor H, Frouin V, Gallinat Messing RO, Mayfield RD, Harris RA. Toll-like receptor 3 J, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot activation increases voluntary alcohol intake in C57BL/6J JL, Martinot MP, Nees F, Papadopoulos-Orfanos D, Paus male mice. Brain Behav Immun. 2018 Dec 11. pii: S0889- T, Poustka L, Smolka MN, Vetter NC, Walter H, Whelan R, 1591(18)30386-6. doi: 10.1016/j.bbi.2018.12.004. [Epub Sommer WH, Bakalkin G, Ciccocioppo R, Schumann G; IMA- ahead of print] PubMed PMID: 30550931. GEN consortium (2018) Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adoles- Warden AS, Azzam M, DaCosta A, Mason S, Blednov YA, cents. J Child Psychol Psychiatry 59: 650-658. Messing RO, Mayfield RD, Harris RA. Toll-like receptor 3 dynamics in female C57BL/6J mice: Regulation of alco- Streit F, Treutlein J, Frischknecht U, Hermann D, Mann K, hol intake. Brain Behav Immun. 2018 Dec 11. pii: S0889- Kiefer F, Sack M, Hall ASM, Frank J, Witt SH, Foo JC, Degen- 1591(18)30387-8. doi: 10.1016/j.bbi.2018.12.006. [Epub hardt F, Heilmann-Heimbach S, Nöthen MM, Sommer WH, ahead of print] PubMed PMID: 30550930. Spanagel R, Rietschel M, Ende G (2018) Glutamate concen- tration in the anterior cingulate cortex in alcohol depen- Blasio A, Wang J, Wang D, Varodayan FP, Pomrenze MB, dence: association with alcohol withdrawal and explora- Miller J, Lee AM, McMahon T, Gyawali S, Wang HY, Ro- tion of contribution from glutamatergic candidate genes. berto M, McHardy S, Pleiss MA, Messing RO. Novel Small- Psychiatr Genet. 28: 94-95. Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice. Biol Psychiatry. 2018 Aug Foo JC, Streit F, Treutlein J, Ripke S, Witt SH, Strohmaier J 5 1;84(3):193-201. doi: 10.1016/j.biopsych.2017.10.017. Epub , Degenhardt F, Forstner AJ, Hoffmann P, Soyka M, Dahmen 2017 Dec 2. PubMed PMID: 29198469; PubMed Central N, Scherbaum N, Wodarz N, Heilmann- Heimbach S, Herms PMCID: PMC5984071. S, Cichon S, Preuss U, Gäbel W, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Blednov YA, Da Costa AJ, Tarbox T, Ponomareva O, Mess- Ridinger M, Hoffmann S, Schulze TG, Maier W, Zill P, Müller- ing RO, Harris RA. Apremilast Alters Behavioral Responses Myhsok B, Ising M, Lucae S, Nöthen MM, Mann K, Kiefer F, to Ethanol in Mice: I. Reduced Consumption and Prefer- Rietschel M, Frank J (2018) Shared genetic etiology be- ence. Alcohol Clin Exp Res. 2018 May;42(5):926-938. doi: tween alcohol dependence and major depressive disorder. 10.1111/acer.13616. Epub 2018 Mar 24. PubMed PMID: Psych Genetics 28: 66-70. 29469962; PubMed Central PMCID: PMC5915912.

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Zou X, Durazzo TC, Meyerhoff DJ. Regional Brain Vol- Moreno, C.; Mueller, S.; Szabo, G. Non-invasive diagnosis ume Changes in Alcohol-dependent Individuals during and biomarkers in alcohol-related liver disease. J Hepatol Short-term and Long-term Abstinence, Alc Clin Exp Res 70:273-283; 2019. 42(6):1062-1072 (2018) Elssner, C.; Goeppert, B.; Longerich, T.; Scherr, A. L.; Stindt, Sanford R, Ances BM, Meyerhoff DJ, Price RW, Fuchs D, J.; Nanduri, L. K.; Rupp, C.; Kather, J. N.; Schmitt, N.; Kautz, Spudich S, Collins DL. Longitudinal trajectories of brain N.; Breuhahn, K.; Ismail, L.; Heide, D.; Hetzer, J.; Garcia- volume and cortical thickness in treated and untreated pri- Beccaria, M.; Hovelmeyer, N.; Waisman, A.; Urbanik, T.; mary HIV infection, Clin Infect Dis. 67(11):1697-1704 (2018). Mueller, S.; Gdynia, G.; Banales, J. M.; Roessler, S.; Schirm- acher, P.; Jager, D.; Scholch, S.; Keitel, V.; Heikenwalder, M.; Zou Y, Murray DE, Durazzo TC, Schmidt TP, Murray TA, Schulze-Bergkamen, H.; Kohler, B. C. Nuclear Translocation Meyerhoff DJ. White matter microstructural correlates of of RELB Is Increased in Diseased Human Liver and Promotes relapse in alcohol dependence, Psychiatry Research Neuro- Ductular Reaction and Biliary Fibrosis in Mice. Gastroenter- imaging, 281:92-100 (2018) ology 156:1190-1205 e1114; 2019.

