AUSTRALIAN INSTITUTE FOR BIOENGINEERING AND NANOTECHNOLOGY (AIBN)

ANNUAL REPORT 07 contents

2 DIRECTOR’S REPORT` 4 DYNAMIC RESEARCH ENVIRONMENT 6 INDUSTRY FOCUS 8 RESEARCH EXCELLENCE 10 BUILDING AUSTRALIA’S RESEARCH CAPABILITY

15 RESEARCH PROJECTS 16 MAMMALIAN CELL LINES AND STEM CELL BIOPROCESSES 17 BIOPROCESS TECHNOLOGY 17 SYSTEMS BIOTECHNOLOGY 18 TISSUE ENGINEERING AND MICROFLUIDICS 18 VASCULAR RESEARCH 19 STEM CELL ENGINEERING 20 BIOPOLYMER PROCESSING 21 NANOTOXICOLOGY, BIOMATERIALS AND TISSUE ENGINEERING 21 POLYMER CHEMISTRY 22 BIOMOLECULAR ENGINEERING 22 ADVANCED MATERIALS FROM COMPLEX POLYMER ARCHITECTURES 23 GENE AND DRUG DELIVERY RESEARCH 24 SINGLE MOLECULE NANOTECHNOLOGY 25 NANOTECHNOLOGY AND BIOMATERIALS 26 ENERGY INTERFACE ARCHITECTURE FOR POWER SYSTEMS 27 FUNCTIONAL NANOMATERIALS 27 COMPUTATIONAL BIO AND NANOTECHNOLOGY

28 AIBN GRADUATE PROGRAM 31 RESEARCH TRANSLATION AND COMMERCIALISATION

32 APPENDICES 33 RESEARCH GRANTS 36 AIBN PUBLICATIONS 41 AIBN STUDENTS 42 AIBN SEMINARS 44 AIBN MEDIA COVERAGE VICE-CHANCELLOR’S MESSAGE

The University of Queensland’s Australian Institute for Bioengineering and Nanotechnology (AIBN) is rapidly gaining global traction by blending excellence in discovery with attention to the needs of industry and other end-users of research.

Focussing on outcomes that will benefi t students, one quarter of whom are Professor Paul Greenfi eld AO human health and the environment, from overseas. In addition the AIBN VICE-CHANCELLOR AIBN scientists and engineers integrate has implemented new programs by THE UNIVERSITY OF QUEENSLAND the physical, chemical and biological which undergraduate students can sciences. They utilise some of Australia’s gain important laboratory experience newest and best bio infrastructure to that contributes toward their degrees. apply innovative ideas and techniques, This laboratory experience exposes and have the added advantage of the students to the leading edge of access to high-quality equipment and Australian bio/nano research, further people throughout UQ. enriching their undergraduate studies. AIBN is part of UQ’s suite of research The year also saw the expansion of institutes. Staff maximise the impact of AIBN’s intellectual property portfolio; their own expertise by collaborating with there were three completed fi lings, – in particular – peers in the Institute for three national phase entries and fi ve Molecular Bioscience, the Diamantina provisional patents fi led. A start-up, Institute for Cancer, Immunology and Pepfactants Pty Ltd, raised pre-seed Metabolic Medicine, the Queensland investment, and two new ventures, Brain Institute, the Sustainable Minerals DendriMed Pty Ltd and TenasiTech Institute, the Faculty of Biological and Pty Ltd, emerged. As well, fi ve AIBN Chemical Sciences, the Faculty of projects attracted more than $150,000 in Engineering, Physical Sciences and proof-of-concept funds from UQ’s main Architecture, and the Faculty of Health commercialisation entity, UniQuest. Sciences. Gaining almost $12 million in research Under the stewardship of Professor grants and forging formal collaborations Peter Gray, AIBN staff and students took with The Dow Chemical Company and full advantage of 2007 as their fi rst full Korea Advanced Institute of Science and year in new $72 million headquarters. Technology are other initiatives for which Success in grant acquisition, international Professor Gray and his team deserve collaboration and commercialisation, in great credit. addition to strong growth in research These and other highlights of higher degree (RHD) student numbers, 2007 will be a platform for future signalled expansion in international and success by AIBN researchers national recognition of the AIBN. and their partners in discovery The Institute’s fl edgling graduate and commercialisation across program grew by more than 100 the national and international percent. The building houses 90 RHD communities.

