HTA Report Treatment for Convicted Adult Male Sex Offenders

Total Page:16

File Type:pdf, Size:1020Kb

HTA Report Treatment for Convicted Adult Male Sex Offenders HTA Report Treatment for Convicted Adult Male Sex Offenders July 2010 INSTITUTE OF HEALTH ECONOMICS The Institute of Health Economics (IHE) is an independent, not-for-profit organization that performs research in health economics and synthesizes evidence in health technology assessment to assist health policy making and best medical practices. IHE BOARD OF DIRECTORS Chair Dr. Lorne Tyrrell – Chair, Institute of Health Economics and Professor and CIHR/GSK, Chair in Virology, University of Alberta Government Mr. Jay Ramotar – Deputy Minister, Alberta Health and Wellness Ms. Annette Trimbee – Deputy Minister, Advanced Education and Technology Dr. Jacques Magnan – Interim President and CEO, Alberta Innovates Health Solutions Academia Dr. Renée Elio – Associate VP Research, University of Alberta Dr. Tom Feasby – Dean of Medicine, University of Calgary Dr. Philip Baker – Dean of Medicine, University of Alberta Dr. Tom Noseworthy – Professor and Head, Community Health Sciences, University of Calgary Dr. James Kehrer – Dean of Pharmacy, University of Alberta Dr. Herb Emery Svare – Chair, Health Economics, University of Calgary Dr. Doug West – Chair, Department of Economics, University of Alberta Industry Mr. Terry McCool – Vice President, Corporate Affairs, Eli Lilly Canada Inc. Mr. Gregg Szabo – Executive Director, Corporate Affairs, Merck Frosst Canada Ltd. Dr. Bernard Prigent – Vice President & Medical Director, Pfizer Canada Inc. Mr. Grant Perry – Director, Public Affairs, GlaxoSmithKline Inc. Mr. William Charnetski – Vice President, Corporate Affairs, AstraZeneca Canada Inc. Other Mr. Chris Mazurkewich – Executive Vice President & CFO, Alberta Health Services CEO Dr. Egon Jonsson - Executive Director and CEO, Institute of Health Economics, Professor, University of Alberta, University of Calgary IHE Mr. Doug Gilpin – Chair, Audit & Finance Committee Board Secretary Dr. Egon Jonsson – Executive Director and CEO, Institute of Health Economics, Professor, University of Alberta, University of Calgary TREATMENT FOR CONVICTED ADULT MALE SEX OFFENDERS Prepared by: Paula Corabian, BSc, MPH Maria Ospina, BSc, MSc Christa Harstall, BSc, MLS, MHSA Reproduction, redistribution, or modification of the information for any purposes is prohibited without the express written permission of the Institute of Health Economics © Institute of Health Economics, 2010 www.ihe.ca Treatment of Convicted Adult Male Sex Offenders i ACKNOWLEDGMENTS The Institute of Health Economics is most grateful for the following individuals for review and provision of information and comments on the draft report. The views expressed in the final report are those of the Institute. —— Dr. R. Karl Hanson, Corrections Research, Public Safety Canada, Ottawa, Ontario —— Dr. David Moher, Ottawa Hospital Research Institute, Ottawa Methods Centre, The Ottawa Hospital General Campus, Ottawa, Ontario INFORMATION SERVICES SUPPORT The literature search for the review was undertaken by Ms Liz Dennett, Information Specialist, Institute of Health Economics, University of Alberta, Edmonton, Canada. COMPETING INTEREST The author(s) of this report declared no competing interest. Production of this document has been made possible by a financial contribution from Health and Wellness and under the auspices of the Alberta Health Technologies Decision Process initiative: the Alberta Model for health technology assessment and policy analysis. The views expressed herein do not necessarily represent the official policy of Alberta Health and Wellness. ii Treatment of Convicted Adult Male Sex Offenders EXECUTIVE SUMMARY BACKGROUND Sexual offending has become a major challenge for social policy because of the high human and financial costs to victims and the social and health services as well as the high public investment in policing, prosecuting, and incarcerating sex offenders. There is an expectation that the correctional systems should make reasonable efforts to reduce the potential that convicted sex offenders will reoffend. One common approach to sex offenders’ management in countries with developed market economies is to provide specialized treatment programs. A number of different sex offender treatment (SOT) programs have been developed and are currently operating, but there continues to be controversy regarding how well they work. ObJECTIVES To evaluate the effectiveness of psychotherapy and pharmacotherapy interventions delivered within SOT programs to reduce the likelihood of reoffending in convicted adult male sex offenders. RESULTS Eight systematic reviews (SRs) conducted on the effectiveness of SOT interventions and programs met the inclusion criteria of this overview. All eight SRs focused on the use of psychotherapy for convicted sex offenders, whereas one also included surgical castration and