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Bohnsack J.P., Hughes, B.A., O’buckley, T.K., Edokpolar, K., Silva, I.; Rausch, V.; Peccerella, T.; Millonig, G.; Seitz, H. K.; Besheer, J.B. And Morrow, A.L. Histone deacetylases medi- Mueller, S. Hypoxia enhances H2O2-mediated upregulation ate GABAAreceptor expression, physiology, and behavioral of hepcidin: Evidence for NOX4-mediated iron regulation. maladaptations in rat models of alcohol dependence. Redox Biol 16:1-10; 2018. Neuropsychopharmacology (2018) Feb 27. doi: 10.1038/ s41386-018-0034-8. PMCID:PMC5983537 Seitz, H. K.; Bataller, R.; Cortez-Pinto, H.; Gao, B.; Gual, A.; Lackner, C.; Mathurin, P.; Mueller, S.; Szabo, G.; Tsukamoto, 30 H. Alcoholic liver disease. Nat Rev Dis Primers 4:16; 2018. Mueller, S.; Seitz, H. K. Alkoholsucht und Leber: Wie wichtig ist ein Leberscreening auch für Suchttherapeuten? Sucht- Rosendahl, J.; Kirsten, H.; Hegyi, E.;… Mueller, S.;… Sahin- medizin 20:1-9; 2018. Toth, M.; all members of the PanEuropean Working group on, A. C. P. Genome-wide association study identifies inver- Mueller, S.; Peccerella, T.; Qin, H.; Glassen, K.; Waldherr, R.; sion in the CTRB1-CTRB2 locus to modify risk for alcoholic Flechtenmacher, C.; Straub, B. K.; Millonig, G.; Stickel, F.; and non-alcoholic chronic pancreatitis. Gut 67:1855-1863; Bruckner, T.; Bartsch, H.; Seitz, H. K. Carcinogenic Etheno 2018. DNA Adducts in Alcoholic Liver Disease: Correlation with Cytochrome P-4502E1 and Fibrosis. Alcohol Clin Exp Res Rausch, V.; Mueller, S. Suppressed Fat Mobilization Due 42:252-259; 2018. to PNPLA3 rs738409 -Associated Liver Damage in Heavy Drinkers: The Liver Damage Feedback Hypothesis. Adv Exp Mueller, S. Liver Stiffness Prior And After Alcohol Detoxi- Med Biol 1032:153-172; 2018. fication As A Novel Prognostic Marker In Heavy Drinkers: First Data From A Prospective Cohort. Alcoholism-Clinical Piecha, F.; Paech, D.; Sollors, J.; Seitz, H. K.; Rossle, M.; and Experimental Research 42:81A-81A; 2018. Rausch, V.; Mueller, S. Rapid change of liver stiffness after variceal ligation and TIPS implantation. Am J Physiol Gas- Matte, A.; De Falco, L.; Federti, E.; Cozzi, A.; Iolascon, A.; trointest Liver Physiol 314:G179-G187; 2018. Levi, S.; Mohandas, N.; Zamo, A.; Bruno, M.; Lebouef, C.; Janin, A.; Siciliano, A.; Ganz, T.; Federico, G.; Carlomagno, F.; Piecha, F.; Mandorfer, M.; Peccerella, T.; Ozga, A. K.; Poth, Mueller, S.; Silva, I.; Carbone, C.; Melisi, D.; Kim, D. W.; Choi, T.; Vonbank, A.; Seitz, H. K.; Rausch, V.; Reiberger, T.; S. Y.; De Franceschi, L. Peroxiredoxin-2: A Novel Regulator Mueller, S. Pharmacological decrease of liver stiffness is of Iron Homeostasis in Ineffective Erythropoiesis. Antioxid pressure-related and predicts long-term clinical outcome. Redox Signal 28:1-14; 2018. American Journal of Physiology-Gastrointestinal and Liver Physiology 315:G484-G494; 