AIBN ANNUAL REPORT 07 1 DIRECTOR’S REPORT

It has been gratifying to note that the endeavours of AIBN’s staff and students over the last 12 months has enhanced the Institute’s national and international reputation in three key areas that collectively distinguish it from other institutes in the country, namely the AIBN’s Research Excellence; Industry Focus; and Dynamic Research Environment.

During 2007, AIBN experienced a period Alliances Program and from a number of of rapid consolidation and growth as other Australian and International funding the research groups took advantage of sources as detailed in this report. the excellent facilities provided in the In addition, Professor Max Lu’s ARC Institute’s new building. Centre for Functional Nanomaterials During the year, the number of research was successfully reviewed and as a groups grew to 17 and by the end of the result awarded the prestigious Centre of year the Institute numbered 340 staff and Excellence status. research higher degree students. The As is befi tting for a translational research reputation of AIBN is rapidly growing, institute with a strong technology both nationally and internationally, as focus, 2007 saw AIBN rapidly expand a place to carry out research of the its commercialisation and technology highest quality at the bio/nano interface. transfer operations. There are increasing This is demonstrated by the excellent interactions with local small to medium staff and students that our Group enterprises active in nanotechnology Leaders are attracting to the Institute and biotechnology, as well as with approximately two thirds of our growing linkages with a number of researchers moving to Brisbane to join key multinational partners. The report AIBN. Now that the Institute is housed in outlines AIBN start-up companies its state-of-the-art building, it has been formed during the year, and the close particularly pleasing to see an increase links developing between the Innovation in the number of research collaborations and Commercial Development team and between groups. These collaborations research groups in the Institute are opening up new, productive areas of It is for me to again acknowledge the research. efforts and contributions of the Institute’s AIBN performed particularly well in 2007 17 Group Leaders, led ably by the AIBN in attracting competitive research funding Executive consisting of Professors Julie from the Australian Research Campbell, Max Lu, Anton Middelberg Council (ARC), the National and Matt Trau. I also congratulate Ms Health and Medical Donna Hannan for her hard work and Research Council, dedication in the formation and growth the Cooperative of the Institute. In 2007 the University Research Centre fi ttingly recognised the major role she Scheme, from the continues to play in the smooth running Queensland State of AIBN by appointing her Deputy Government’s Director (Operations). National and The year has also been characterised by International a rapid increase in the physical facilities Research in the building, and I thank Dr Steve Love

2 AIBN ANNUAL REPORT 07 and his team for their hard work in rapidly Bioscience), Professor Perry Bartlett FAA commissioning a wide range of complex (Queensland Brain Institute), Professor equipment, in particular the three NCRIS Ian Frazer (The Diamantina Institute for facilities described in the report. Cancer, Immunology and Metabolic I must thank the unstinting support of The Medicine) and Professor Chris Moran University of Queensland, in particular (Sustainable Minerals Institute). the past Vice-Chancellor Professor John I also thank the Head of the School Hay who was a tireless advocate for the of Engineering Professor Graham AIBN. We acknowledge his contribution Schaffer and the Head of the and look forward to forging a similarly School of Molecular and Microbial close and enduring relationship with Sciences Professor Alastair UQ’s new Vice-Chancellor Professor Paul McEwan. Greenfi eld. Finally I acknowledge the I also thank the Deputy Vice-Chancellor contribution of Sir Sydney (Research) Professor David Siddle and Schubert, the foundation Chair his staff for their support in the past 12 of our State Government months. I acknowledge the support of Review Committee, who Professors Mick McManus, Stephen retired from this position Walker and Peter Brooks; the Executive in 2007. Deans of the Faculty of Biological and Professor Peter Gray Chemical Sciences, the Faculty of AIBN DIRECTOR Engineering, Physical Sciences and Architecture, and the Faculty of Health Sciences respectively. In particular I look forward to strengthening relationships with my fellow UQ Research Institute Directors, particularly Professor Brandon Wainwright (Institute for Molecular

