DLK1 Rabbit Pab

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Leader in Biomolecular Solutions for Life Science DLK1 Rabbit pAb Catalog No.: A2715 Basic Information Background Catalog No. This gene encodes a transmembrane protein that contains multiple epidermal growth A2715 factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is Observed MW located in a region of chromosome 14 frequently showing unparental disomy, and is 41kDa imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, Calculated MW where heterozygotes carrying an active paternal allele express the phenotype, while 33kDa/41kDa mutant homozygotes are normal. Category Primary antibody Applications WB,IHC,IF Cross-Reactivity Human, Mouse, Rat Recommended Dilutions Immunogen Information WB 1:500 - 1:2000 Gene ID Swiss Prot 8788 P80370 IHC 1:50 - 1:100 Immunogen 1:50 - 1:100 IF Recombinant protein of human DLK1 Synonyms DLK1;DLK;DLK-1;Delta1;FA1;PREF1;Pref-1;ZOG;pG2 Contact Product Information www.abclonal.com Source Isotype Purification Rabbit IgG Affinity purification Storage Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. Validation Data Western blot analysis of extracts of various cell lines, using DLK1 antibody (A2715) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. Immunohistochemistry of paraffin- embedded rat pancreatic islet using DLK1 antibody (A2715) at dilution of 1:200 (40x lens). Antibody | Protein | ELISA Kits | Enzyme | NGS | Service For research use only. Not for therapeutic or diagnostic purposes. Please visit http://abclonal.com for a complete listing of recommended products..

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Biochemical Mechanisms of Thyroid Hormone Deiodination
THYROID Volume 15, Number 8, 2005 © Mary Ann Liebert, Inc. Biochemical Mechanisms of Thyroid Hormone Deiodination George G.J.M. Kuiper, Monique H.A. Kester, Robin P. Peeters, and Theo J. Visser Deiodination is the foremost pathway of thyroid hormone metabolism not only in quantitative terms but also because thyroxine (T4) is activated by outer ring deiodination (ORD) to 3,3’,5-triiodothyronine (T3), whereas both T4 and T3 are inactivated by inner ring deiodination (IRD) to 3,3’,5-triiodothyronine and 3,3’- diiodothyronine, respectively. These reactions are catalyzed by three iodothyronine deiodinases, D1-3. Although they are homologous selenoproteins, they differ in important respects such as catalysis of ORD and/or IRD, deiodination of sulfated iodothyronines, inhibition by the thyrostatic drug propylthiouracil, and regulation during fetal and neonatal development, by thyroid state, and during illness. In this review we will briefly discuss recent developments in these different areas. These have resulted in the emerging view that the biological activity of thyroid hormone is regulated locally by tissue-specific regulation of the different deiodinases. HYROID HORMONE is essential for growth, development, thyrostatic drug 6-propyl-2-thiouracil (PTU). D1 activity is Tand regulation of energy metabolism (1–3). Amphibian positively regulated by T3, reflecting regulation of D1 ex- metamorphosis is an important example of thyroid hormone pression by T3 at the pretranslational level. actions on development (4). Equally well known is the crit- In humans, D2 activity is found in brain, anterior pitu- ical role of thyroid hormone in development and function itary, placenta, thyroid and skeletal muscle, and D2 mRNA of the human central nervous system (5,6).
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REVIEW Iodothyronine Deiodinase Structure and Function
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Downloaded from genesdev.cshlp.org on September 27, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION entially methylated cis-acting imprinting control ele- The Dlk1 and Gtl2 genes are ment (Thorvaldson et al. 1998). Third, a majority of im- linked and reciprocally printed genes for which a function has been identified imprinted code for proteins involved in the control of embryonic growth (Tilghman 1999). Jennifer V. Schmidt,1,2 Paul G. Matteson,2 Given the role of imprinted genes in fetal growth it is Beverly K. Jones, Xiao-Juan Guan, not surprising that they are often expressed in the pla- and Shirley M. Tilghman3 centa, the primary tissue regulating nutrient transfer be- tween mother and fetus. To identify new imprinted Howard Hughes Medical Institute and Department genes, we designed an allelic differential display strategy of Molecular Biology, Princeton University, Princeton, (Hagiwara et al. 1997) using placental mRNA derived New Jersey 08544 USA from two closely related species of North American deer mice, Peromyscus maniculatus (BW) and Peromyscus Genes subject to genomic imprinting exist in large chro- polionotus (PO). These mice display a high degree of mosomal domains, probably reflecting coordinate regu- polymorphism (Vrana et al. 1998), making them useful lation of the genes within a cluster. Such regulation has for screens that depend on allelic differences. been demonstrated for the H19, Igf2, and Ins2 genes that We report here the paternal-specific expression of the share a bifunctional imprinting control region. We have Delta-like (Dlk1) gene in both Peromyscus and the labo- identified the Dlk1 gene as a new imprinted gene that is ratory mouse genus Mus.
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