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Annual Report 2013 Institute for Surgical Research 2 Annual report 2013 Institute for Surgical Research 2 Photo: Øystein H. Horgmo, UiO “Odyssé hender i Paris” Jenny Alnæs Institute for Surgical Research Division of Cardiovascular and Pulmonary Diseases Oslo University Hospital P.O. Box 4950 Nydalen 0424 Oslo, Norway Visiting address: Oslo University Hospital Rikshospitalet, Building A3, Sognsvannsveien 20, Oslo. Telephone: (+47) 23073520 Telefax: (+47) 23073530 email: [email protected] www.ous-research.no/isr Print: Møklegaard Print Shop AS, Fredrikstad - www.mprint.no 3 Table of Contents Preface ................................................................................................................................................................ 5 Organizational charts Division of Cardiovascular and Pulmonary Diseases .................................................................................................. 6 Institute for Surgical Research ................................................................................................................................... 7 Abbreviations ............................................................................................................................................................ 9 Research Groups ............................................................................................................................................ 11 Surgical Intensive Care Medicine ............................................................................................................................... 13 Molecular Cardiology ................................................................................................................................................ 19 Integrated Cardiovascular Function ........................................................................................................................... 23 Center for Cardiological Innovation ............................................................................................................................ 27 Vilhelm Magnus Laboratory for Neurosurgical Research ............................................................................................ 31 Experimental Orthopaedic Research ......................................................................................................................... 37 Cell Transplantation and Tissue Engineering .............................................................................................................. 41 Experimental microsurgery and Transplantation ......................................................................................................... 49 Transplantation and Malignancy ................................................................................................................................ 55 Plastic and reconstructive surgery ............................................................................................................................. 61 Projects guided by external project leaders ...................................................................................... 67 Training Courses and Seminars (in Norwegian) ................................................................................ 71 Basalkurs i laparoskopisk kirurgi ............................................................................................................................... 72 Introduksjon til nyfødtmedisinske teknikker og prosedyrer ......................................................................................... 72 Thorako-/laparoskopisk kirurgi .................................................................................................................................. 73 Seminars .................................................................................................................................................................. 74 Publications and PhD-Theses .................................................................................................................. 75 Publications 2008 – 2013 ......................................................................................................................................... 76 PhD-Theses .............................................................................................................................................................. 85 Egil Amundsen Lecture ................................................................................................................................ 92 4 Photo: Øystein H. Horgmo, UiO 5 Preface I am pleased to present this report on the activities at the Marit Kristine Smedsrud, 10 April 2013, Assessment of Institute for Surgical Research in 2013. incipient global myocardial dysfunction by speckle tracking echocardiography. The report provides merely comprehensive overviews of the developments and the results we have obtained during the Jørgen Gravning, 23 May 2013, Cardioprotective past 12 months and I am delighted to report very positive Mechanisms in Ischemia-Reperfusion Injury and Heart results for 2013 at the institute. I hope the report will Failure - Experimental and Clinical Studies Dissecting the illustrate our commitment to scientific work aiming at Functional Effects of Connective Tissue Growth Factor improving medical practice, and thereby contribute to (CTGF/CCN2) in the Heart. provide the best patient care. Thomas Helle-Valle, 24 May 2013, New Non-invasive 2013 was a year in which important strategic decisions in Methods for Quantification of Regional and Global the project on Regenerative Medicine and Tissue Engineering Myocardial Function in the Normal and Ischemic Left were made. Three years ago, three of the Clinics at Oslo Ventricle. University Hospital (OUH) (Division of Cardiovascular and Pulmonary Diseases, Division of Cancer Medicine, Surgery Sebastian Imre Sarvari, 18 September 2013, Detection of and Transplantation, and Division of Surgery and Clinical subtle myocardial alterations by echocardiographic Neuroscience) decided to start a joint project with the aim to techniques for improved prognostic information in patients provide patients with treatment solutions based on tissue with heart disease. engineering techniques. Professor Aksel Foss was chosen as Mrinal Joel, 10 December 2013, Characterization of stem project leader. During 2013, a formal collaboration has been cell-enriched glioblastoma cells in vitro and in xenotypic established with Karolinska Institute in Stockholm, Sweden, tissue environments. and activities on Regenerative Medicine and Tissue Engineering at the hospital and at the University in Oslo were My special thanks go to the enthusiastic and hard work of all joined in Oslo Regenerative Medicine Initiative. This initiative staff at the institute. Our progresses in 2013 would not have has recently been selected as Focused Area of Research at been possible without their tireless efforts, service to all and OUH for 2014 – 2018. support of the institute’s strategy. The following members of the staff deserve to be particularly acknowledged for taking The Egil Amundsen Lecture 2013 was held by Prof. Dr. med. care of important in-house administrative responsibilities: Dr. h.c. mult. Markus W. Büchler and was entitled “Clinical Jorunn Hestenes Larsen (Executive Assistant), Magali Remy- trials in surgery; towards evidence”. It was a strongly analytic Stockinger (Advisor), Signe Flood Kjeldsen (Laboratories), and inspiring presentation which was very well received by all Vivi Bull Stubberud, Sera Sebastian, Aurora Pamplona, attending the conference. Professor Büchler is Managing Roger Ødegård (Operating Theatres), Irene Stensrud Director of the Department of Surgery at Heidelberg University Andersen (Housekeeping), Shakil Ahmed, Biljana Stangeland, Hospital, and Director of the European Pancreas Centre in Espen Remme and Håvard Attramadal (Seminars). Heidelberg, Germany. Under his stewardship The Centre has developed to one of the leading institutions in the world for the The institute is very grateful for very good cooperation with the treatment of pancreatic disease. He has served as President clinical departments of the hospital which form an important of the German Society of Surgery (2011–2012) and is an hon- link between research and clinical practice. orary member of numerous international surgical societies and associations. Since 2009 Professor Büchler has been a The institute sincerely thanks Oslo University Hospital, Univer- member of the German Academy of Sciences Leopoldina. sity of Oslo and external institutions including The Norwegian Research Council, The Norwegian Advisory Committee for 29 articles, with an average impact factor of 4.3, have been Cardiovascular Diseases and the Health Authority of published from the institute in 2013. South-Eastern Norway for important financial support. The following 7 doctoral theses from the institute were The annual report 2013 was edited by Jorunn Hestenes defended in 2013: Larsen, Magali Remy-Stockinger, Håvard Attramadal and Ansgar O. Aasen. Petter K. Risøe, 31 January 2013, Inflammatory Modulation in Sepsis – Role of Adenylyl Cyclases. Institute for Surgical Research, March 2014 Anders Opdahl, 8 March 2013, Mechanisms of left ventricular early-diastolic untwisting and lengthening. Ansgar O. Aasen, Professor /Head of Institute 6 Division of Cardiovascular and Pulmonary Diseases 7 Institute for Surgical Research 8 Photo: OUH 9 Abbreviations AHUS Akershus University Hospital CAST Cancer, stem cell innovatin
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