AIBN ANNUAL REPORT 07 3 DYNAMIC RESEARCH ENVIRONMENT

AIBN formalises ties with leading Korean research institute

Demonstrating that AIBN’s dynamic research environment is at the front line of the global bioproduct industry, the then Premier of Queensland Honourable Peter Beattie MP witnessed a new partnership with the Korean Advanced Institute of Science and Technology (KAIST) in May 2007.

Regarded as the “MIT of Korea”, KAIST be a signifi cant reduction in the amount has outstanding programs in science and of energy used in chemical production engineering education and research. It is which currently accounts for seven Korea’s foremost centre of strategic R&D percent of global energy use. projects with interests complementary to This will reduce Australia’s reliance on those of the AIBN. the world’s diminishing supply of fossil AIBN and KAIST have teamed up to fuels, assist the economic growth develop the synthetic biology techniques of both Korea and Australia, and required to convert sugar cane into contribute signifi cantly to a better global “green” plastics and chemicals. environment. This work involves conducting systems- As part of this combined effort it is level analysis and engineering of E. coli in anticipated that platform technologies order to produce chemicals and materials in systems biotechnology will be from sucrose and other related carbon collaboratively developed. In addition, substrates. high quality publications and international Researchers Professor Sang Yup Lee patents based on the research outcomes (KAIST) and Professor Lars Nielsen are expected. (AIBN) aim to refi ne the technology so This relationship formalises existing that bacteria will produce the start- partnerships between the organisations up molecules required for plastic and and will provide opportunities to apply chemical production. for external grant funding from various Substituting sucrose for oil in the research agencies and foster the production of chemicals will reduce the development of exchange programs use of non-renewable resources by up for graduate students and researchers to 90 percent. Furthermore, there will between the two organisations.

4 AIBN ANNUAL REPORT 07 The Meniscus Project

In any average group of people, one in two has sustained damage to the meniscus in their knee.

The meniscus is the cartilage spacer Faculty of Health Sciences and Dr Peter The Meniscus Project came about in in the knee found between the thigh Myers, a leading Australian orthopaedic 2004 as part of the AIBN’s Challenge and shin bones that absorbs about one surgeon. Project initiative, which aimed to identify third of impact load. Damage to the Success in this project depends on ambitious, long-term endeavours meniscus manifests as early arthritis combining the expertise of these focussing on delivering practical and decreased mobility, leading to a groups to solve complex biological and outcomes and promoting interdisciplinary decline in quality of life. This obviously research within the Institute. engineering problems, particularly: has signifi cant implications for Australia’s Critical to the further success of 1. Producing scaffolds that encourage ageing population. the Meniscus Project has been the the growth of mesenchymal stem cells Unlike other body tissues, the meniscus attraction of competitive funding from the so that they form the shape and size is not supported by an extensive network Australian Research Council. of a meniscus; of blood vessels and consequently is not The research environment at the AIBN, 2. Understanding how mesenchymal able to repair itself. combining the skills of engineers stem cells differentiate to form the However, some hope does exist for biologists, chemists and computer cartilaginous material that is the those affected. modelling experts, has played a critical meniscus, and inducing this process role in establishing and advancing this AIBN’s Meniscus Challenge Project in controlled conditions; is a multi-disciplinary research effort project. Without the input of both teams 3. Ensuring that there is a method for developing methods to grow an artifi cial it is unlikely the project would have reliably delivering the required amount meniscus in a patient’s knee. It combines progressed to its current stage in such a of blood to the meniscus. the research of AIBN’s Professors Justin short period of time. Cooper-White and Julie Campbell with Researchers are currently undertaking trials that of Professor Peter Brooks from UQ’s in animals to assess their progress to date.

