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Clinical Toxicology of 'Magic Mushroom' Ingestion N Postgrad Med J: first published as 10.1136/pgmj.57.671.543 on 1 September 1981. Downloaded from Postgraduate Medical Journal (September 1981) 57, 543-545 Clinical toxicology of 'magic mushroom' ingestion N. R. PEDEN ANN F. BISSETT M.A., M.R.C.P. M.A., S.R.N. K. E. C. MACAULAY J. CROOKS M.B., Ch.B. M.D., F.R.C.P. A. J. PELOSI* M.B., M.R.C.P. Department of Therapeutics, University of Dundee, and *Department ofMedicine, Perth Royal Infirmary Summary following the ingestion of magic mushrooms in the The clinical features are reported in 27 cases of months of September and October of 1979 and 1980. 'magic mushroom' ingestion. Mydriasis and hyper- The authors personally admitted or subsequently reflexia were common as were disorders of perception interviewed 8 of the patients and the case records of and affect. Psilocybe semilanceata appears to have all the patients have been reviewed. The mean age been the species of fungus involved. was 16 3 years (range 12-24 years) and 10 were by copyright. school children. Seven patients were self-referrals. Introduction Of the remainder, 12 were brought to hospital by Hallucinogenic mushrooms have been used for concerned parents, 5 by friends, 2 by the police and magico-religious purposes by the Indians of Mexico one had telephoned the Samaritans. for many centuries (Wasson, 1959) but the active constituents, psilocybin and psilocin were not Mushrooms and mode of ingestion identified until 1958 (Hofman et al., 1958). These The authors have identified P. semilanceata compounds were subsequently found in the British growing on sites described by patients and also in species Psilocybe semilanceata (Benedict, Tyler and gastric contents aspirated from patients. Illustrated Watling, 1967; Mantle and Waight, 1969) but, descriptions of the fungus have been published despite widespread use of psilocybin mushrooms for (Watling, 1973a; Cooper, 1979). http://pmj.bmj.com/ 'recreational purposes' elsewhere (Pollock, 1975), The number of mushrooms ingested varied from it was not until 1978 that such use was described in 'a handful' to 100, (mean 56 in those patients who Britain (Hyde et al., 1978) from 3 patients from quantified it). Eighteen patients ate the mushrooms Manchester. There have since been further case raw while in 6 cases the mushrooms were brewed in reports form Glasgow (Mills, Lesinkas and Watkin- boiling water and the liquor consumed. Two patients son, 1979) and Aberdeen (Cooles, 1980) and the ate dried mushrooms and one a mushroom stew. subject has also received comment in a national newspaper (The Observer, 1980). Two handbooks Clinical features on October 1, 2021 by guest. Protected for would-be users of these mushrooms have recently Tachycardia of > 100 beats per minute (b/min) been published (Cooper, 1979; Release Collective, was noted in 10 patients while only one was signifi- 1979). cantly hypertensive (BP 180/110 mmHg). Pupils Ingestion of these so-called 'magic mushrooms' were dilated (but reacting to light) in 20 of the 23 has been popular amongst teenagers in the Tayside patients in whom pupil size was noted. Deep tendon region in the past 2 Autumns and the authors feel reflexes were brisk in 12 of 18 patients from whom that a description of the clinical features will be this information was recorded. Three patients useful for clinicians who may see such patients for exhibited facial flushing, 3 suffered transient acute medical or psychiatric assessment. abdominal pain and nausea, one patient was vomiting on admission and one was incontinent of Patients urine. Twenty-seven patients presented to hospital Alterations in perception occurred in 23 patients 0032-5473/81/0900-0543 $02.00 () 1981 The Fellowship of Postgraduate Medicine Postgrad Med J: first published as 10.1136/pgmj.57.671.543 on 1 September 1981. Downloaded from 544 N. R. Peden et al. and chiefly affected vision. Colours appeared to be was very frightened. The hallucinatory episodes particularly vivid and kaleidoscopic phenomena and responded rapidly to treatment with chlorpromazine flashes of coloured light were described. Facial but recurred on 3 successive evenings despite no appearance received special comment with faces further ingestion of mushrooms. appearing to change shape and colour and also to Two patients presented again, one 7 days and one stare at the patient. Fully formed visual hallucina- 9 days after the initial episode of mushroom in- tions of people occurred in 4 patients and in one case gestion, both with acute panic attacks and in both these were interpreted as being Martians. cases after ingestion of considerable quantities of Two patients noted that perception of sound was alcohol. heightened while 2 suffered auditory hallucinations. Body image perception was affected in 4 patients Management who complained of apparent swelling of bodily Twenty-four patients were admitted to hospital parts including the