hormonal medication. In these studies there was considerable variability in how interventions were classified, the types of sex offenders involved, and the definition of outcomes. According to the reviewed evidence, studies in the area of SOT outcome research have improved over the past 10 years. However, the need for more rigour remains. The following are highlights from the reviewed evidence. —— Although the debate in the scientific literature on what SOT interventions and programs are most effective for convicted adult male sex offenders remains, the results from seven moderate- to-high quality SRs show small but statistically significant reductions in sexual and general recidivism rates among convicted adult male sex offenders treated with various cognitive behavioural therapy (CBT) approaches. —— The most recently published high quality SR found that SOT programs using CBT approaches that adhered to the risk/need/responsivity (RNR) model for offender assessment and rehabilitation were most effective in reducing the risk of recidivism in convicted male sexual offenders. On average, programs that followed all three RNR principles reported recidivism rates that were less than half the recidivism rates for comparison groups. In contrast, there was no effect on recidivism rates for programs that did not follow the RNR model. Treatment of Convicted Adult Male Sex Offenders iii —— Confidence in these findings, however, must be tempered as the available evidence is based mostly on poor quality primary research studies. —— Although one SR of moderate quality reported promising results on the use of hormonal treatments as an adjuvant to psychotherapy, well- conducted and reported controlled studies are needed to establish the effectiveness of adjuvant hormonal treatment to reduce the risk of recidivism among sex offenders. —— Overall, the results reported by the selected SRs provide little direction regarding how to improve current treatment practices. • It is still not clear whether all sex offenders require treatment or whether current interventions are more appropriate for certain subgroups and typologies of offenders. • There are still uncertainties regarding the most useful elements and components of a SOT program for convicted adult male sex offenders. • There is no clear answer on whether the setting of the SOT program affects its impact on recidivism rates. CONCLUSIONS While the evidence from seven moderate-to-high quality SRs suggests that SOT has the potential to reduce sexual and nonsexual recidivism, the reported findings provide stronger support for the effectiveness of CBT approaches and for programs adhering to the RNR model. Any conclusions drawn from this overview of SRs remain tentative. Given the methodological problems of the available primary research, it is difficult to draw strong conclusions about the effectiveness of SOT programs using various CBT approaches for such a heterogeneous population. The reviewed evidence does not provide clear answers to what are the components of an optimal SOT program and to whether where the program is delivered matters. All SRs concluded that more and better research is needed to clearly answer these questions. METHODOLOGY SRs that by virtue of design and quality of reporting were most likely to provide high levels of evidence, were selected to formulate the evidence base for this overview. All SRs were identified through a systematic search of the relevant scientific literature published in English between January 1998 and June 2010. The searched databases included: MEDLINE, EMBASE, The Cochrane Library, The Campbell Collaboration Library, CRD Databases (HTA, DARE), PsycINFO, Violence and Abuse Abstracts, iv Treatment of Convicted Adult Male Sex Offenders Criminal Justice Abstracts, Sociological Abstracts, SocINDEX with Full Text, Social Work Abstracts, Social Services Abstracts, Gender Studies Database, National Criminal Justice Reference Service Abstracts, and Web of Science. Also searched were the University of Alberta library catalogue, clinical trials websites, websites of pertinent agencies and departments of corrections, health technology assessment (HTA) agency websites. In addition, the Internet was searched using the Google search engine. The methodological quality of the SRs included in this overview was appraised independently by two reviewers using the AMSTAR quality assessment tool. One reviewer extracted the data from the selected SRs and a second reviewer verified the data extraction. The evidence was qualitatively synthesized and is presented in summary tables. Treatment of Convicted Adult Male Sex Offenders v ABBREVIATIONS All abbreviations that have been used in this report are listed below unless the abbreviation is
Recommended publications
  • How a Judicial Paradigm Shift Could Prevent Recidivism by Sex Offenders Geoffrey S
