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SUPPLEMENTAL TABLE 3 Codes Used for Building Normal and Hydronephrosis Cohorts: Associated Diagnostic Codes (For Inclusion or Exclusion) Code Description Hydroureteronephrosis 591 Hydronephrosis 753.29 Other obstructive defects of renal pelvis and ureter 593.5 Hydroureter 753.22 Congenital obstruction of UVJ VUR 593.7 VUR 593.70 VUR unspecified or without reflux nephropathy 593.71 VUR with reflux nephropathy, unilateral 593.72 VUR with reflux nephropathy, bilateral 593.73 Other VUR with reflux nephropathy NOS Obstruction 593.3 Stricture or kinking of ureter 599.6 Urinary obstruction, unspecified 599.69 Urinary obstruction NOS UPJO 753.2 Unspecified obstructive defect of renal pelvis and ureter 753.21 Congenital obstruction of the UPJ 753.29 Other obstructive defect of renal pelvis and ureter UVJ obstruction 753.22 Congenital obstruction of the UVJ Ureterocele 753.23 Congenital ureterocele PUV or urethral atresia 753.6 Atresia and stenosis of urethra and bladder neck, includes PUVs NOS, not otherwise specified; UPJ, ureteropelvic junction; UVJ, ureterovesical junction.

PEDIATRICS Volume 142, number 1, July 2018 1 SUPPLEMENTAL TABLE 4 Codes Used for Building Normal and Hydronephrosis Cohorts: Urological Surgical Codes for Exclusion in Building Normal Cohort CPT ICD-9 Description Pyeloplasty 50544 — Laparoscopy, surgical; pyeloplasty 50400 55.87 Pyeloplasty 50405 — Complicated pyeloplasty; secondary or congenital 50740 55.86 Ureteropyelostomy, anastomosis of ureter and renal pelvis 50750 — Ureterocalycostomy, anastomosis of ureter to renal calyx Endoscopic 50575 — Renal endoscopy with endopyelotomy 52342 — Cystourethroscopy; with treatment of UPJ stricture 52346 — Cystourethroscopy with ureteroscopy, with treatment of intrarenal stricture Nephrectomy — 55.51 Nephroureterectomy 50548 — Laparoscopy, surgical; nephrectomy with total ureterectomy 50545 — Laparoscopy, surgical; radical nephrectomy 50546 — Laparoscopy, surgical; nephrectomy, including partial ureterectomy 50220 55.5 Nephrectomy, including partial ureterectomy, any open approach including rib resection 50225 55.5 Nephrectomy; including partial ureterectomy, any open approach including rib resection; complicated because of previous surgery on same kidney 50240 55.4 Partial nephrectomy 50543 — Laparoscopy, surgical; partial nephrectomy Ureteroneocystostomy 50947 — Laparoscopy, surgical ureteroneocystostomy with cystoscopy and ureteral stent placement 50948 — Laparoscopy, surgical; ureteroneocystostomy without cystoscopy and ureteral stent placemen 50780 56.74 Ureteroneocystostomy; anastomosis of single ureter to bladder 50781 — Ureteroneocystostomy 50782 56.74 Ureteroneocystostomy; anastomosis of duplicated ureter to bladder 50783 — Ureteroneocystostomy; with extensive ureteral tailoring 50785 — Ureteroneocystostomy; with vesico-psoas hitch or bladder flap Subureteric bulking 52327 — Cystourethroscopy; with subureteric injection of implant material Urostomy 51980 57.2 Cutaneous vesicostomy — 55.12 Pyelostomy — 44.6 Urinostomy status NOS, nephrostomy — 56.61 Formation of other cutaneous ureterostomy PUV 52400 — Cystourethroscopy with resection, incision, or fulguration of PUVs 52340 — Cystourethroscopy with resection, incision, or fulguration of PUVs Ureterocele 52300 — Cystourethroscopy; with resection or fulguration orthotopic ureterocele(s), unilateral or bilateral 52301 — Cystourethroscopy; with resection or fulguration of ectopic ureterocele(s), unilateral or bilateral 51535 — Cystotomy for excision, incision, or repair of ureterocele ICD-9, International Classification of Diseases, Ninth Revision; NOS, not otherwise specified; UPJ, ureteropelvic junction;— , not applicable.

SUPPLEMENTAL TABLE 5 Sensitivity Analysis of UTI Risk in Circumcised (N = 2386) and Uncircumcised (N = 3174) Boys With and Without Hydronephrosis Hydronephrosis Group Healthy Group UTI, N (%) OR (95% CI) UTI, N (%) OR (95% CI) Circumcised 25 (1.0) 0.28 (0.18–0.43) 6 (0.1) 0.28 (0.11–0.69) Uncircumcised 116 (3.7) — 20 (0.4) — —, not applicable.

2 ELLISON et al