AIBN ANNUAL REPORT 07 5 INDUSTRY FOCUS

The AIBN and Dow research alliance

In a signifi cant development for Australian research and development, AIBN and world leading chemical company Dow announced a research alliance in late 2007.

This alliance will subject the Institute’s and escalating oil costs, concerns about Associate Professor Michael Monteiro, science to the intensity of industry carbon dioxide emissions and global as well as the chemical self-assembly demands and global market forces. warming, make it imperative to develop processing research of Professor Anton The Alliance will initially focus on two new manufacturing processes. Middelberg is being capitalised on by the key areas, bio-mimicry and developing AIBN’s research excellence in cell Dow Chemical Company. new manufacturing systems using biology and metabolism led by Professor The alliance will ultimately deliver new bio-feedstocks. Lars Nielsen, the polymer chemistry materials and processes capable of The current plastics industry is almost structure and function work undertaken producing desired molecules from exclusively dependent on petrochemicals by Professor Andrew Whittaker and renewable resources in a cost effective manner to achieve long term benefi ts for the consumer. Together AIBN and Dow will fi nd more resource effi cient ways to deliver even better products to markets. The importance of this alliance is underscored by Dow’s position in the global chemical market. With annual sales of $54 billion and 46,000 employees worldwide, Dow delivers a broad range of products and services in around 160 countries. It was ranked 40th in the 2007 Fortune 500 with profi ts of over USD$3.7 billion. The research alliance is a signifi cant development in the Institute’s industry focus and a relationship that the Institute will nurture with the aim of establishing a long term arrangement.

Clockwise from top left: Present Vice-Chancellor Professor Paul Greenfi eld AO, AIBN Director Professor Peter Gray, Dow CEO Mr Andrew Liveris and past Vice-Chancellor Professor John Hay AO

6 AIBN ANNUAL REPORT 07 TenasiTech Pty Ltd

Ground breaking AIBN work improving the strength and fl exibility of thermoplastic elastomers is being commercialised under the name TenasiTech.

The work of Dr Darren Martin increases the strength of thermoplastic polyurethane elastomers whilst maintaining fl exibility. The secret to his discovery is synthetic nanoparticles – nanoscale disc-like particles – that when added to conventional thermoplastic polyurethane (TPU) extend its benefi ts and performance. Dr Martin’s work has resulted in a 120 percent increase in tensile strength with a minimal increase in stiffness and a 10 fold increase in elongation with no loss in dynamic performance. Although golf balls and condoms were initially targeted, Dr Martin’s work also has applications in mining hoses, sports equipment, biomedical elastomers and surgical gloves, to name a few. Basically this technology can be used wherever polyurethane is used. It will be a new entrant on the global polyurethane market, particularly the soft and fl exible polyurethane areas, believed to be worth around USD$12 billion a year. The invention is the subject of a patent application currently in National Phase Entry. TenasiTech Pty Ltd is a start-up company formed around the technology to drive the business development and capital- raising to further advance the technology towards products.

AIBN ANNUAL REPORT 07 7 RESEARCH EXCELLENCE

International Alliances: part of AIBN’s research excellence

Critical to any successful research program are innovative ideas, from a variety of sources, coupled with the ability to act on these ideas.