    Washington and Lee Journal of Civil Rights and Social Justice Volume 20 | Issue 2 Article 8 3-2014 Ending Recidivism: How a Judicial Paradigm Shift Could Prevent Recidivism by Sex Offenders Geoffrey S. Weed Follow this and additional works at: https://scholarlycommons.law.wlu.edu/crsj Part of the Civil Rights and Discrimination Commons, Criminal Law Commons, and the Human Rights Law Commons Recommended Citation Geoffrey S. Weed, Ending Recidivism: How a Judicial Paradigm Shift Could Prevent Recidivism by Sex Offenders, 20 Wash. & Lee J. Civ. Rts. & Soc. Just. 457 (2014). Available at: https://scholarlycommons.law.wlu.edu/crsj/vol20/iss2/8 This Article is brought to you for free and open access by the Washington and Lee Journal of Civil Rights and Social Justice at Washington & Lee University School of Law Scholarly Commons. It has been accepted for inclusion in Washington and Lee Journal of Civil Rights and Social Justice by an authorized editor of Washington & Lee University School of Law Scholarly Commons. For more information, please contact [email protected]. Ending Recidivism: How a Judicial Paradigm Shift Could Prevent Recidivism by Sex Offenders Geoffrey S. Weed* Table of Contents I. Introduction ......................................................................... 457 II. Recidivism by Sex Offenders: Defining the Problem ........ 460 III. The Psychology of Sex Offenders: Paraphilias, Recidivism, and Treatment ................................................. 470 IV. Changing the Paradigm ......................................................
    [Show full text]
  • How to Select Pharmacologic Treatments to Manage Recidivism Risk in Sex Off Enders
    How to select pharmacologic treatments to manage recidivism risk in sex off enders Consider patient factors when choosing off -label hormonal and nonhormonal agents ® Dowden Healthex offenders Media traditionally are managed by the criminal justice system, but psychiatrists are fre- Squently called on to assess and treat these indi- CopyrightFor personalviduals. use Part only of the reason is the overlap of paraphilias (disorders of sexual preference) and sexual offending. Many sexual offenders do not meet DSM criteria for paraphilias,1 however, and individuals with paraphil- ias do not necessarily commit offenses or come into contact with the legal system. As clinicians, we may need to assess and treat a wide range of sexual issues, from persons with paraphilias who are self-referred and have no legal involvement, to recurrent sexual offenders who are at a high risk of repeat offending. Successfully managing sex offenders includes psychological and pharmacologic interven- 2009 © CORBIS / TIM PANNELL 2009 © CORBIS / tions and possibly incarceration and post-incarceration Bradley D. Booth, MD surveillance. This article focuses on pharmacologic in- Assistant professor terventions for male sexual offenders. Department of psychiatry Director of education Integrated Forensics Program University of Ottawa Reducing sexual drive Ottawa, ON, Canada Sex offending likely is the result of a complex inter- play of environment and psychological and biologic factors. The biology of sexual function provides nu- merous targets for pharmacologic intervention, in- cluding:2 • endocrine factors, such as testosterone • neurotransmitters, such as serotonin. The use of pharmacologic treatments for sex of- fenders is off-label, and evidence is limited. In general, Current Psychiatry 60 October 2009 pharmacologic treatments are geared toward reducing For mass reproduction, content licensing and permissions contact Dowden Health Media.
    [Show full text]
  • Handbook of Herbs and Spices
    Handbook of herbs and spices Edited by K. V. Peter Published by Woodhead Publishing Limited Abington Hall, Abington Cambridge CB1 6AH England www.woodhead-publishing.com Published in North and South America by CRC Press LLC 2000 Corporate Blvd, NW Boca Raton FL 33431 USA First published 2001, Woodhead Publishing Limited and CRC Press LLC ß 2001, Woodhead Publishing Limited The authors have asserted their moral rights. This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. Reasonable efforts have been made to publish reliable data and information, but the authors and the publishers cannot assume responsibility for the validity of all materials. Neither the authors nor the publishers, nor anyone else associated with this publication, shall be liable for any loss, damage or liability directly or indirectly caused or alleged to be caused by this book. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing from the publishers. The consent of Woodhead Publishing Limited and CRC Press LLC does not extend to copying for general distribution, for promotion, for creating new works, or for resale. Specific permission must be obtained in writing from Woodhead Publishing Limited or CRC Press LLC for such copying. Trademark notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation, without intent to infringe. British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library.
