antioxidants Article Gypenosides Alleviate Cone Cell Death in a Zebrafish Model of Retinitis Pigmentosa Xing Li 1,†, Reem Hasaballah Alhasani 2,3,† , Yanqun Cao 1, Xinzhi Zhou 2, Zhiming He 1, Zhihong Zeng 4, Niall Strang 5 and Xinhua Shu 1,2,5,* 1 School of Basic Medical Sciences, Shaoyang University, Shaoyang 422000, China;
[email protected] (X.L.);
[email protected] (Y.C.);
[email protected] (Z.H.) 2 Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow G4 0BA, UK;
[email protected] (R.H.A.);
[email protected] (X.Z.) 3 Department of Biology, Faculty of Applied Science, Umm Al-Qura University, Makkah 21961, Saudi Arabia 4 College of Biological and Environmental Engineering, Changsha University, Changsha 410022, China;
[email protected] 5 Department of Vision Science, Glasgow Caledonian University, Glasgow G4 0BA, UK;
[email protected] * Correspondence:
[email protected] † Joint first authors. Abstract: Retinitis pigmentosa (RP) is a group of visual disorders caused by mutations in over 70 genes. RP is characterized by initial degeneration of rod cells and late cone cell death, regardless of genetic abnormality. Rod cells are the main consumers of oxygen in the retina, and after the death of rod cells, the cone cells have to endure high levels of oxygen, which in turn leads to oxidative damage and cone degeneration. Gypenosides (Gyp) are major dammarane-type saponins of Gynostemma pentaphyllum that are known to reduce oxidative stress and inflammation. In this project we assessed Citation: Li, X.; Alhasani, R.H.; Cao, the protective effect of Gyp against cone cell death in the rpgrip1 mutant zebrafish, which recapitulate Y.; Zhou, X.; He, Z.; Zeng, Z.; Strang, the classical pathological features found in RP patients.