2018. Jansen, C.; Moller, P.; Meyer, C.; Kolbe, C. C.; Bogs, C.; Pohlmann, A.; Schierwagen, R.; Praktiknjo, M.; Abdullah, Z.; Piecha, F.; Mandorfer, M.; Peccerella, T.; Ozga, A. K.; Poth, Lehmann, J.; Thomas, D.; Strassburg, C. P.; Latz, E.; Mueller, T.; Vonbank, A.; Seitz, H. K.; Rausch, V.; Reiberger, T.; Muel- S.; Rossle, M.; Trebicka, J. Increase in liver stiffness after ler, S. Pharmacological decrease of liver stiffness is pres- transjugular intrahepatic portosystemic shunt is associ- sure-related and predicts long-term clinical outcome. Am J ated with inflammation and predicts mortality. Hepatology Physiol Gastrointest Liver Physiol 315:G484-G494; 2018. 67:1472-1484; 2018.

Peccerella, T.; Arslic-Schmitt, T.; Mueller, S.; Linhart, K. B.; Elssner, C.; Goeppert, B.; Longerich, T.; Scherr, A. L.; Stindt, Seth, D.; Bartsch, H.; Seitz, H. K. Chronic Ethanol Consump- J.; Nanduri, L. K.; Rupp, C.; Kather, J. N.; Schmitt, N.; Kautz, tion and Generation of Etheno-DNA Adducts in Cancer- N.; Breuhahn, K.; Ismail, L.; Heide, D.; Hetzer, J.; Garcia- Prone Tissues. Adv Exp Med Biol 1032:81-92; 2018. Beccaria, M.; Hovelmeyer, N.; Waisman, A.; Urbanik, T.; Mueller, S.; Gdynia, G.; Banales, J. M.; Roessler, S.; Schirm- Nickel, F.; Tapking, C.; Benner, L.; Sollors, J.; Billeter, A. T.; acher, P.; Jager, D.; Scholch, S.; Keitel, V.; Heikenwalder, M.; Kenngott, H. G.; Bokhary, L.; Schmid, M.; von Frankenberg, Schulze-Bergkamen, H.; Kohler, B. C. Nuclear Translocation M.; Fischer, L.; Mueller, S.; Muller-Stich, B. P. Bariatric of RELB is Increased in Diseased Human Liver and Promotes Surgery as an Efficient Treatment for Non-Alcoholic Fatty Ductular Reaction and Biliary Fibrosis in Mice. Gastroenter- Liver Disease in a Prospective Study with 1-Year Follow-up : ology; 2018. BariScan Study. Obes Surg 28:1342-1350; 2018. Ammon, F. J.; Kohlhaas, A.; Elshaarawy, O.; Mueller, J.; Nguyen-Khac, E.; Thiele, M.; Voican, C.; Nahon, P.; Moreno, Bruckner, T.; Sohn, C.; Fluhr, G.; Fluhr, H.; Mueller, S. Liver C.; Boursier, J.; Mueller, S.; de Ledinghen, V.; Starkel, P.; stiffness reversibly increases during pregnancy and inde- Gyune Kim, S.; Fernandez, M.; Madsen, B.; Naveau, S.; pendently predicts preeclampsia. World J Gastroenterol Krag, A.; Perlemuter, G.; Ziol, M.; Chatelain, D.; Diouf, M. 24:4393-4402; 2018. Non-invasive diagnosis of liver fibrosis in patients with alcohol-related liver disease by transient elastography: an Natalia Osna individual patient data meta-analysis. Lancet Gastroenterol Murali Ganesan, Irina Tikhanovich, Shiva Shankar Vangi- Hepatol 3:614-625; 2018. malla, Raghubendra Singh Dagur, Weimin Wang, Larisa I. Poluektova, Yimin Sun, David F. Mercer, Dean Tuma, Ste- 31 ven A. Weinman, Kusum K. Kharbanda, Natalia A. Osna. (2019). Restraint stress exacerbates cell degeneration Demethylase JMJD6 as a new regulator of interferon induced by acute binge ethanol in the adolescent, but not signaling: effects of HCV and ethanol metabolism. Cell Mol in the adult or middle-aged, brain. Behav. Brain Research. Gastroenterol Hepatol 2018; 5:101–112. 364, pp. 317-327 doi.org/10.1016/j.bbr.2019.02.035.