To facilitate the exchange of innovative both in the United States, along with is a collaborative venture led by AIBN’s ideas, the Queensland Government Warwick University and the University of Professor Matt Trau which partners with awarded National and International Nottingham in the UK. the Fred Hutchinson Cancer Research Research Alliance Program (NIRAP) IBRA is unique in bringing together Centre, the University of Washington grants to AIBN researchers Professor fundamental chemical scientists (Washington State US) and Seattle Andrew Whittaker and Professor with clinical researchers working in Biomedical Research Institute in the US Matt Trau. Queensland hospitals. Its vision is and Nanomics Biosystems. These grants are designed to support to provide a “bench-top to bedside” This Alliance aims to address the paucity the delivery of research, development path for biomaterials developed in of tools available for early, molecular- and innovation outcomes made by Queensland through collaborations with level diagnosis of cancer and infectious AIBN researchers and their national and international partners. diseases. As a consequence of early diagnosis the Alliance believes treatments international partners. The benefi ts for Queensland include: will become easier to administer and more AIBN’s two successful NIRAP grants > the establishment of a high-quality effective, thereby reducing the impact of commenced in 2007. network of researchers developing disease on the individual, their family and The International Biomaterials Research new biomaterials to address specifi c the community as a whole. Alliance (IBRA), led by Professor medical needs The project draws upon facilities and Whittaker, was awarded $1.17 million > access to international experts and expertise in biological and clinical areas for the development of biomaterials for technologies not currently found in not currently accessible in Queensland. medical applications focussing on: Australia The successful AIBN applications > the generation of signifi cant intellectual > Dental Bone repair were deemed to be of national and property which will bring a number of > Vascular Regeneration international signifi cance with potential technologies to market > Vision to benefi t the future economic, social > Medical Imaging. > high quality PhD graduates to support and environmental development of The Alliance consists of international Queensland’s growing bio- and nano- Queensland. Furthermore, these grants researchers from the AIBN, University technology industries. will build a critical mass of internationally of California at Santa Barbara, and The Novel Nanotechnology Platforms for recognised competitive research, Washington University, St Louis Disease Biomarker Diagnostics alliance development and innovation networks.

8 AIBN ANNUAL REPORT 07 Modelling at the Atomic Level

One of Australia’s largest dedicated molecular modelling facilities is to be found in the computational bio and nanotechnology laboratory of AIBN’s Professor Sean Smith.

This facility has the capability to model In this way the research teams open up also has strong research programs interactions between materials, proteins two fronts of attack on the problem with in modelling the photophysics and and molecules down to the atomic level. the groups attempting to meet each structural features of fl uorescent proteins; modelling complexation of short Characterisation at this atomic level other in the middle. stranded DNA/RNA with dendrimers requires a large amount of computing A recent notable success was achieved and nanoparticles for gene delivery power, with calculations taking anywhere with the characterisation and design applications; and hydrogen and CO between days and months before a of catalysts for enhancing functional 2 transport within nanoporous materials. result is available. mobile hydrogen storage materials. Both Several AIBN research groups In collaboration with Professor Max Lu’s computational and experimental aspects successfully applied for an Australian group they are exploring how to effectively were pursued in two papers published in the Journal of the American Chemical Research Council Linkage Infrastructure store hydrogen for use as a clean energy Equipment Facilities grant led by Society during 2007. source; a vitally important project in light Professor Smith for a new high of growing concerns about green house This unique approach to research better performance cluster computing gas emissions caused by burning the informs future progress, as well as facility to drive modelling within the world’s fi nite supply of fossil fuels. directing and amplifying outcomes. It Institute. Clusters of comparable size Professor Smith’s team characterises couples interesting experimental results typically service the Australian research the interactions of hydrogen with with the best available explanation of community whereas this facility is different materials at the atomic level. what is actually occurring. It provides a exclusively available to AIBN researchers. This information subsequently guides quantifi able understanding of what might This further demonstrates the experiments in Professor Lu’s lab to otherwise be interesting phenomena. multidisciplinary nature of the research improve the interactions. Professor Smith’s research group environment at the AIBN.

AIBN ANNUAL REPORT 07 9 BUILDING AUSTRALIA’S RESEARCH CAPABILITY

As one of Australia’s leading research institutes the AIBN has a unique and comprehensive suite of facilities spanning microfabrication, biotechnology products and metabolomics.

