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Digestive Diseases We Are Now in the Midst of a Transition David Geffen School of Medicine at UCLA in Leadership

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Digestive Diseases We Are Now in the Midst of a Transition David Geffen School of Medicine at UCLA in Leadership DigestiveUCLA Division of Diseases Spring 2008 Newsletter David Geffen School of Medicine at UCLA Probiotics: In this issue page 2.....Letter from the Chief page 3.....First-Rate Fellows From Bugs to Drugs page 5.....Why Philanthropy Matters page 6.....Obesity and the Digestive Tract page 7.....Passing Two Hats page 8.....In Memoriam Specialists in Pancreatic Cancer page 9.....Meet our Alumni page 10...UCLA Clinic Treats Genetic Disorder page 11...Meet a Pioneering Researcher Grocery products containing probiotics. ncreasingly, we see rows upon rows of refrigerated health. Probiotics are live microorganisms that, when products containing live bacteria in supermarkets consumed in proper amounts, can provide you with I and health food stores. What could live bacteria health benefits and a protective effect against potentially possibly do for you? Advertisers tout the benefits of harmful bacteria that also live in the GI tract. Including yogurt and other foods containing live cultures that you probiotics in your diet can support healthy gut flora, and can eat to shorten or prevent illness. With the myriad some can help in treating diseases. claims many commercial enterprises make, how do you There is plenty of “food for thought” as you face the know what to believe? Although “good bugs” can protect heavy advertising of probiotics. Dr. Fergus Shanahan your stomach from a variety of ills, there is more than says, “Everything has to be put in perspective. In healthy meets the eye when you look deeper into the science people, they probably aren’t necessary, but probiotics surrounding their potential use. would be helpful if you are taking antibiotics.” Dr. The gastrointestinal (GI) tract is the largest source Shanahan and his colleagues are investigating how of our immune system, and keeping it healthy is vitally to cure and prevent illnesses in the GI tract, carefully important. The human GI tract is inhabited by a conducting scientific studies and clinical trials to little more than four pounds of bacteria, representing use probiotics as an ally to treat these and other more than 400 different species. These bacteria are specific diseases. The aim is to transform “bugs to critical for normal development of the intestine and drugs” – in other words, to make sure variables such for defense against infections – and are critical for our as dosages, strains, product quality, and stability are Continued on page 4 unlike that seen anywhere in the world. From the Division Chief Our training program is thriving, and UCLA Division of Digestive Diseases we are now in the midst of a transition David Geffen School of Medicine at UCLA in leadership. Dr. Wilfred “Fred” M. Gary Gitnick, M.D. Weinstein is handing over the reins to Dr. Spiegel and Dr. Bennett Roth. UCLA, is a clinician and educator in They anticipate continued growth am proud. Once again, U.S.News general gastroenterology. and excellence in producing the next I& World Report rated the UCLA The team of seven scientists from generation of top clinicians and scientists Division of Digestive Diseases as best in Harvard headed by Dr. Charalabos in this field. the Western United States and among “Harry” Pothoulakis is flourishing at The progress and success in clinical the top five in the nation. This standing UCLA, having built an extremely strong care and research that come out of this reflects the remarkable and talented program. The IBD Affinity Group, which division are made possible in large part by faculty on board, who are productive has been successfully developed, includes the generosity of our donors. Their funds leaders and whose numbers continue to 12 senior investigators and their colleagues underwrite the infrastructure that allows increase. Our division has grown to the from multiple disciplines on campus. In us to thrive. Federal, state, and university point where we have expertise throughout addition, many of our faculty members resources are not available for essential the field. Moreover, our research programs have been recognized for their outstanding positions, such as secretaries and fund reflect unparalleled depth, covering work, for example, Dr. Brennan Spiegel managers, who keep the organization myriad basic science and clinical pursuits. and Dr. Emeran Mayer. strong and productive. In addition, our We have several new additions to our The advances in signal transduction donors support the largest part of our division. Dr. Kirin Bhat is an advanced of Dr. Enrique Rozengurt and his group training program budget and provide biliary endoscopist with training in are defining the basic mechanisms in the the moneys necessary to recruit new endoscopic ultrasonography. Dr. Wendy development of cancer and other chronic