Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
15-Hydroxy Lubiprostone Human plasma 1-150 pgmL EDTA 15-Hydroxy Lubiprostone 35-7000 pg/mL Rat plasma EDTA Lubiprostone 35-7000 pg/mL 17-Desacetyl-Norgestimate Human plasma 50-5000 pg/mL EDTA 25-Hydroxy-vitamin D2 (Calciferol) Human plasma 5-250 ng/mL EDTA (DEQAS certified) 25-Hydroxy-vitamin D3 (Calcifediol) Human plasma 5-250 ng/mL EDTA (DEQAS certified) 3-Ketodesogestrel Human plasma 0.05-10 ng/mL EDTA
Acetaminophen Human plasma 200-10000 ng/mL EDTA
Acetazolamine Human plasma 50-20000 ng/mL EDTA
Acetylsalicylic Acid Human plasma 5-2000 ng/mL Fluoride/Oxalate 20-8000 ng/mL Acetylsalicylic Acid, Salicylic acid and Human plasma 80-32000 ng/mL Fluoride/Oxalate Butalbital 10-4000 ng/mL Afatinib Human plasma 0.1-50 ng/mL EDTA
Albuterol Human plasma 0.25-50 ng/mL EDTA
Page 1 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Alendronate Human urine 1-200 ng/mL N/A
Alfuzosin Human plasma 0.15-30 ng/mL EDTA
Aliskiren Human plasma 1-500 ng/mL EDTA
Alprazolam Human plasma 0.25-25 ng/mL EDTA
Amlodipine Human plasma 0.1-15 ng/mL EDTA
Anagrelide Human plasma 0.05-11 ng/mL EDTA 0.5-150 ng/mL D,L-Amphetamine Human plasma EDTA 0.25-30 ng/mL Anastrazole Human plasma 0.1-20 ng/mL EDTA
Aripiprazole Human plasma 0.5-100 ng/mL EDTA
Asenapine Human plasma 0.05-20 ng/mL EDTA
Asoxime Human plasma 0.1-30 µg/mL EDTA
Asoxime Human urine 1-300 µg/mL N/A
Page 2 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Atomoxetine Human plasma 2-2000 ng/mL EDTA 0.15-150 ng/mL Atorvastatin, O-Hydroxy-Atorvastatin and Human plasma 0.15-150 ng/mL EDTA P-Hydroxy-Atorvastatin) 0.1-15 ng/mL 0.02-20 ng/mL Atorvastatin, O-Hydroxy-Atorvastatin and Human plasma 0.02-20 ng/mL EDTA P-Hydroxy-Atorvastatin 0.01-1.5 ng/mL Atorvastatin Human plasma 0.25-200 ng/mL EDTA
Atovaquone Human plasma 50-25000 ng/mL EDTA 5-1000 ng/mL Benazepril and Benazeprilat Human plasma EDTA 7.5-1500 ng/mL 0.5-200 ng/mL Bexarotene Human plasma EDTA 1-500 ng/mL Betamethasone Human plasma 0.5-250 ng/mL Heparin
Bezafibrate Human plasma 15-5000 ng/mL EDTA
Bicalutamide Human plasma 10-1000 ng/mL EDTA Bicalutamide Chiral S and R form 4-300 ng/mL Human plasma EDTA 16-1200 ng/mL
Page 3 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Bisoprolol Human plasma 1-100 ng/mL EDTA 0.04-8 ng/mL Buprenorphine and Norbuprenorphine Human plasma EDTA 0.02-4 ng/mL 2.5-500 ng/mL Bupropion, Hydroxybupropion, Erythro- 12.5-2500 ng/mL Hydroxybupropion and Threo- Human plasma EDTA 4-800 ng/mL Hydroxybupropion 8-1600 ng/mL 1-200 ng/mL Buproprion and hydroxybupropion Human plasma EDTA 4-800 ng/mL Calcifediol Human plasma 5-250 ng/mL EDTA
Calcitriol Human plasma 10-200 pg/mL EDTA Carbamazepine and Carbamazepine 10,11- 25-5000 ng/mL Human plasma EDTA epoxide 1.25-250 ng/mL 1-250 ng/mL Carbidopa and Levodopa Human plasma 8-2000 ng/mL EDTA 2-400 ng/mL Carbidopa and Levodopa Human plasma Fluoride/Oxalate 10-2000 ng/mL 0.5-200 ng/mL Carbidopa, Levodopa and Etilevodopa Human plasma 6.25-2500 ng/mL Fluoride/Oxalate 0.05-20 ng/mL