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Saitz R. Treatment for Opioid Addiction Must Be Offered Miller SC, Fiellin DA, Rosenthal RN, Saitz R. The ASAM Prin- in General Hospitals: But How? J Addict Med. 2019 Jan 14. ciples of Addiction Medicine. 2019. PMID: 30652975. Barocas JA, Saitz R. Being Explicit About Decisions: Pre- Saitz R. Treating opioid addiction. Terminology and Con- scribe Medications for Opioid Use Disorder on the Basis of ceptualization of Opioid Use Disorder and Implications for Proven Effectiveness, Not Beliefs. Ann Intern Med. 2018 Treatment. Springer. 2019. Dec 18.View Related Profiles. PMID: 30557444.

Saitz R. Post TW (ed) UpToDate. Brief intervention for Hernandez Y, Meyers-Ohki S, Farkas S, Ball S, Leonard K, unhealthy alcohol and other drug use: Goals and compo- Rotrosen J, Saitz R. How Massachusetts, Vermont, and New nents. Wolters Kluwer. Waltham. 2019. York Are Taking Action to Address the Opioid Epidemic. Am J Public Health. 2018 Dec; 108(12):1621-1622. PMID: Bertholet N, Saitz R. Herron A, Brennan T (eds) The ASAM 30403507. Essentials of Addiction Medicine. Screening and brief inter- vention for pregnant women. Wolters Kluwer. Philadelphia. Saitz R. Post TW (Ed). UpToDate. Approach to treating alco- 34 hol use disorder. Wolters Kluwer. Waltham. 2018. Alcohol & Other Drug Use in Medical Settings: An Exten- sion of SBIRT. SBIRT Change Guide 1.0. National Council on Bazzi A, Saitz R. Screening for Unhealthy Alcohol Use. Behavioral Health. Washington, DC. 2018. JAMA. 2018 11 13; 320(18):1869-1871.View Related Pro- files. PMID: 30422181; DOI: 10.1001/jama.2018.16069;. Johnson NA, Kypri K, Latter J, Dunlop A, Brown A, Saitz R, Saunders JB, Attia J, Wolfenden L, Doran C, McCam- Saitz R. Medications for Alcohol Use Disorder and Predict- bridge J. Effect of electronic brief intervention on uptake ing Severe Withdrawal. JAMA. 2018 08 28; 320(8):766-768. of specialty treatment in hospital outpatients with likely alcohol dependence: Pilot randomized trial and qualitative Johnson NA, Kypri K, Saunders JB, Saitz R, Attia J, Latter J, interviews. Drug Alcohol Depend. 2018 02 01; 183:253-260. McElduff P, Dunlop A, Doran C, Wolfenden L, McCambridge PMID: 29306817. J. Effect of electronic screening and brief intervention on hazardous or harmful drinking among adults in the hospital Miller S, Fiellin D, Rosenthal R, Saitz R (Eds). American outpatient setting: A randomized, double-blind, controlled Society of Addiction Medicine. The American Society of Ad- trial. Drug Alcohol Depend. 2018 10 01; 191:78-85. diction Medicine Principles of Addiction Medicine. Wolters- Kluwer. Boston. 2018. Saitz R, Heeren TC, Zha W, Hingson R. Transitions To and From At-Risk Alcohol Use in Adults in the United States. J Wakeman SE, Saitz R. Chronic Illness Care: Principles and Subst Use. 2019; 24(1):41-46.View Related Profiles. Practice (Daaleman TP, Helton MR, eds.). Alcohol and Other Wakeman SE, Saitz R. Daaleman TP, Helton MR (eds) Drug Use Disorders. Springer. New York. 2018. Chronic Illness Care: Principles and Practice. Alcohol and other drug use disorders. Springer. 