Munich Center for

Munich Center for Neurosciences – Brain & Mind LMU Biocenter Ludwig-Maximilians-Universität Munich (LMU) Grosshaderner Straße 2 www.mcn.lmu.de 82152 Planegg-Martinsried +49 (0)89 / 2180-74303 [email protected] Munich C enter for N eurosciences 4 | 5

The Free State of Bavaria is a first-rate location for science and research, All these results are both promising and encouraging. With innovative where life sciences play an eminent role. They find one of their strongest projects like the “Munich Center for Neurosciences“, we can successfully bases in Munich. The Bavarian capital is home to two great research advance the further development of our research landscape and maintain our universities – both winners of the Germany- wide Initiative for Excellence – as leading position in the life sciences. well as numerous highly-specialized and well-known non-university research institutions. It is no wonder that Munich is the ideal place for committed I am sure that the great work of the scientists at the “Munich Center for scientists to deliver prime scientific results at the highest international level. Neurosciences“ will continue its success and wish the centre all the best for the future. Today, top science demands close co-operation – beyond the limits of institutes and disciplines. The “Munich Center for Neurosciences“ provides the integrative platform to take the strong interdisciplinary approach the Munich, August 2011 complexity of the different fields of neurosciences asks for. Its being open to integrating perspectives and findings from neighbouring fields of research Dr. Wolfgang Heubisch even allows a holistic reflection of burning neuroscientific questions. Bavarian State Minister of Sciences, Research and the Arts Through various teaching programmes – above all, the Graduate School for Systemic Neurosciences – young scientists are integrated in this excellent Dr. Wolfgang Heubisch research environment and can fully develop their potential. The fact that the Graduate School for Systemic Neurosciences was successful in the first round of the Initiative for Excellence emphasizes that it can serve as a superb role model.

Its brilliant concept has established the “Munich Center for Neurosciences“ as a beacon of science in Munich‘s research environment. The list of its distinguished members, the great amount of third-party funding as well as the high demand for its teaching programmes clearly prove the centre‘s great success. Bavarian State Minister of Sciences, Research and the Arts Bavarian State Minister of Sciences, Research 6 | 7

Ludwig-Maximilians-Universität München is one of the leading research One essential requirement for the success of the MCNLMU is the intense intensive universities worldwide, with a more than 500-year-long tradition. cooperation with its partners, the Technische Universität München, different It is LMU’s mission to combine excellent research with outstanding teaching, Max Planck Institutes, the Helmholtz Zentrum München and the Bernstein to conduct basic research and tackle the grand challenges of our time. The Center for Computational . It also maintains close ties to extraordinary research output of the university is based on the exceptional renowned international partners in Europe, the United States and Australia achievements of our researchers and scientists. This is proved by our success and thus creates an important global network for the exchange of knowledge. in the first round of the Excellence Initiative in 2006. In addition to that, This brochure offers interesting insights into the Munich Center for LMU also offers the best possible education for its 46,000 students with Neurosciences – Brain and Mind, its research projects and teaching programs degree programs in 150 subjects and thus ideally preparing young people as well as an overview on the excellent researchers who are working at the for a career in academia or outside university. MCNLMU. The multiplicity, interdisciplinarity and internationality of this top- class institution strongly contributes to LMU’s vision to address the key areas One of LMU’s very successful institutions is the “Munich Center for of research and innovation of the 21 century. Neurosciences – Brain and Mind (MCNLMU)” which contributes essentially Prof. Dr. Bernd Huber to LMU’s top position within the life sciences. MCNLMU aims towards President building up a network of groups and disciplines with interest in questions Ludwig-Maximilians-Universität of neurobiology, cognition, and “brain and mind”. With its interdisciplinary München approach, MCNLMU combines various research fields at LMU ranging from the natural sciences to the humanities. Scientists from the field of experimental and theoretical neurosciences, philosophy and psychology do research and teach in the numerous projects and programs within the MCNLMU. Prof. Dr. Bernd Huber The Center is an excellent example for transferring new and broad knowledge in an emerging field of science to the new student generations: The two specialized Master programs in Neurosciences and Neuro-Cognitive Psychology, funded by the Elite Network of Bavaria, are the successful teaching institutions at MCNLMU. The Graduate School of Systemic Neurosciences which is funded within the German Excellence Initiative promotes young scientists by offering them the best possible framework for doing their first independent research. President Ludwig-Maximilians-Universität München Ludwig-Maximilians-Universität President 8 | 9

Dear Reader,

Modern sciences increasingly depend on the ability of crossing disciplinary In Munich, research related to the neurosciences spans a wide spectrum boarders as well as collaborations that allow sharing expertise and of current areas of investigation, ranging from neural stem cells and the infrastructure. This holds particularly true for an area like the neurosciences. molecular mechanisms of early brain development, via cellular and systems The structure and function of the and the question of how neurobiology (including ), neurocognition and behavior (including its activity relates to our concepts of the mind cannot be studied in “theory of mind”), to epistemology, philosophy of science, logic, and isolation, but only through extensive networking. The “Munich Center ethics. It involves numerous research groups working in various institutes for Neurosciences – Brain and Mind (MCNLMU)” was founded in 2005 to and departments of the LMU (in particular, biology, medicine, philosophy, create a local network in and around Munich that connects all groups and psychology), most of them in close collaboration with the Max Planck disciplines with interests related to questions of neurobiology, cognition, and Institutes of Neurobiology, , and Ornithology, the institutes of “brain and mind”. It provides a platform for interdisciplinary interactions, the HelmholtzCenter Munich (HMGU), several institutes at the Technical supports the establishment of new collaborative research programs and has University of Munich (TUM; electrical engineering, medicine, physics, life Prof. Dr. Benedikt Grothe developed a teaching concept that attracts excellent students at all levels sciences) as well as with the computer industry. MCNLMU Chair of the Board of training. The program M.Sc. Neurosciences, generously funded by the of Directors Elite Network of Bavaria and the Ph.D. program of the Graduate School of MCNLMU was implemented to make Munich, with its multitude of expertise, Systemic Neurosciences GSNLMU, funded by the German Excellence Initiative, not only one of the real “hot spots” in the neurosciences, but also one of the are offspring of the MCNLMU Teaching Concept (see page 88). The SFB 870: few neuroscience hubs where the bridge from experimental neurobiology to Assembly and Function of Neuronal Circuits in Sensory Processing is a the philosophy of brain and mind can be competently spanned. new collaborative research center that resulted from scientific interactions of many members of the MCNLMU, and several other research and training networks such as the Bernstein Center for Computational Neuroscience (BCCN) Munich or the Research Training Group 1091 Orientation and Motion in Space have profited greatly from established networks within MCNLMU and also from its teaching concept. This only begins to exemplify how MCNLMU fosters Munich as an internationally attractive site for training and research in the neurosciences. Prof. Dr. Benedikt Grothe Chair of the Board of Directors 10 | 11

to an extensive group of excellent researchers who have been brought the agenda for the future. A major aim of the Center will be the creation of together within the framework of the MCNLMU and associated research an efficient communication structure to promote scientific interaction within entities. Significant amounts of research funding were drawn from federal the MCNLMU. Additionally, MCNLMU internal research grants help to set up sources (Bundesministerium für Bildung und Forschung, Deutsche collaborative interactions between members. Forschungsgemeinschaft), Bavarian-wide initiatives (Elite Network of Bavaria), as well as private organisations and industry (AMGEN). Successful The beauty of the Center is that it combines elaborate efforts in research research initiatives that were substantially supported by the Center range from world-class scientists with a wide range of teaching measures that from fundamental research on neuronal circuits (Collaborative Research cumulate in the Graduate School of Systemic Neurosciences (GSNLMU). Here, Center 870) to theoretical and computational neurosciences (Bernstein neuroscience teaching from B.Sc. to Ph.D. is provided in a well-structured Center for Computational Neuroscience Munich). Beyond the circuit level, form that undergoes continuous evaluation. The teaching within the GSNLMU the Center‘s focus is also set on research on cognitive processes. The huge is complemented by undergraduate programmes like the Amgen Scholars potential for translating results from research into tangible applications Program which provide insight into the Center and its School to international becomes evident by successful initiatives applying research to technical students at an early stage. While these initiatives potentially scout for well Prof. Dr. Oliver Behrend systems (Excellence Cluster Cognition for Technical Systems). This holds educated students from abroad, other complementary MCNLMU initiatives MCNLMU Managing Director especially true for those initiatives applying top-notch scientific results on advanced Ph.D. and postdoctoral levels – like the Harvard-LMU Young directly to the benefit of patients, i.e. within centers that integrate research Scientists‘ Forum and the QBI-MCNLMU Symposium aim to promote an Dear Readers, and treatment (e.g. Integrated Center for Research and Treatment of Vertigo, exchange of young scientists with other excellent neuroscience institutions Dear Members and Friends of the Munich Center for Neurosciences, Systems Neurology Cluster Initative). around the world.

This compendium of the Center‘s activities is meant to reach out to the wider These initiatives also have substantial influence on the society‘s perception To effectively secure a straightforward curriculum with the multitude neuroscience community, both nationally and internationally, and also to of neurosciences and help in forging a general consensus that neuroscience of options available to students within the MCNLMU / GSNLMU a teaching make individual research interests of the Center‘s members visible to each research is critical for a healthy development of our society in the future. coordinator has been appointed, and a student relations coordinator helps other. Furthermore, this publication was designed to communicate some of A number of initiatives keep Munich as a Center for neurosciences on the students to adjust their path towards graduation on an individual basis. The the richness and sophistication of the neurosciences in the greater Munich screen of local, national, and international . For instance, more sound education of future neuroscientists within the Center will help to further area to non-scientists. The LMU-wide Ringvorlesung (Theme Lecture Series) than 40 well-recognised researchers were brought to the Center by invitation develop the Munich area as an outstanding neuroscience hub in the world. “Der Mensch und sein Gehirn“ was already an important step in that to participate in the prestigious MCNLMU Monday Lecture Series since 2007. On a personal note – enjoy the read! direction. Beyond presenting the Center‘s scientific wealth, this document Other events, like the envisaged Christmas Lecture in collaboration with the attempts to clarify the aims of the Center, and the advantages that arise Bavarian Ministry of Science, Research and the Arts will further strengthen With kind regards, from bringing together such a vast variety of neuroscientific expertise. the Centers public outreach. In the future, also the online presence of the Center and associated entities will be revised substantially. In order to cover The university’s initiativ LMUinnovativ led to the formation of the that increasingly important field of public relations, a PR coordinator and IT MCNLMU. As a major outcome, the attraction of third party funding (joint staff were recently funded by the MCNLMU, and the implementation of modern grants ~60 million, 2007 – 2011) was facilitated by being able to resort means of internal and external communication, e.g. podcasts, iMCNLMU, is on Prof. Dr. Oliver Behrend Managing Director Managing 12 | 13 The network | Research & Collaborations & Collaborations | Research LMU MCN 14 | 15

Zoology TUM Institute of Electrical Neurosciences Engineering TUM TUM Bernstein Center for Computational Theoretical Neuroscience Medicine Physics TUM The network TUM Bio-inspired Clinical Medicine information processing LMU University TUM Hospital Biomedical Center Medical LMU Psychology MPI of LMU Neurobiologie MPI for Ornithology

Biology LMU LMU MCN Biocenter MPI of Psychiatry

Philosophy LMU Psychology LMU

Institute Munich of Stem Cell Compentence Research Center Helmholtz for EthicsLMU Institute of Developmental Genetics Helmholtz | Research & Collaborations | Research LMU MCN 16 | 17

BCCN – Bernstein Center for Computational Neuroscience Munich

Neuronal representations of space and time are basic functions of nervous systems. Yet, in • in-vitro recordings, in-vivo recordings as well as of fundamental importance for cognition and recent years, there have been numerous exciting psychophysics and fMRI behavior – from localizing prey by auditory new discoveries about neuronal representations • studies in different neuronal structures: brain cues and visually detecting moving objects to of space-time, as also shown by many stem, cortex, as well as insect receptor neurons the planning and neuronal control of future publications from BCCN Munich. and interneurons movements. Goal-directed self-motion relies • scientists from Ludwig-Maximilians-Universität on continually evaluating changing sensory Research projects at Bernstein Center Munich München (LMU), Technische Universität inputs in real time and taking previously stored cover and connect: München (TUM), Max-Planck-Institute of information into account to generate spatially • experiment, data analysis, modeling and Neurobiology (MPI), MED-EL Deutschland, coordinated and appropriately timed motor theoretical approaches and NPI – Electronic Instruments for the Life actions. Our brain solves these challenging • neurobiology, , Sciences computational tasks with apparent ease, using biomathematics, physics, computer science, intricate feedback circuits in distributed neural and engineering Together with five other Bernstein Centers, the circuits whose functional architecture adapts • computational modeling on various levels; BCCN Munich forms the core of the National in time. Pathologies of visuomotor control and compartmental models of dendritic trees, Network Computational Neuroscience (www. age-related navigation deficits reveal that the simplified single-neuron models, networks of nncn.de). Supported by highly competitive start- underlying processes hang in a delicate balance; spiking neurons, and models at the systems up funds from the Federal Ministry of Education limitations and failures of current technical level and Research, more than 20 faculty positions have applications demonstrate that we have only • investigations on auditory, electrosensory, been newly created within the Network, five of Director: Prof. Dr. Andreas Herz rather restricted insight into some of the most vestibular, and visual information processing which are located at BCCN Munich. BCCN | Bernstein Center for Computational Neuroscience Munich BCCN | Bernstein Center for Computational Neuroscience 18 | 19

CoTeSys – Cognition for Technical Systems the need to write computer programmes for all German Federal Armed Forces University of possible events that may occur. Munich and the German Aerospace Center DLR CoTeSys is one of the largest projects in providing machines in Oberpfaffenhofen. CoTeSys, therefore, belongs and robots with biology-inspired cognitive capabilities. Be it servicerobots or industrial robots – the to the largest interdisciplinary research clusters in scientists in CoTeSys work devotedly on the the field of cognition. realization of robots as assistants for many aspects of life. Cognition technology poses CoTeSys can report numerous success stories all kinds of questions in brain research, giving examples on how to bridge the gap The mission of the scientists working in the Cognitive technologies are the crux. They psychology and biophysics, computer science, between fundamental research in neurocognition, Cluster of Excellence CoTeSys (Cognition differ from other technical systems as they mechanical engineering, control engineering psychology and informatics, and engineering. for Technical Systems) is the transfer of have cognitive capabilities and hence perform and mechatronics, solutions that are found only CoTeSys attracts top international scientists as cognitive skills which are attributed to animals cognitive control. Cognitive control orchestrates in close, interdisciplinary teams. The practical new junior and tenured professors and has a and humans, to technical systems such as reflexive and habitual behaviour towards long implementation of the theoretical findings is significant impact on academia, industry, future robots, manufacturing systems, and vehicles. term autonomy and intentions. Cognitive of high importance to CoTeSys. Therefore, all societies and the general public. CoTeSys is They study how robots can perceive their capabilities include perception, reasoning, theoretical results have to be demonstrated in highly successful in establishing Independent environment and react appropriately to it, how learning, goal-oriented planning, and result technical demonstration scenarios, to verify and Junior Research Groups and is involved in several machines can cooperate with people in a way in systems of higher autonomy, flexibility, validate the superiority of cognitive approaches. educational gender projects, attracting young girls that humans are supported physically and adaptivity, reliability, robustness featuring These scenarios provide means for applying, and boys to scientific and technical professions. intellectually. This requires that machines can better interaction with humans and improved integrating, validating and analyzing new research It is an explicit goal of CoTeSys to promote learn. A service-robot in the “cognitive kitchen“ collaboration capabilities. methods in the context of real-world scenarios more women into senior positions. CoTeSys has learns not only the locations and functions of that are of critical importance economically and to successfully established two Central Robotics drawers and cupboards, but also movements, In order for machines and humans to work society. Laboratories CCRL-I in Barerstraße and CCRL-II in manipulations, grasping, and procedures, e.g., together, machines must learn to accomplish Karlstraße, both located in downtown Munich. to set a table, bake pancakes. In the “Cognition- tasks the way humans do. Only if robots are Since 2006, CoTeSys has pooled the expertise enabled factory”, an industrial robot equipped able to recognize their environment, react of around 100 scientists of the Technische CoTeSys is one of the strategic projects supported with cameras, touch and force sensors, assists flexibly, intuitively, and, to a certain extent Universität München, the Max Planck Institute of with federal and state funds through the German humans in the assembly of custom-tailored autonomously, are they able to assist human Neurobiology, the Ludwig-Maximilians-Universität Excellence Initiative. Director: Prof. Dr. Martin Buss products. beings in an overall manner and spare them München, Universität der Bundeswehr, the CoTeSys | Cognition for Technical Systems | Cognition for Technical CoTeSys 20 | 21

Integrated Center for Research and Treatment of Vertigo, Balance and Ocular Motor Disorders (IFBLMU)

The Integrated Center for Research and organise the study infrastructure for prospective should also be seen as an incentive that will attract furthermore, plans to establish a “Clinical Scientist Treatment of Vertigo, Balance and Ocular multicentre clinical studies as well as to free the best young scientists; (8) to incorporate IFBLMU” curriculum which shall be integrated Motor Disorders (IFBLMU), established in clinical scientists from administrative tasks; (5) IFBLMU competence into the existing medical and in the degree awarding process for M.Sc. Munich in 2010, brings a novel approach to promote translational research with a focus biological graduate schools. (Epidemiology, Public Health) and M.D./Ph.D. towards integrating basic research and clinical on the innovative topics of molecular, functional programmes focussed on clinical research. treatment. During the last decades, Munich has and structural imaging, experimental and clinical Translational research within the IFBLMU is become the site of a unique concentration of pharmacotherapy, clinical research of vertigo supported by up to eight young scientist groups, leading experts on vertigo, balance and ocular and balance disorders, mathematical modelling, working independently and self-reliantly within the motor disorders, both in the clinical and basic interaction between biological and technical IFBLMU and up to eight (tenure track) professors. sciences. systems (robotics), and research on functionality The access to patients and methods is ensured and the quality of life; (6) to offer new attractive by cooperation contracts among the clinics and Using this unique expertise, the IFBLMU seeks educational paths and career images for medical institutes involved in the IFBLMU. (1) to create an independent patient-oriented doctors, students of the natural sciences, and clinical research centre; (2) to overcome engineers in clinical research in order to overcome Training within the IFBLMU builds on existing existing clinical and academic barriers traditional hierarchical structures. This should scientific training programmes such as the M.Sc. separating the traditional specialisations; (3) promote the principles of efficiency and self- programs in Clinical Epidemiology and Human Chief Executive Director: Prof. Thomas Brandt, MD, FRCP to establish a standardised interdisciplinary reliance; (7) to supplement the existing expertise Functioning Sciences and the Ph.D. program in Deputy Director: Prof. Michael Strupp, MD longitudinal and transversal network at one with up to eight groups of young scientists and Neuroscience through the Graduate School of

| Integrated Center for Research and Treatment of Vertigo, Balance and Ocular Motor Disorders of Vertigo, and Treatment Center for Research | Integrated Chief Administrator: Dr. Andreas Schepermann site for the management of patients; (4) to up to eight professorships (tenure-track). This Systemic Neurosciences (GSNLMU). The IFBLMU, LMU IFB 22 | 23

Collaborative Research Center 870 – Assembly and Function of Neuronal Circuits in Sensory Processing