Page 4 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant 10-2500 ng/mL Carisoprodol and Meprobamate Human plasma EDTA 10-2500 ng/mL 5-2500 ng/mL Carisoprodol and Meprobamate Dog plasma EDTA 5-2500 ng/mL 0.5-100 ng/mL Carvedilol and 4-Hydroxyphenyl Carvedilol Human plasma EDTA 0.1-10 ng/mL 0.25-50 ng/mL Carvedilol and 4-Hydroxyphenyl Carvedilol Human plasma EDTA 0.05-10 ng/mL Cellulose acetate butyrate Mini Pig plasma 20-200 µg/mL EDTA
Cellulose acetate butyrate Rat plasma 20-200 µg/mL EDTA Chlorambucil and Phenylacetic Acid 5-1600 ng/mL Human serum N/A Mustard 5-1600 ng/mL 0.1-15 ng/mL Cholecalciferol (Vitamin D3), Calcitriol and Human serum 0.01-1.5 ng/mL N/A Calcifediol (25-hydroxy-vitamin D3) 2-300 ng/mL
Cholecalciferol (Vitamin D3) Human plasma 0.1-30 ng/mL EDTA 50-8000 ng/mL Ciprofloxacin and Gatifloxacin Human plasma EDTA 50-8000 ng/mL Ciprofloxacin Human plasma 30-6000 ng/mL EDTA
Page 5 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Clarithromycin Human plasma 15-6000 ng/mL EDTA
Clarithromycin Human plasma 10-2000 ng/mL EDTA
Clonidine Human plasma 1-200 pg/mL EDTA
Clonidine Human plasma 10-2000 pg/mL EDTA
Clonidine Rabbit plasma 10-2000 pg/mL EDTA 0.5-125 ng/mL Codeine and Caffeine Human plasma EDTA 10-2500 ng/mL Cyclobenzaprine Human plasma 0.05-20 ng/mL EDTA
Cyclobenzaprine Human plasma 0.1-40 ng/mL EDTA
Cyproterone Acetate Human plasma 0.9-180 ng/mL EDTA
Cyproterone Acetate Human plasma 0.25-50 ng/mL EDTA
Danazol Human plasma 0.8-200 ng/mL EDTA
Darifenacin Human plasma 0.05-10 ng/mL EDTA
Page 6 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Dasatinib Human plasma 0.5-200 ng/mL EDTA 25-6250 pg/mL Desloratadine and 3-Hydroxy-Desloratadine Human plasma EDTA 12-3000 pg/mL Dexmethylphenidate Human plasma 0.15-45 ng/mL EDTA
Dexmethylphenidate Human plasma 0.1-30 ng/mL EDTA
Diclofenac Human plasma 8-4000 ng/mL EDTA
Didanosine Human plasma 10-1500 ng/mL EDTA
Dienogest Human plasma 0.5-150 ng/mL EDTA 1.5-500 ng/mL Diltiazem, N-Desmethyl Diltiazem and Human plasma 0.3-100 ng/mL EDTA Desacetyl Diltiazem 0.15-50 ng/mL Dipyridamole Human plasma 10-4000 ng/mL Fluoride/Oxalate
Donepezil Human plasma 0.1-20 ng/mL EDTA 0.5-50 ng/mL Donepezil and Memantine Human plasma EDTA 0.5-50 ng/mL Doxazosin Human plasma 0.5-125 ng/mL EDTA
Page 7 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Doxercalciferol and Ercalcitriol Human serum 2-80 pg/mL N/A 2-80 pg/mL Doxercalcifero and Ercalcitriol Human plasma EDTA 2-80 pg/mL Doxycycline Human plasma 5-1000 ng/mL EDTA 0.5-150 ng/mL Doxylamine and Pyridoxine Human plasma EDTA 0.25-100 ng/mL Drospirenone Human plasma 0.5-150 ng/mL EDTA
Drospirenone Human plasma 0.075-30 ng/mL EDTA
Elesclomol and Metabolites Human plasma 1-1000 ng/mL Heparin 0.5-125 ng/mL Enalapril and Enalaprilat Human plasma EDTA 0.25-62.5 ng/mL Entacapone Human Plasma 25-2500 ng/mL EDTA
Enzalutamide Human Plasma 20-8000 ng/mL EDTA 0.5-250 ng/mL EPA ethyl ester and DHA ethyl ester Human plasma EDTA 0.5-250 ng/mL 1.6 -120 µg/mL EPA Total and DHA Total Human plasma EDTA 8-200 µg/mL