2018. Bertholet N, Cheng DM, Palfai TP, Lloyd-Travaglini C, Samet JH, Saitz R. Anxiety, Depression, and Pain Symptoms: As- Saitz R, Mesic A, Ventura AS, Winter MR, Heeren TC, Sul- sociations With the Course of Marijuana Use and Drug Use livan MM, Walley AY, Patts GJ, Meli SM, Holick MF, Kim Consequences Among Urban Primary Care Patients. J Ad- TW, Bryant KJ, Samet JH. Alcohol Consumption and Bone dict Med. 2018 Jan/Feb; 12(1):45-52.View Related Profiles. Mineral Density in People with HIV and Substance Use PMID: 28984682. Disorder: A Prospective Cohort Study. Alcohol Clin Exp Res. 2018 Jun 06.View Related Profiles. PMID: 29873812; DOI: Lorkiewicz SA, Ventura AS, Heeren TC, Winter MR, Walley 10.1111/acer.13801;. AY, Sullivan M, Samet JH, Saitz R. Lifetime marijuana and al- cohol use, and cognitive dysfunction in people with human Saitz R. Editor’s Note: Congratulations to the 2018 Author immunodeficiency virus infection. Subst Abus. 2018 01 02; and Reviewer Award Winners. J Addict Med. 2018 May/Jun; 39(1):116-123.View Related Profiles. PMID: 29058572. 12(3):169. PMID: 29794617. Bagley SM, Hadland SE, Carney BL, Saitz R. Addressing Stig- Hodgkin D, Gao W, Merrick EL, Drebing CE, Larson MJ, ma in Medication Treatment of Adolescents With Opioid Horgan CM, Sharma M, Petry NM, Saitz R. Implementing Use Disorder. J Addict Med. 2017 Nov/Dec; 11(6):415-416. single-item screening for drug use in a Veterans Health Ad- View Related Profiles. PMID: 28767537. ministration outpatient setting. Subst Abus. 2018 Mar 29; 1-9.View Related Profiles. PMID: 29595402. Kim TW, Walley AY, Ventura AS, Patts GJ, Heeren TC, Lerner GB, Mauricio N, Saitz R. Polypharmacy and risk of falls and Saitz R. Absence of a quick fix does not mean ‘do nothing:’ fractures for patients with HIV infection and substance time to address drug use in the ED. Emerg Med J. 2018 05; dependence. AIDS Care. 2018 Feb; 30(2):150-159.View Re- 35(5):280-281. PMID: 29599111. lated Profiles. PMID: 29034725.

Hettema JE, Cockrell SA, Reeves A, Ingersoll KS, Lum PJ, Chavez KE, Palfai TP, Squires LE, Cheng DM, Lloyd-Travaglini Saitz R, Murray-Krezan CM, Carrejo VA. Development and C, Saitz R. Perceived discrimination and drug involvement differentiability of three brief interventions for risky alco- among black primary care patients who use drugs. Addict hol use that include varying doses of motivational inter- Behav. 2018 Feb; 77:63-66.View Related Profiles. PMID: viewing. Addict Sci Clin Pract. 2018 Feb 27; 13(1):6. PMID: 28965068. 29482632. Kim TW, Walley AY, Heeren TC, Patts GJ, Ventura AS, Lerner SBIRT Change Guide Expert Panel. Implementing Care for GB, Mauricio N, Saitz R. Polypharmacy and risk of non-fatal 35 overdose for patients with HIV infection and substance Spanagel R. Alterations of the Biological Clock May Contrib- dependence. J Subst Abuse Treat. 2017 Oct; 81:1-10.View ute to the Emergence of Mental Disorders During Adoles- Related Profiles. PMID: 28847449. cence. Biol Psychiatry. 2018 Jun 15;83(12):978-980. doi: 10.1016/j.biopsych.2018.04.004. Rainer Spanagel Noori HR, Mücksch C, Vengeliene V, Schönig K, Takahashi Broccoli L, Uhrig S, von Jonquieres G, Schönig K, Bartsch D, TT, Mukhtasimova N, Bagher Oskouei M, Mosqueira M, Justice NJ, Spanagel R, Sommer WH, Klugmann M, Hansson Bartsch D, Fink R, Urbassek HM, Spanagel R, Sine SM. Alco- AC. Targeted overexpression of CRH receptor subtype 1 in hol reduces muscle fatigue through atomistic interactions central amygdala neurons: effect on alcohol-seeking behav- with nicotinic receptors. Commun Biol. 2018 Oct 3;1:159. ior. Psychopharmacology (Berl). 2018 Jun;235(6):1821-1833. doi: 10.1038/s42003-018-0157-9. eCollection 2018. doi: 10.1007/s00213-018-4908-6. Epub 2018 Apr 26.