These facilities are located in the AIBN Not only do these facilities dovetail with as a result of the Institute’s successful the Institute’s research priorities, they involvement in Australia’s National service the broader Australian research Collaborative Research Infrastructure community by providing accessible Strategy (NCRIS). infrastructure that meets long term needs and enables the growth of transnational collaborative projects.

10 AIBN ANNUAL REPORT 07 NCRIS Biologics Facility

The sale of biopharmaceuticals already accounts for US$60 billion per year and currently represents 25 percent of the new drugs approved by the US Food and Drug Administration. As a result biopharmaceuticals are having an increasing impact on the global pharmaceutical industry.

The path from laboratory bench to clinic is through-put capabilities. Equipment such a complex one with a key challenge being as a Fluorescence Activated Cell Sorter the production of potentially valuable (FACS) and robotic high-expressing compounds in amounts large enough to clonal selector (ClonePix™) further support pre-commercialisation trials. strengthen the Facility’s competence The AIBN’s Biologics Facility is part of and capabilities in mammalian cell the National Collaborative Research technology. Infrastructure Strategy (NCRIS) and aims The Facility is equipped with a variety to provide Australian researchers with of bioreactors, including stirred tank access to state-of-the-art equipment and and single-use disposable bioreactors, facilities, as well as superior technical ranging from 1L to 100L capacity expertise suitable for cell line and and is capable of processing high bioprocess development along with pilot volume of biologics material with the scale manufacturing. newly acquired downstream process The Facility specialises in mammalian equipment. cell expression technology to develop The Facility’s staff have experience recombinant proteins with potential in international biopharmaceutical therapeutic and commercial value. Key industry, and expertise in GMP/GLP in staff in the areas of molecular biology, pharmaceutical development. antibody engineering, mammalian cell Working together with many of the culture/biology, and protein function and academic staff at AIBN, the Biologics characterisation have been appointed. Facility can truly provide strong research In addition, funding from the Queensland and manufacturing capabilities to State Government Smart State Australian researchers involved in Innovation Building Fund has enabled the developing recombinant biologics for purchase of the Biologics Facility’s high therapeutic use.

AIBN ANNUAL REPORT 07 11 NCRIS Metabolomics Facility

As part of NCRIS’s Bioplatforms Australia, AIBN is establishing building blocks for plastics, which if a metabolomics node which will provide specialised expertise produced in a signifi cant quantity and at the required quality, could be used to in metabolic engineering. establish a new “bioplastics” industry. As a facility available to the wider Metabolomics involves the optimisation Australian research community, the Node of genetic and regulatory processes will also assist other research teams to in cells to increase the production of identify new drug targets and conduct desired products. toxicity screens for drug development. A major focus of the Metabolomics node The Metabolomics Facility is funded will be ‘fl uxomics’, which analyses the under the NCRIS scheme to provide dynamic change of molecules within a infrastructure and expertise in the fi elds cell over time. With the assistance of of genomics, proteomics, bio-informatics AIBN expertise, Australian researchers as well as metabolomics. will have the ability to develop analytical The facility will provide services in: models to improve mammalian, plant > Genome scale modelling and microbial fermentation systems and > Metabolic fl ux analysis increase production of desired products. > Central carbon metabolism analysis A particular example of a desired product > Training in analytical process is polyhydroxyalkenoates (PHAs), the development and data analysis.