Along with major success in molecular and relationships of neuronal circuits, their dynamics determine biologically relevant experimental cellular neurosciences, over the last decades, and computations and intends to gain a deeper approaches. In addition, advanced model-driven brain imaging techniques like fMRI and EEG understanding of the molecular basis of the hypotheses about sensory processing combined provided fascinating data. However, the development, plasticity and regeneration of with new experimental techniques enhance understanding of the brain’s complex functions, sensory circuits as well as processing mechanisms the development of new and more powerful compartments and interrelations still needs for behaviourally relevant information. experimental approaches vital for advancing conjoined research efforts: Fundamental, but systemic neuroscience. Therefore, several projects yet open questions – like the translation of For various reasons, neuronal circuits serve as in the CRC 870 are investigating new approaches cellular mechanisms into higher brain functions ideal model systems to study the principles of for the manipulation of neuronal activity in specific as well as processing of behaviourally relevant neuronal information processing: First, these subpopulations of neurons within neuronal information on intermediate levels of brain circuits process highly specific physical cues, circuits. These include genetic alterations organisation by specific neuronal circuits and which are present in sensory stimuli and can targeting specific subpopulations as well as the neuronal populations within – remain largely be tightly controlled in physiological and/or use of optically controlled, photo-switchable unanswered. behavioural experiments. Efficient analysis molecules that can be used to accentuate the of the information processing in neuronal activity of single neurons. Such methods will In order to address such questions, the circuits is facilitated by parallel, anatomically allow for more efficient and conclusive testing of Collaborative Research Center (CRC) 870 distinguishable pathways specialized for certain hypotheses about the flow of information within Director: Prof. Dr. Benedikt Grothe ‘Assembly and Function of Neuronal Circuits in sensory stimuli. Moreover, sensory circuits show neuronal circuits. Scientific Manager: Dr. Kristina Vaupel Sensory Processing’ comprising 23 scientific specific adaptations to structure and functions projects, aims at elucidating structure-function related to behavioural needs, which help to CRC 870 | Collaborative Research Center 870 Research CRC 870 | Collaborative 24 | 25

first second third third second first research research research research research research 1focus 2focus 3focus 3focus 2focus 1focus Biomedical Neuroscience Dr. Florence Bareyre | 26 58 | Prof. Dr. Andreas V.M. Herz

Dr. Jan Benda | 28 60 | Prof. Dr. Mark Hübener

The Prof. Dr. Martin Biel | 30 62 | Dr. Ilona Grunwald Kadow Behavioral & Cognitive * Prof. Dr. Tobias Bonhoeffer | 32 Neuroscience 64 | Prof. Dr. Ruediger Klein people Prof. Dr. Alexander Borst | 34 66 | Prof. Dr. Arthur Konnerth Prof. Dr. Gordon Cheng | 36 68 | Prof. Dr. Christian Leibold Prof. Dr. Heiner Deubel | 38 70 | Prof. Dr. Hannes Leitgeb

Prof. Dr. Marianne Dieterich | 40 72 | Prof. Dr. Hermann J. Müller

Dr. Veronica Egger | 42 Molecular & Developmental 74 | Prof. Dr. Julian Nida-Rümelin Dr. Felix Felmy | 44 Neuroscience 76 | Prof. Dr. Heidrun Potschka

Dr. Kathrin Finke | 46 78 | Prof. Dr. Gerhard Rigoll

Prof. Dr. Manfred Gahr | 48 Cellular & Systems 80 | Prof. Dr. Hans Straka

Prof. Dr. Magdalena Götz | 50 Neuroscience 82 | Prof. Dr. Michael Strupp

Dr. Oliver Griesbeck | 52 84 | Prof. Dr. Dirk Trauner

Prof. Dr. Benedikt Grothe | 54 Theoretical Neuroscience & 86 | Prof. Dr. Wolfgang Wurst Technical Applications Prof. Dr. Dr. h.c. Christian Haass | 56 * Selection of MCNLMU members. See page 120 for list of all MCNLMU members. MCN | Research & Collaboration MCN | Research 26 | 27 Ludwig-Maximilians-Universität München Dr. Florence Bareyre Promoting axonal growth, pathfinding and synapse Institute of Clinical www.klinikum.uni-muenchen.de/Institut-fuer-Klinische-Neuroimmunologie formation following spinal cord injury Contact information on page 120

Advanced Professional Degrees 2003 PhD, Brain Research Institute, University and ETH Zurich, Switzerland 1997 Master‘s biochemistry, University of Paris VII, France

Awards and Professional Affiliations 2009 Independent BMBF Group leader “Spinal cord repair” 2009 Member of the LMU Center of Advanced Studies (CASy) 2007 Junior Research Award of the German Multiple Sclerosis We are studying the neuronal corticospinal tract after traumatic or these mice we have demonstrated that Society (Sobek price) response to traumatic and inflammatory lesions of the spinal cord. when the main CST tract is lesioned, inflammatory lesions of the spinal We have shown that the recovery of minor CST components remodel to Publications cord. In initial studies we have corticospinal function is achieved by compensate the lesion. We now • Bareyre FM, Garzorz N, Lang C, Misgeld T, Büning H, Kerschensteiner M (2011) In vivo imaging reveals a phase-specific role of STAT3 investigated how therapeutic the formation of new intraspinal detour combine our expertise on axonal during central and peripheral nervous system axon regeneration. strategies can limit neuronal cell circuits involving propriospinal relay remodeling with emerging imaging Proc Natl Acad Sci U S A. 108(15):6282-7. death following CNS injury (Bareyre neurons (Bareyre et al., 2004; techniques that allow the direct • Bareyre FM, Kerschensteiner M, Misgeld T and Sanes JR (2005) et al., 1997; 1999; 2000; 2001). Kerschensteiner et al., 2004). We are visualization of regrowing axons and Transgenic tracing of the corticospinal tract: a new tool to study now trying to address the following their path to the target cells in vivo axonal regeneration and remodeling. Nature Medicine. 11(12):1355- We are currently trying to understand important questions: (i) how do (Misgeld et al. 2007; Nikic et al., 2011). 1360. how we can promote axonal repair of increase axon growth following SCI, (ii) We use this approach in combination • Bareyre FM, Kerschensteiner M, Raineteau O, Mettenleiter TC, Weinmann O and Schwab ME (2004) Spontaneous formation of a new surviving neurons by focusing on the how do growing axons find the with viral gene therapy to dissect the axonal circuit in the rat injured spinal cord. Nature Neuroscience. molecular and anatomical mechanisms appropriate path to their intraspinal molecular regulation of the neuronal 7(3):269-277. underlying axonal plasticity after targets and (iii) how do they form and growth response in vivo (Bareyre et al., traumatic and inflammatory spinal cord stabilize synapses onto these targets? 2011). We also focus on dissecting the Lab members lesions (Bareyre et al., 2002; 2004; In order to gain first insight into the molecules and mechanisms underlying Peter Bradley, Claudia Lang, Anne Jacobi, Catherine Sorbara, Kerschensteiner, al., 2004). By principles that can regulate axonal efficient target finding and synapse Fabian Laage-Gaupp, Anja Schmalz microarray analysis, we have identified pathfinding and synapse formation, we formation during post-traumatic detour a number of candidate molecules that engineered methods to visualize circuit formation. might impact axonal outgrowth and synapses via tagged peptides (McCann, Members pathfinding during post-traumatic Bareyre et al., 2005) and generated LMU recovery (Bareyre et al., 2002). To transgenic mice in which the

MCN further understand how spontaneous corticospinal tract is selectively and recovery of function is achieved we specifically labelled with a fluorescent study the reorganization of the protein (Bareyre et al., 2005). Using 28 | 29 Ludwig-Maximilians-Universität München Dr. Jan Benda Function of intrinsic noise in sensory Division of Neurobiology Department Biology II signal processing www.bio.lmu.de/~benda Contact information on page 120

Awards and Professional Affiliations • BMBF Bernstein Award Computational Neurosciene 2007

Publications • Tilo Schwalger, Karin Fisch, Jan Benda & Benjamin Lindner (2010): How noisy adaptation of neurons shapes interspike interval histograms and correlations. PLoS Computational Biology, 6(12): e1001026 • Jan Benda, Leonard Maler & André Longtin (2010): Linear versus The main goal of our research recorded neural responses. Currently, nonlinear signal transmission in neuron models with adaptation- on sensory systems is to identify we focus on potentially advantageous currents or dynamic thresholds. Journal of 104: common principles of signal roles of intrinsic noise source in sensory 2806-2820 processing in various neural processing. • K. Jannis Hildebrandt, Jan Benda & R. Matthias Hennig (2009): The origin of adaptation in the auditory pathway of locusts is specific to systems and to investigate their cell type and function. Journal of Neuroscience 29(8): 2626-2636 implementation on the cellular level. In addition, we characterize the Our experimental approaches are statistics of natural stimuli for the Lab members strongly influenced by theories on electrosensory systems of weakly Jan Grewe, Henriette Walz, Jörg Henninger, Anna Stöckl, Charlotte Pix, neural function as dynamical systems electric fish both in well-controlled Franziska Kümpfbeck, Anatoli Ender and on information theoretical experiments in the lab and in natural considerations. habitats in South-America. For the Vice versa, we develop new theoretical latter we are developing a grid of concepts that are inspired by our electrodes that continuously record the experimental findings. In particular, we electric fields of the fish. From the data perform electrophysiological we reconstruct the position as well as recordings on the active and the passive the communication signals for each fish electrosensory systems of wave-type individually. This novel method weakly-electric fish and on the auditory eventually allows us to record natural system of grasshopper and crickets. signals in natural habits on Both systems have the advantage to unprecedented spatial and temporal Members allow for comparative studies between scales. The resulting data will be very LMU related species. We contrast our data important for discussing our findings

MCN with well known properties of canonical from the comparative electro- integrate-and-fire type models in order physiological experiments on neural to identify non-trivial features of tuning properties. 30 | 31 Ludwig-Maximilians-Universität München Prof. Dr. Martin Biel Ion channels in the CNS: from genes to disease Department of Pharmacy – Center for Drug Research www.cup.uni-muenchen.de/ph/aks/biel/ Contact information on page 120

Advanced Professional Degrees • Professor and Chair of Pharmacology, Department of Pharmacy, LMU

Awards and Professional Affiliations • Honorary Professorship, Fudan University, Shanghai, PR China (2004) • Fritz-Winter-Preis (1997) • Heinz Maier Leibnitz Forschungsförderungspreis (1994)

Publications Our laboratory aims at achieving physiological relevance using genetic diseases. As for CNG channels, we • Michalakis S, Mühlfriedel R, et al., Biel M, Seeliger MW (2010) Gene insights into the role of ion channels mouse lines produced in our laboratory. examine the role of HCN channels on therapy restores missing cone-mediated vision in the CNGA3-/- in normal physiology and disease. Ion We are particularly interested in retinal the molecular and systemic level using mouse model of achromatopsia. Mol Ther 18:2057-2063. channels are protein complexes that CNG channels since dysfunction of biophysical tools and genetic mouse • Wahl-Schott C, Baumann L, Cuny H, Eckert C, Griessmeier K, Biel M (2006) Switching off calcium-dependent inactivation in L-type confer the flux of ions through cellular these channels can lead to visual models. calcium channels by an autoinhibitory domain. Proc Acad Sci.USA membranes. These proteins are vital impairment and even blindness. We 103:15657-15662. for virtually every cell in the body. recently developed advanced gene The third group of ion channels we are • Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M (1998) A family In neurons, ion channels provide the therapy approaches to restore vision in studying are calcium channels. Recently of hyperpolarization-activated mammalian cation channels. Nature basis for action potential generation a genetic mouse model of a special kind our laboratory discovered a novel class 393:587-591. and information processing. of blindness (achromatopsia). of calcium channels (TPCNs “two-pore Dysfunction of ion channels causes channels”) that are strictly localized in Lab members Elvir Becirovic, Xiaochun Cao-Ehlker, Stefanie Fenske, acquired or inherited diseases Another focus of our work is on HCN lysosomes which represent the smallest Verena Hammelmann, Stylianos Michalakis, Xiangang Zong (“channelopathies”) including channels. Our group discovered these organelles of cells. We found that numerous diseases of the nervous ion channels in 1998. HCN channels TPCNs are specifically activated by the system (e.g. epilepsy, migraine, are activated by membrane novel second messenger NAADP disorders, depression). hyperpolarization (H) and cyclic (nicotinic acid adenine diphosphate). nucleotides (CN) and play a crucial role Our long-term goal is to achieve a One class of ion channels we are in controlling basic excitability and complete understanding of the specific interested in are the cyclic nucleotide- rhythmic firing of neurons. HCN physiological roles of TPCNs.To this end regulated cation channels (CNG and channels are also involved in other we are developing a variety of tools Members HCN channels). CNG channels are neuronal functions including memory (including planar patch-clamp LMU crucial for olfactory and visual formation, control and dendritic approaches) to characterize TPCNs in

MCN transduction. We have characterized integration. Dysfunction of HCN native lysosomes. several members of this ion channel channels has been associated with class and have investigated their epilepsy, ataxia and other neurological 32 | 33 Max Planck Institute of Neurobiology Prof. Dr. Tobias Bonhoeffer Structural correlates of synaptic plasticity Department of Cellular and Systemsneurobiology http://www.neuro.mpg.de/24259/bonhoeffer Contact information on page 120

Advanced Professional Degrees • Professor • Director at the Max-Planck-Institute of Neurobiology

Awards and Professional Affiliations • Member of the German Academy of Sciences Leopoldina • Ernst Jung Prize for Medicine • Associate, Neuroscience Research Program (NRP), The Neurosciences Institute, San Diego, USA The department is investigating the fundamental principles of synaptic Publications plasticity at a number of different • Hofer SB, TD Mrsic-Flögel, T Bonhoeffer, M Hübener (2009) levels, ranging from molecular Experience leaves a lasting structural trace in cortical circuits. Nature 457:313-317. approaches to studies of the intact • Nägerl UV, KI Willig, B Hein, SW Hell, T Bonhoeffer (2008) Live-cell nervous system. Recent results from imaging of dendritic spines by STED microscopy. Proc. Natl. Acad. the lab have shown that synaptic Sci. USA 105:18982-18987. plasticity is accompanied by structural • Hofer, SB, TD Mrsic-Flogel, T Bonhoeffer, M Hübener (2006) Prior changes of dendritic spines, they experience enhances plasticity in adult visual cortex, Nature Neurosci have demonstrated the importance of 9:127-132. neurotrophins in synaptic plasticity, Lab members and they have revealed the detailed Cvetalina Coneva, Onur Gökce, Susanne Falkner, Rosa Garcia Verdugo, structure of functional maps in the Mark Hübener, Claudia Huber, Julian Jäpel, Ron Jortner, Georg Keller, visual cortex. Marcus Knopp, Anne Kreile, Marcus Leinweber, Sabine Liebscher, 1 Daniel Meyer, Fiona Müllner, Tobias Rose, Alexandre Ferrao Santos, Volker Scheuss, Anne Schümann, Max Sperling, Volker Staiger, (1) Pyramidal neurons of mouse cortex Frank Voss, Corette Wierenga, Pawel Zmarz Members LMU MCN 34 | 35 Max Planck Institute of Neurobiology Prof. Dr. Alexander Borst Motion processing in the fly visual system www.neuro.mpg.de Contact information on page 120

Advanced Professional Degrees 2001 – present Director MPI of Neurobiology 1999 – 2001 Professor at UC Berkeley, ESPM, Division of Biology 1993 – 1999 Junior Group Leader at the FML, Tübingen

Awards and Professional Affiliations • Otto-Hahn Medal of the Max Planck Society 1989 • Dupont Lecturer, Tucson 2001 • Erasmus Lecturer, Rotterdam 2003 Our department is interested in how and transmit this information to the • Human Frontier Science Program (HFSP) Awardee 2006 motion information from the changing neck motor neurons or, via the cervical • Leopoldina 2011 retinal images is computed in the fly connective, to motor centers for legs • EMBO 2011 visual system and how this information and wings in the thorax. Publications is decoded for flight control. In general, • Eichner H, Joesch M, Schnell B, Reiff DF, Borst A (2011): Internal this processing is done in two steps: In Our work combines experimental and reconstruct important parts of the optic structure of the fly elementary motion detector. Neuron 70: 1155-1164. the first step, local motion vectors are theoretical analysis ranging from visual lobes of both species at the • Joesch M, Schnell B, Shamprasad VR, Reiff DF, Borst A (2010) ON and calculated from local changes in retinal responses, membrane properties and ultrastructural level using his recently OFF pathways in Drosophila motion vision. Nature 486: 300-304. brightness. This calculation is done pharmacology of individual neurons up developed Serial Block Face Scanning • Weber F, Machens CK, Borst A (2010): Spatio-temporal response according to the Reichardt model of to network responses to natural image Electron Microscope (‘BlueFly’). properties of optic-flow processing neurons. Neuron 67: 629-642. local motion detection, most likely in sequences created by the fly’s own Biophysically realistic compartmental models of individual neuronBiophysically Lab members the fly‘s medulla. From the resulting flight maneuvers. Our experimental Georg Ammer, Alexander Borst, Alexander Arenz, Armin Bahl, vector fields (the ‘neural optic flow’), animals are the blow fly Calliphora realistic compartmental models of Hubert Eichner, Wolfgang Essbauer, Renate Gleich, Jürgen Haag, important course control parameters vicina (‘BigFly’) and the fruitfly individual neurons obtained from Väinö Haikala, Elisabeth Hopp, Christoph Kapfer, Isabella Kauer, are extracted in a second step. This Drosophila melanogaster (‘LittleFly’). 2P-image stacks allow us to reconstitute Romina Kutlesa, Matthew Maisak, Alex Mauss, Matthias Meier, is realized in the fly visual system While the first species allows for the network of motion processing Katarina Pankova, Johannes Plett, Etienne Serbe, Christine Thalhammer, at the level of the lobula plate. Here, intracellular and optical recording from neurons in computer simulations Christian Theile, Franz Weber tangential cells integrate, by their large individual neurons, the latter provides (‘ModelFly’). As a joint project with dendrites, the output signals of in addition a wealth of genetic Martin Buss and Kolja Kuehnlenz retinotopically arranged local motion- techniques including tissue specific (TUM, Munich, sponsored by the Members sensitive neurons and, in addition, expression of genetically encoded BMBF within the excellence cluster LMU interact amongst each other. indicators and blockers of nervous CoTeSys), our knowledge about the

MCN Postsynaptic to these tangential cells, activity. In collaboration with Winfried fly motion vision system goes into the descending neurons become further Denk (MPI for Medical Research, development of miniature airborne selective for specific optic flow fields Heidelberg), we also try to fully vehicles (‘RoboFly’). 36 | 37 Technical University Munich Prof. Dr. Gordon Cheng Humanoid robotics and neuroscience: Institute for Cognitive Systems www.ics.ei.tum.de science, engineering and society Contact information on page 120

Advanced Professional Degrees 2001 Ph.D. (Systems Engineering), The Australian National University, Australia 1993 Master of Computer Science, University of Wollongong, Australia 1991 Bachelor of Computer Science, University of Wollongong, Australia

Awards and Professional Affiliations Our research interests fall in line with • IEEE Gennai Medal (2007) the notion of “Understanding through • Center of Excellence (COE) Fellow (2000) Creating“, three essential aspects • Japan Science and Technology Agency (STA) Fellow (1998) motivate our approach in the area of Publications Humanoid Robotics and Neuroscience: • Gordon Cheng. (2012) Humanoid Robotics and Neuroscience: Science, Engineering and Society: Science, Engineering and Society (Frontiers in Neuroengineering Series). In Engineering – Engineers can gain a • Thierry Chaminade and Gordon Cheng. 2009. Social cognitive great deal of understanding through the neuroscience and humanoid robotics. Journal of Physiology – Paris, studies of biological systems, which can Volume 103, Issues 3-5, Pages 286-295 (May-September 2009). provide guiding principles for • Gordon Cheng, Sang-Ho Hyon, Jun Morimoto, Ales Ude, Joshua Hale, Glenn Colvin, Wayco Scroggin, Stephen Jacobsen. (2007). developing sophisticated and robust CB: A humanoid research platform for exploring neuroscience. artificial systems. Journal of Advance Robotics, 21, 10, 1097-1114. Scientifically – Building of a human-like Lab members machine and the reproduction of Takaaki Kuratate, Samer Alfayad, Andreas Holzbach, Brennand Pierce, human-like behaviours can in turn teach Marcia Riley, Ewald Lutscher, Philipp Mittendorfer, John Nassour, us more about how humans deal with Erhard Wieser, Rong Li the world, and the plausible mechanisms involved. Members LMU For society – In turn we will gain

MCN genuine knowledge toward the development of systems that can better serve our society. 38 | 39 Ludwig-Maximilians-Universität München Prof. Dr. Heiner Deubel Sensory-motor integration Experimental Psychology, Department of Psychology http://www.paed.uni-muenchen.de/~deubel/ Contact information on page 120

Advanced Professional Degrees • 2005 Professor (apl), Department of Psychology, LMU • 2007 Academic Director, Department of Psychology, LMU

Publications • Baldauf, D. & Deubel, H. (2010). Attentional landscapes in reaching and grasping – Minireview. Vision Research 50:999-1013. • Jonikaitis, D. & Deubel, H. (2011). Independent allocation of attention to eye and hand targets in coordinated eye-hand movements. The research in our laboratory studies One striking example for such a strong is perceived as stable, despite the Psychological Science 22(3):339-347. the interplay between mechanisms relationship between perception and notorious shifts of the retinal image due • Rolfs, M., Jonikaitis, D., Deubel, H., & Cavanagh, P. (2011) Predictive related to visual perception and action relates to the role of spatial to continuous eye and body movements remapping of attention before eye movements. Nature Neuroscience mechanisms related to the generation attention and movement preparation. (e.g., Rolfs et al., 2011). 14:252-258. of simple actions such as eye In a series of recent studies we Lab members movements, manual reaching, and demonstrated that before the execution Methods used in our research include Donatas Jonikaitis, Rene Gilster, Saurabh Dhawan, Anna Klapetek, grasping. of movements such as sequential various psychophysical procedures, Giulia Manca reaching movements, bimanual eye and hand tracking, EEG, and On the one hand, we are interested movements, and manual grasps, all transcranial magnetic stimulation in precisely how visual information is those regions and objects in the visual (TMS). processed in order to finally allow for field are selectively processed that are a goal-directed movement – in other relevant for the planned action This words, how the visual input projected results in an “attentional landscape” on the retina is ultimately transformed that closely reflects the requrements into an appropriate motor response of the motor task (Baldauf & Deubel, such as an accurate saccade. On the 2010). other hand, our research (along with recent findings from other laboratories) Another research line in our lab has indicated that the way how visual concerns mechanisms of oculomotor information is processed depends learning, i.e., the question of how the Members strongly on the actually planned motor brain is able to continuously adjust the LMU action – that is, what we “see” at each parameters of eye movements such

MCN moment in time depends on which that they are appropriate over lifetime actions we currently plan to perform. despite of fatique, disease, and aging. Finally, we investigate why the world 40 | 41 Ludwig-Maximilians-Universität München Prof. Dr. Marianne Dieterich, MD Cortical interaction between different sensory Head of the Department of Neurology Department of Neurology systems in healthy subjects and patients http://klinikum.uni-muenchen.de/de/kliniken/neurologie/index.html Contact information on page 120

Awards and Professional Affiliations 2004 Hallpike-Nylén Prize of the International Bárány Society 2000 Elfriede-Aulhorn Prize for Neuro- Ophthalmology 1999 Vertigo-Prize of the German Society of Neurology (DGN) 2011 Award of the German Society of and Functional Imaging (DGKN) for outstanding teaching.

