Anti-MTA2 Monoclonal Antibody, Clone FQS9648(3) (DCABH-5548) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-MTA2 monoclonal antibody, clone FQS9648(3) (DCABH-5548) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit monoclonal to MTA2

Antigen Description The p53 tumor suppressor gene integrates numerous signals that control cell life and death. There are several proteins that are involved in the p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and MTA2. The transcriptional activity of p53 is modulated by protein stability and acetylation. MTA2, also termed MTA1L1, was found to be a subunit of nucleosome remodeling and deacetylating (NuRD) complex. MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by MTA2 represses p53 dependent transcriptional activation and modulates p53 mediated cell growth arrest and apoptosis. MTA2 is ubiquitously expressed in human tissues.

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Clone FQS9648(3)

Purity Tissue culture supernatant

Conjugate Unconjugated

Applications ICC/IF, Flow Cyt, IHC-P, WB

Positive Control MCF7, HeLa and SW480 cell lysates. Paraffin-embedded Human kidney and Human colonic carcinoma tissue. HeLa cells.

Format Liquid

Size 100 μl

Buffer Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA

Preservative 0.01% Sodium Azide

Storage Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

GENE INFORMATION

Gene Name MTA2 metastasis associated 1 family, member 2 [ Homo sapiens ]

Official Symbol MTA2

Synonyms MTA2; metastasis associated 1 family, member 2; metastasis associated gene family, member 2 , MTA1L1; metastasis-associated protein MTA2; MTA1 L1; MTA1-L1 protein; metastasis- associated 1-like 1; metastasis-associated protein 2; metastasis -associated gen

Entrez Gene ID 9219

Protein Refseq NP_004730

UniProt ID A0A024R534

Chromosome Location 11q12-q13.1

Pathway EGFR1 Signaling Pathway, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem;

Function RNA polymerase II transcription factor binding; histone deacetylase activity; metal ion binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor binding transcription factor

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]