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Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays

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Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays For further information on our validated assays, please contact your Business development representative or via [email protected] Compound (Metabolite) Species/Matrix Range Anticoagulant 15-Hydroxy Lubiprostone Human plasma 1-150 pgmL EDTA 15-Hydroxy Lubiprostone 35-7000 pg/mL Rat plasma EDTA Lubiprostone 35-7000 pg/mL 17-Desacetyl-Norgestimate Human plasma 50-5000 pg/mL EDTA 25-Hydroxy-vitamin D2 (Calciferol) Human plasma 5-250 ng/mL EDTA (DEQAS certified) 25-Hydroxy-vitamin D3 (Calcifediol) Human plasma 5-250 ng/mL EDTA (DEQAS certified) 3-Ketodesogestrel Human plasma 0.05-10 ng/mL EDTA Acetaminophen Human plasma 200-10000 ng/mL EDTA Acetazolamine Human plasma 50-20000 ng/mL EDTA Acetylsalicylic Acid Human plasma 5-2000 ng/mL Fluoride/Oxalate 20-8000 ng/mL Acetylsalicylic Acid, Salicylic acid and Human plasma 80-32000 ng/mL Fluoride/Oxalate Butalbital 10-4000 ng/mL Afatinib Human plasma 0.1-50 ng/mL EDTA Albuterol Human plasma 0.25-50 ng/mL EDTA Page 1 of 28 Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays For further information on our validated assays, please contact your Business development representative or via [email protected] Compound (Metabolite) Species/Matrix Range Anticoagulant Alendronate Human urine 1-200 ng/mL N/A Alfuzosin Human plasma 0.15-30 ng/mL EDTA Aliskiren Human plasma 1-500 ng/mL EDTA Alprazolam Human plasma 0.25-25 ng/mL EDTA Amlodipine Human plasma 0.1-15 ng/mL EDTA Anagrelide Human plasma 0.05-11 ng/mL EDTA 0.5-150 ng/mL D,L-Amphetamine Human plasma EDTA 0.25-30 ng/mL Anastrazole Human plasma 0.1-20 ng/mL EDTA Aripiprazole Human plasma 0.5-100 ng/mL EDTA Asenapine Human plasma 0.05-20 ng/mL EDTA Asoxime Human plasma 0.1-30 µg/mL EDTA Asoxime Human urine 1-300 µg/mL N/A Page 2 of 28 Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays For further information on our validated assays, please contact your Business development representative or via [email protected] Compound (Metabolite) Species/Matrix Range Anticoagulant Atomoxetine Human plasma 2-2000 ng/mL EDTA 0.15-150 ng/mL Atorvastatin, O-Hydroxy-Atorvastatin and Human plasma 0.15-150 ng/mL EDTA P-Hydroxy-Atorvastatin) 0.1-15 ng/mL 0.02-20 ng/mL Atorvastatin, O-Hydroxy-Atorvastatin and Human plasma 0.02-20 ng/mL EDTA P-Hydroxy-Atorvastatin 0.01-1.5 ng/mL Atorvastatin Human plasma 0.25-200 ng/mL EDTA Atovaquone Human plasma 50-25000 ng/mL EDTA 5-1000 ng/mL Benazepril and Benazeprilat Human plasma EDTA 7.5-1500 ng/mL 0.5-200 ng/mL Bexarotene Human plasma EDTA 1-500 ng/mL Betamethasone Human plasma 0.5-250 ng/mL Heparin Bezafibrate Human plasma 15-5000 ng/mL EDTA Bicalutamide Human plasma 10-1000 ng/mL EDTA Bicalutamide Chiral S and R form 4-300 ng/mL Human plasma EDTA 16-1200 ng/mL Page 3 of 28 Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays For further information on our validated assays, please contact your Business development representative or via [email protected] Compound (Metabolite) Species/Matrix Range Anticoagulant Bisoprolol Human plasma 1-100 ng/mL EDTA 0.04-8 ng/mL Buprenorphine and Norbuprenorphine Human plasma EDTA 0.02-4 ng/mL 2.5-500 ng/mL Bupropion, Hydroxybupropion, Erythro- 12.5-2500 ng/mL Hydroxybupropion and Threo- Human plasma EDTA 4-800 ng/mL Hydroxybupropion 8-1600 ng/mL 1-200 ng/mL Buproprion and hydroxybupropion Human plasma EDTA 4-800 ng/mL Calcifediol Human plasma 5-250 ng/mL EDTA Calcitriol Human plasma 10-200 pg/mL EDTA Carbamazepine and Carbamazepine 10,11- 25-5000 ng/mL Human plasma EDTA epoxide 1.25-250 ng/mL 1-250 ng/mL Carbidopa and Levodopa Human plasma 8-2000 ng/mL EDTA 2-400 ng/mL Carbidopa and Levodopa Human plasma Fluoride/Oxalate 10-2000 ng/mL 0.5-200 ng/mL Carbidopa, Levodopa and Etilevodopa Human plasma 6.25-2500 ng/mL Fluoride/Oxalate 0.05-20 ng/mL Page 4 of 28 Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays For further information on our validated assays, please contact your Business development representative or via [email protected] Compound (Metabolite) Species/Matrix Range Anticoagulant 10-2500 ng/mL Carisoprodol and Meprobamate Human plasma EDTA 10-2500 ng/mL 5-2500 ng/mL Carisoprodol and Meprobamate Dog plasma EDTA 5-2500 ng/mL 0.5-100 ng/mL Carvedilol and 4-Hydroxyphenyl Carvedilol