Page 8 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
EPA ethyl ester Human plasma 1-1000 ng/mL EDTA
Esomeprazole Human plasma 4-2000 ng/mL EDTA
Ethinyl estradiol Human plasma 2-500 pg/mL EDTA
Estradiol Free Human plasma 1-150 pg/mL EDTA
Estradiol Total Human serum 2-400 pg/mL N/A 4-300 pg/mL Estrone Free and Equilin Free Human plasma EDTA 2-150 pg/mL 10-1000 pg/mL Estrone Free and Estradiol Free Human plasma EDTA 2-200 pg/mL 5-1000 pg/mL Estrone Free, Equilin Free and Delta 8,9- Human plasma 2-400 pg/mL EDTA Dehydroestrone 2-400 pg/mL 4-300 pg/mL Estrone Free, Estradiol Free, Equilin Free 2-150 pg/mL Human plasma EDTA and Dihydroequilin Free 2-150 pg/mL 2-150 pg/mL Human plasma 50-10000 pg/mL EDTA Estrone Total and Equilin Total 50-10000 pg/mL
Page 9 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant 50-10000 pg/mL Estrone Total, Equilin Total and Delta 8,9- Rabbit plasma 50-10000 pg/mL EDTA Dehydroestrone 15-3000 pg/mL Estrone Total Human serum 0.15-75 ng/mL N/A
Ethoxutimide Human plasma 0.1-10 ng/mL EDTA
Etidronate Human plasma 10-2000 ng/mL Heparin
Ezetimibe Free Human plasma 0.05-10 ng/mL EDTA
Ezetimibe Total Human plasma 0.5-150 ng/mL EDTA
Felodipine Human plasma 10-5000 pg/mL EDTA
Fenofibric Acid Rat plasma 10-10000 ng/mL EDTA
Fenofibric Acid Human plasma 50-15000 ng/mL EDTA
Fentanyl Human plasma 0.01-1.5 ng/mL EDTA 1-400 ng/mL Fexofenadine and Pseudoephedrine Human plasma EDTA 1.5-600 ng/mL 0.05-10 ng/mL Fidaxomicin and Desisobutyryl Fidaxomicin Human plasma Fluoride/Oxalate 0.05-20 ng/mL
Page 10 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Finasteride Human plasma 0.5-50 ng/mL EDTA
Finasteride Human plasma 0.1-10 ng/mL EDTA
Fluticasone Propionate Human plasma 1-200 pg/mL Fluoride/Oxalate
Fosinoprilat Human plasma 5-750 ng/mL EDTA
Gabapentin Human plasma 50-10000 ng/mL EDTA
Galanthamine Human plasma 0.1-30 ng/mL EDTA 70-12600 ng/mL Ganciclovir and Valganciclovir Human plasma EDTA 5-900 ng/mL 50-8000 ng/mL Gatifloxacin and Ciprofloxacin Human plasma EDTA 50-8000 ng/mL Glimepiride Human plasma 1-500 ng/mL EDTA
Glipizide Human plasma 10-1500 ng/mL EDTA
Glyburide Human plasma 2.5-300 ng/mL EDTA
Guanfacine Human plasma 40-8000 pg/mL EDTA
Page 11 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Guaifenesin Human plasma 30-6000 ng/mL EDTA
Hydrochlorothiazide Human plasma 1.5 -250 ng/mL EDTA
Hydrochlorothiazide Human plasma 3-500 ng/mL EDTA
Hydrocodone Human plasma 0.2-50 ng/mL EDTA
Hydrocortisone Human plasma 10-1000 ng/mL EDTA
Hydromorphone Human plasma 20-6000 pg/mL EDTA
Ibuprofen Human plasma 0.2-40 µg/mL EDTA 5-2000 ng/mL Iacvita and Tempol Rat plasma EDTA 5-2000 ng/mL Irbesartan Human plasma 30-6000 ng/mL EDTA
Isradipine Human plasma 0.05-10 ng/mL EDTA 1-400 ng/mL Itraconazole and Hydroxy-Itraconazole Human plasma EDTA 1.25-500 ng/mL 0.1-20 ng/mL Ivabradine and N-Desmethyl Ivabradine Human plasma EDTA 0.05-10 ng/mL