    [Show full text]
  • Internal Communication Clearance Form
    HAUT-COMMISSARIAT AUX DROITS DE L’HOMME • OFFICE OF THE HIGH COMMISSIONER FOR HUMAN RIGHTS PALAIS DES NATIONS • 1211 GENEVA 10, SWITZERLAND Mandates of the Special Rapporteur on extrajudicial, summary or arbitrary executions; the Special Rapporteur on the sale of children, child prostitution and child pornography and the Special Rapporteur on torture and other cruel, inhuman or degrading treatment or punishment REFERENCE: OL IDN 6/2016: 21 June 2016 Excellency, We have the honour to address you in our capacities as Special Rapporteur on extrajudicial, summary or arbitrary executions; Special Rapporteur on the sale of children, child prostitution and child pornography and Special Rapporteur on torture and other cruel, inhuman or degrading treatment or punishment, pursuant to Human Rights Council resolutions 26/12, 25/6 and 25/13. In this connection, we would like to bring to the attention of your Excellency’s Government information we have received concerning the Presidential decree (Perppu No.1/2016), which modifies the 2002 Law No.23 on Child Protection and provides additional punishments for perpetrators of sexual violence against children such as chemical castration and the death penalty. According to the information received: On 25 May 2016, the President signed the decree Perppu No.1/2016, which amends Law No.23 on Child Protection from 2002. Article 81 has reportedly been modified and stipulates in a new paragraph 5 that, if the perpetrator of sexual violence against children has caused to the child victim serious injuries, mental disorders, infectious diseases, impairment or loss of reproductive functions, and/or the child victim dies, he or she shall be sentenced to death, life imprisonment or ten years of imprisonment with a maximum of 20 years.
    [Show full text]
  • Chemical Castration of Sexual Offenders
    Fordham Law Review Volume 65 Issue 6 Article 8 1997 California's Unconstitutional Punishment for Heinous Crimes: Chemical Castration of Sexual Offenders Raymond A. Lombardo Follow this and additional works at: https://ir.lawnet.fordham.edu/flr Part of the Law Commons Recommended Citation Raymond A. Lombardo, California's Unconstitutional Punishment for Heinous Crimes: Chemical Castration of Sexual Offenders, 65 Fordham L. Rev. 2611 (1997). Available at: https://ir.lawnet.fordham.edu/flr/vol65/iss6/8 This Article is brought to you for free and open access by FLASH: The Fordham Law Archive of Scholarship and History. It has been accepted for inclusion in Fordham Law Review by an authorized editor of FLASH: The Fordham Law Archive of Scholarship and History. For more information, please contact [email protected]. CALIFORNIA'S UNCONSTITUTIONAL PUNISHMENT FOR HEINOUS CRIMES: CHENICAL CASTRATION OF SEXUAL OFFENDERS Raymond A. Lombardo INTRODUCrION On September 17, 1996, Governor Pete Wilson signed legislation (the "California Statute") making California the first state to require that paroled recidivist sex offenders receive chemical injections that will suppress their sex drives.' This injection, of the drug known as Depo-Provera 2 is popularly called "chemical castration."13 The law that Governor Wilson signed, applicable to sex offenses such as sodomy, rape, and child molestation,4 altered section 645 of the California Penal Code by making chemical castration mandatory for repeat paroled sex offenders.5 The prior law had left it within the discretion of the judge to offer Depo-Provera as a choice of punish- ment to a paroled repeat offender.6 Under the new law, the judge retains discretion to offer the drug to first time offenders.7 1.