Publications Most of our current knowledge vestibular neuritis). This pathological functional imaging studies of visual- • Strupp M, Zingler V, Arbusow V, Niklas D, Maag KP, Dieterich M, Bense of multisensory vestibular brain pattern was similar to that described in vestibular interactions (e.g., in patients S, Theil D, Jahn K, Brandt T: Effects of methylprednisolone, structures and their functions healthy volunteers during unilateral with lesions within the peripheral or valacyclovir, or the combination in vestibular neuritis. New Engl J in humans derive from brain vestibular stimulation. In the acute central vestibular system, the visual and Med 351: 354-361 (2004). • Dieterich M, Bauermann T, Best C, Stoeter P, Schlindwein P: Evidence activation studies with PET and fMRI stage of vestibular neuritis, the regional somatosensory systems). for cortical visual substitution of chronic bilateral vestibular failure conducted over the past decade cerebral metabolic rate glucose (an fMRI study). Brain 30: 2108-2116 (2007). [review: Dieterich & Brandt 2008]. (rCMRglc) increases in the multisensory References: • Zu Eulenburg P, Stoeter P, Dieterich M: Voxel-based morphometry The patterns of activations and vestibular cortical and subcortical • Bense S, Bartenstein P, Lochmann M, depicts central compensation after vestibular neuritis. Ann Neurol deactivations during caloric and areas, while decreasing in the visual et al. Metabolic changes in vestibular 68(2): 241-9 (2010). galvanic vestibular stimulations in and somatosensory cortex areas [Bense and visual cortices in acute vestibular healthy subjects have been compared et al., 2004]. Although we can now neuritis. Ann Neurol 2004; 56: Lab members Iskra Stefanova, Sandra Bense, Caroline Cyran, Regina Feuerecker, with those in patients with acute begin to attribute particular patterns of 624-630. Thomas Stephan, Rainer Boegle, Mattias Bögelein and chronic peripheral and central cerebral activation and deactivation to • Dieterich M, Brandt T. Functional vestibular disorders. the particular functional deficits in imaging of peripheral and central distinct peripheral vestibular disorders, vestibular disorders. Brain 2008; 131: These findings have provided a better the complex puzzle of the various 2538-52. insight into the complex cortical multisensory and sensorimotor interactions between the vestibular functions of the phylogenetically system and other sensory systems. ancient vestibular system is still Among the most notable findings, it imperfectly understood. The current Members was shown that the central vestibular project will concentrate on the LMU system exhibits a spontaneous visual- differential effects of acute ischemic

MCN vestibular activation-deactivation cortical lesions with vestibular signs on pattern in patients with an acute multi-modal sensory interactions. peripheral vestibular disorder (such as Particular emphasis will be placed on 42 | 43 Ludwig-Maximilians-Universität München Dr. Veronica Egger Sensory processing in the olfactory bulb Division of Neurobiology http://neuro.bio.lmu.de/research_groups/res-egger_v/index.html Contact information on page 121

Advanced Professional Degrees 1999 PhD, Max-Planck-Institute for Medical Research Heidelberg, Germany 1996 Diploma in Physics, Technical University Munich, Germany

Awards and Professional Affiliations • 2011 Independent BMBF Group leader “Function of reciprocal synapses” While odours appear to be rather Methods: Main current projects: • 2010 Member of the LMU Center of Advanced Studies (CAS) simple sensory stimuli, it is, as of We use two-photon laser scan • Reciprocal action between granule • 2001 Schloessman Award “Optical Methods in Modern Biology“ yet, unknown how the olfactory code microscopy in conjunction with cells and mitral cells: Role of TRPC operates: how is an olfactory image whole-cell patch clamp recordings from channels Publications • Abraham N.M., Egger V., Shimshek D.R., Renden R., Fukunaga I., synthesized from the structural individual neurons in acute brain slices • Long-term plasticity at the mitral cell Sprengel R., Seeburg P.H., Klugmann M., Margrie T.W., Schaefer A.T. & groups of the odour molecule that are to study calcium signals and correlated – granule cell synapse Kuner T. (2010) Synaptic inhibition in the olfactory bulb accelerates recognized by the odorant receptors? electrical activity in response to • Role of newborn interneurons odor discrimination in mice. Neuron 65, 399-411. sensory-like input from mitral cells. • Conditions for release from the • Egger V. Synaptic spikes in olfactory bulb granule cells cause long- Our lab is interested in the These techniques allow us to optically granule cell spine lasting depolarization and calcium entry. (2008) Eur. J. Neurosci. 27, microcircuitry of the olfactory bulb that detect synaptic activity at the level of 2066-2075. processes olfactory sensory information, individual synapses, that are located in • Egger V., Svoboda K. & Mainen Z.F. Dendrodendritic synaptic signaling in olfactory bulb granule cells: Local spine boost and global in particular the role of granule cells. large granule cell spines. To be able to low-threshold spike. J. Neurosci. 25, 3521-3530 (2005) Granule cells are axonless local investigate release from the reciprocal • Egger V., Feldmeyer D. & Sakmann B. (1999) Coincidence detection inhibitory interneurons that represent synapse, we are currently establishing and changes in synaptic efficacy in pairs of spiny layer 4 neurons of the largest fraction of the neuronal two-photon uncaging of glutamate. rat barrel cortex. Nature Neurosci. 2, 1098-1105 (1999) population of the olfactory bulb and interact exclusively with mitral Lab members and tufted cells via dendrodendritic Mahua Chatterjee, Wolfgang Bywalez, Michael Mörschel, reciprocal synapses. Hortenzia Jacobi Members LMU MCN 44 | 45 Ludwig-Maximilians-Universität München Dr. Felix Felmy Cellular physiology of auditory brainstem circuits Department Biology II, Division of Neurobiology Contact information on page 121

Awards and Professional Affiliations • Otto-Hahn-Medal of the Max-Planck-Society, 2004

Publications • Porres CP, Meyer EM, Grothe B, Felmy F (2011) NMDA Currents Modulate the Synaptic Input-Output Functions of Neurons in the Dorsal Nucleus of the Lateral Lemniscus in Mongolian Gerbils. J Neurosci 31:4511-4523. • Couchman K, Grothe B, Felmy F (2010) Medial superior olivary Sounds arriving at the ear contain functional specializations will be key to neurons receive surprisingly few excitatory and inhibitory inputs only information about intensity understand how these circuits process with balanced strength and short-term dynamics. J Neurosci and frequency, yet our auditory sound information. 30:17111-17121. system enables us to build an • Rautenberg PL, Grothe B, Felmy F (2009) Quantification of the three-dimensional morphology of coincidence detector neurons auditory environment that contains Our focus is herby on cellular n the medial superior olive of gerbils during late postnatal features from detected sound source specializations that allow for the development. J Comp Neurol 517:385-396. localizations up to complex speech exquisite temporal precision that is recognition. maintained even at high firing rates of Lab members many neurons in the auditory Julian Ammer, Christina Berger, Christian Porres, Lina Yassin To achieve such a representation of brainstem. Common features of these auditory space our auditory system is neurons are for example a very low specialized in extracting all possible input resistance to increase the speed features of incoming sounds and of postsynaptic integration or the computing their correlations for presence of large synapses that allow example between left and right ear. synaptic information transfer with little These computational features dominate temporal jitter. Using in vitro patch- the information processing in sub- clamp recordings combined with cortical circuits starting already in the imaging and light activation techniques cochlear and continue throughout the we aim to quantitatively understand the auditory brainstem circuits up to the strength and time course of synaptic Members midbrain. To achieve such computational transmission and of postsynaptic LMU tasks, neurons that form auditory integration mechanisms shaped by

MCN brainstem circuits have specialized in voltage gated ion channels in auditory many ways. To quantitatively brainstem circuits. understand these morphological and 46 | 47 Ludwig-Maximilians-Universität München Dr. Kathrin Finke Assessment and modification of attentional General and Experimental Psychology Neuro-Cognitive Psychology functions and dysfunctions http://www.psy.lmu.de/exp/people/ma/finke/index.html Contact information on page 121

Advanced Professional Degrees • Dr. phil., in Psychology, LMU, / Max Planck Institute of Psychiatry, Munich • PD, Venia legendi in Psychology, LMU Munich • Akademische Oberrätin, LMU Munich, General and Experimental Psychology / Neuro-Cognitive Psychology

Awards and Professional Affiliations • Max-Planck-Institute of Psychiatry, Munich, Postdoc Stipend Visual attention enables us to select characterisation of the relative decline have identified correlations to genetic • Assistant Prof., Catholic University Eichstätt/Ingolstadt a limited amount of relevant objects of some attentional functions and the abnormalities and to metabolic activity • Assistant Prof., LMU Munich, General and Experimental Psychology / from our environment in order to relative stability of others in healthy (Positron Emission Tomography, PET) Neuro-Cognitive Psychology effectively control behaviour. In our elderly (such as the participant shown in neurodegenerative diseases. Publications research group, we assess attention in the picture). Having established Similarly, in ADHD patients, we aim at • Finke K, Schwarzkopf W, Müller U, Frodl F, Müller HJ, Schneider WX, by psychophysical experiments, “normal” attentional parameters, we characterizing their attentional deficits Engel RR, Riedel M, Möller HJ, Hennig-Fast F (2011). Disentangling which are analyzed using a can use these sensitive parameters for and identifying anatomical deviations in the adult attention-deficit hyperactivity disorder endophenotype: mathematically formalized theory. the identification of impairments critical brain regions by magnetic parametric measurement of attention. J Abnorm Psychol (in press). induced by pathological neural resonance imaging (MRI). Using • Bublak P, Redel P, Sorg C, Kurz A, Förstl H, Müller HJ, Schneider WX, We describe the attentional functions of processes. We have shown e.g. a electroencephalography (EEG), we look Finke K (2011). Staged decline of visual processing capacity in mild a given participant by independent, systematic decline of attention in early for specific electrophysiological cognitive impairment and Alzheimer’s disease. Neurobiol Aging 32:1219-30. quantifiable parameters: the speed of Alzheimer’s disease and even in Mild correlates which reflect the different • Finke K, Bublak P, Dose M, Müller HJ, Schneider WX (2006). visual information uptake and the Cognitive Impairment, a high-risk stage attentional parameters and EEG- Parameter-based assessment of spatial and non-spatial attentional capacity of visual short-term memory for the development of this disease. biomarkers of age-related changes. deficits in Huntington’s disease. Brain 129: 1137–51. are relevant for fast and parallel uptake Furthermore, we showed that of information in a given instant. attentional parameters differentiate Recently, we have started to assess Lab members Selection parameters describe how normal participants from patients with whether and how the attentional Petra Redel, Johanna Funk, Wolfgang Schwarzkopf, Iris Wiegand, effectively we can filter specific attention-deficit-hyperactivity disorder parameters might be modifiable by Ingo Pals information on the basis of e.g. colour (ADHD). changes of the general arousal state of or location and ignore other, irrelevant the brain, using e.g. neuropharma- Members information. In these groups of interest, we also cological and electrical stimulation. The LMU analyse, how the attentional parameters aim is to analyze the degree of cognitive

MCN Some of these functions are prone and their changes are related to plasticity of these attentional functions to changes across the lifespan. One genetics and to underlying brain in healthy and disordered brain systems. line of our research focuses on the structures and activity patterns. We 48 | 49 Max Planck Institute of Ornithology Prof. Dr. Manfred Gahr Mechanisms of vocal learning and its sex-specific http://www.orn.mpg.de/2525/Abteilung_Gahr Contact information on page 121 implementation

Advanced Professional Degrees • Director at Max Planck Institute for Ornithology

Awards and Professional Affiliations • Scientific member of the Max Planck Society

Publications • Gahr, M.: Sexual Differentiation of the Vocal Control System of Birds. Adv Genet., 59: 67-105 (2007). In most bird species, male singing In order to produce learned sounds, endocrinology, of , of • Hartog, T. E., Dittrich, F., Pieneman, A. W., Jansen, R. F., Frankl-Vilches, behaviour functions for direct or birds need a “songbird“ genetic gene-expression, and of electro- C., Lessmann, V., Lilliehook, C., Goldman, S. A., and Gahr, M.: indirect competition for females, and background and sex steroids physiology in constrained, semi-natural, Brain-Derived Neurotrophic Factor Signaling in the HVC Is Required female mate choice involve vocal (androgens and estrogens) to develop and natural conditions. for Testosterone-Induced Song of Female Canaries. Journal of Neuroscience 29: 15511-15519 (2009) performances of the males. In the neural vocal control system into • Beckers, G.J.L. and Gahr, M.: Neural processing of short-term songbirds, songs consist of genetically a male or female configuration, Projects: recurrence in songbird vocal communication. PLoS One 5, e11129 determined and learned components. which differs between species. Song • The molecular mechanisms that (2010) doi:10.1371/journal.pone.0011129 Further, learning is changing female production in adulthood is sensitive determine the differentiation of the preferences for male songs. Thus, to sex steroid hormones (androgens song control system Lab members learning is crucial for both, the and estrogens) and other endocrine • Sex hormones and cellular Andries ter Maat, Falk Dittrich, Carolina Frankl-Vilches, production of sexual signals and the systems (e.g. melatonin) that signal mechanisms of song learning Wolfgang Goymann, Gabriel Beckers, Moritz Hertel, Albertine Leitao, Vincent van Meir response to sexual signals, i.e. learning environmental changes (ecological and • Hormone-dependent development is central for vocalization-based socio-sexual) to the vocal control. and importance of gender-specific sexual selection in songbirds. The brain structures acquisition of auditory memories, the The anatomical and functional • Electrophysiological studies of transformation of auditory memories distinctness of the vocal system of hormone dependent song learning into, and the use of motor memories songbirds as well as the large data base and production is influenced by the physiological on natural behaviour of songbirds • Song development under semi-natural conditions and/or the socio-sexual makes the vocal system very attractive conditions experience of an individual. This to study the genetic and environmental • Evolutionary and environmental Members suggests that vocalization-based sexual causes of neural sex differences and physiology LMU selection in songbirds is anchored on its consequences for sexual behavior

MCN the life-history of males and females. (sex specific functions). The projects are multidisciplinary and integrate works on the level of behavior, of 50 | 51 Ludwig-Maximilians-Universität München and Helmholtz Center Munich Prof. Dr. Magdalena Götz Neurogenesis in the developing and adult brain; LMU – Physiological Genomics Helmholtz Center Munich, Institute Stem Cell Research neuronal repair after brain injury http://www.genom.physiol.med.uni-muenchen.de/index.html & see below http://www.helmholtz-muenchen.de/en/isf/members/index.html Contact information on page 121

Advanced Professional Degrees 2001 Habilitation in Zoology 2004 Director Institute of Stem Cell Research 2004 Full Professor for Physiological Genomics

Awards and Professional Affiliations • Gottfried-Wilhelm Leibniz Award 2007 • Leopoldina Member 2008 • Breuer Price 2008 Our research aims to elucidate the key Our key questions are: We tackle these questions at three mechanisms of neurogenesis in the • What are the intrinsic determinants of levels: during development, at early Publications developing and adult brain. In contrast neurogenesis and how can they be postnatal stages when neurogenesis • Ninkovic J., Pinto L., Petricca S., Sun J., Rieger M.A., Schroeder T., to organs such as the skin, the small re-activated again in the adult brain to comes to an end and gliogenesis peaks Cvekl A., Favor J. and Götz M. (2010) The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via intestine or the hematopoietic system, reconstitue neurons in adult brains? in the mammalian forebrain, and in the crystallin αA. Neuron 68, 682-694. most cells in the adult mammalian • What are the intrinsic and extrinsic adult brain, where neurogenesis is • Beckervordersandforth R., Tripathi P., Ninkovic J., et al. and Götz M. nervous system are permanently differences between radial glial cells restricted to two specific regions, the (2010) In vivo fate mapping and expression analysis reveals unique postmitotic, such as the neurons and endowed with stem cell properties subependymal zone of the lateral molecular hallmarks of prospectively isolated adult neural stem cells. the oligodendrocytes, and are not and the majority of ependymal ventricle and the dentate gyrus of the Cell Stem Cell 7, 744-58. highlighted by Faculty of 1000 turned over nor regenerated once they cells and astroglial cells, the hippocampus. In order to better • Robel, S., Berninger, B. and Götz M. (2011) The stem cell potential die. Neurogenesis persists only in very closest relatives of radial glia, in understand the physiology after injury from glia – lessons from reactive gliosis. Nature Reviews Neuroscience 12, 88-104. few regions of the adult mammalian the remainder of the brain? and the mechanisms of neurogenesis, forebrain, and neurons degenerated • Why do most astrocytes in the adult we implement a broad range of genetic, Lab members after acute or chronic injury are not mammalian brain fail to generate genomic, cell biological, molecular and Beckervordersandforth, Cappello, Dimou, Fischer, Gascon, Haupt, replaced in the adult mammalian neurons after injury in vivo? physiological techniques. Heinrich, Johansson, Ninkovic, Sirko, Barbosa, Bardehle, Behrendt, brain. To overcome this, we study • What are the key mechanisms Deshpande, Lerch, Murenu, Petricca, Petrone, Pilz, Simon, Stahl, Walcher neurogenesis when and where it specifying neuronal subtypes? works with the aim to reactivate these mechanisms and re-instruct neurogenesis after brain injury. Members LMU MCN 52 | 53 Max Planck Institute of Neurobiology Dr. Oliver Griesbeck Probing cells and tissues with fluorescent proteins http://www.neuro.mpg.de/24427/griesbeck Contact information on page 121