Page 12 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant 0.5-500 ng/mL Chiral Ketamine and Norketamine Human plasma EDTA 0.5-500 ng/mL 0.5-500 ng/mL Chiral Ketamine, Norketamine and Dog plasma 0.5-500 ng/mL EDTA Dehydronorketamine 0.5-500 ng/mL Ketoprofen Racemic Human plasma 50-10000 ng/mL EDTA
Lansoprazole Human plasma 3-3000 ng/mL EDTA
Letrozole Human plasma 1-200 ng/mL EDTA
Levetiracetam Human plasma 0.25-50 µg/mL EDTA
Levofloxacin Rabbit plasma 0.1-12 ng/mL Heparin
Levomefolate Chiral Human plasma 1-100 ng/mL EDTA
Levonorgestrel Human plasma 0.15-15 ng/mL EDTA
Levonorgestrel Human plasma 0.25-40 ng/mL EDTA
Levonorgestrel Human plasma 0.08-5 ng/mL EDTA 0.25-100 ng/mL Lisdexamfetamine and D-Amphetamine Human plasma EDTA 1.25-125 ng/mL
Page 13 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Lisinopril Human plasma 1-200 ng/mL EDTA 0.04-10 ng/mL Loratadine and Descarboethoxyloratadine Human plasma EDTA 0.04-10 ng/mL Lorazepam Human plasma 0.3-45 ng/mL EDTA
Losartan Human plasma 6-1200 ng/mL EDTA
Medroxyprogesterone 17-Acetate Human plasma 0.025-10 ng/mL EDTA
Meloxicam Dog plasma 5-1000 ng/mL EDTA
Meloxicam Human plasma 10-2000 ng/mL EDTA 0.5-50 ng/mL Memantine and Donepezil Human plasma EDTA 0.5-50 ng/mL 1-1500 ng/mL Mesalamine and N-acethylmesalamine Human plasma EDTA 1-1500 ng/mL Mesalamine Human plasma 14-3500 ng/mL EDTA
Mesalamine Human plasma 7-1750 ng/mL EDTA
Metformin Human plasma 25-3000 ng/mL EDTA
Page 14 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant 25-3000 ng/mL Metformin and Sitagliptin Human plasma EDTA 5-1000 ng/mL Methylphenidate Human plasma 0.05-15 ng/mL EDTA
Methylphenidate Human plasma 0.1-30 ng/mL EDTA 5-1500 ng/mL Metopimazine and Metopimazine Acid Human plasma EDTA 10-3000 ng/mL 1-2000 ng/mL Metopimazine and Metopimazine Acid Human urine N/A 10-60000 ng/mL 1-300 ng/mL Metopimazine , Metopimazine Acid and Human plasma 5-1500 ng/mL EDTA Metopimazine Sulfoxide 1-300 ng/mL Metoprolol Human plasma 0.5-500 ng/mL EDTA
Metoprolol Human plasma 0.1-25 ng/mL EDTA 0.05-50 ng/mL Midazolam and 1’-Hydroxymidazolam Human plasma EDTA 0.05-25 ng/mL Minocycline Human plasma 10-1000 ng/mL EDTA
Mirtazepine Human plasma 0.1-60 ng/mL EDTA
Misoprostol Acid Human plasma 10-1250 pg/mL EDTA
Page 15 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Misoprostol Acid Human plasma 2-800 pg/mL EDTA
Monomethyl Fumarate Human plasma 20-4000 ng/mL Fluoride/Oxalate 0.8-80 ng/mL Morphine and Morphine-6β-D-Glucuronide Human plasma EDTA 4-400 ng/mL 0.5-50 ng/mL Morphine and Morphine-6β-D-Glucuronide Human plasma EDTA 2.5-250 ng/mL 0.1-30 ng/mL Morphine , Morphine-6β-D-Glucuronide and Human plasma 0.5-150 ng/mL EDTA Oxycodone 0.1-30 ng/mL Moxifloxacin Human plasma 25-6000 ng/mL EDTA
Mycophenolate Mofetil Human plasma 20-4000 pg/mL Fluoride/Oxalate
Mycophenolic Acid Human plasma 100-20000 ng/mL Fluoride/Oxalate 1-1000 pg/mL Naltrexone and 6-β-Naltrexol Human plasma EDTA 0.5-500 pg/mL Naproxen Human plasma 1.5-150 µg/mL EDTA
Naproxen Human plasma 1-100 µg/mL EDTA
Naratriptan Human serum 0.075-15 ng/mL N/A