Hansson AC, Gründer G, Hirth N, Noori HR, Spanagel R, Vengeliene V, Takahashi TT, Dravolina OA, Belozertseva I, Sommer WH. Dopamine and opioid systems adaptation in Zvartau E, Bespalov AY, Spanagel R. Efficacy and side -ef alcoholism revisited: Convergent evidence from positron fects of baclofen and the novel GABAB receptor positive emission tomography and postmortem studies. Neurosci allosteric modulator CMPPE in animal models for alcohol Biobehav Rev. 2018 Sep 19. pii: S0149-7634(18)30110-6. and cocaine addiction. Psychopharmacology (Berl). 2018 doi: 10.1016/j.neubiorev.2018.09.010. [Epub ahead of print] Jul;235(7):1955-1965. doi: 10.1007/s00213-018-4893-9. Epub 2018 Apr 12. Noori HR, Mervin LH, Bokharaie V, Durmus Ö, Egenrieder L, Fritze S, Gruhlke B, Reinhardt G, Schabel HH, Staudenmaier Pfarr S, Schaaf L, Reinert JK, Paul E, Herrmannsdörfer F, S, Logothetis NK, Bender A, Spanagel R. Systemic neu- Roßmanith M, Kuner T, Hansson AC, Spanagel R, Körber C, rotransmitter responses to clinically approved and experi- Sommer WH. Choice for Drug or Natural Reward Engages mental neuropsychiatric drugs. Nat Commun. 2018 Nov Largely Overlapping Neuronal Ensembles in the Infralimbic 8;9(1):4699. doi: 10.1038/s41467-018-07239-1. Prefrontal Cortex. J Neurosci. 2018 Apr 4;38(14):3507-3519. doi: 10.1523/JNEUROSCI.0026-18.2018. van den Brink W, Addolorato G, Aubin HJ, Benyamina A, Caputo F, Dematteis M, Gual A, Lesch OM, Mann K, Bazov I, Sarkisyan D, Kononenko O, Watanabe H, Yakovl- Maremmani I, Nutt D, Paille F, Perney P, Rehm J, Reynaud eva T, Hansson AC, Sommer WH, Spanagel R, Bakalkin G. M, Simon N, Söderpalm B, Sommer WH, Walter H, Spana- Dynorphin and κ-Opioid Receptor Dysregulation in the gel R. Efficacy and safety of sodium oxybate in alcohol-de- Dopaminergic Reward System of Human Alcoholics. Mol pendent patients with a very high drinking risk level. Addict Neurobiol. 2018 Aug;55(8):7049-7061. doi: 10.1007/s12035- Biol. 2018 Jul;23(4):969-986. doi: 10.1111/adb.12645. 017-0844-4.

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38 Applying for ISBRA Membership ISBRA Contact Information:

If you are already a member in good standing of one of Michelyn Lintz, MPA ISBRA’s affiliated regional societies (ESBRA, JMSAAS, RSA, Email: [email protected] APSAAR or LASBRA) you need only complete the online Telephone: (303) 355-6420 ISBRA Membership Application Form, which can be found FAX: (303) 355-1207 at http://isbra.com/membership (if you have questions, please contact Ms. Lintz at [email protected]). Annual P.O. Box 202332 dues for these members are $45. If you are not a member Denver, Colorado 80220, USA of an affiliated Society, you must submit an up-to-date Curriculum Vitae and the Membership Application Form. Website: https://www.isbra.com Annual dues for these members are $60, and all informa- tion can be submitted online at http://isbra.com/mem- bership. The Membership Committee reviews applica- tions 4 times a year. Application deadlines are: January 2, April 1, July 1 and October 1. You will be notified in writing of your formal acceptance into ISBRA.

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