Advanced Professional Degrees • PhD Awarded July 3, 1997 • Habilitation Awarded June 3, 2009

Awards and Professional Affiliations • HFSP Young Investigator Award 2007

Publications • Q.-T. Nguyen, L. F. Schroeder, M. Mank , A. Muller, P. W. Taylor, One of the greatest challenges in The fluorophore we use is the Green O. Griesbeck, D. Kleinfeld (2010). An in vivo biosensor for neuroscience has been to monitor Fluorescent Protein (GFP) and its release and exogenous receptor activity. activity and biochemistry in populations related variants from other organisms. Nature Neuroscience 13: 127-32. of identified neurons in vivo and to • M.W. Friedrich, G. Aramuni, M Mank, J. Mackinnon, O. Griesbeck (2010). Imaging CREB activation in living cells. J. Biol. Chem. relate their activity patterns to Our preferred approach is the design 285:23285-95. behaviour. Previous work on new and engineering of genetically encoded • M. Mank, A. Ferrao Santos, S. Direnberger, T. Mrsic-Flögel, S. Hofer, microscopy techniques has moved the biosensors, from the cuvette via V. Stein, C. Levelt, D.F. Reiff, T. Hendl, A. Borst, T. Bonhoeffer, field considerably further in that imaging of single cells in culture to the M.Hübener, O. Griesbeck (2008). A genetically encoded calcium direction. In particular the combination generation of whole transgenic indicator for chronic in vivo two photon imaging. Nature Methods 5: of modern imaging technology and indicator organisms which harbor the 805-811. genetic labeling methods heralds a biosensor of choice in the cells and Lab members bright future for neuronal circuit tissues that one wishes to study. This Jonathan MacKinnon, Gayane Aramuni, Stefan Direnberger, analysis. Our work complements these opens up new avenues for the study of Anja Schulze-Schenke, Thomas Thestrup, Martina Schifferer, efforts on the “indicator side” by structure-function relationships of Julia Litzlbauer, Anselm Geiger, Birgit Kunkel, David Ng, providing probes for key events crucial intact neuronal circuits. Michael Rehman for an understanding of neuronal function and plasticity and aims at overcoming long-standing limitations in the ability to monitor neuronal activity and biochemistry in intact tissues. Members LMU MCN 54 | 55 Ludwig-Maximilians-Universität München Prof. Dr. Benedikt Grothe Auditory Processing Division of Neurobiology, Department Biology II http://neuro.bio.lmu.de/ Structure and Function of Neuronal Circuits Contact information on page 121 Spatial Orientation

a b c Monaural cues Interaural time difference Interaural level difference Advanced Professional Degrees “spectral notches“ ITD ILD Sound Sound source source

f < 2kHz f < 2kHz 1996 Dr.rer.nat.habil (LMU) +45° 1991 Dr.rer.nat. (LMU Munich) 0° Δt 1988 Diploma in Biology (LMU Munich)

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0 20 Awards and Professional Affiliations Frequ. [kHz]

a b c • Chair of Neurobiology (LMU Munich) since 2003 Monaural cues Interaural time difference Interaural level difference “spectral notches“ ITD ILD Sound Sound • Head of Graduate School of Systemic Neurosciences (LMU Munich) source source

f < 2kHz f < 2kHz since 2007 Auditory neurons concerned with Approaches and Techniques Teniques include +45° • Dean, Faculty of Biology (LMU Munich) 2009-2011 temporal processing are the most We use a comparative approach • extracellular recording 0°single unit Δt

precise time analyzing units in the investigating animals living in different techniques in vivo combined with Δ I -45° Publications dB 0 20 mammalian brain. Some auditory ‚auditory worlds‘ (high frequency acoustic stimulation (dichoticFrequ. [kHz] and • Grothe B, Pecka M, McAlpine D (2010) Mechanisms of sound localization in mammals. Physiol Rev 90: 983-1012 neurons exhibit time resolutions of specialists like bats; models for ancient free-field) • Magnusson AK, Park TJ, Pecka M, Grothe B, Koch U (2008) Retrograde only a few µs. We are interested in mammalian hearing like short tailed • manipulation of early auditory GABA signaling adjusts sound localization by balancing excitation the neuronal mechanisms of temporal opossums; low frequency specialists experience (combined with and inhibition in the brainstem. Neuron 59:125–137 auditory processing and their like gerbils; mice and rats as “standard” anatomical and/or physiological • Brand A, Behrend O, Marquardt T, McAlpine D, Grothe B (2002) Precise evolution in mammals. In particular, models for hearing in modern placental investigations) inhibition is essential for microsecond interaural time difference our studies are concerned with the mammals. Additionally, we are using • multi-electrode recordings coding. Nature 417: 543-547 role of neural inhibition in temporal transgenic mice to study developmental • patch-clamp recording techniques in Lab members processing. Inhibition has been more mechanisms. vitro (acute brain slices and in vivo) Felix Felmy, Todd Jennings, Alexander Kaiser, Lars Kunz, Ursula Koch, or less neglected as a possible player • immunohistochemistry (confocal Mike Myoga, Michael Pecka, Susanne Radtke-Schuller, Ida Siveke, in neuronal filtering of temporal cues. microsopy) Lutz Wiegrebe, Mario Wullimann However, recent results from several • classical anatomical techniques (e.g. groups indicate a link of age related tracing studies) hearing deficits in temporal processing, • transgenic mice (collaboration with age related down-regulation of the Wolfgang Wurst, HelmholtzZentrum inhibitory transmitters GABA and München) glycine, and the role of inhibition in • modeling of spatial and temporal Members temporal filtering as found in the bat and auditory processing LMU gerbil auditory brainstem. The analysis • human and animal psychoacoustics

MCN of temporal cues of sounds is important • behavoral approaches for the two basic tasks of sound localization and sound recognition. 56 | 57 Ludwig-Maximilians-Universität München Prof. Dr. Dr. h.c. Christian Haass Cellular mechanisms of Adolf Butenandt Institute, Biochemistry http://www.biochemie.abi.med.lmu.de Contact information on page 122

Advanced Professional Degrees • Assistant Professor of Neurology/Harvard Med. School • Professor (C3) of Molecular Biology/Heidelberg • Professor (C4) of Biochemistry/LMU

Awards and Professional Affiliations • Gottfried Wilhelm Leibniz-Award of the Deutsche Forschungsgemeinschaft • Potamkin Award of the American Academy of Neurology MetLife In my laboratory we focus on the Moreover, by identifying the active site posttranscriptional mechanism via the Foundation Award for Medical Research generation of Alzheimer‘s disease motifs of the γ-secretase activity in 5’ untranslated region of the (AD) Amyloid ß-peptide (Aß), which presenilins, we were able to define a ß-secretase mRNA. The function of Publications accumulates during aging in our completely novel class of aspartyl ß-secretase and its homologues is • Steiner et al., Nat. Cell Biololgy, 2, 848, 2000 • Edbauer et al., Nat. Cell Biology, 5, 486, 2003 brains and becomes deposited as proteases of the GxGD type. By using investigated in zebrafish and mice. We • Willem et al., Science, 314, 646, 2006 insoluble aggregates called amyloid C. elegans and zebrafish as a model could demonstrate that ß-secretase is plaques. system in combination with biochemical required for myelination via neuregulin Lab members and cell biological technologies, we signaling. More recently we also started Anja Capell, Bettina Schmid, Harald Steiner, Michael Willem, Back in 1992 I made the very surprising could demonstrate that presenilins are to investigate the cellular mechanisms Sven Lammich, Regina Fluhrer, Akio Fukumori, Richard Page, observation that Aß is produced directly involved in the Notch signaling of frontotemporal lobar dementia with Dorothee Dormann, Domink Paquet, Frauke van Bebber, Matthias Voss, constantly throughout life. These pathway. However, PS alone could not ubiquitin positive deposits as well as Daniel Fleck, Eva Bentmann, Nicole Exner, Laura Hasenkamp, Barbara Solchenberger, Katrin Strecker observations changed the concept of perform proteolysis and we could amyotrophic lateral sclerosis. Here we AD pathogenesis, and it is now clear demonstrate that a complex composed are again interested how genetically that AD constitutes a major part of of four different proteins is required to inherited mutations in the genes normal aging. Since Aß has a central reconstitute γ-secretase activity in encoding for example TDP-43, FUS and role in AD pathology, we investigate the yeast. Currently we are investigating Progranulin cause neurodegeneration. cellular mechanisms behind its the assembly of the γ-secretase generation. Aß is generated by complex and the interaction sites of the proteolytic processing involving two individual components. In parallel we types of proteases, ß-, and -secretase. are studying the function and regulation Members γ Our work on -secretase focuses on its of ß-secretase (BACE1). Here we are LMU γ identification, function, assembly, and specifically interested in regulative

MCN reconstitution. It turned out that mechanisms, which may be responsible γ-secretase cleaves its substrates for the increased ß-secretase activity multiple times within the membrane. during aging. First evidence suggests a 58 | 59 Ludwig-Maximilians-Universität München Prof. Dr. Andreas V.M. Herz Computational neuroscience: Department Biology II Bernstein Center Munich Cellular biophysics, network dynamics, http://neuro.bio.lmu.de/ Contact information on page 122 and neural information processing

Advanced Professional Degrees 2007 – present Chair for Computational Neuroscience, LMU München 1996 – 2008 Chair for Theoretical Neuroscience, Humboldt-Universität zu Berlin 1996 – 1997 C3-Professor for Theoretical Biophysics, Bremen University

Awards and Professional Affiliations • Speaker, National Bernstein Network for Computational Neuroscience The brain is, without any doubt, neuroscience, computer science and we have started to investigate spatial • Coordinator, German Node, International one of the most complex biological various technical application domains. navigation in rodents and learning in Coordinating Facility systems. Thoroughly understanding Using grasshopper communication as bees and flies and currently focus on its fascinating dynamics and a model system, we have addressed these two topics. Publications • Herz AVM, Gollisch T, Machens CK, Jaeger D (2006) Modeling information processing strategies a whole range of biophysical and single-neuron dynamics and computations: a balance of detail and remains a great challenge. The neurobiological questions: How do We also develop novel experimental abstraction. Science 314:80-85. theory of non-linear dynamics, sensory systems integrate information approaches, e.g., to find the most • Gollisch T, Herz AVM (2005) Disentangling sub-millisecond processes complex systems, and stochastic over multiple time scales to solve relevant set of stimuli for a given within an auditory transduction chain. PLoS Biology 3:e8. processes, together with methods complex pattern recognition tasks? neuron or to disentangle its intrinsic • Machens CK, Gollisch T, Kolesnikova O, Herz AVM (2005) Testing the from theoretical biophysics, computer How are external signals analyzed in processing steps. To do so, test efficiency of sensory coding with optimal stimulus ensembles. science, and statistical physics offers real time despite the constant influx of stimuli are adapted in response to Examples for five levels of single-cell modeling. Neuron 47:447-456. a broad spectrum of concepts and large quantities of new sensory inputs? the measured neural behavior, on-line I: Detailed compartmental model. The dendritic tree is segmented into electrically coupled Lab members techniques to answer the question of Is firing-rate adaptation a spurious and while the neurophysiological Hodgkin-Huxley–type compartments (level Arne Hartz, Alex Loebel, Alexander Mathis, Johannes Nagele, how living organisms (have learnt to) byproduct of neural dynamics or does it experiment is running. From a III). II: Two-compartment model. The dendrite Johannes Nehrkorn, Dinu Patirniche, Martin Stemmler solve hard computational problems. serve a computational purpose? How conceptual point of view, our approach receives synaptic inputs and is coupled to the soma where the neuron’s response is do neural systems handle the dilemma extends traditional concepts to describe generated. III: Hodgkin-Huxley model, the Vice versa, we can use the results of of “insulation versus interaction“ neural response patterns, such as prototype of single-compartment models. these investigations to further our basic inherent to any distributed information “tuning curve” or “optimal stimulus”, The cell’s inside and outside are separated by a capacitance and ionic conductances in concepts of “computing“ and create processing? Which biophysical into the information theoretic domain, series with batteries describing ionic reversal novel paradigms that surpass the limits mechanisms allow robust computations and introduces concepts well known in potentials. IV: Linear-nonlinear cascade. Members of traditional algorithms. This double in an animal whose temperature may psychology to neurophysiology, such as Stimuli S(t) are convolved with a filter and LMU then fed through a nonlinearity to generate role of Computational Neuroscience has fluctuate by more than ten degrees the notion of iso-response manifolds in responses R(t), typically time-dependent

MCN led to major scientific advances and will within a few minutes? What is the stimulus space. firing rates. V: Black-box model. Neglecting have a large impact on the future neural basis for time-warp invariant biophysical mechanisms, conditional probabilities p(R|S) describe responses R for development of theoretical biophysics, sequence recognition? More recently, given stimuli S. (Herz et al., Science 314:80-85 (2006)) 60 | 61 Max Planck Institute of Neurobiology Prof. Dr. Mark Hübener Development, plasticity and function of http://www.neuro.mpg.de/24276/huebener Contact information on page 122 the mammalian visual system

Advanced Professional Degrees • Habilitation, Faculty of Biology, LMU • Affiliate Professor of Zoology, LMU

Awards and Professional Affiliations • Research Group leader “Visual System Development”, Dept. of Cellular and Systems Neurobiology, MPI of Neurobiology

Publications During development, specific the two eyes in the visual cortex, such MD increased the number of dendritic • Keck T, Scheuss V, Jacobsen RI, Wierenga CJ, Eysel UT, Bonhoeffer connections among neurons within that inputs from the deprived eye are spines, tiny protrusions that correspond T, Hübener M (2011) Loss of sensory input causes rapid structural the visual cortex as well as its in- and weakened, while open eye inputs gain to synaptic inputs. We believe that changes of inhibitory neurons in adult mouse visual cortex. Neuron outputs are formed, ultimately leading influence. We could recently show that these newly formed synapses mediate 71:869-882 • Hofer SB, TD Mrsic-Flogel, T Bonhoeffer, M Hübener (2009) to a functional network enabling fine the visual cortex retains a lasting the strengthening of open eye inputs Experience leaves a lasting structural trace in cortical circuits. Nature grain analysis of the visual world. memory of this experience: If an animal seen after MD. Importantly, the added 457:313-317 While the basic circuitry is set up undergoes a second episode of MD spines did not disappear after • Mrsic-Flogel TD, Hofer SB, Ohki K, Reid RC, Bonhoeffer T and Hübener early in life, the visual cortex of adult many weeks later, the shift in eye reopening of the temporary closed eye, M (2007): Homeostatic regulation of eye-specific responses in visual animals displays some degree of balance is induced much faster and suggesting that they might form a cortex during ocular dominance plasticity. Neuron 54: 961-972 plasticity, too. We study the cellular lasts longer than in naïve mice. Thus, lasting structural trace which mediates • Hofer, SB, TD Mrsic-Flogel, T Bonhoeffer, M Hübener (2006) Prior and synaptic mechanisms underlying the animal has learned to learn, the enhanced plasticity seen after a experience enhances plasticity in adult visual cortex, Nature Neurosci 9:127-132 circuit formation and plasticity in the reminding us of our own experience second MD. Indeed, a second closure of visual cortex during development that exposure to an altered sensory the eye did not result in the further Lab members and in adult animals. To address environment, a new sensorimotor task, addition of spines, despite the fact that Susanne Falkner, Alexandre Ferrão Santos, Rosa Garcia-Verdugo, these questions at the functional as or a foreign language makes for easier the shift in eye representation occurred Ron Jortner, Georg Keller, Anne Kreile, Marcus Leinweber, well as the structural level, we make learning of the similar information later even faster than in inexperienced mice. Sabine Liebscher, Frank Voss use of imaging techniques, such as in life. These experiments indicate that two-photon microscopy and intrinsic specific structural modifications serve signal imaging. In order to unravel the cellular to store information about past mechanisms underlying this enhanced experiences, thereby endowing the Members In mouse visual cortex, plasticity can be plasticity by prior experience, we cortex with an improved ability to adapt LMU readily induced by closing one eye for a studied the fine structure of neurons in to similar experiences in the future.

MCN few days. This intervention, termed the visual cortex. Repeated two-photon monocular deprivation (MD), shifts the imaging of neurons expressing green balance between the representation of fluorescent protein demonstrated that 62 | 63 Max Planck Institute of Neurobiology Dr. Ilona Grunwald Kadow Development and function of neural circuits www.neuro.mpg.de Contact information on page 122 in the olfactory system

Advanced Professional Degrees • PhD Neurobiology • Dr. rer. nat. • Master of Biology

Awards and Professional Affiliations • Career development award • Otto Hahn Medal • Emmy Noether Grant The sense of smell allows another important goal of our research different insect species were subject to discrimination of a large number is the identification of neural processing evolutionary pressure and change. The Publications of odorants using precisely wired centers and eventually single neurons detection of CO2 plays a specific role in • Hartl, M, Loschek LF, Stephan D, Siju KP, Knappmeyer C and Grunwald- projections from neurons in the that underpin different innate the life of many insect species. The Kadow, IC (2011) A New Prospero and microRNA-279 Pathway Restricts CO2 Receptor Neuron Formation. J Neurosci 2011 Nov periphery expressing specific behaviors. Ultimately, we aim to malaria vector mosquito is attracted to 2;31(44):15660-73. olfactory receptors to neurons in understand how neural circuits and CO2 and uses it to find human hosts. In • Cayirlioglu P*, Grunwald Kadow I*, Zhan X, Okamura K, Gunning D, Lai higher brain centers that process the genetic programs have changed during contrast, Drosophila melanogaster flies

EC, Zipursky SL (2008). Hybrid Neurons in a microRNA mutant are information. The ability to recognize evolution to give rise to nervous detect CO2 as part of the so-called putative evolutionary intermediates in insect CO2 sensory systems. a particular odor and to activate the systems that are perfectly adapted to stress odor, and thus are strongly Science, 319: 1256-1260 * These authors contributed equally appropriate neurons in the brain is the specific biological niches of repelled by it. We are addressing how • Jones WD, Cayirlioglu P, Grunwald Kadow I,.Vosshall LB (2007). Two instrumental in driving important different species. genes and gene networks have changed chemosensory receptors together mediate carbon dioxide detection in Drosophila. Nature 445: 86-90 behaviors. to give rise to the olfactory system of • Grunwald IC*, Korte M*, Adelmann G, Plueck A, Kullander K, Adams To this aim, we mainly use the fruitfly different insects. We look at behavioral RH, Frotscher M, Bonhoeffer T, Klein R (2004). Hippocampal plasticity We are interested in the genetic Drosophila with its rich, unmatched and structural divergence between requires postsynaptic ephrinBs. Nat Neurosci 7: 33-40 * These authors program that controls the formation repertoire of genetic tools and robust species, and by using Drosophila contributed equally and function of olfactory neuronal innate behaviors. We combine genetics genetics, we aim at finding the circuits. One aim is to identify the genes with behavioral testing, state of the art responsible genes that were critical for Lab members that specify neuronal identity, link them anatomy, in vivo electrophysiology, and development and evolution of these Daniel Stephan, Marion Hartl, Juhi Sardana, Lasse Braecker, to the connectivity of a neuron, and imaging. differences. Laura Loschek, Siju Purayil, Christiane Knappmeyer, Mo Zhang, ultimately to its integration into Members Habibe Ucpunar, Laurence Lewis, Yukiko Yamada-Ho functional nervous systems. The neural Different insects feed on different kinds LMU networks that control olfactory of food, aim at attracting only mating

MCN behavioral responses and other innate partners of their species, and face very behaviors remain largely unknown in specific dangers in their environment. any animal or human. Therefore, Therefore, olfactory systems of 64 | 65 Max Planck Institute of Neurobiology Prof. Dr. Ruediger Klein, PhD Finding their way – Axon guidance in the spinal cord www.neuro.mpg.de Contact information on page 122

Advanced Professional Degrees 1993 – 2001 Group Leader at the European Molecular Biology Laboratory, Heidelberg, Germany 2001 – present Director and Scientific Member at the Max-Planck- Institute of Neurobiology, Martinsried, Head of Department of Molecular Neurobiology