Page 16 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant 1-500 ng/mL Nefopam and N-Desmethylnefopam Human plasma 1-500 ng/mL EDTA
1-500 ng/mL Nefopam, N-Desmethylnefopam and Human plasma 1-500 ng/mL EDTA N-Oxidenefopam 1-500 ng/mL 1-500 ng/mL Nefopam, N-Desmethylnefopam and Human urine 1-500 ng/mL N/A N-Oxidenefopam 1-500 ng/mL 10-6000 ng/mL Niacin and Nicotinuric Acid Human plasma EDTA 10-3000 ng/mL Nicotine Human plasma 1-50 ng/mL EDTA
Nicotine Human plasma 0.2-15 ng/mL EDTA
Nomegestrol Acetate Human plasma 0.1-15 ng/mL Fluoride/Oxalate
Norethindrone Human plasma 0.2-25 ng/mL EDTA
Norethindrone Human plasma 0.4-50 ng/mL EDTA
Norgestrel Human plasma 0.08-10 ng/mL EDTA
Norgestrel Human plasma 0.15-15 ng/mL EDTA
Page 17 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Olanzapine Human plasma 0.1-15 ng/mL Heparin
Omeprazole Human plasma 1-1000 ng/mL EDTA 0.5-100 ng/mL Oseltamivir and Oseltamivir Carboxylic Acid Human plasma Fluoride/Oxalate 2-400 ng/mL Oxcarbazepine and 10,11 Dihydro-10- 20-6000 ng/mL Human plasma EDTA Dihydrooxcarbazepine 50-15000 ng/mL Oxybutynin Dog plasma 0.2-10 ng/mL EDTA 1-500 ng/mL Oxybutynin and Desethyloxybutynin Dog plasma EDTA 1-500 ng/mL Oxycodone Human plasma 0.3-75 ng/mL EDTA Oxymorphone and 20-5000 pg/mL Human plasma EDTA 6β-Hydroxyoxymorphone 10-2500 pg/mL Paracalcitol Human plasma 10-1000 pg/mL EDTA
Paracalcitol Human plasma 5-500 pg/mL EDTA
Paroxetine Human plasma 0.1-60 ng/mL EDTA
Pazopanib Human plasma 0.5-100 µg/mL EDTA
Page 18 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Phentermine Human plasma 1-200 ng/mL EDTA
Posaconazole Human plasma 2-1000 ng/mL Fluoride/Oxalate 40-2000 pg/mL Pramlintide and DesLyspramlintide Human plasma EDTA 40-2000 pg/mL Pravastatin Human plasma 0.5-500 ng/mL EDTA
Praziquantel Human plasma 5-1500 ng/mL EDTA
Progesterone Human plasma 0.1-150 ng/mL EDTA
Progesterone Human plasma 0.05-30 ng/mL EDTA
Progesterone Dog plasma 0.2-300 ng/mL EDTA 0.2-300 ng/mL Propafenone and 5-Hydroxy Propafenone Human plasma EDTA 0.1-150 ng/mL Propranolol Free Human plasma 1-500 ng/mL EDTA 2-500 ng/mL Propranolol Total and 4-OH Propanolol Human plasma EDTA 0.5-150 ng/mL Propoxyphene Human plasma 0.25-100 ng/mL EDTA
Page 19 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant Pseudoephidrine Human plasma 1.5-600 ng/mL EDTA
Pyridostigmine Human plasma 1-200 ng/mL EDTA 0.5-200 ng/mL Pyridoxal and Pyridoxal-5-Phosphate Human plasma EDTA 2.5-200 ng/mL Quetiapine Human Plasma 4-1000 ng/mL EDTA
Rabeprazole Human Plasma 1-500 ng/mL EDTA 5-1250 pg/mL Raloxifene, Raloxifene-4-Glucuronide and Human plasma 2-500 ng/mL EDTA Raloxifene-6-Glucuronide 0.3-75 ng/mL Ramipril Human plasma 0.2-80 ng/mL EDTA
Ranolazine Human plasma 10-4000 ng/mL EDTA 0.015-10 ng/mL Rasagiline and 1-Aminoindan Human plasma EDTA 0.125-10 ng/mL Rasagiline Dog plasma 0.2-500 ng/mL EDTA
Repaglinide Human plasma 0.2-60 ng/mL EDTA
Risedronic acid Human plasma 0.2-150 ng/mL EDTA
Page 20 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Risperidone Human plasma 0.05-10 ng/mL EDTA