Human plasma EDTA 0.1-10 ng/mL 0.25-50 ng/mL Carvedilol and 4-Hydroxyphenyl Carvedilol Human plasma EDTA 0.05-10 ng/mL Cellulose acetate butyrate Mini Pig plasma 20-200 µg/mL EDTA Cellulose acetate butyrate Rat plasma 20-200 µg/mL EDTA Chlorambucil and Phenylacetic Acid 5-1600 ng/mL Human serum N/A Mustard 5-1600 ng/mL 0.1-15 ng/mL Cholecalciferol (Vitamin D3), Calcitriol and Human serum 0.01-1.5 ng/mL N/A Calcifediol (25-hydroxy-vitamin D3) 2-300 ng/mL Cholecalciferol (Vitamin D3) Human plasma 0.1-30 ng/mL EDTA 50-8000 ng/mL Ciprofloxacin and Gatifloxacin Human plasma EDTA 50-8000 ng/mL Ciprofloxacin Human plasma 30-6000 ng/mL EDTA Page 5 of 28 Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays For further information on our validated assays, please contact your Business development representative or via [email protected] Compound (Metabolite) Species/Matrix Range Anticoagulant Clarithromycin Human plasma 15-6000 ng/mL EDTA Clarithromycin Human plasma 10-2000 ng/mL EDTA Clonidine Human plasma 1-200 pg/mL EDTA Clonidine Human plasma 10-2000 pg/mL EDTA Clonidine Rabbit plasma 10-2000 pg/mL EDTA 0.5-125 ng/mL Codeine and Caffeine Human plasma EDTA 10-2500 ng/mL Cyclobenzaprine Human plasma 0.05-20 ng/mL EDTA Cyclobenzaprine Human plasma 0.1-40 ng/mL EDTA Cyproterone Acetate Human plasma 0.9-180 ng/mL EDTA Cyproterone Acetate Human plasma 0.25-50 ng/mL EDTA Danazol Human plasma 0.8-200 ng/mL EDTA Darifenacin Human plasma 0.05-10 ng/mL EDTA Page 6 of 28 Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays For further information on our validated assays, please contact your Business development representative or via [email protected] Compound (Metabolite) Species/Matrix Range Anticoagulant Dasatinib Human plasma 0.5-200 ng/mL EDTA 25-6250 pg/mL Desloratadine and 3-Hydroxy-Desloratadine Human plasma EDTA 12-3000 pg/mL Dexmethylphenidate Human plasma 0.15-45 ng/mL EDTA Dexmethylphenidate Human plasma 0.1-30 ng/mL EDTA Diclofenac Human plasma 8-4000 ng/mL EDTA Didanosine Human plasma 10-1500 ng/mL EDTA Dienogest Human plasma 0.5-150 ng/mL EDTA 1.5-500 ng/mL Diltiazem, N-Desmethyl Diltiazem and Human plasma 0.3-100 ng/mL EDTA Desacetyl Diltiazem 0.15-50 ng/mL Dipyridamole Human plasma 10-4000 ng/mL Fluoride/Oxalate Donepezil Human plasma 0.1-20 ng/mL EDTA 0.5-50 ng/mL Donepezil and Memantine Human plasma EDTA 0.5-50 ng/mL Doxazosin Human plasma 0.5-125 ng/mL EDTA Page 7 of 28 Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays For further information on our validated assays, please contact your Business development representative or via [email protected] Compound (Metabolite) Species/Matrix Range Anticoagulant Doxercalciferol and Ercalcitriol Human serum 2-80 pg/mL N/A 2-80 pg/mL Doxercalcifero and Ercalcitriol Human plasma EDTA 2-80 pg/mL Doxycycline Human plasma 5-1000 ng/mL EDTA 0.5-150 ng/mL Doxylamine and Pyridoxine Human plasma EDTA 0.25-100 ng/mL Drospirenone Human plasma 0.5-150 ng/mL EDTA Drospirenone Human plasma 0.075-30 ng/mL EDTA Elesclomol and Metabolites Human plasma 1-1000 ng/mL Heparin 0.5-125 ng/mL Enalapril and Enalaprilat Human plasma EDTA 0.25-62.5 ng/mL Entacapone Human Plasma 25-2500 ng/mL EDTA Enzalutamide Human Plasma 20-8000 ng/mL EDTA 0.5-250 ng/mL EPA ethyl ester and DHA ethyl ester Human plasma EDTA 0.5-250 ng/mL 1.6 -120 µg/mL EPA Total and DHA Total Human plasma EDTA 8-200 µg/mL Page 8 of 28 Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays For further information on our validated assays, please contact your Business development representative or via [email protected] Compound (Metabolite) Species/Matrix Range Anticoagulant EPA ethyl ester Human plasma 1-1000 ng/mL EDTA Esomeprazole Human plasma 4-2000 ng/mL EDTA Ethinyl estradiol Human plasma 2-500 pg/mL EDTA Estradiol Free Human plasma 1-150 pg/mL EDTA Estradiol Total Human serum 2-400 pg/mL N/A 4-300 pg/mL Estrone Free and Equilin Free Human plasma EDTA 2-150 pg/mL 10-1000 pg/mL Estrone Free and Estradiol Free Human plasma EDTA 2-200 pg/mL 5-1000 pg/mL Estrone Free, Equilin Free and Delta 8,9- Human plasma 2-400 pg/mL EDTA Dehydroestrone 2-400 pg/mL 4-300 pg/mL Estrone Free, Estradiol Free, Equilin Free 2-150 pg/mL Human plasma EDTA and Dihydroequilin Free 2-150 pg/mL 2-150 pg/mL Human plasma 50-10000 pg/mL EDTA Estrone Total and Equilin Total 50-10000 pg/mL Page 9 of 28 Biotrial Bioanalytical Services Inc.
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