Awards and Professional Affiliations 2008 Remedios Caro Almela Prize for Research in Our neurons are cells highly cascade, followed by negative, repulsive autonomy. Can you guess what this Developmental Neurobiology specialized in processing and cellular response: Eph-containing axons means for the walking behavior of the 2006 – present Honorary Professor, Faculty of Biology, transmitting information. To establish turn away from ephrin-expressing cells, mouse? Indeed, an Eph or ephrin Ludwig-Maximilian-University of München networks of communication, they and continue searching for another, deficient animal moves both hindlegs in 2005 Family-Hansen-Prize extend long, fine processes – also potentially correct target. Now, what a synchronous manner, thereby hopping Publications called axons – which establish happens if the Eph/ephrin system is not like a little rabbit. This is a beautiful • Yamagishi S, et al. (2011). FLRT2 and FLRT3 act as repulsive guidance physical contact with their targets, functioning properly? Let’s take a look example for the fundamental role the cues for Unc5-positive neurons. EMBO Journal, in press. such as other neurons or muscle at the spinal cord, a part of the nervous Eph/ephrin signaling system plays • Dudanova, I., et al. (2010). GDNF acts as a chemoattractant to support cells. Finding the correct target is system we are especially interested in. during development of neuronal networks. ephrinA-induced repulsion of limb motor axons. Current Biology 20: essential for the development of There, two neuronal circuits control the 2150-2156. neuronal networks – but how do locomotor, or walking behavior of the • Filosa, A., et al. (2009). Neuron-glia communication via EphA4/ ephrinA3 modulates LTP through glial glutamate transport. Nature neurons achieve that? This is not mouse, our favorite model system. Neuroscience 10:1285-92. only the founding question of the During development, these two circuits axon guidance field, but also a major are kept separate by the Eph/ephrin Lab members research topic of our group. system, so they can finally function Aarathi Balijepalli, Graziana Gatto, Falko Hampel, Pontus Klein, independently from each other and Jorg Körner, Hakan Kücükdereli, Daniel Nagel, Andreas Schaupp, We focus on the Eph/ephrin signal control the movement of the left and Daniel del Toro, Irina Dudanova, Tom Gaitanos, Jingyi Gong, transduction pathway, a receptor-ligand right hindleg, respectively. This is why Christine Hassler, Archana Mishra, Sonia Paixao, Maria Sakkou, system essential for correct guidance of a healthy mouse walks by moving its Senthil Thyagarajan, Louise Gaitanos, Pilar Alcala, Gönül Seyit, neuronal processes. Ephs and ephrins hindlegs in an alternate manner: First Members Jana Lindner, Kristin Reuter sit in the plasma membrane of axons the left hindleg, then the right, then LMU and their target cells, respectively. If an again the left, and so on. However, if

MCN axon comes along and contacts a the Eph/ephrin systen is not functioning potential target, Ephs bind to ephrins; properly, these circuits contact each this initiates a signal transduction other by mistake, and lose their 66 | 67 Technical University Munich Prof. Dr. Arthur Konnerth Cortical circuits; Cerebellar function; Dendritic signaling; http://www.ifn.me.tum.de/new/ Contact information on page 122 Neurodegeneration; In vivo 2P-Imaging

Advanced Professional Degrees 2005 – present Full Professor, Endowed Friedrich-Schiedel-Chair of Neuroscience, TU Munich 1983 MD Dissertation, MPI Psychiatrie and LMU 1975 – 1981 Undergrad. Medicine, LMU

Awards and Professional Affiliations • Gottfried Wilhelm Leibniz Prize • Max Planck Prize Cellular and molecular mechanisms of Dendritic signaling and integration Development of imaging technology • Carl-von-Linde Fellow of the Institute for Advanced Study TUM cortical circuit function in vivo We develop and implement two-photon We use in vivo two-photon calcium Our major aim is the visualization and imaging devices with a high spatial and Publications imaging in different areas of the mouse mapping of sensory-evoked signals on temporal resolution for the functional • Chen X, Leischner U, Rochefort N, Nelken I and Konnerth A (2011) Functional mapping of single spines in cortical neurons in vivo. cortex (visual, auditory, sensorymotor) the level of individual synaptic inputs in analysis of networks, cells and NATURE 475, 501-505. combined with targeted patch-clamp defined neurons of the mouse cortex. subcelullar compartments in vitro and • Jia H, Rochefort N, Chen X and Konnerth A (2010) Dendritic recordings and optogenetics to study We investigate the dendritic in vivo. Recent developments include organization of sensory input to cortical neurons in vivo. NATURE electrical signaling and plasticity of mechanisms that determine the the implementation of a new two- 464, 1307-1312. specific types of neurons in neurons‘ output signals. photon imaging variant, named LOTOS • Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, behaviorally-defined conditions. (low power temporal oversampling), Haass C, Staufenbiel M, Konnerth A and Garaschuk O (2008) Clusters Molecular mechanisms of cortical In vivo neurophysiology of that is highly sensitive and minimizes of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease. SCIENCE 321, 1686-1689. circuit function are determined by Alzheimer‘s disease phototoxic damage, allowing functional analyzing various genetically-modified We focus on the impairments in imaging of individual spines in vivo. Lab members mouse lines. synaptic signaling of cortical and Helmuth Adelsberger, Nathalie Rochefort, Jana Hartmann, Jia Hongbo, hippocampal neurons in mouse models Xiaowei Chen, Zsuzsanna Varga, Albrecht Stroh, Valerie Bonfardin, Cerebellar function and plasticity of Alzheimer’s disease. Of special Dan Hill, Christine Grienberger, Elvira Shariffulina, Ulrich Leischner, We are interested in synaptic interest are the molecular and cellular Rosa Maria Karl mechanisms, including the roles of mechanisms underlying both neuronal mGlu receptors, TRPC channels, silencing and neuronal hyperactivity calcium signaling as well as in observed in the diseased brain. Members cerebellar sensory integration. We use LMU various mutant mouse lines, in which

MCN specific types of cerebellar neurons (e.g. Purkinje cells) are genetically modified. 68 | 69 Ludwig-Maximilians-Universität München Prof. Dr. Dr. Christian Leibold Models of learning and memory in recurrent LMU Biocenter Martinsried www.neuro.bio.lmu.de neuronal networks Contact information on page 123

Advanced Professional Degrees • Dr. rer. nat. (theoretical physics, TU Munich) • Diploma in Physics (TU Munich)

Awards and Professional Affiliations • Editor-in-Chief Network: Computation in Neural Systems • Coordinator Bernstein Focus Neural Basis of Learning

Publications Recurrent neuronal networks are to gain understanding of the • Maier N, Tejero-Cantero A, Dorrn A, Winterer J, Beed P, Morris G, thought to serve as a physical computations that are performed by Kempter R, Poulet JF, Leibold C, Schmitz D (2011) Coherent phasic basis for learning and memory. For the recurrent connections. excitation during hippocampal ripples Neuron 72:137-152 example, the recurrent networks in • Lüling H, Siveke I, Grothe B, Leibold C (2011) Frequency-Invariant Representation of Interaural Time Differences in Mammals PLoS the hippocampus exhibit the replay Current projects include: Analysis of Comput Biol 7: e1002013 of stored sequences of previously postsynaptic currents in an in-vitro experienced events. This replay is model of sharp-wave ripples and their Lab members accompanied with field potential- relation to models of replay and preplay Simon Lehnert, Li Lu, Hannes Lüling, Axel Kammerer, Sven Schörnich, phenomenon of sharp wave-ripple of hippocampal memory sequences; Alvaro Tejero Cantero, Kay Thurley, Chun-Wei Yuan complexes. We study the mechanistic Modelling readout of spatial basis of this phenomenon on the representations in the hippocampal cellular and population level. formation; Formation of grid fields in the entorhinal cortex; Assessment of This includes the development of the computational performance of data analysis methods for electro- recurrent networks. physiological recordings and for local connectivity measurements in brain slices. We also develop a behavioral virtual reality setup for rodents that allows recordings of memory-related Members brain activity in-vivo. The goal of the LMU research group is to use dynamical,

MCN structural, and functional constraints to build computational models of recurrent networks and in particular 70 | 71 Ludwig-Maximilians-Universität München Prof. Dr. Hannes Leitgeb Mathematical Philosophy: Logical and Mathematical Faculty of Philosophy, Philosophy of Science and Study of Religion http://www.philosophie.uni-muenchen.de/lehreinheiten/logik_sprachphil/ Methods in Philosophy and Cognitive Science Contact information on page 123

Advanced Professional Degrees • Ph.D., Philosophy, University of Salzburg, 02/07/01 • Ph.D., Mathematics, University of Salzburg, 09/07/98 • M.Sc., Mathematics, University of Salzburg, 20/02/97

Awards and Professional Affiliations • Chair in Logic and Philosophy of Language • Alexander von Humboldt Professorship, Alexander von Humboldt Foundation, 2010. “Mathematical philosophy“ means the • Friedrich Wilhelm Bessel Research Award, Alexander von Humboldt application of logical and mathematical Foundation, 2007. methods to various questions and • Philip Leverhulme Prize, Leverhulme Trust, 2007. problems in philosophy and cognitive Publications science. Amongst others, I use such • “An Objective Justification of Bayesianism I: Measuring Inaccuracy” methods in order to shed new light on (with R. Pettigrew), Philosophy of Science 77/2 (2010), 201-235. • formal theories of truth that avoid • Inference on the Low Level. An Investigation into Deduction, notorious semantical paradoxes Nonmonotonic Reasoning, and the Philosophy of Cognition, • the logic, semantics, and pragmatics Dordrecht: Kluwer, 2004, 384 pp. of conditionals (if-then statements) • “Nonmonotonic Reasoning by Inhibition Nets”, Artificial Intelligence • the representation of logical inference 128[1-2] (2001), 161-201. with conditionals in artificial neural Lab members networks For members of the Munich Center for Mathematical Philosophy, see • formal systems of inductive logic, http://www.philosophie.uni-muenchen.de/lehreinheiten/logik_sprachphil/ belief revision, and metacognition personen/index.html • justifications for the probability calculus • structuralist foundations of mathematics. Members LMU MCN 72 | 73 Ludwig-Maximilians-Universität München Prof. Dr. Hermann J. Müller Mechanisms of attention in perception, cognition, General & Experimental Psychology / Neuro-cognitivePsychology, LMU http://www.psy.lmu.de/exp/index.html and action Contact information on page 123

Advanced Professional Degrees • Ph.D., Dipl. Psych.

Awards and Professional Affiliations • Wilhelm Wundt Prize 2010 of the Wilhelm Wundt Society, awarded “for excellent achievements in fundamental psychological research” (2010) • Member of the CASLMU Center for Advanced Studies (2007 –) • LMUexcellent Research Professorship (2007 –) • Elected “DFG Fachgutachter” (DFG Special Reviewer) for experimental From the vast amount of information have contributed to elucidate the the weight sets for performing and physiological psychology (1999 – 2003) reaching the senses at any point in principles governing selection as particular tasks are buffered across task time, only a small fraction becomes space-, object-, and feature -based. One switches, and that the sets are task- Lab members available for conscious report and the highlight of this work has been the component-specific, i.e., separate tasks Markus Conci, Heiner Deubel, Kathrin Finke, Thomas Geyer, Dragan Rangelov, Torsten Schubert, Zhuanghua Shi, Paul Taylor, control of voluntary actions. Attention clarification of the links between spatial sharing the same components share the Thomas Töllner, Agnieszka Wykowska, Michael Zehetleitner, etc. refers to a set of principles and selection and the planning of sequential same weight sets. On this basis, we mechanisms that realize this function motor actions, e.g., target-directed have proposed a multiple-weighting- of perceptual ‘selection’ in the pursuit hand and eye movements. Another systemsframework, with independent of behavioral goals. One principle highlight is the theory of ‘dimension weight systems operating at all levels of is that attention biases processing weighting’, which describes how the cognitive hierarchy. We have shown by enhancing representations encountering particular perceptual how the weighting principle operates at that are goal-relevant, and/or events (e.g., a particular target in a the behavioral and brain levels, and we suppressing representations that visual scene) biases the perceptual have started to develop computational are irrelevant. Attention may be system to ‘expect’ similar events in the accounts of its operation. One further biased either by stimuli encountered next instant of time, leading to highlight has been our work on the in the environment or by our action facilitated processing of similar events simultaneous performance of dual or, intentions. Intentional, or `top-down´ or compromised processing of changed more generally, multiple tasks, the control relies on a set of executive events. We have shown that these limitations in multi-tasking, and the functions that coordinate perceptual biases operate at early, preattentive executive-coordinative processes that with action systems in what is levels of visuo-cortical processing may be optimized as a result of multi- Members referred to as ‘task set’. (though they are top-down modulable), tasking practice. LMU but influence also post-selective levels

MCN Over the years, my group has made of attentional stimulus analysis and major contributions to this field. translation of stimuli into choice Regarding perceptual selection, we responses. Further, we have shown that 74 | 75 Ludwig-Maximilians-Universität München Prof. Dr. Julian Nida-Rümelin Former Federal State Minister for Culture and the Media Lehrstuhl für Philosophie IV www.philosophie.uni-muenchen.de/lehreinheiten/philosophie_4 Contact information on page 123

Advanced Professional Degrees • Chair of Political Philosophy and Theory at the Faculty of Philosophy of the Ludwig-Maximilians-University, Munich • Professor of Political Theory and Philosophy at the Geschwister- Scholl-Institut at the Faculty of Social Sciences, Ludwig-Maximilians- University, Munich

Awards and Professional Affiliations • Since July 2006 Visiting Professor for Political Theory and Philosophy at Rational Choice Theory Political Theory and Philosophy the University of St. Gallen, Switzerland What role do reasons play in decision What are the normative assumptions of • Since 2005 Chairman of the board of trustees at the Centre for Ethical making and which is the importance democracy and the modern theory of Research and Teaching (Münchner Kompetenzzentrum Ethik), Ludwig- of rational choice theory for practical political authority? Maximilians-University, Munich • President of the German Society of Philosophy philosophy in general? Anthropological Implications of the Publications Metaethics Lifesciences • “Über menschliche Freiheit“. Stuttgart: Reclam (Universal-Bibliothek Can we conceive of a metaethical Can reasons be naturalized and is there Nr. 18365) 2005. realism without controversial such thing as free will? • Reasons against naturalising epistemic reasons, in: A. Carsetti (Hrsg.), ontological implications? “Causality, Meaningful Complexity and Embodied Cognition”, Spinger Verlag, 2010. • “Demokratie und Wahrheit“. C. H. Beck Verlag, München 2006. Ethics Research interests in animal, environmental and bioethics as well as the ethics of science and risk- management. Members LMU MCN 76 | 77 Ludwig-Maximilians-Universität München Prof. Dr. Heidrun Potschka Pharmacology and pathophysiology of epilepsy Inst. of Pharmacology, Toxicology and Pharmacy www.pharmtox.vetmed.uni-muenchen.de/personen/ag_potschka/potschka Contact information on page 123

Advanced Professional Degrees 2006 – present Professor and Chair, Inst. of Pharmacology, Toxicology, and Pharmacy, Faculty of Veterinary Medicine, LMU 2004 – 2006 Juniorprofessor and Privatdozentin, Dept. of Pharmacology, Toxicology, and Pharmacy Vet. School Hannover

Awards and Professional Affiliations 2009 – present Chair of the Basic Research Task Force of the Epilepsy represents one of the and in vivo testing procedures including Mechanisms of epilepsy development International League against Epilepsy most common chronic neurological chronic rodent models with selection of (epileptogenesis) are elucidated in 2006 Falk Medical Research Trust Award (US Foundation disorders. Pharmacological treatment drug-resistant animals. Translational chronic rodent models. Preventive CURE) concepts are currently limited to development is based on functional approaches target neuronal plasticity, 2005 International Award of the Michael Foundation symptomatic approaches with studies using patient tissue dissected neuronal cell loss, inflammatory Publications suppression of seizure activity by during epilepsy surgery. In reactions and blood-brain barrier • Potschka H (2010) Targeting regulation of ABC efflux transporters chronic administration of antiepileptic collaboration with positron emission alterations. For instance we currently in brain diseases: a novel therapeutic approach. Pharmacol Ther. drugs. Unfortunately, multidrug tomography experts imaging tools are assess the potential of novel peptide 125:118-127. resistance remains a major problem developed for the prediction of drug mimetics which mimic selected effects • Schlichtiger J, Pekcec A, Bartmann H, Winter P, Fuest C, Soerensen J, in clinical epileptology with sensitivity in patients rendering of complex ‘parent’ molecules such as Potschka H (2010) Celecoxib treatment restores pharmacosensitivity more than thirty percent of patients guidance for personalized therapeutic erythropoietin, adhesion molecules, or in a rat model of pharmacoresistant epilepsy. Br J Pharmacol 160:1062-1071. not adequately responding to concepts. Considering that transporter- neurotrophic factors. In collaboration • Löscher W, Potschka H (2005) Drug resistance in brain diseases: role pharmacotherapy. associated drug resistance seems to we analyze whether targeting of of drug efflux transporters. Nat. Rev. Neurosci. 6:591-602. play a role in various central nervous the endocannabinoid system can Research of the group aims to identify system diseases the imaging tools interfere with the development of a Lab members mechanisms of drug resistance. In this as well as the novel therapeutic hyperexcitable epileptic network. Janine Avemary, Natalie Seeger, Christina Zellinger, Mehrnoosh Jafari context, recent experimental data approaches are of interest for different Considering that psychiatric Khaled Abadi, Thomas Licko, Eva-Lotta von Rüden, Vera Rußmann, substantiated the ‘transporter neurological conditions. comorbidities and cognitive impairment Josephine Salvamoser, Christina Michler, Marion Fisch, Sieglinde hypothesis’ indicating enhanced active might increase the burden in a Fischlein, Katharina Gabriel, Angela Vicidomini, Andrea Wehmeyer efflux of several antiepileptic drugs at Another focus of the group is the subgroup of epilepsy patients, it is also Members the blood-brain barrier. Currently, we prevention of symptomatic epilepsies tested whether respective approaches LMU develop innovative therapeutic which can occur following brain insults interfere with the development of

MCN approaches to overcome transporter- such as traumatic brain injury, hypoxia, behavioral alterations and cognitive associated drug resistance. These ischemia, tumors or infection. deficits in experimental models. approaches are validated using in vitro 78 | 79 Technical University Munich Prof. Dr. Gerhard Rigoll Multi-Modal Human-Machine Interaction TUM, Institute for Human-Machine Communication www.mmk.ei.tum.de Contact information on page 124

Advanced Professional Degrees 2002 – present Professor (C4) for Human-Machine Communication, TUM 1993 – 2001 Professor (C4) of Technical Informatics, Uni Duisburg 1992 – 1993 Visiting Scientist, NTT Human Interface Laboratories, Tokio, Japan

Awards and Professional Affiliations • Member of the Overview Editorial Board of the IEEE Signal Processing Society (since 2009) The research activities of Gerhard e.g. Neural Networks, Hidden-Markov- Learning the asynchronous relation • IEEE Senior Membership; Acoustics, Speech, and Signal Processing Rigoll are in the area of multi-modal Models or Probabilistic Graphical between the streams and resolving the Society (1998) human-machine communication, Models. Statistical machine learning semantic meaning resulting from • Heisenberg-Stipendium, DFG (1993) covering areas such as speech and techniques are also mostly used for the decoding both streams simultaneously Publications handwriting recognition, gesture fusion of different modalities. A popular is typically a very complex problem in • Kroschel K., Rigoll G., Schuller B.: Statistische Informationstechnik. recognition, face detection & example for information fusion is the machine learning. Other typical Signal- und Mustererkennung, Parameter- und Signalschätzung. identification, action & emotion combination of speech and gestures for application scenarios for this Springer-Verlag, 2011. recognition and interactive computer interaction in smart environments, such recognition and fusion problem can be • Schenk J, Rigoll G: Mensch-Maschine-Kommunikation, Grundlagen graphics. as e.g. intelligent houses or smart e.g. found in human-driver dialogues von sprach- und bildbasierten Benutzerschnittstellen. Berlin: meeting rooms. In this case, the user for infotainment applications in the car Springer-Verlag, 2010. The most important scientific basis for might control a device such as a TV by or interaction of a user within virtual • Rigoll G, Schuller B, Müller R, Ablassmeier M, Reifinger S, Poitschke T: “Speech Communication and Multimodal Interfaces”. In: Advanced these activities is the area of pattern voice commands and typical hand environments. Man-Machine Interaction. Editor: Kraiss KF. 2005; 141 – 190. recognition, where a signal that shall be gestures, for instance to point to one recognized (e.g. a speech signal or a of several devices while speaking handwritten letter) is first transformed a command to switch a TV channel. into a suitable feature representation In this case, the acoustic modality using methods from signal processing is augmented by the visual and then classified to one of a large communication channel and the variety of possible classes (e.g. words problem is to fuse the combined or letters in speech or handwriting information coming from both Members recognition) by methods from statistical channels. These information streams LMU pattern recognition. In most cases, the will be asynchronous in time, since

