Association Between Vitamin D Receptor Rs731236 (Taq1
Medicine® OBSERVATIONAL STUDY Association Between Vitamin D Receptor rs731236 (Taq1) Polymorphism and Risk for Restless Legs Syndrome in the Spanish Caucasian Population Fe´lix Javier Jime´nez-Jime´nez, MD, PhD, Elena Garcı´a-Martı´n, MD, PhD, Hortensia Alonso-Navarro, MD, PhD, Carmen Martı´nez, MD, PhD, Martı´n Zurdo, MD, Laura Turpı´n-Fenoll, MD, PhD, Jorge Milla´n-Pascual, MD, Teresa Adeva-Bartolome´, MD, PhD, Esther Cubo, MD, PhD, Francisco Navacerrada, MD, Ana Rojo-Sebastia´n, MD, Lluisa Rubio, MD, Sara Ortega-Cubero, MD, Pau Pastor, MD, PhD, Marisol Calleja, CN, Jose´ Francisco Plaza-Nieto, Bele´n Pilo-De-La-Fuente, MD, PhD, Margarita Arroyo-Solera, MD, Esteban Garcı´a-Albea, MD, PhD, and Jose´ A.G. Agu´ndez, MD, PhD Abstract: Several recent works suggest a possible role of vitamin D carrying the allelic variant rs731236G had an earlier age at onset, and deficiency in the etiology or restless legs syndrome (RLS). We analyzed those carrying the rs731236GG genotype had higher severity of RLS, the possible relationship of 2 common single nucleotide polymorphisms although these data disappeared after multivariate analyses. None of (SNPs) in the vitamin D3 receptor (VDR) gene with the risk for RLS. the SNPs studied was related with the positivity of family history of We studied the genotype and allelic variant frequencies of VDR RLS. rs2228570 and VDR rs731236 SNPs in 205 RLS patients and 445 These results suggest a modest, but significant association between healthy controls using a TaqMan essay. VDR rs731236 SNP and the risk for RLS. The frequencies of the rs731236AA genotype and the allelic variant (Medicine 94(47):e2125) rs731236A were significantly lower in RLS patients than in controls (P < 0.005 and < 0.01, respectively).
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