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NFASC Antibody

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NFASC Antibody Product Datasheet NFASC antibody Catalog No: #38553 Orders: [email protected] Description Support: [email protected] Product Name NFASC antibody Host Species Rabbit Clonality Polyclonal Purification Antibodies were purified by affinity purification using immunogen. Applications WB Species Reactivity Human,Mouse,Rat Specificity The antibody detects endogenous level of total NFASC antibody. Immunogen Type Peptide Immunogen Description A synthetic peptide of human NFASC. Target Name NFASC Other Names NF; NRCAML Accession No. Swiss-Prot#: O94856NCBI Gene ID: 23114 SDS-PAGE MW 150kd Concentration 1.0mg/ml Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage Store at -20°C Application Details WB 1:500 - 1:2000 Images Western blot analysis of extracts of various cell lines, using NFASC at 1:1000 dilution. Background This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 1 intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined. Note: This product is for in vitro research use only and is not intended for use in humans or animals. Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 2.
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