    [Show full text]
  • HANDBOOK of Medicinal Herbs SECOND EDITION
    HANDBOOK OF Medicinal Herbs SECOND EDITION 1284_frame_FM Page 2 Thursday, May 23, 2002 10:53 AM HANDBOOK OF Medicinal Herbs SECOND EDITION James A. Duke with Mary Jo Bogenschutz-Godwin Judi duCellier Peggy-Ann K. Duke CRC PRESS Boca Raton London New York Washington, D.C. Peggy-Ann K. Duke has the copyright to all black and white line and color illustrations. The author would like to express thanks to Nature’s Herbs for the color slides presented in the book. Library of Congress Cataloging-in-Publication Data Duke, James A., 1929- Handbook of medicinal herbs / James A. Duke, with Mary Jo Bogenschutz-Godwin, Judi duCellier, Peggy-Ann K. Duke.-- 2nd ed. p. cm. Previously published: CRC handbook of medicinal herbs. Includes bibliographical references and index. ISBN 0-8493-1284-1 (alk. paper) 1. Medicinal plants. 2. Herbs. 3. Herbals. 4. Traditional medicine. 5. Material medica, Vegetable. I. Duke, James A., 1929- CRC handbook of medicinal herbs. II. Title. [DNLM: 1. Medicine, Herbal. 2. Plants, Medicinal.] QK99.A1 D83 2002 615′.321--dc21 2002017548 This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing from the publisher.
    [Show full text]
  • III B.Sc., MICROBIOLOGY HERBS and DRUG ACTION Mrs.T
    III B.Sc., MICROBIOLOGY HERBS AND DRUG ACTION Mrs.T.TAMILVANI, ASSISTANT PROFESSOR, PG AND RESEARCH DEPARTMENT OF MICROBIOLOGY STET WOMEN’S COLLEGE, MANNARGUDI III B.Sc., MICROBIOLOGY SEMESTER: V SKILL BASED ELECTIVE III HERBS AND DRUG ACTION -16RSBE5:3 Ins. Hrs/Week: 5 Credit: 3 Unit I Terminologies – Definitions – Classification of medicinal plants based on their effects with special reference to India. Unit II Allergens – types – sources – active principles – Chemical nature – Cell modifiers – Lectins – mutagens, teratogens – Allergic reactions with known examples. Unit III Drugs acting on brain and nervous system – Rheumatic arthritis – Psychoactive drugs – Depressants, Stimulants, hallucinogens – sources, effects, basic mechanism of action. Unit IV Cardiovascular diseases – blood pressure – cardiac drugs of plant origins – alkaloids, anticoagulants – basic mechanism of action. Pulmonary / respiratory disorders – asthma – bronchitis – common cold – allergy – Remedy from plants. Unit V Drugs for urinogenital disorders – roots of Withania somnifera – Memory stimulants – Centella asiatica – Drugs for dissolving kidney stones – Musa paradisica (pseudostem) – Antiinflammatory drugs – Cardiospermum – Anticancer drugs – Catharanthus roseus. References Kumar, N.C., An Introduction to Medical botany and Pharmacognosy. Emkay Publications, NewDelhi. 1993 Rao, A.P. Herbs that heal. Diamond Pocket Books (P) Ltd., New Delhi, 1999 SKILL BASED ELECTIVE - III HERBS AND DRUG ACTION UNIT : 1 Terminologies - definition - classification of medicinal plants based on their effects with the special reference to Indian and classification based on the effects. TERMINOLOGIES AND DEFINITION : Herbalism, as its often called, can include the use of whole plants or plant extracts in the form of foods, teas, powdered herbs, liquid extracts, incense, smudges and skin preparations. These preparations, along with the types of herbs themselves, have an impressive variety of names.
    [Show full text]
  • The Chemical Castration of Recidivist Sex Offenders in Canada: a Matter of Faith
    Dalhousie Law Journal Volume 33 Issue 2 Article 7 10-1-2010 The Chemical Castration of Recidivist Sex Offenders in Canada: A Matter of Faith Matthew R. Kutcher Dalhousie University Follow this and additional works at: https://digitalcommons.schulichlaw.dal.ca/dlj Part of the Criminal Law Commons Recommended Citation Matthew R. Kutcher, "The Chemical Castration of Recidivist Sex Offenders in Canada: A Matter of Faith" (2010) 33:2 Dal LJ 193. This Article is brought to you for free and open access by the Journals at Schulich Law Scholars. It has been accepted for inclusion in Dalhousie Law Journal by an authorized editor of Schulich Law Scholars. For more information, please contact [email protected]. Matthew R. Kutcher* The Chemical Castration of Recidivist Sex Offenders in Canada: A Matter of Faith Chemical castration refers to the use of medication to reduce male testosterone to pre-pubertal levels. Since the mid-20th century reports have detailed this practice in attempts to control pathological sexual behaviour. In 2006, the Canadian Federal Court of Appeal ruled it constitutional for the National Parole Board to require that recidivist sex offenders, if found to be long-term offenders, be chemically castrated under their conditions of release. This paper examines the chemical castration of recidivist sex offenders in Canada through a review of long-term offender hearings reported between 1997 and 2009. The practice is analyzed from ethical, medical and legal perspectives. It is concluded that chemical castration of sex offenders is ethically problematic, that evidence for its effectiveness in preventing recidivism is limited and of poor quality and that judges should avoid excessive reliance on chemical castration when deciding to grant conditional release to recidivist sex offenders.