Rivastigmine Human plasma 0.2-60 ng/mL Fluoride/Oxalate
Rivastigmine Human plasma 0.02-6 ng/mL Fluoride/Oxalate
Ropinirole Human plasma 10-2000 pg/mL EDTA
Rosiglitazone Human plasma 2-900 ng/mL EDTA
Rotigotine Human plasma 2-400 pg/mL EDTA
Sertraline Human plasma 0.25-75 ng/mL EDTA
Scopolamine Human plasma 1-300 pg/mL Fluoride/Oxalate 0.25-100 ng/mL Sirolimus and Tacrolimus Human blood EDTA 0.1-40 ng/mL 0.1-50 ng/mL Simvastatin and Simvastatin Hydroxy Acid Human plasma EDTA 0.1-20 ng/mL Sotalol Human plasma 20-2000 ng/mL EDTA
Spironolactone Human Plasma 0.5-150 ng/mL Fluoride/Oxalate
Page 21 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Compound (Metabolite) Species/Matrix Range Anticoagulant
Sumatriptan Human plasma 0.5-100 ng/mL EDTA
Tadalafil Human plasma 4-600 ng/mL EDTA
Tamsulosin Human plasma 0.25-50 ng/mL EDTA
Tapentadol Human plasma 0.5-200 ng/mL EDTA
Telmisartan Human plasma 4-1000 ng/mL EDTA
Terbinafine Human plasma 1-2000 ng/mL EDTA
Theophylline Human plasma 2-500 ng/mL Fluoride/Oxalate
Tofacitinib Human plasma 0.5-100 ng/mL EDTA
Topiramate Human plasma 25-2500 ng/mL EDTA
Topiramate Human plasma 5-500 ng/mL EDTA 2-1000 ng/mL Tramadol and O- Desmethyl-Tramadol Pig serum N/A 1-500 ng/mL 1-200 ng/mL Tramadol and O-Desmethyl-Tramadol Human plasma EDTA 0.2-40 ng/mL
Page 22 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
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Compound (Metabolite) Species/Matrix Range Anticoagulant 10-1000 ng/mL Tramadol and O-Desmethyl-Tramadol Human plasma EDTA 1.25-250 ng/mL Trientine and N1-Acetyl 4-600 ng/mL Human plasma EDTA Triethylenetetramine 4-600 ng/mL 1-400 ng/mL Trimebutine and N-Desmethyl Trimebutine Human plasma EDTA 12.5-5000 ng/mL Trimetazidine Dog plasma 0.075-200 µg/mL EDTA
Trimetazidine Human plasma 10-1000 ng/mL EDTA
Trimetazidine Human urine 0.2-200 µg/mL N/A
Trimetazidine Rat plasma 0.1-200 µg/mL EDTA
Thiostrepton Human plasma 1-2000 ng/mL EDTA
Thiostrepton Human pleural fluid 1-2000 ng/mL N/A
Valproic Acid Human plasma 1-200 µg/mL EDTA
Valsartan Human plasma 10-2500 ng/mL EDTA 2.5-750 ng/mL Venlafaxine and O-Desmethyl Venlafaxine Human plasma EDTA 2.5-750 ng/mL
Page 23 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
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Compound (Metabolite) Species/Matrix Range Anticoagulant 1-300 ng/mL Verapamil and Norverapamil Human plasma EDTA 1-300 ng/mL Voriconazole Human plasma 10-2500 ng/mL EDTA
Ziprasidone Human serum 0.4-80 ng/mL N/A
Zolmitriptan Human plasma 40-8000 pg/mL EDTA 150-30000 ng/mL Zolmitriptan and N-Desmethylzolmitriptan Rat plasma EDTA 15-3000 ng/mL Zolpidem Human plasma 1-250 ng/mL EDTA
Zolpidem Human plasma 0.25-62.5 ng/mL EDTA
Page 24 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Qualified Bioanalytical Assays and Under Development
Qualified Under Species/Matrix Range Anticoagulant Compound development Exenatide √ Beagle plasma 20-10000 pg/mL EDTA
Exenatide γ Pig plasma 20-10000 pg/mL EDTA
Exenatide √ Human plasma 20-20000 pg/mL EDTA