MCN classifier parameters are automatically hand gestures will be most likely trained from collected samples with performed not exactly at the starting machine learning techniques, such as or ending points of voice commands. 80 | 81 Ludwig-Maximilians-Universität München Prof. Dr. Hans Straka Functional organization and plasticity of sensory- Department Biology II, Faculty of Biology http://neuro.bio.lmu.de/members/systems_neuro_straka/straka_h/index.html motor transformation for gaze and posture control Contact information on page 124

Advanced Professional Degrees 1989 PhD (Dr. rer. nat.) in Zoology 1995 Habilitation to Dr. rer. nat. habil. in Zoology 2009 Professor for Systemic Neurosciences

Awards and Professional Affiliations 2003 – 2007 Chargé de Recherche (CNRS), Université Paris Descartes 2007 – 2009 Directeur de Recherche (CNRS), Université Paris Descartes All vertebrates, whether running, has major implications for limb-based propulsion in adult frogs 2009 – present Professor for Systemic Neurosciences at the Faculty of swimming or flying, are confronted with understanding gaze control in general. along with corresponding changes in Biology, LMU Munich the effects of their locomotor actions on Our central project concerns the gaze-stabilizing eye movements. This the ability to perceive their surrounding interaction and developmental plasticity raises general neurobiological Publications • Straka H., Vibert N., Vidal P.P., Moore L.E. and Dutia M.B. (2005) environment. Potential consequences of of CPG-derived intrinsic signals and questions on adaptive plasticity of Intrinsic properties of vertebrate vestibular neurons: function, self-generated body motion include visuo-vestibular sensory feedback in cellular properties and network development and plasticity. Prog. Neurobiol. 76: 349-392. head movements that cause retinal the amphibian model Xenopus laevis. connectivity. These questions are • Lambert F.M., Beck J.C., Baker R. and Straka H. (2008) Semicircular image displacements with a resultant This requires understanding of how studied by a variety of morpho- canal size determines the developmental onset of angular degradation of visual information individual network components are physiological approaches that mostly vestibuloocular reflexes in larval Xenopus. J. Neurosci. 28: 8086-8096. processing. In order to maintain visual ontogenetically assembled and how employ isolated, semi-intact brain • Straka H. (2010) Ontogenetic rules and constraints of vestibulo-ocular acuity during locomotion, retinal image spatial and dynamic specificity is preparations with intact sensory organs reflex development. Curr. Opin. Neurobiol. 20: 689-695. drift must be counteracted by dynamic established. The delayed developmental and motor components of Xenopus Lab members compensatory eye and/or head- onset of semicircular canal-evoked laevis. Intra- and extracellular Boris Chagnaud, Francisco Branoner, Michael Faust, Johanna Schuller, adjustments that derive from vestibulo- vestibulo-ocular reflexes compared to recordings, Calcium-imaging together Haike Dietrich, Roberto Banchi, Carlana Ramlochansingh ocular, optokinetic and proprioceptive otolith-evoked responses renders with morphological reconstructions reflexes. In addition, efference copies of differentiation between tilt and allow determining the functional rhythmic neural signals produced by translational acceleration impossible organization and plasticity of sensory- locomotor CPG circuitry within the and opens the question of how an motor circuit formation and spinal cord of larval Xenopus are appropriate intrinsic reference frame reconfiguration during ontogeny. conveyed to the brainstem extraocular for body-motion in space is centrally Members motor nuclei and potentially contribute formed. The transition from larval to LMU to gaze stabilization during locomotion. adult frogs involves a drastic

MCN The use of inherent feed-forward and restructuring of central circuitry that sensory feedback signals to counteract correlates with the switch from an the visual consequences of self-motion undulatory swimming in tadpoles to a 82 | 83 Ludwig-Maximilians-Universität München Prof. Dr. Michael Strupp When the world goes round: diagnosis and Professor of Neurology and Clinical Neurophysiology, MD Department of Neurology and IFBLMU treatment of vertigo, eye movement disorders http://www.klinikum.uni-muenchen.de Contact information on page 124 and nystagmus

Advanced Professional Degrees 1988 MD, RWTH Aachen 2003 Professor of Neurology and Clinical Neurophysiology, LMU Munich

Awards and Professional Affiliations 2003 Robert-Wartenberg Lecture and Award 2005 Hans-Jörg-Weitbrecht Award for clinical neuroscience 2010 Award of the German Neurological Society, belonging to Pharmacotherapy of vertigo, Role of viral infections in acute the five best teachers of the last five years of the Academy dizziness, ocular motor disorders and unilateral vestibular failure nystagmus There is some evidence that vestibular Publications One of my major interests is developing neuritis is caused by the reactivation • Strupp M, Kalla R, Claassen J, Adrion C, Mansmann U, Klopstock T, Freilinger T, Neugebauer H, Spiegel R, Dichgans M, Lehmann-Horn F, and evaluating new therapeutic of a latent herpes simplex virus 1 Jurkat-Rott K, Brandt T, Jen JC, Jahn K (2011) A randomized trial of principles. We are, therefore, currently infection. The underlying patho- 4-aminopyridine in EA2 and related familial episodic ataxias performing prospective randomized physiology and mechanisms leading to • Strupp M, Schüler O, Krafczyk S, Jahn K, Schautzer F, Büttner trials a) on the treatment of Menière‘s the damage are not clear and are U, Brandt T (2003) Treatment of downbeat nystagmus with disease with high dosages of therefore evaluated by virological 3,4-diaminopyridine: a placebo-controlled study. Neurology betahistine, b) on how to improve techniques. 61:165-170 central vestibular compensation in • Strupp M, Zingler V, Arbusow V, Niklas D, Maag KP, Dieterich M, Bense S, Theil D, Jahn K, Brandt T (2004) Methylprednisolone, valacyclovir, acute vestibular neuritis, and c) on Interaction between the vestibular or the combination for vestibular neuritis. N Engl J Med 351:354-361 central disorders such as vestibular system and the hippocampus migraine, downbeat nystagmus, We demonstrated an atrophy of the Lab members episodic ataxia type 2 and cerebellar hippocampus and impaired spatial Roger Kalla, Jens Claassen, Katharina Hüfner, Olympia Kremmyda, gait disorders. navigation and memory in patients with Roman Schniepp, Caroline Fischer, Stefan Teufel, Katharina Feil, a bilateral loss of vestibular function. Otmar Bayer The cause and the consequences are now further evaluated by multimodal imaging techniques. Members LMU MCN 84 | 85 Ludwig-Maximilians-Universität München Prof. Dr. Dirk Trauner Optochemical Genetics Department of Chemistry http://www.cup.uni-muenchen.de/oc/trauner/ Contact information on page 124

Advanced Professional Degrees 2008 – present Professor (Chair) for Chemical Biology and Genetics, Dept. of Chemistry, LMU 2006 – 2010 Associate Professor (Tenure), Dept. of Chemistry, UC Berkeley 2000 – 2006 Assistant Professor, Dept. of Chemistry, UC Berkeley

Awards and Professional Affiliations • Japanese Society for the Promotion of Science (JSPS) (2010) Transmembrane receptors allow a hybrid photoreceptors can be used to • European Research Council Advanced Investigator Grant (2011) cell to communicate with its optically control neurons with very high • From 2011 on: Member ÖAW (Österreichische Akademie der environment in response to a variety precision. They have been used to Wissenschaften) of input signals. These can be changes dissect neural networks and might find Publications in the concentration of ligands applications in the restoration of vision • Mourot A, Kienzler MA, Banghart MR, Fehrentz T, Huber FME, Stein (e.g. hormones or ), and the control of other sensations M, Kramer RH, Trauner D (2011) Tuning Photochromic Ion Channel temperature, pressure (e.g. via (such as pain). This combination of Blockers. ACS Chem Neurosci 2:536–543. acoustic waves or touch), synthetic photoswitches and receptor • Banghart MR, Mourot A, Fortin DL, Yao JZ, Kramer RH, Trauner D transmembrane potential, or light proteins augments the field of (2009) Photochromic Blockers of Voltage-Gated Potassium Channels. intensity. Many important receptors Optogenetics and adds a new functional Angew Chem Int Ed 48:9097-9101. have now been characterized in dimension to Chemical Genetics. • Volgraf M, Gorostiza P, Numano R, Kramer RH, Isacoff E, Trauner D (2006) Allosteric Control of an Ionotropic Glutamate Receptor with an atomic detail and our understanding As such, we propose to call it “Opto- Optical Switch. Nature Chem Bio 2:47–52. of their functional properties has chemical Genetics”. markedly increased in recent years. Lab members Johannes Broichhagen, Timm Fehrentz, Elena Herrero-Gómez, As a consequence, these sophisticated Florian Huber, Holger Moroder, Alwin Reiter, Matthias Schönberger, molecular machines can be Philipp Stawski, Marco Stein, Martin Sumser reprogrammed to respond to unnatural input signals. Arguably, the most useful of these signals is light. Both ligand- Members gated ion channels, and G-protein LMU coupled receptors, as well as voltage-

MCN gated ion channels, can be manipulated with synthetic photoswitches to become light-sensitive. The resulting 86 | 87 Helmholtz Center Munich Prof. Dr. Wolfgang Wurst Generation and analysis of animal models for Institute of Developmental Genetics http://www.helmholtz-muenchen.de/en/idg/ neuropsychiatric diseases Contact information on page 125

Advanced Professional Degrees 1988 Ph.D. Thesis at the Max-Planck-Institute of Immunobiology, Freiburg and at the Department of Immunogenetics, University Goettingen, Germany, Prof. E. Guenther (grade: summa cum laude) 04 / 1983 State Examination in Biology and Chemistry

Awards and Professional Affiliations Since May 2002 Professor of Developmental Genetics, Dept. of Life In view of a steadily increasing life a prerequisite to develop novel understanding of the mechanisms Sciences, Technical University Munich; Director of the Institute of expectancy, the amount of older preventive and/or therapeutic underlying plasticity and regeneration Developmental Genetics, Helmholtz Zentrum München, Munich / people within the society becomes strategies. Therefore, our goal is to in the central nervous system. Here the Neuherberg, Germany greater than ever. As a consequence unravel the molecular basis of the focus is put on developmental signalling Publications the prevalence of chronic age-related pathoetiology of psychiatric and pathways and mechanisms which • Di Salvio M, ..., Prakash N*, Wurst W*, Simeone A: Otx2 controls diseases of the nervous system such as neurological diseases by generating potentially are neuroprotective and/or neuron subtype identity in ventral tegmental area and antagonizes degenerative diseases (i.e. Parkinson’s and comprehensively analysing genetic support neurogenesis in the adult brain. vulnerability to MPTP. Nat. Neurosci. 13, 1481‑1488 (2010). Disease, Alzheimer’s Disease as well animal models. In doing so, we The Mouse Genetics Teams generate • Meyer M, Hrabé de Angelis M, Wurst W, Kühn R: Gene targeting by as chronic depression and other specifically take into account the role of targeted mouse mutants for internal homologous recombination in mouse zygotes mediated by zinc psychiatric diseases will be gradually environmental factors on the etiology scientific projects and external finger nucleases. Proc. Natl. Acad. Sci. USA 107, 15022 15026 (2010). rising with serious personal but also and progress of the diseases. As a collaborations. The Large Scale • Piccoli G, ..., Vogt-Weisenhorn DM, Wurst W, Gloeckner CJ, Matteoli M, Sala C, Ueffing M. LRRK2 controls synaptic vesicle storage and societal and economical impacts. consequence the IDG is structurally Mutagenesis Team participates in the mobilization within the recycling pool. J Neurosci.31(6):2225-37 divided into two research areas. international EUCOMM large scale (2011). Thus, OUR VISION is to help improving Within the IDG different groups in the mutagenesis program to create a the quality of life for patients suffering Research Area “Disease Modelling“ are genome-wide resource of conditional Lab members from psychiatric (depression) and approaching the central question of the targeted ES cells and mice. Within the Group Leaders: Andrea Huber Broesamle, Chichung Lie, Jochen Graw, neurological diseases (Parkinson´s pathoetiology of neuropsychiatric national DIGTOP (disease genes to Andreas Hörlein Disease, dementia) by contributing to diseases from different angles using proteins) project the proteomic Teamleaders: Jan Deussing, Thomas Floss, Jens Hansen, the development of new therapies and systemic, cellular and molecular interactions of disease-related genes in Sabine Hölter-Koch, Ralf Kühn, Nilima Prakash, Damian Refojo, preventive measures. Since it is approaches. In this context the IDG is stem cells and mice are analysed. The Members Joel Schick, Daniela Vogt Weisenhorn apparent that these neurological and focusing specifically on synaptic, Technology Development and Animal LMU Generation (top: genetic modification) and psychiatric diseases are multifactorial mitochondrial, and neuroendocrino- Model Generation teams develop new analysis of animal models for neuropsychiatric

MCN disorders, an integrative research logical dysfunction and its consequence mutagenesis tools and provide infra- diseaes at the molecular, cellular (2nd: approach is needed to understand the on behaviour. The IDG also integrates structure and a provide infrastructure mitochondria in a neuron and 3rd: dopaminergic neuron) and systemic (4th: sagital mouse brain etiopathogenesis of the diseases – groups which are dedicated to the for the generation of mouse mutants. section, 5th and 6th: behavioural analysis of mouse mutants, i.e. gait analysis) 88 | 89 Teaching Teaching 90 | 91 Teaching LMU GSN IMPRS-LS GRADUATE SCHOOL International Max-Planck Postdoctoral Level LMU OF SYSTEMIC Research School for Harvard/LMU Molec. & Cell. Life Sciences Young Scientists/ MCN NEUROSCIENCES Forum (YSF) RTG 1091 Queensland PhD Systemic Neurosciences DFG Research Training Group Brain Institute/ Orientation and Motion in Space MCNLMU Symposium Undergraduate EliteNetzwerkBayern AMGEN Scholars MSc Neurosciences Program RTG 1373 FUN EliteNetzwerkBayern DFG Research Training Group Faculty for MSc NeuroCognitive Psych. Brain Signaling: From Neurons Undergraduate Neuroscience to Circuits

Bachelor of Science Programs Teaching 92 | 93

Graduate School of Systemic Neurosciences The hub of neuroscience education in Munich

The Graduate School of Systemic Neurosciences The School’s Objective From the beginning, the GSNLMU set out to become What makes the GSNLMU so attractive? GSNLMU is the teaching entity for neuroscience Under the umbrella of the MCNLMU the GSNLMU the hub for neuroscience education in Munich. First of all, the scientific environment in which education in Munich. In tight collaboration links research groups from cellular and systems After five years ~100 students are enrolled in the the GSNLMU operates is one of the neuroscience with the master programs Neurosciences and neuroscience, computational neuroscience, program, numbers rising. This is possible as the hot-spots worldwide. Besides the excellent Neurocognitive Psychology the GSNLMU offers neurocognitive psychology and neurophilosophy, GSNLMU is a distinct institution of LMU governed research opportunities the structure of the an integrated teaching program taking students thus providing a stimulating environment for independently and independently awarding the degree program at GSNLMU has many advantages from their bachelor to a master or PhD degree. novel formulations and concepts. A special PI doctoral degree, thus making GSNLMU not only on to a traditional doctorate. All GSNLMU students The proposal for the GSNLMU was successful lecture series introduces the various key topics a working basis, but also from a formal point of have thesis advisory committees (TACs) rather in the first round of the Excellence Initiative and methods to all students in the GSNLMU. Thus, view, truly interdisciplinary. Implementing GSNLMU than single supervisors. These TACs comprise in 2006. With the tailwind of the innovative students keep a broad scope even though their as an independent, degree awarding institution 3 or more researchers from different fields and drive ignited by the Excellence Initiative, the own research is getting more and more focussed. was the key innovation in the original concept. may include junior faculty as well as external GSNLMU was established as an interdisciplinary A special stipend program was initiated by Another key feature is the fact that the doctoral members. In regular meetings with student and institution of LMU Munich which is governed GSNLMU to promote especially those PhD research degree the GSNLMU awards is the internationally TAC individual research plans are developed and independently and awards a doctoral degree projects which go along the boundaries between compatible PhD. For international students this is documented (Training Objectives). At least once a independently from the traditional faculty subdivisions, bearing a higher risk but also high a very important issue when choosing the location year the Training Objectives have to be evaluated structure of the universities. potential. The field of neurophilosophy for example for their education. A proportion of currently and updated. This leads to maximal transparency is still developing in Germany. While the MCNLMU almost 40% international students (aiming for in the process and to maximal security of “staying promotes this development by inviting very 50%) GSNLMU demonstrates its attractiveness. on track”. What has proven to be best practice in Director: Prof. Dr. Benedikt Grothe renowned visting professors to support the local educating and supervising doctoral students in Management & Administration: Lena Bittl (beginning October 2011), teaching, the GSNLMU declares special stipends over the past years, has found implementation in Dr. Alexandra Stein (until October 2011) for up to five new neurophilosophy PhD projects the PhD regulations for the GSNLMU. Next to the each year. TAC supervision, students need to earn credit Teaching | Graduate School of Systemic Neurosciences | Graduate Teaching 94 | 95

point by acquiring a variety of competencies Fast-track education Next to the awarded degree, the structure of the Cellular and Circuit Neurosciences, Clinical required for scientific working next to While still many students especially from program is highly compatible to other programs Neuroscience, Computational Neuroscience, methodological expertise: participating in Germany and other European countries enter worldwide. Especially the different entry Developmental Neuroscience, Molecular regular lab meetings and progress reports, the program with a MSc or equivalent degree, points to the program and flexibility to change Neuroscience and Neurophilosophy. going to conferences to present their work, the GSNLMU offers the opportunity to enter the the course as students go along. Whether visiting summer school, gain own teaching program with a BSc degree in neuroscience suitable candidates come with a BSc degree and supervision experience. The GSNLMU related areas. During the first two semesters a MSc or Diploma in related field or come as defines the minimum amount of credit points students go through a preparatory year career changers with a MSc or Diploma from to be earned with qualification measures. The receiving basic training in neuroscience in more distant fields, the GSNLMU can offer an content is individually defined for each student close collaboration with the master programs individually tuned program, making sure that in together with the TAC and also recorded in Neurosciences and Neurocognitive Psychology. the end all students leave GSNLMU with profound the training objectives. All this leads not only A special advisory commission with permanent knowledge in different areas of neuroscience. to close supervision for the research project, members close watches the achievements of but automatically extends to very individual the fast-track students. Personal mentors from As neuroscience is a rapidly developing career advice. Of course science is not all in the GSNLMU faculty give additional individualized field bringing up new topics and methods, life. The GSNLMU has vivid interactions between advice to the students. After the preparatory GSNLMU will respond by integrating these new members. Regularly GSNLMU organizes informal year, the advisory committee, together with the developments into the teaching concept. To get-togethers like a summer barbeque or an student a decision is made to continue in the structure this large variety of participating annual dinner when the new cohort arrives. Also MSc or PhD track. researchers, methods and topics, the GSNLMU events like hiking, theatre, museum and movie defined scientific sections and each faculty nights regularly take place. Being a part of member is assigned to a section. These sections GSNLMU is being part of a community. are Behavioural and Cognitive Neurosciences, Teaching | Graduate School of Systemic Neurosciences | Graduate Teaching 96 | 97

