Incidence, Prevalence and Healthcare Outcomes in Idiopathic Intracranial

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Incidence, Prevalence and Healthcare Outcomes in Idiopathic Intracranial Published Ahead of Print on January 20, 2021 as 10.1212/WNL.0000000000011463 Neurology Publish Ahead of Print DOI: 10.1212/WNL.0000000000011463 Incidence, Prevalence and Healthcare Outcomes in Idiopathic Intracranial Hypertension: A Population Study Latif Miah MBBCh1*; Huw Strafford MSc1*; Beata Fonferko-Shadrach MPH1; Joe Hollinghurst PhD1; Inder MS Sawhney MD1,2; Savvas Hadjikoutis MD2, Mark I Rees DSc1,3; Rob Powell PhD1,2; Arron Lacey PhD1; W Owen Pickrell PhD1,2 The Article Processing Charge was funded by Health Data Research (HDR) UK. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Neurology® Published Ahead of Print articles have been peer reviewed and accepted for publication. This manuscript will be published in its final form after copyediting, page composition, and review of proofs. Errors that could affect the content may be corrected during these processes. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. Author affiliations: 1Swansea University Medical School, Swansea University, Swansea; 2Neurology Department, Morriston Hospital, Swansea Bay University Health Board; 3Faculty of Medicine and Health, University of Sydney. *These authors contributed equally to the manuscript Online supplementary data (uploaded as a separate file to Zenodo repository): Tables e-1 to e-8, Figures e-1 to e-5 Web Address: https://zenodo.org/record/4064064 File name: Supp_Data_IIH.docx Keywords: Idiopathic intracranial hypertension, Cohort studies, Prevalence studies, Incidence studies, Quality of life Publication History: This article has not been published previously Submission Type: Article Title character count: 104 Number of Tables: 2 Number of Figures: 5 Number of References: 23 Word count (abstract): 244 Word count (paper): 3567 Corresponding author: Dr. William Owen Pickrell [email protected]. DISCLOSURES The authors report no relevant disclosures to this manuscript. STATISTICAL ANALYSIS was conducted by Mr, Huw Strafford MSc, Dr Joe Hollinghurst PhD and Dr W Owen Pickrell PhD. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. STUDY FUNDING The study was not directly funded but we acknowledge support from the Brain Repair and Intracranial Neurotherapeutics (BRAIN) Unit and the Wales Gene Park which are funded by Health and Care Research Wales. This work was supported by Health Data Research UK, which receives its funding from HDR UK Ltd (HDR-9006) funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation (BHF) and the Wellcome Trust. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. ABSTRACT Objective: To characterise trends in incidence, prevalence, and healthcare outcomes in the idiopathic intracranial hypertension (IIH) population in Wales using routinely collected healthcare data. Methods: We used and validated primary and secondary care IIH diagnosis codes within the Secure Anonymised Information Linkage databank, to ascertain IIH cases and controls, in a retrospective cohort study between 2003 and 2017. We recorded body mass index (BMI), deprivation quintile, CSF diversion surgery and unscheduled hospital admissions in case and control cohorts. Results: We analysed 35 million patient years of data. There were 1765 cases of IIH in 2017 (85% female). The prevalence and incidence of IIH in 2017 was 76/100,000 and 7.8/100,000/year, a significant increase from 2003 (corresponding figures=12/100,000 and 2.3/100,000/year) (p<0.001). IIH prevalence is associated with increasing BMI and increasing deprivation. The odds ratio for developing IIH in the least deprived quintile compared to the most deprived quintile, adjusted for gender and BMI, was 0.65 (95% CI 0.55 to 0.76). 9% of IIH cases had CSF shunts with less than 0.2% having bariatric surgery. Unscheduled hospital admissions were higher in the IIH cohort compared to controls (rate ratio=5.28, p<0.001) and in individuals with IIH and CSF shunts compared to those without shunts (rate ratio=2.02, p<0.01). Conclusions: IIH incidence and prevalence is increasing considerably, corresponding to population increases in BMI, and is associated with increased deprivation. This has important implications for healthcare professionals and policy makers given the comorbidities, complications and increased healthcare utilization associated with IIH. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. INTRODUCTION Idiopathic Intracranial Hypertension (IIH) is a condition of unknown etiology that is strongly associated with obesity. IIH predominantly affects women of childbearing age and causes chronic disabling headaches, visual disturbance and, in a minority of patients, permanent visual loss. The definitive management is weight loss but a minority of patients require surgery in order to preserve vision.1,2 People with IIH potentially have high rates of healthcare utilization due to their comorbidities, multiple specialist consultations, diagnostic tests, CSF diversion procedures and complications related to CSF diversion surgery. Given the increasing global burden of obesity and the strong association of IIH with obesity, it would seem plausible to assume that the incidence of IIH, as well as associated healthcare utilization, is increasing.3,4 Although there is some evidence to support this,1,4 overall there is a paucity of data regarding the epidemiology, healthcare utilization and outcomes of people with IIH. Large population level studies of IIH in Wales are rare, if available. In this retrospective cohort study, we aimed to determine the temporal trends of IIH incidence and prevalence in Wales, and healthcare utilization associated with IIH. We also investigated the effects of socioeconomic deprivation and obesity on IIH epidemiology. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. METHOD This was a retrospective cohort study using anonymized, routinely collected Welsh healthcare data within the Secure Anonymised Information Linkage databank (SAIL) at Swansea University, Wales, United Kingdom (UK).5,6,7 SAIL contains anonymized linked datasets from a range of Welsh health sources including hospital admission and demographic data for the complete Welsh population (3.1 million, 2017 population estimate) and primary care records for approximately 80% of the Welsh population. SAIL uses an established and validated split-file approach for anonymized data linkage.5,6 In the UK, primary care consists primarily of general practitioners (GP). Patients with IIH can first present to their GP, optometry, neurology or the emergency department before being given a diagnosis by ophthalmologists or neurologists in secondary care. To validate the accuracy of IIH diagnosis codes in routinely collected data, we anonymously linked a list of successive definite and probable IIH cases in 2016 and 2017 from Morriston Hospital Swansea (the regional neurosciences center) with SAIL data. The IIH cases were reviewed by clinicians and classed as definite if they met all IIH criteria or probable if they met the criteria but a record of fundoscopy at the time of diagnosis could not be found (table e-1).8 Additionally, we reviewed all patients that were admitted to Morriston hospital in 2017 with an IIH ICD10 diagnosis code in their hospital admission record and checked whether they had also been given a diagnosis of IIH by a consultant neurologist. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. To identify patients with IIH throughout Wales, we selected patients who had been given primary care and/or secondary care IIH diagnosis codes (table e- 2) within the study window (1st January 2003 to 31st December 2017). We excluded likely cases of secondary intracranial hypertension (central nervous system malignancies, venous sinus thrombosis and malignant hypertension) (table e-3). We also excluded patients with less than one year of primary care data prior to diagnosis, insufficient demographic data and those who were diagnosed on their death date (figure e-1). We recorded bariatric surgery procedures and CSF diversion and revision procedures within the IIH cohort (tables e-4, e-5 and e-6 for codes). We calculated incidence and prevalence for every year within the study window and also calculated incidence and prevalence for each of the seven health boards within Wales. We recorded deprivation using the Welsh Index of Multiple Deprivation (WIMD), 2011 version, in which Wales is divided into 1897 Lower Super Output Areas (LSOAs) containing an average of 1600 people.9 Weighted scores from eight domains, representing different types of deprivation, are aggregated to form a WIMD score for each LSOA. The following are the eight domains which provide the
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