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OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for TA319805 Bim (BCL2L11) Mouse Monoclonal Antibody [Clone ID: 1C2C8] Product data: Product Type: Primary Antibodies Clone Name: 1C2C8 Applications: IF, WB Recommend Dilution: WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL Reactivity: Human, Mouse Host: Mouse Isotype: IgG1 Clonality: Monoclonal Immunogen: Mouse monoclonal Bim antibody was raised against a recombinant protein corresponding to amino acids 2 to 198 of human Bim. Formulation: Bim Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide. Concentration: 1ug/ul Purification: Bim Monoclonal Antibody is immunoaffinity chromotography purified IgG. Gene Name: BCL2 like 11 Database Link: NP_001191035 Entrez Gene 12125 MouseEntrez Gene 10018 Human Background: Bim Monoclonal Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim is another BH3 domain containing protein which can induce apoptosis. Bim interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines. Synonyms: BAM; BIM; BOD Protein Families: Druggable Genome This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2020 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 2 Bim (BCL2L11) Mouse Monoclonal Antibody [Clone ID: 1C2C8] – TA319805 Product images: Western blot analysis of (A) 5 and (B) 25 ng of Bim recombinant protein with Bim antibody at 1 ug/mL. Immunofluorescence of Bim in K562 cells with Bim antibody at 20 ug/mL. Immunocytochemistry of Bim in K562 cells with Bim antibody at 10 ug/mL. This product is to be used for laboratory only. Not for diagnostic or therapeutic use. ©2020 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 2 / 2.

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Targeting BCL-2 in Cancer: Advances, Challenges, and Perspectives
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