Master of Science in Neurosciences Teaching Concept – Career Tailored Education In order to guide our students in acquiring excellent researchers. In addition, besides the mandatory Based on their teaching and research expertise, knowledge and practical proficiency in our key general courses, the students can choose from a Basic and individual teaching in a dynamic and interdisciplinary the members of our teaching faculty, which are focus areas, our teaching concept is based on four broad spectrum of methods and interdisciplinary scientific field also part of the Graduate School of Systemic major measures (see also schematic of curriculum): courses. Finally, of course, the students Neurosciences or guest lecturers from external complement their education in neuroscience institutions, believe that the overwhelming 1. General education: The educational program with their master thesis. The LMU Master Program in Neurosciences Munich – An important international center In order to implement the standardization of complexity of the human brain can only be is based on four main scientific topics: is supported by the Elite Network of Bavaria for neurosciences European university education according to the explained by applying different approaches and systems neurobiology, molecular and cellular 3. Complementary Skills: Our training concept (http://www.elitenetzwerk-bayern.de) and The essential question in modern neurosciences Bologna consensus, the strong neuroscience methods of the disciplines in neuroscience. Thus, neurobiology, computational neuroscience would not be complete without the training of is, together with the LMU master program is to understand how the human brain is community of the LMU immediately developed our progam will constantly work on educating and neurophilosophy. Our curriculum takes complementary skills, which supplement our Neurocognitive Psychology, embedded into the functioning on all levels from molecules to and implemented a program in neurosciences, a new generation of neuroscientists starting at the students on a “round trip” providing a core curriculum and help to optimally prepare Graduate School of Systemic Neurosciences. cognition. In order to approach these questions which nowadays serves as an educational role the level of graduate students. With an exellent profound understanding of the biological students for their future career goals. In their It provides a basic and individual teaching researchers and thinkers in Neurosciences model. Right from the beginning, the LMU understanding of the molecular, the cellular and principles in brain structure and neuron-neuron second year our students obtain first practice concept for bachelor and master students with develop and use a wide spectrum of experimental master program in neurosciences was supported the systemic principles of neurobiology, our communication before broadening the scope (and credits) in teaching by tutoring their an educational backgound in neurosciences but and analytical methods from a broad variety of within the the exclusive Elite Network by the students acquire a deeper knowledge of neuron- towards cognition and higher brain functions, younger fellows. In addition to the scientific also from other related field like life sciences, disciplines. As the techniques and the thinking government of Bavaria and was launched in the neuron interaction, the dynamics of neuron-glia computational methods and philosophical education, the Master Program includes modular math, physics, computational sciences, are mostly interdisciplinary, it is not suprising winter term of 2007. After the end of the first interaction, the rules of information transfer in aspects in neurosciences. The main part of the workshops on general working techniques in science engineering and as an Munich speciality also that the demand of researchers and thinkers with funding period the program was re-evaluted simple and complex circuits of single brain centers, general education takes place in the first two such as communication training, presentation philosophy. an interdisciplinary and integrative educational in June 2011, with excellent statements of the interaction of different brain centers, and the semesters and includes also GSNLMU Fast Track skills, scientific writing, and time management. background is increasing permanently. Based on the scientific reviewers and the government function of the human brain. This educational Students and students from the GSNLMU PhD its strong history and today proficient expertise of Bavaria. Initiated by the Bavarian State concept of the Master Program in Neurosciences is program with unrelated backgrounds. 4. Mentoring: Each student has his or her own Contact infomation: in neurosciences, Munich is by all measures one Government, the Elite Network of Bavaria reflected in the key focus areas, which include: mentor from the GSNLMU faculty. The mentors Our Master Program Neurosciences always starts of the most important centers for neurosciences contributes to excellent education for highly • Systems Neurobiology 2. Individual research training: In each semester, serve as academic advisors, helping the students every year in winter semester term. Applications worldwide and thus, an important international qualified students at top facilities. Selected • Sensory Physiology the student has to complete an individual plan their educational career and facilitate will only be accepted as online aplications from site for interdisciplinary research and education students receive intensive individual tutoring and • Computational Neuroscience research project. This will guarantee hands- contacts to collaborating insitutions. In mainly December 1st until February 1st. in the field. get the chance to study in a challenging scientific • Molecular and Cellular Neurobiology on research training from the very beginning informal meetings the students have an excellent Homepage: www.mcn.lmu.de environment. • Neurophilosophy and gives students the opportunity to become opportunity to discuss problems, receive email: [email protected] • Complementary Skills acquainted with participating laboratories and guidance or have an informative scientific chat. Teaching | Elitenetzwerk Bayern Master Programm Teaching 98 | 99

Amgen Scholars European Undergraduate Amgen Scholars – From Molecules to • Participation at the European Amgen Scholars Behavior Summer Symposium at the University of Summer Research Program Amgen Scholars at LMU Munich engage in 8 Cambridge weeks of intensive laboratory research. Each • Networking events with local graduate students summer up to 25 undergraduate students gain and extra-curricular excursions exposure to cutting edge science in laboratories • Concluding local symposium with poster at LMU’s HighTechCampus offering a unique presentations academic and scientific life science environment with numerous renowned life science research The Amgen Scholars Program aims to create institutions and world leading scientists. balanced top-level educational opportunities across Europe by supporting the mobility and Participants conduct mentor-guided, hands-on networking of academics at a very early stage, research in the fields of biochemistry, structural, thus enhancing the interest of the participants in molecular, cell, and developmental biology, a scientific career. neurobiology, computational neuroscience, cancer research and physiological sciences. Target Group The research program includes: Selected undergraduate students from relevant fields; only European countries (according to • 4 day orientation retreat in the Bavarian the European Higher Education Area (EHEA)) countryside • Weekly lectures and workshops on state- In Europe the program is conducted in partnership Faculty Director: Prof. Dr. Benedikt Grothe of-the-art research topics and methods, with the University of Cambridge (UK) and the Program Director: Lena Bittl bioethics, poster presentation, abstract Karolinska Institutet (Sweden). The program Program Administrator: Liz Atwood writing and scientific career paths is financed through the generosity of the Amgen • 8 weeks of hands-on research in a host Foundation. www.amgenscholars.mcn.uni-muenchen.de laboratory under the supervision of an www.amgenscholars.eu assigned faculty mentor Teaching | Amgen Scholars Undergraduate Summer Research Program Program Summer Research Undergraduate | Amgen Scholars Teaching 100 | 101

FUN – Faculty for Undergraduate Neuroscience (U.S.A.) Summer Course

In 2011 the GSNLMU launched a cooperation with The mission of FUN is: In order to further develop and enhance the To get a glance about the long-lasting impression the Faculty For Undergraduate Neuroscience international neuroscience network, in June 2011 and enthusiasm the summer school evoked in (U.S.A.) FUN is an international organization • Enhancing undergraduate participation in undergraduate students and faculty members of the students, view our photos and video at http:// that is focused on neuroscience education and research and the presentation of research at the FUN visited Munich and Berlin each for a 2-week blogs.cofc.edu/germanneuro/ and http://blogs. research at the undergraduate level. FUN’s SFN meeting (Society for Neuroscience, U.S.A.) summer school on Neuroscience. The courses cofc.edu/germanneuro/about members and supporters include businesses • Disseminating innovations in undergraduate included lecturers, practical course work and and organizations; private liberal arts colleges, neuroscience education lab visits throughout the faculty of the Graduate state and research university departments and • Recognizing excellence in undergraduate School of Neurosciences in Munich and the programs; and individual faculty and students, neuroscience education Graduate School of Mind and Brain in Berlin. In all sharing a common interest in undergraduate • Developing national and regional networks that additon to the scientfic education, the students neuroscience. enhance undergraduate neuroscience education had many opportunities to socialize with local and research and faculty development sudents and faculty members and visit local and regional attractions, like alpine excursions, city tours and, of course, beer gardens. The summer school was a great success for students and faculty and will be continued on an annual basis. Teaching | FUN – Faculty for Undergraduate Neuroscience for Undergraduate | FUN – Faculty Teaching 102 | 103

RTG 1091 – DFG Research Training Group Orientation and Motion in Space

The DFG Research Training Group Orientation “From Biology to Medicine” and the Bernstein the program. We also investigate the effect of the training group is to look beyond the narrow and Motion in Space is supported by scientific Center for Computational Neuroscience (BCCN). lesions on orientation and motion analysis in topic of the individual project. These are the best groups from different disciplines and faculties We offer challenging research topics of high patients and animal experiments. Thus, with the preconditions for better problem solving strategies of the Ludwig Maximilians University Munich biological relevance and permit the detailed different scientific backgrounds the participants and new approaches. There is a tight link to (biology, clinical neurology, psychology), investigation of complex central nervous are working on a common theme, using different clinical problems such as Ataxia and dizziness. together with neurobiological groups from processes. These also include the essential approaches and problem-solving strategies. the Max Planck Institute for Neurobiology in sensory inputs (acoustic, vestibular, visual), as Last but not least, the students can choose from Martinsried. well as the psychophysical and motor reactions in Furthermore, a wide spectrum of methods is a whole range of specially organised soft skill regard to the control of movements and balance in available. These include extra cellular recordings courses, lectures and workshops we organise for The participating senior scientists, together space. from individual neurons, optical recordings to them. with their co-operating group members, provide establish maps in central nervous structures, optimal training, education and support for The latter are investigated in normal subjects as well as eye movement recordings and doctoral students from various fields (Biology, and patients, whereas animal experiments with psychophysics. Computer science, Engineering, Medicine, optical and extra cellular single unit recordings are Physics and Psychology). planned in order to study information processing The common scientific theme, combined with within the central nervous system. Attention and different backgrounds and the wide range of We cooperate closely with the Graduate memory are also decisive factors for adequate methods, gives the graduate students a unique Head: Prof. Dr. Andreas Straube School of Systemic Neuroscience (GSNLMU), orientation and movement in space. These opportunity to apply interdisciplinary approaches Coordinator: Maj-Catherine Botheroyd the International Max-Planck Research School topics are specifically addressed by projects in and broaden their scientific view. A major goal of Teaching | RTG 1091 Orientation and Motion in Space | RTG Teaching 104 | 105

RTG 1373 – DFG Research Training Group Brain Signaling: From Neurons to Circuits

The Research Training Group 1373 Brain The scientific aim of this Research Training Group The educational concept of our Research Training signaling: from neurons to circuits focuses is to elucidate the cellular and molecular signaling Group will specialize in providing in-depth on basic and disease-related neuroscience. underlying brain function in health and disease. scientific training to students with a medical Neuroscience promises to improve our A special focus is to relate physiological processes background, as well as offering disease-related strategies to treat neurological disorders, which to disturbances of signaling in neurological research opportunities to young scientist from in aging societies present an ever-growing disease conditions. For this purpose, members natural science disciplines. Training will be problem. New technologies enable us to explore of the Research Training Group analyze animal conducted in the form of a study program directly brain signaling with unprecedented precision, models utilizing high-resolution in vivo imaging inspired by the successful M.D./Ph.D. programs but also require increasingly complex and techniques and electrophysiological methods. that present the gold standard for training of diverse interdisciplinary skills. The special Complementary efforts of other groups focus on clinician-scientists. Over the past years, this requirements of the multi-disciplinarity inherent the analysis of molecular mechanisms of brain program has proven a sounding success with in neuroscience mandate the establishment of function, including the development of new mouse exceptionally talented students applying in large new, formalized training programs for young models. Finally, imaging and electrophysiology numbers. Renewal of this Research Training Group neuroscientists-to-be. Our Research Training approaches that can be applied to small animal will provide us the opportunity to consolidate Group aims to provide such specialized training, models as well as human patients form a the pioneering efforts of our first funding period while at the same time addressing central technological bridge towards clinical translation. and expand our research program aimed at questions in neuroscience with cutting-edge in elucidating brain signaling in health and disease. vivo technology. Thus, multi-disciplinary training in disease-related Head: Prof. Dr. Arthur Konnerth neuroscience will be firmly established at our partnering universities. Teaching | RTG 1373 Brain Signaling: From Neurons to Circuits Neurons Signaling: From 1373 Brain | RTG Teaching 106 | 107

LMU-Harvard Young Scientists’ Forum (YSF) QBI-MCNLMU Symposium

The LMU-Harvard Young Scientists’ Forum Speakers in 2011: The inaugural symposium on Systems Speakers at the 2011 QBI-MCNLMU Symposium (YSF) seeks to unite Ph.D. students and Neuroscience between the Queensland Brain included: postdoctoral fellows from Harvard University LMU Munich: Institute (QBI) and the Munich Center for and the Ludwig-Maximilians-Universität (LMU) Prof. Tobias Bonhoeffer Neurosciences (MCNLMU) took place at the From MCNLMU: with core faculty from the two universities to Prof. Thomas Carell University of Queensland, Brisbane, QLC, Prof. Benedikt Grothe, Director MCNLMU create a framework for an interdisciplinary Prof. Christian Haass Australia in September 2011. The symposium Prof. Heiner Deubel

Symposium exchange of ideas. Prof. Matthias Mann brings together leading researchers from both Prof. Magdalena Götz

LMU universities in sensory, cognitive, cellular and Prof. Mark Hübener The first conference of the series was held Harvard: to share their recent Prof. Rüdiger Klein at LMU Munich in June 2009, followed by a Prof. Catherine Dulac findings with the Australian neuroscience Prof. Christian Leibold conference at Harvard University in 2010. Prof. Venkatesh Murthy community including student participants from Prof. Lutz Wiegrebe Prof. Eric Rubin LMU Munich. Further joint efforts will include LMU-Harvard YSF was held in 2011 at the Prof. William Shih a second symposium in 2012, a Summer School From QBI: Center for Advanced Studies (CASLMU) of the in 2013, long term student exchange (1-2 Prof. Perry Bartlett, Director QBI LMU Munich. years) and on-going short-term exchange (2-3 Prof. Geoff Goodhill weeks) between faculty members and advanced Prof. Ottmar Lipp researchers from both institutions. Prof. Justin Marshall Prof. Linda Richards Prof. Pankaj Sah Teaching | Young Forum & QBI-MCN Forum | Young Teaching 108

LMU | MCN Community Outreach 109 110 | 111

MCNLMU Central office

Awards Lectures & Events - Young Scientist Award - LMU Lecture Series ("Ringvorlesung") - LMU/Scopus Neuroscience Award - MCNLMU Monday Lecture Series - Scopus Young Award - MCNLMU Christmas Lecture - Brain Navigator Award - Neurohistory Workshop Community Outreach LMU MCN 112

LMU | MCN Community Outreach | Lectures & Events 113 Lectures &Events brain development and regeneration, epilepsy, the evolutionary basis of the human brain, was co-organized by MCN by co-organized was Gehirn“ sein und Mensch “Der titled lectures 15 of series interdisciplinary university-wide, year, a academic 2010/2011 the During public: general the and community neuoscience the both to open lectures organizing by community greater issues and topics within neuroscience to the center also strives to bring publically relevant initiatives and research collaborations, the mind”. In addition to direct support of teaching of neurobiology, cognition, and “brain and questions to related interests with disciplines a network bringing together all groups and Neurosciences – Brain and Mind” is to create for Center “Munich the of goal ultimate The LMU . Topics included held yearly at the Residenz in Munich. The of the Munich Christmas Lecture Series to be has coorganized the upcoming inaugural lecture Campus in Martinsried. See the MCN the See Martinsried. in Campus academic semesters on Munich‘s high-tech both during monthly place take Lectures research. current of spectrum interdisciplinary an covering experts international and local neuroscience community, features high-profile The Monday Lecture Series, open to the www.lmu.de/ringvorlesung see details more For ethics. and Disease, Alzheimer‘s logic, plasticity, and learning balance, controls which system vestibular the of Science, Research and the Arts, the MCN the Arts, the and Research Science, of Upon invitation by the Bavarian State Ministry information. more for LMU website website LMU

aesthetics. and beauty on (Netherlands) in Nijmegen the Max Planck Institute for Psycholinguistics December 19th, 2011 by Wolfgang Klein from Royal Institution. The first lecture will be held on traditional Christmas Lecture of the British the by inspired is Series Lecture Christmas 114

LMU | MCN Community Outreach | Neurohistory Workshop 115 Neurohistory Workshop ideally, vice versa). (and, history understand to us help might workshop focused on ways that neuroscience interdisciplinary The Germany. in Munich, held 6-7 June 2011 at the Rachel Carson Center aworkshop at addressed was question This Past? the Understand Neurohistory: How Can Neuroscience Help Us 1. addressed: were main questions Four 4. 3. 2.

environment in the past and present? and past in the environment the interaction between people and their on light shed neurohistory might How overcome? be they can developing neurohistory as a field, and how to challenges biggest the are What versa)? vice (and historians for suggest neuroscience What new research questions can versa)? vice (and past the on light new shed to use can historians that developed What ideas and methods have neuroscientists 116

LMU | MCN Community Outreach | Awards 117 Awards from the neurosciences. researchers young to restricted are Award“) Neuroscientist Award“ and “Brain Navigator Young “Scopus Award“, Neuroscience Scopus (“LMU/ awards three remaining the while medicine), and bioinformatics biochemistry, biology, (including sciences life the from Munich LMU of candidates doctoral to dedicated is Award“ Young Scientist Life “LMU The Munich. from scientists young to neurosciences sciences/ life in the publications excellent for Euros 5000 and 1500 between awards four Center for Neurosciences and Elsevier assigned Munich the GraduateCenter-LMU, the 2010, In A (2010), Nature 464). (Hongbo J, Rochefort NL, Chen X and Konnerth of sensory input to cortical neurons in vivo.“ organization “Dendritic publication his for Hongbo Jia, Technische Universität München Award: Young Neuroscientist Scopus 68(4)). Neuron M(2010), Götz J, Rieger M, Schroeder T, Cvekl A, Favor J and Sun A, Lepier S, Petricca L, Pinto J, (Ninkovic olfactory bulb neurons via crystallin aA.“ factor Pax6 regulates survival of dopaminergic Munich, for his publication “The transcription Dr. Jovica Ninkovic, Helmholtz Zentrum Award: Neuroscience LMU/Scopus in 2010 Awardees Mann M (2010), Cell 141(5)). (Zielinska DF*, Gnad F*, Wisniewski JR and Sequence Constraints“ and Topological Rigid Reveals N-Glycoproteome publication “Precision Mapping of an In Vivo her for Munich /LMU Biochemistry for Dorota Zielinska, Max Planck Institute Award: Young Scientist LMU Life The Neuroscience 13(4)). FM, Kretzschmar H and Herms J (2010), Nature LaFerla C, Haass G, Mitteregger RM, Page S, Burgold CKE, Jung T*, M*, Bittner (Fuhrmann mouse model“ prevents neuron loss in an Alzheimer‘s disease knockout CX3CR1 “Microglial publication the for Dr. Munich, TobiasLMU Bittner, Award: Navigator Brain The

