Description of Ph.D. project in EXSS for Oct 2021 Entry Project title: Quantum Cascade Laser s-SNOM for intracellular imaging Principal Prof Chris Phillips Project No: CCP_1 Supervisor: Email:
[email protected] Telephone x47575 Other Dr Holger Auner, Prof Alexandra Porter, Prof Charles Coombes. supervisors: Aims of the project: Very recently we gave found out how to use a Solid- State near field imaging technique, so- called s-SNOM, to look inside cells for the first time. It beats the diffraction limits of ordinary microscopy by a factor of ~3000, and the spatial resolution it gives (~3nm) already rivals the very best of electron microscopy at a fraction of the time effort and cost. We believe it has the potential to transform the biomedical sciences. We have shown how it can image the organelles inside a cell optically for the first time first time ever. Also , because it works at mid-IR wavelengths where chemical bonds have characteristic vibrational absorption bands that give them spectral “fingerprints” , the technique can be used to provide nanoscal chemical maps that, e.g. reveal where drugs bind inside the cell. The initial aims of the project will be to trail and develop the technology with Imperial cinicians, with a focus on themes, (1) the pathology pf Breast Cancer, (2) Drug resistance in multiple myeloma, and (3) the nanoscale causes of osteporosis. However, the potential applications are limitless and we will likely establish more collaborations as the programme progresses. Also Recent developments in the field of quantum imaging have demonstrated new methods of imaging objects by detecting photons that have not actually interacted with it.