    [Show full text]
  • Voluntary Surgical Castration of Sex Offenders: Waiving the Eighth Amendment Protection from Cruel and Unusual Punishment Lystra Batchoo
    Brooklyn Law Review Volume 72 | Issue 2 Article 7 2007 Voluntary Surgical Castration of Sex Offenders: Waiving the Eighth Amendment Protection from Cruel and Unusual Punishment Lystra Batchoo Follow this and additional works at: https://brooklynworks.brooklaw.edu/blr Recommended Citation Lystra Batchoo, Voluntary Surgical Castration of Sex Offenders: Waiving the Eighth Amendment Protection from Cruel and Unusual Punishment, 72 Brook. L. Rev. (2007). Available at: https://brooklynworks.brooklaw.edu/blr/vol72/iss2/7 This Note is brought to you for free and open access by the Law Journals at BrooklynWorks. It has been accepted for inclusion in Brooklyn Law Review by an authorized editor of BrooklynWorks. Voluntary Surgical Castration of Sex Offenders WAIVING THE EIGHTH AMENDMENT PROTECTION FROM CRUEL AND UNUSUAL PUNISHMENT INTRODUCTION In July 2005, Keith Raymond Fremin was about to go on trial in Covington, Louisiana for four counts of aggravated rape1 involving an eleven-year-old girl and her thirteen-year- old sister.2 Fremin, a neighborhood resident, first gained the girls’ trust before victimizing them.3 Fremin started playing basketball with the young girls,4 eventually invited them to his home and sexually abused them.5 One of the victims told a classmate about the abuse and later reported the incidents to her teacher.6 Police arrested Fremin on January 27, 2004.7 Like most sex offenders, this was not Fremin’s first offense. When police charged him with the 1999 rapes of these sisters, 1 Under Louisiana law, aggravated rape occurs when the anal, oral, or vaginal sexual intercourse is deemed to be without lawful consent of the victim because it is committed under any one or more of the following circumstances: (1) When the victim resists the act to the utmost, but whose resistance is overcome by force.
    [Show full text]
  • Receptor Af®Nity and Potency of Non-Steroidal Antiandrogens: Translation of Preclinical ®Ndings Into Clinical Activity
    Prostate Cancer and Prostatic Diseases (1998) 1, 307±314 ß 1998 Stockton Press All rights reserved 1365±7852/98 $12.00 http://www.stockton-press.co.uk/pcan Review Receptor af®nity and potency of non-steroidal antiandrogens: translation of preclinical ®ndings into clinical activity GJCM Kolvenbag1, BJA Furr2 & GRP Blackledge3 1Medical Affairs, Zeneca Pharmaceuticals, Wilmington, DE, USA; 2Therapeutic Research Department, and 3Medical Research Department, Zeneca Pharmaceuticals, Alderley Park, Maccles®eld, Cheshire, UK The non-steroidal antiandrogens ¯utamide (Eulexin1), nilutamide (Anandron1) and bicalutamide (Casodex1) are widely used in the treatment of advanced prostate cancer, particularly in combination with castration. The naturally occurring ligand 5a-DHT has higher binding af®nity at the androgen receptor than the non-steroidal antiandrogens. Bicalutamide has an af®nity two to four times higher than 2-hydroxy¯utamide, the active metabolite of ¯utamide, and around two times higher than nilutamide for wild-type rat and human prostate androgen receptors. Animal studies have indicated that bicalutamide also exhi- bits greater potency in reducing seminal vesicle and ventral prostate weights and inhibiting prostate tumour growth than ¯utamide. Although preclinical data can give an indication of the likely clinical activity, clinical studies are required to determine effective, well-tolerated dosing regimens. As components of combined androgen blockade (CAB), controlled studies have shown survival bene®ts of ¯utamide plus a luteinising hormone-releasing hormone analogue (LHRH-A) over LHRH-A alone, and for nilutamide plus orchiectomy over orchiectomy alone. Other studies have failed to show such survival bene®ts, including those comparing ¯utamide plus orchiectomy with orchiectomy alone, and nilutamide plus LHRH-A with LHRH-A alone.