118 | 119 Appendix Appendix 120 | 121 B Prof. Dr. Martin Biel | Page 30 C PD Dr. Christoph Draxler Dr. Kathrin Finke | Page 46 Prof. Dr. Helmut Glünder Ludwig-Maximilians-Universität München LMU, Fakultät für Sprach- und Literaturwissenschaften LMU, NCP, Department für Psychologie TU Darmstadt, Elektrotechnik und Informationstechnik Department of Pharmacy – Center for Drug Research, Schellingstraße 3 Leopoldstraße 13 Dreimühlenstraße 9 Dr. Florence Bareyre | Page 26 Pharmacology Prof. Dr. Gordon Cheng | Page 36 80799 Munich 80802 Munich 80469 Munich Institute of Clinical Neuroimmunology Butenandtstraße 7, Building C TUM, Kognitive Systeme Phone +49 (0)89 / 2180-2807 Phone +49 (0)89 / 2180-6779 Phone +49 (0)89 / 7466 4169 Ludwig-Maximilians-Universität München 81377 Munich Barer Straße 21 E-Mail [email protected] E-Mail [email protected] E-mail [email protected] Marchioninistraße 17 Phone +49 (0)89 / 2180-77327 80290 Munich www http://www.esp.phonetik.uni-muenchen.de/ www www.psy.lmu.de www http://www.rtr.tu-darmstadt.de/rtr/unserteam/ 81377 Munich E-mail [email protected] Phone +49 (0)89 / 289-01 personen/professoren/draxler/index.html mitarbeiter_rtr/details_5125.de.jsp Phone +49 (0)89 / 2180 78279 www http://www.cup.uni-muenchen.de/ph/aks/biel/ E-Mail [email protected]. E-mail [email protected] Prof. Dr. Frank Fischer www www.klinikum.uni-muenchen.de/Institut-fuer- E LMU, Fakultät für Psychologie und Pädagogik, Department Prof. Dr. Georg Goldenberg Klinische-Neuroimmunologie Prof. Dr. Tobias Bonhoeffer | Page 32 Prof. Dr. Jörg Conradt Psychologie TUM, Klinikum München Bogenhausen, Department of Cellular and Systemsneurobiology TUM, Neurowissenschaftliche Systemtheorie Leopoldstraße 13 Abteilung Neuropsychologie Max-Planck-Institute of Neurobiology Barer Straße 21 Dr. Veronica Egger | Page 42 80802 Munich Englschalkingerstraße 77 Dr. Gabriel Beckers Am Klopferspitz 18 80333 Munich Physiologisches Institut der LMU Phone +49 (0)89 / 2180-5146 81925 Munich MPI für Ornithologie 82152 Martinsried Phone +49 (0)89 / 289-26925 Pettenkoferstraße 12 E-mail [email protected] Phone +49 (0)89 / 92702106 Eberhard-Gwinner-Straße Haus Nr. 6 Phone +49 (0)89 / 8578-3750 E-Mail [email protected] 80336 Munich www www.psy.lmu.de/ E-mail [email protected] 82319 Seewiesen E-Mail [email protected] www www.lsr.ei.tum.de Phone +49 (0)89 / 2180-75572 www www.kh-bogenhausen.de Phone +49 (0)8157 / 932-273 www http://www.neuro.mpg.de/24259/bonhoeffer E-Mail [email protected] E-Mail [email protected] www www.eggerlab.web.med.uni-muenchen.de G www http://www.orn.mpg.de/mitarbeiter/beckers.html PD Dr. Paul Cumming, PhD Prof. Dr. Magdalena Götz | Page 50 Prof. Dr. Alexander Borst | Page 34 LMU, Medizinische Fakultät, Dept. f. Nuklearmedizin Fakultät für Medizin der LMU, Physiologische Genomik MPI für Neurobiologie – Abteilung Systems und Marchioninistraße 15 Dr. Ulrich Ettinger Prof. Dr. Manfred Gahr | Page 48 Pettenkoferstraße 12 Prof. Dr. Jürgen Beckmann Computationale Neurobiologie 81377 Munich Emmy Noether Research Group Leader, Department of MPI für Ornithologie 80336 Munich TUM Fakultät für Sportwissenschaften Am Klopferspitz 18 E-Mail nikum.uni-muenchen.de/perschemie.php Psychiatry and Psychotherapy and Department of Psychology Eberhard-Gwinner-Straße Phone +49 (0)89 / 2180-75252 Lehrstuhl für Sportpsychologie 82152 Martinsried Leopoldstraße 13 82319 Seewiesen E-mail [email protected] Connollystraße 32 Phone +49 (0)89 / 8578-3251 80802 Munich Phone +49 (0)8157 / 932-276 www www.physinst.web.med.uni-muenchen.de 80809 Munich E-Mail [email protected] D Phone +49 (0)89 / 343856 E-mail [email protected] Phone +49 (0)89 / 289-24540 www www.neuro.mpg.de E-Mail [email protected] www http://www.orn.mpg.de/2525/Abteilung_Gahr E-Mail [email protected] Dr. Oliver Griesbeck | Page 52 www www.sp.tum.de Prof. Dr. Heiner Deubel | Page 38 Max-Planck-Institute of Neurobiology Prof. Dr. Dr. h.c. Thomas Brandt, FRCP LMU, Fakultät für Psychologie und Pädagogik, F Dr. Steffen Gais Am Klopferspitz 18 LMU, Klinikum Großhadern, Institut für Neurologie Department Psychologie Emmy Noether-Group „Memory Consolidation“ General and 82152 Martinsried Prof. Dr. Oliver Behrend Marchioninistraße 15 Leopoldstraße 13 Experimental Psychology Phone +49 (0)89 / 8578 3270 LMU,Department Biologie II, MCNLMU 81377 Munich 80802 Munich Dr. Felix Felmy | Page 44 Leopoldstraße 13 E-mail [email protected] Grosshaderner Straße 2 Phone +49 (0)89 / 7095 2570 Phone +49 (0)89 / 2180 5282 LMU, Department Biologie II, Abteilung Neurobiologie 80802 Munich www http://www.neuro.mpg.de/24427/griesbeck 82152 Martinsried E-Mail [email protected] E-Mail [email protected] Großhadernerstraße 2 Phone +49 (0)89 / 2180-9828 Phone +49 (0)89 / 2180-74363 www www.nefo.med.uni-muenchen.de www www.paed.uni-muenchen.de 82152 Martinsried E-mail [email protected] E-Mail [email protected] Phone +49 (0)89 / 2180-74308 Prof. Dr. Benedikt Grothe | Page 54 www www.mcn.lmu.de E-Mail [email protected] LMU, Department Biologie II, Lehrstuhl Neurobiologie Prof. Dr. Thomas Buchheim Prof. Dr. Martin Dichgans www www.bio.lmu.de PD Dr. Stefan Glasauer Großhadernerstraße 2 Fakultät für Philosophie der LMU, Philosophie Department, LMU, Klinikum Großhadern, Institut für Neurologie Zentrum für Sensomotorik, Neurologische Klinik und 82152 Martinsried Dr. Jan Benda | Page 28 Lehrstuhl III Marchioninistraße 15 Poliklinik der LMU Phone +49 (0)89 / 2180 74 302 LMU, Department Biologie, BCCN Geschwister-Scholl-Platz 1 81377 Munich Dr. Thomas Fenzl Marchioninistraße 23 E-mail [email protected] Großhaderner Straße 2 80539 Munich Phone +49 (0)89 / 7095-3670 (-6670) MPI für Psychiatrie – Abteilung Neurogenetik des Schlafes 81377 Munich www www.bio.lmu.de 82152 Martinsried Phone +49 (0)89 / 2180-2004 E-Mail [email protected] Ingolstädter Landstraße 1 Phone +49 (0)89 / 7095 4839 Phone +49 (0)89 / 2180-74137 E-Mail [email protected] www www.nefo.med.uni-muenchen.de 85764 Neuherberg E-mail [email protected] E-Mail [email protected] www www.thomas-buchheim.de Phone +49 (0)89 / 30622-498 www www.nefo.med.uni-muenchen.de www www.bio.lmu.de E-Mail [email protected] Prof. Dr. Marianne Dieterich | Page 40 www www.mpipsykl.mpg.de Prof. Dr. Ulrich Büttner LMU, Klinikum Großhadern, Institut für Neurologie LMU, Klinikum Großhadern, Institut für Neurologie Marchioninistraße 15 Marchioninistraße 15 81377 Munich | Members 81377 Munich Phone +49 (0)89 / 7095 2571

LMU Phone +49 (0)89/ 7095 2560 E-Mail [email protected] E-Mail [email protected] www www.nefo.med.uni-muenchen.de

MCN www www.nefo.med.uni-muenchen.de 122 | 123 H Prof. Dr. Andreas V. M. Herz | Page 58 K PD Dr. Lars Kunz M N LMU, Department Biologie II, Department Biologie II der LMU, Division of Neurobiologie Computational Neuroscience Großhadernerstraße 2 Prof. Dr. Dr. h.c. Christian Haass | Page 56 Großhadernerstraße 2 Dr. Ilona Grunwald Kadow | Page 62 82152 Martinsried Prof. Dr. Kaspar Matiasek Prof. Dr. Julian Nida-Rümelin Adolf Butenandt Institut der LMU, 82152 Martinsried Max-Planck Institute of Neurobiology Phone +49 (0)89 / 2180-74299 Institut für Tierpathologie Former Federal State Minister for Culture Department für Biochemie Phone +49 (0)89 / 2180 74 138 Sensory Research Group E-mail [email protected] Veterinär Str. 13 and the Media | Page 74 Schillerstraße 44 E-mail [email protected] Am Klopferspitz 18 www www.neuro.bio.lmu.de 80539 Munich Lehrstuhl für Philosophie IV 80336 Munich www www.bio.lmu.de 82152 Martinsried Phone +49 (0)89 / 2180-2530 Geschwister-Scholl-Platz 1 Phone +49 (0)89 / 2180-75 471 Phone +49 (0)89 / 8578 3159 Fax +49 (0)89 / 2180-2544 80539 Munich E-mail [email protected] E-mail [email protected] L www http://www.patho.vetmed.uni-muenchen.de/ Phone +49 (0)89 / 2180-9020 www www.med.uni-muenchen.de/haass/ Prof. Dr. Franz Hofmann www www.neuro.mpg.de E-mail [email protected] Fakultät für Medizin der TUM, www www.philosophie.uni-muenchen.de/ Institut für Pharmakologie und Toxikologie Prof. Dr. Rainer Landgraf Dr. Aye Mint Mu lehreinheiten/philosophie_4 Prof. Dr. Jonathan Harrington Biedersteiner Straße 29 Dr. Alexander Kaiser MPI für Psychiatrie, Verhaltensneuroendokrinologie Klinik für Psychiatrie und Psychotherapie der LMU, LMU, Fakultät für Sprach- und Literaturwissenschaften 80802 Munich LMU, Department Biologie II, Abteilung Neurobiologie Kraepelinstraße 2 Laborfachgruppe Schellingstraße 3 Phone +49 (0)89 / 4140 3260 Großhadernerstraße 2 80804 Munich Nussbaumstraße 7 P 80799 Munich E-mail [email protected] 82152 Martinsried Phone +49 (0)89 / 30622-495 80336 Munich Phone +49 (0)89 / 2180-2758 www www.ipt.med.tu-muenchen.de Phone +49 (0)89 / 2180-74182 E-mail [email protected] Phone +49 (0)89 / 5160 3433 E-mail [email protected] E-mail [email protected] www www.mpipsykl.mpg.de E-mail [email protected] Prof. Dr. Reinhard Pekrun www http://www.en.esp.phonetik.uni-muenchen.de/ www www.zi.biologie.uni-muenchen.de www www.pni-net.de Department Psychologie der LMU personen/professoren/harrington/index.html Prof. Dr. Reinhard Hohlfeld Leopoldstraße 13 Klinische Immunologie, Klinikum Grosshadern der LMU Prof. Dr. Christian Leibold | Page 68 80802 Munich Marchioninistraße 15 Prof. Dr. Ruediger Klein, PhD | Page 64 LMU, Department Biologie II, Computationale Prof. Dr. Ulises Moulines Phone +49 (0)89 / 2180-5148 Prof. Dr. Werner Hemmert 81377 Munich MPI für Neurobiologie, Department für Moleculare Neurowissenschaften Fakultät für Philosophie der LMU, Lehrstuhl Philosophie, E-mail [email protected] TUM, Bioanaloge Informationsverarbeitung Phone +49 (0)89 / 7095-4780 (-4781) Neurobiologie Großhadernerstraße 2 Logik und Wissenschaftstheorie www www.psy.lmu.de Boltzmannstraße 11 E-mail [email protected] Am Klopferspitz 18 82152 Martinsried Ludwigstraße 31 85748 Garching www www.nefo.med.uni-muenchen.de 82152 Martinsried Phone +49 (0)89 / 2180 74309 80539 Munich Phone +49 (0)89 / 289 10853 Phone +49 (0)89 / 8578 3151 E-mail [email protected] Phone +49 (0)89 / 2180-3320 Prof. Dr. Ernst Pöppel E-mail [email protected] E-mail [email protected] www www.bio.lmu.de E-mail [email protected] Fakultät für Medizin der LMU, Institut für Medizinische www www.imetum.tum.de Prof. Dr. Mark Hübener | Page 60 www www.neuro.mpg.de www www.philosophie.uni-muenchen.de Psychologie MPI für Neurobiologie Goethestraße 31 Am Klopferspitz 18 Prof. Dr. Dr. Hannes Leitgeb | Page 70 80336 Munich Prof. Dr. Jochen Herms 82152 Martinsried Prof. Dr. Florian Kolb LMU, Chair of Logic and Philosophy of Language, Prof. Dr. Hermann J. Müller | Page 72 Phone +49 (0)89 / 218075-650 (-651) Fakultät für Medizin der LMU, Phone +49 (0)89 / 8578-3697 Fakultät für Medizin der LMU, Department für Physiologie Head of the Munich Center for Mathematical Philosophy Fakultät für Psychologie der LMU, Allgemeine und E-mail [email protected] Zentrum für Neuropathologie und Prionforschung E-mail [email protected] Pettenkoferstraße 12 Ludwigstraße 31 Experimentelle Psychologie www www.imp-muenchen.de Feodor-Lynen-Straße 23 www http://www.neuro.mpg.de/24276/huebener 80336 Munich 80539 Munich Leopoldstraße 13 81377 Munich Phone +49 (0)89 / 2180-75-224 Phone +49 (0)89 / 2180 6171 80802 Munich Phone +49 (0)89 / 2180-78010 E-mail [email protected] E-mail [email protected] Phone +49 (0)89 / 2180 5327-5212 Prof. Dr. Heidrun Potschka | Page 76 E-mail [email protected] Prof. Dr. Axel Hutter www www.physinst.web.med.uni-muenchen.de www http://www.philosophie.uni-muenchen.de E-mail [email protected] Institut für Pharmakologie, Toxikologie und Pharmazie www www.znp-muenchen.de Fakultät für Philosophie der LMU, Philosophie II www www.psy.lmu.de der LMU Geschwister-Scholl-Platz 1 Königinstraße 16 80539 Munich Prof. Dr. Arthur Konnerth | Page 66 Prof. Dr. Harald Luksch 80539 Munich Prof. Dr. Joachim Hermsdörfer Phone +49 (0)89 / 2180-2488 TUM, Institute of Neuroscience Wissenschaftszentrum Weihenstephan der TUM, Prof. Dr. Norbert Müller Phone +49 (0)89 / 2180-2663 Klinikum Bogenhausen der TUM, EKN, E-mail [email protected] Biedersteiner Straße 2 Lehrstuhl für Zoologie Klinik für Psychiatrie und Psychotherapie der LMU E-mail [email protected] Arbeitsgruppe Sensomotorische Störungen www www.philosophie.uni-muenchen.de 80802 Munich Hochfeldweg 2 Nussbaumstraße 7 www www.pharmtox.vetmed.uni-muenchen.de Dachauer Straße 164 Phone +49 (0)89 / 4140-3370 85350 Freising-Weihenstephan 80336 Munich 80335 Munich E-mail [email protected] Phone +49 (0)8161 / 712800 Phone +49 (0)89 / 5160-0 Phone +49 (0)89 / 15 77 895 www http://www.ifn.me.tum.de/ E-mail [email protected] E-mail [email protected] E-mail [email protected] www www.wzw.tum.de www www.psywifo.klinikum.uni-muenchen.de www www.lrz-muenchen.de/~EKN/pjh.html Prof. Dr. Stephan Kröger Fakultät für Medizin, Institut für Physiologie Schillerstraße 46 | Members 80336 Munich

LMU Phone +49 (0)89 / 2180-75526 E-mail [email protected]

MCN www www.stephan-kroeger.de 124 | 125 R Prof. Dr. Torsten Schubert Prof. Dr. Andreas Straube Prof. Dr. Christoph W. Turck W Prof. Dr. Walter Zieglgänsberger Fakultät für Psychologie der LMU, Allgemeine und Neurologische Klinik und Poliklinik der LMU, MPI für Psychiatrie MPI für Psychiatrie, Klinische Neuropharmakologie Experimentelle Psychologie Forschungsgruppe Kopfschmerz Kraepelinstraße 2 Kraepelinstraße 2 Prof. Dr. Gerhard Rigoll | Page 78 Leopoldstraße 13 Marchioninistraße 15 80804 Munich Prof. Dr. Lutz Wiegrebe 80804 Munich Fakultät für Elektrotechnik der TUM, 80802 Munich 83177 Munich Phone +49 (0)89 / 30622-317 Fakultät für Biologie, Department Biologie II der LMU Phone +49 (0)89 / 30622-350 Lehrstuhl für Mensch-Maschine-Kommunikation Phone +49 (0)89 / 2180-5216 Phone +49 (0)89 / 7095 3900 E-mail [email protected] Großhadernerstraße 2 E-mail [email protected] Arcisstraße 21 E-mail [email protected] E-mail [email protected] www www.mpipsykl.mpg.de 82152 Martinsried www www.mpipsykl.mpg.de 80333 Munich www www.psy.lmu.de www www.nefo.med.uni-muenchen.de Phone +49 (0)89 / 2180-74314 Phone +49 (0)89 / 289-28541 E-mail [email protected] E-mail [email protected] U www www.biologie.uni-muenchen.de www www.mmk.ei.tum.de Prof. Dr. Gerd Schuller Prof. Dr. Michael Strupp | Page 82 Department Biologie II der LMU, Abteilung Neurobiologie Neurologische Klinik und Poliklinik der LMU, Großhadernerstraße 2 Department für Neurologie Prof. Dr. Rainer Uhl PD Dr. Carsten Wotjak Prof. Dr. Till Roenneberg 82152 Martinsried Marchioninistraße 15 Bio Imaging Zentrum MPI für Psychiatrie, AG Neuronale Plastizität Fakultät für Medizin der LMU, Phone +49 (0)89 / 2180 74307 81377 Munich Am Klopferspitz 19 Kraepelinstraße 2 Institut für Medizinische Psychologie E-mail [email protected] Phone +49 (0)89 / 7095-3678 82152 Martinsried 80804 Munich Goethestraße 31 www www.bio.lmu.de E-mail [email protected] Phone +49 (0)89 / 899232-22 Phone +49 (0)89 / 30622-652 80336 Munich www www.nefo.med.uni-muenchen.de E-mail [email protected] E-mail [email protected] Phone +49 (0)89 / 2180-75608 www www.botanik.biologie.uni-muenchen.de E-mail [email protected] PD Dr. Markus Schwarz www www.tpsec.de Klinik für Psychiatrie und Psychotherapie der LMU, Prof. Dr. Bernd Sutor PD Dr. Mario Wullimann Abteilung Neurochemie Physiologisches Institut der LMU, V LMU, Department Biology II Nussbaumstraße 7 Department Physiologische Genomik Großhaderner Straße 2 Prof. Dr. Dan Rujescu 80336 Munich Pettenkoferstraße 12 82152 Martinsried Klinik für Psychiatrie und Psychotherapie der LMU Phone +49 (0)89 / 5160-2761 80336 Munich Prof. Dr. Leo van Hemmen Phone +49 (0)89 / 2180-74322 Nußbaumstraße 7 E-mail [email protected] Phone +49 (0)89 / 5996-234 TUM, Physik Department T35 E-mail [email protected] 80336 Munich www www.pni-net.de E-mail [email protected] James-Franck-Straße www www.bio.lmu.de Phone +49 (0)89 / 5160-5756 www www.uni-muenchen.de 85748 Garching E-mail [email protected] Phone +49 (0)89 / 289-12362 www psywifo.klinikum.uni-muenchen.de/ Prof. Dr. Stephan Sellmaier E-mail [email protected] Prof. Dr. Wolfgang Wurst | Page 86 Fakultät für Philosophie der LMU, MKE T www www.t35.ph.tum.de Helmholtz Zentrum München, Institut für Entwicklungsgenetik Geschwister-Scholl-Platz 1 Ingolstädter Landstraße 1 S 80539 Munich 85764 Neuherberg Phone +49 (0)89 / 2180 - 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Managing Director Prof. Dr. Benedikt Grothe Prof. Dr. Ulrich Dirnagl LMU, Division of Neurobiology Charite, Medical Faculty Prof. Dr. Oliver Behrend Managing Director | MCNLMU Prof. Dr. Christian Haass Prof. Dr. Godehard Link LMU, Medical Faculty LMU, Faculty of Philosophy, Emeritus

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Prof. Dr. Heidrun Potschka Office Management LMU, Faculty of Veterinary Medicine

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