tongue, while 2 patients felt a for observation, 2 having refused admission and generalized numbness. Two patients described one having been sent home fully recovered. Gastric deja vu phenomena while sexual fantasies were lavage was performed in 12 patients and 5 were given experienced by one patient. ipecacuanha. In 4 cases mushrooms were identified in One patient (a 12-year-old boy) had been running the gastric contents. One patient required admin- out in front of passing cars and was confused and istration of chlorpromazine for hallucinations while disorientated on admission. Seven patients were one patient presenting with a late panic attack agitated and one ran away from the Admissions required diazepam. and Emergency Department, leaving behind his shoes and shirt. Five patients were initially euphoric Discussion and of these 4 later became drowsy. Three patients The practice of magic mushroom ingestion has were drowsy but easily rousable when first seen and been common in the Tayside area in the last 2 2 were uncommunicative and staring blankly. Autumns and in a sample of 59 children aged 14 - 15 Two patients exhibited pressure of speech and years from 2 school classes, interviewed by A.F.B.,by copyright. one was talking to himself. Twelve patients described approximately 66% had heard of the properties of their experiences as frightening either on admission these fungi. In contrast to the report from or after recovery, and 3 had felt that they were going Manchester (Hyde et al., 1978) where the use of to die. magic mushrooms was centered on the 'hippy' The principal clinical features are summarized in subculture and the report (The Observer, 1980) on a Table 1. group of 'new gypsies' from mid-Wales, the problem in Tayside is clearly different, involving teenagers TABLE 1. Summary of principal clinical features in 27 and young adults throughout the social classes. cases of magic mushroom ingestion Solvent abuse by teenagers has also been a problem No. of patients in this area. The important features noted on physical exam-http://pmj.bmj.com/ Perceptual disorder 23 ination were mydriasis, hyperreflexia and tachy- Mydriasis 20 Dysphoria 13 cardia of which mydriasis was the most constant Hyperreflexia 12 feature. Hyde et al., (1978) have commented on Tachycardia ( > 100 b/min) 10 sympathomimetic effects and in initial volunteer Drowsiness 7 studies (Isbell, 1959; Malitz et al., 1960; Holister Euphoria 5 et al., 1960 and Rinkel et al., 1960) utilizing pure psilocybin, mydriasis and facilitation of reflexes Time course were prominent features while changes in pulse on October 1, 2021 by guest. Protected Twenty patients were entirely recovered after rate and BP were less constant, with one observer overnight observation, a maximum of 12 hr, and (Malitz et al., 1960) noting that tachycardia and indeed, in about 50% of these patients the entire hypertension occurred only in association with experience was over within 6 hr. Ofthe other patients: anxiety. in one the pupils remained dilated at 12 hr (normal at A range of psychological responses has been 18 hr) in one the BP was elevated at 12 hr (normal noted in this study. Changes in mood ranged from at 18 hr) and one was still drowsy at 18 hr (normal at euphoria to severe anxiety and agitation, while a 24 hr). One patient was still hallucinating 12 hr after variety of perceptual abnormalities occurred. Hal- admission but not at 24 hr. lucinations were on occasion complex and elaborated One patient required admission to a psychiatric by secondary delusions while one patient suffered an unit because of hallucinations in which he identified hallucinosis which persisted for 3 days. This variety voices speaking to him as God and the Devil. He of effects has been noted previously (Hyde et al., Postgrad Med J: first published as 10.1136/pgmj.57.671.543 on 1 September 1981. Downloaded from 'Magic mushroom' ingestion 545 1978). A similar range of response to pure psilocybin consultant staff who gave permission to report on patients when administered to volunteers has also been noted under their care and Mrs Lynn Connolly for secretarial help. (Isbell, 1959; Malitz et al., 1960; Holister et al., 1960; Rinkel et al., 1960; Parashos, 1976-7) and identical doses of have References psilocybin may widely BENEDICT, R.G., TYLER, V.E. & WATLING, R. (1967) Blueing differing effects in different individuals. It has been in Conocybe, Psilocybe and a Stropharia species and the suggested that the effect on mood in particular is detection of psilocybin. Lloydia, 30, 150. dependent on the subject's pre-exposure personality COOLES, P. (1980) Abuse of the mushroom Panaeolus foeni- traits secii. British Medical Journal, 1, 446. (Parashos, 1976-7). COOPER, R. (1979) A Guide to British Psilocybin Mushrooms. Treatment by gastric lavage or induced emesis Revised Edition. Hassle Free Press, London. was instituted in 17 patients in this study, the HOFMANN, A., HEIM, R., BRACK, A.
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