faculty. Thus, I am proud, as well, that Ho, from Massachusetts General diseases; their publications are among the UCLA Division of Digestive Diseases Hospital/Harvard Medical School, the most widely quoted. In addition, continues to merit the encouragement is a clinician and educator in general Dr. Peter Anton and his associates have and commitment of our friends in the gastroenterology. Dr. Daniel Cho, from built a program in mucosal immunology community and beyond. n DDD Faculty Inform Patients in the Community hysicians in the UCLA Division of Digestive Diseases, been growing every year. Psuch as Dr. Sammy Saab and Dr. Eric Esrailian, dedicate The presenters try to tell the story about the liver: what themselves to community service in the normal course of it does, how it functions, how to know when it’s damaged their careers in medicine. (based on blood test results), and how to take care of it when Seminars for Patients with Liver Disease being treated. Soon after Dr. Sammy Saab, Associate Professor of IBD Hot Topics Medicine and Surgery and a former Fellow in the Division, Among his many other community involvements, Dr. came to UCLA eight years ago, he established a yearly Eric Esrailian is co-chair of a yearly symposium for several seminar for patients and families to discuss problems they hundred patients with Crohn’s disease and ulcerative colitis. are having with liver disease. The seminars are taught The half-day course is free, and the lectures highlight in English and Spanish, and he looks forward to plans the latest on inflammatory bowel disease (IBD) treatment, to expand into Arabic and other languages, as well. The management, research, psychosocial support, and patients’ half-day meetings are conducted at UCLA and are free for rights. Also, health professionals get an up-to-date all attendees, with breakfast provided. The presenters are education on these diseases. doctors, surgeons, and oncologists from UCLA, The Greater Los Angeles/Orange County Chapter of and other high-profile individuals. From 150 to the Crohn’s and Colitis Foundation of America (CCFA) 200 people usually attend, and the numbers have sponsors the yearly symposium, as well as walks and other 2 events. Patients can go to the CCFA Website UCLA Division of Digestive Diseases - Spring 2008 First-Rate Fellows Aspire to Make an Impact in Treating Digestive Diseases xemplary doctors Karen Simon and Omid Shaye aim high to E shape the future treatment and prevention of digestive diseases with the skills they have learned through their experience in basic science and clinical research at UCLA. Omid Shaye, M.D. Dr. Karen Simon Dr. Shaye attended the UC San Diego Dr. Simon thought she would become School of Medicine. He developed a a doctor like her father but wanted to passion for Gastroenterology “because experience the work world first. She grew it is an area with a wide variety of up in Ohio outside of Cincinnati and then different diseases and does so much. The went to Stanford University, where she intellectual aspect of medicine mixes with majored in Art History. She taught for a the technical, surgical, and anatomical year in Santa Barbara and then decided to Karen Simon, M.D. approach to fixing things.” Dr. Shaye is apply to medical school. After graduating dedicated to improving care in medicine, practically no female role models in from Northwestern University Medical and “being in research allows you to affect General Gastroenterology. “Nowadays, School, Dr. Simon came to Los Angeles the lives of countless people.” private practices are becoming more for her residency. She joined the UCLA He recognizes that almost every aware that they are behind the times, Division of Digestive Diseases Fellowship GI disease is affected by obesity, and with numerous patients asking for a Program in July 2005, pursuing her wants to focus on halting it through woman to handle their cases.” Regarding interest in inflammatory bowel disease effective treatments. Dr. Shaye points her journey in medicine, Dr. Simon (IBD). She says that training at UCLA out, “In recent decades, all innovations reflects, “From the time you decide to provides a lot of opportunity to work with in technologies have been because of the apply to med school to the start of your the “big names in the field” in a cutting- Baby Boomers. Now that age group of career is a dozen years, and now I am edge environment. 80-million people between 40-60 years here, ready to follow in my father’s firmly A pivotal experience in her patient old wants to prevent diseases, prolong life, established footsteps after all.” and know how to live better. We cater to relationships came three years ago, when Dr. Omid Shaye Dr. Simon’s one-year-old daughter had their needs.” From the revolution in Tehran to the open-heart surgery. Being the family or It is important to Dr. Shaye to be basketball courts at UCLA, Dr. Omid patient as opposed to a doctor for the first a positive role model for the doctor/ Shaye has quite an interesting background.
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