    [Show full text]
  • The Unconstitutionality of Louisiana's C
    H.SMITH-FINAL (DO NOT DELETE) 6/18/2013 7:51 PM COMMON ENEMY AND POLITICAL OPPORTUNITY LEAVE ARCHAICALLY MODERN SENTENCING UNCHECKED: THE UNCONSTITUTIONALITY OF LOUISIANA’S CHEMICAL CASTRATION STATUTE I. INTRODUCTION ..................................................................... 212 II. CASTRATION: FROM ANCIENT PRACTICES TO MODERN LAW .................................................................. 219 A. HISTORICAL PERSPECTIVE OF CASTRATION ................... 219 B. WOULD A PRIVATE PSYCHIATRIST PRESCRIBE MPA AS TREATMENT?................................................................. 224 C. STATE LEGISLATURES ENACT CHEMICAL CASTRATION LAWS IN THE UNITED STATES ...................................... 230 1. THE CALIFORNIA-BASED MODEL : PROBATION- CONTINGENT-UPON-CASTRATION FOR CERTAIN SEX OFFENDERS ...................................................... 233 2. THE RECIDIVISM STUDY PILOT MODEL: NOT RECESSION PROOF .................................................. 238 3. TEXAS’S LONE-STATE MODEL ................................. 241 C. LOUISIANA RUNS WITH THE PACK THEN VEERS OFF- TRACK: HOW THE PASSAGE OF THE 2008 CHEMICAL CASTRATION STATUTE CAME TO OVERSHADOW THE PROBATIONARY STATUTE ............................................. 243 D. ADMINISTERING CHEMICAL CASTRATION: EASIER SAID THAN SENTENCED? .............................................. 247 III. CONSTITUTIONAL CHALLENGES TO CHEMICAL CASTRATION LAWS ........................................................ 249 A. SUBSTANTIVE DUE PROCESS .......................................
    [Show full text]
  • Incapacitation Through Maiming: Chemical Castration, the Eighth Amendment, and the Denial of Human Dignity John F
    University of Florida Levin College of Law UF Law Scholarship Repository Faculty Publications Faculty Scholarship 1-1-2006 Incapacitation Through Maiming: Chemical Castration, the Eighth Amendment, and the Denial of Human Dignity John F. Stinneford University of Florida Levin College of Law, [email protected] Follow this and additional works at: http://scholarship.law.ufl.edu/facultypub Part of the Constitutional Law Commons, Criminal Law Commons, and the Human Rights Law Commons Recommended Citation John F. Stinneford, Incapacitation Through Maiming: Chemical Castration, the Eighth Amendment, and the Denial of Human Dignity, 3 U. St. Thomas L. J. 559 (2006), available at http://scholarship.law.ufl.edu/facultypub/215 This Article is brought to you for free and open access by the Faculty Scholarship at UF Law Scholarship Repository. It has been accepted for inclusion in Faculty Publications by an authorized administrator of UF Law Scholarship Repository. For more information, please contact [email protected]. ARTICLE INCAPACITATION THROUGH MAIMING: CHEMICAL CASTRATION, THE EIGHTH AMENDMENT, AND THEDENIAL OF HUMAN DIGNITY JoHN F. STINNEFORD* There are limits to the extent to which a legislatively represented majority may conduct biological experiments at the expense of the dignity and personality and natural powers of a minority-even those who have been guilty of what the majority define as crimes.' To be 'cured' against one's will and cured of states which we may not regard as disease is to be put on a level with those who have not yet reached the age of reason or those who never will; to be classed with infants, imbeciles and domestic animals.' INTRODUCTION ..................................................
    [Show full text]