Apremilast √ Human plasma 2.5-1000 ng/mL EDTA
Bosutinib √ Human plasma 0.1-40 ng/mL EDTA
Carbocysteine √ Human plasma 0.15-15 µg/mL EDTA
Cinacalcet √ Human plasma 0.25-50 ng/mL EDTA Clobazam and N- √ 2-800 ng/mL Human plasma EDTA Desmethylclobazam 0.5-200 ng/mL Clodronic Acid √ Human plasma 5-500 ng/mL EDTA
Clopidogrel √ Human plasma 5-1500 pg/mL EDTA Diosmetin Total and √ 2.8-1000 ng/mL Human plasma EDTA Hesperetin Total 2.9-1000 ng/mL
Page 25 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Entecavir √ Human plasma 0.1-15 ng/mL EDTA
Ergocalciferol √ Human plasma 0.1-30 ng/mL EDTA
Everolimus √ Dried Blood Spots 1-50 ng/mL N/A
Fulvestrant √ Rat plasma 0.5-50 ng/mL EDTA
Genistein √ Rat plasma 1-1000 ng/mL Fluoride/Oxalate √ Human plasma EDTA Ibandronate 0.4-200 ng/mL Human serum N/A Imatinib √ Human plasma 100-7000 ng/mL Heparin
Mefenamic Acid √ Human plasma 5-5000 ng/mL EDTA
Methotrexate √ Human plasma 0.3-150 µg/mL EDTA
Nifedipine √ Human plasma 0.5-200 ng/mL EDTA √ Human plasma Nilotinib 1-500 ng/mL EDTA White cells Nefopam, N- 1-500 ng/mL Desmethylnefopam √ Human plasma 1-500 ng/mL EDTA and N-Oxide Nefopam 1-500 ng/mL Paclitaxel √ Human plasma 30-12000 ng/mL EDTA
Page 26 of 28
Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Sildenafil and N- √ 1-500 ng/mL Human plasma EDTA Desmethyl Sildenafil 0.5-250 ng/mL Peptide SOR C13 √ Dog plasma 10-2000 ng/mL Heparin
Sunitinib √ Human plasma 0.3-150 ng/mL EDTA
Tartaric Acid √ Human plasma 5-100 ng/mL EDTA
Temozolomide √ Human plasma 0.1-15 µg/mL EDTA
Tenofovir √ Human plasma 5-600 ng/mL EDTA
Teriflunomide √ Human plasma 25-4000 ng/mL EDTA
Trospium Chloride √ Human plasma 0.1-10 ng/mL EDTA 10-4000 ng/mL Ursodiol, Tauroursodiol √ Human plasma 2-800 ng/mL EDTA and Glycoursodiol 20-8000 ng/mL √ Human Whole Vinorelbine 1-300 ng/mL Fluoride/Oxalate Blood
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Biotrial Bioanalytical Services Inc. Global List of Validated Bioanalytical Assays
For further information on our validated assays, please contact your Business development representative or via [email protected]
Latest update: 9-July-2020 Update by: Laurentiu Ciochina Directeur - R&D Director - R&D Tel: +1 450 663 6724 ext: 6419 Cellular +1 514 618 6142 [email protected] www.biotrial.com
BIOTRIAL BIOANALYTICAL SERVICES SOLUTION
A fit-for-purpose flexible analyte profiling, screening, identification, quantification, toxicokinetics, drug metabolism and pharmacokinetics screening cascade to support your medicinal chemistry and bioscience innovative compound efforts. Access to a complete array of standard in vivo and in vitro services at worldwide competitive prices. Experienced R&D Scientists can guide you through the discovery process from planning to data delivery for all your innovator drug needs. Method development and validation for small and large molecule assays for the analysis of drugs, metabolites, and biomarkers in a broad range of biological fluids.
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