NCRIS Fabrication Facility

AIBN is home to the Queensland node of the NCRIS Australian The facility is more than a collection of National Fabrication Facility (ANFF). leading-edge equipment and specialist clean rooms minimising unwanted particulate contamination; it is managed and staffed by key senior research This facility’s capabilities support offi cers with extensive expertise. Australian researchers with equipment and expertise in patterning of polymer Australian researchers will have access and glass substrates, the production to state-of-the-art equipment such as: of novel substrates for immunotherapy > A prototyping inkjet printer with organic and drug delivery, and the fabrication of or aqueous solvent based ink capabilities nanoelectric devices. > High throughput photoresist, monomer, The ANFF Queensland node provides polymer and nanoparticle synthesis units a dedicated facility for the synthesis, > Semi automated nanoimprint processing, characterisation and lithography unit and plasma bonder fabrication of functional organics and > A dip pen lithography unit for micro to organic semiconductors, new generation nanometre patterning of surfaces and photoresists, functional polymers devices and nanoparticles and bio-inspired nanomaterials, smart surfaces and > A deep reactive ion etcher unit for micro devices. Services included the needleless drug delivery patches, scale-up prototyping of devices such nanofl uidic devices and surface as organic solar cells, organic templating light emitting diodes and > A surface and device microbioreactors. characterising suite.

12 AIBN ANNUAL REPORT 07 AIBN ANNUAL REPORT 07 13 2007 FAST FACTS AIBN’s 17 Group Leaders attracted almost $6.8 million in new competitive funding in 2007. AIBN Group Leaders advised 103 research higher degrees of which 28 are international students in 2007. AIBN researchers authored 132 journal articles in 2007.

14 AIBN ANNUAL REPORT 07 RESEARCH PROJECTS

AIBN has focussed its research in areas that will alleviate current problems in human health, manufacturing, information technology and the environment.

The unique capabilities of the AIBN > Improving energy and the environment come from merging the skills of though high performance hydrogen engineers, chemists, biologists and storage materials, photocatalysis for computational scientists to conduct environmental remediation and novel world-class research programs. These membranes for water desalination and multidisciplinary teams work at the recycling. interface of the biological, chemical The Institute’s 17 Group Leaders are and physical sciences with research internationally acknowledged for their programs in the following areas: research excellence and have proven > Delivery of therapeutic agents track records in attracting competitive using polymer chemistry, virus like grant funding and fellowships. particles and needleless transdermal The following pages outline the research technologies interests of AIBN’s Group Leaders. > Metabolic engineering of cells to produce new bioproducts > Regenerative medicine using stem cell biology and novel scaffolds > Nanomaterials for orthopaedic applications, enzyme encapsulation and biosensors

AIBN ANNUAL REPORT 07 15 Mammalian Cell Lines and Stem Cell Bioprocesses

GROUP LEADER larger amounts of protein needed for With stem cells the challenge is to initial characterisation and testing Professor Peter Gray accurately defi ne the physical and > developing high throughput chemical environment required for the Professor Gray’s research is focussed approaches which allow the controlled proliferation and subsequent on engineering mammalian cells in order rapid selection of clones stably differentiation of the cells. It is then to improve their effi ciency and utility for expressing high levels of the desired necessary to translate these conditions the production of complex proteins, biopharmaceutical into processes which can be scaled up to produce the number of cells required which are increasingly being used as > using modern ‘omics’ approaches to for clinical testing. biopharmaceuticals. gain better understanding of cellular metabolism which will allow maximal This research is being conducted in protein expression by mammalian cell collaboration with AIBN’s Professor PROJECTS cultures. Justin Cooper-White and Associate The team’s research is aimed at reducing The research approaches which Professor Ernst Wolvetang. some of the ‘bottlenecks’ present when have been used to gain a greater mammalian cells are used to produce understanding of mammalian cell CONTACT DETAILS biopharmaceuticals, particularly: processes are now being applied to even Professor Peter Gray > developing transient protein more complex cells, in other words the Telephone: + 61 7 3346 3899 expression systems which will allow development of bioprocesses based on Email: [email protected] researchers to rapidly produce the embryonic stem cells.

16 AIBN ANNUAL REPORT 07 Bioprocess Technology

GROUP LEADER in diameter), because they wrap are in use ($30-$50/Ha). Further Dr Steve Reid their genomes in large protein coats improvements in yield would allow the (Occlusion Bodies). This enables product to compete on cost alone in all Increased resistance to chemical the virus to be stable in the open markets, including extensive markets in pesticides and concern over their use environment and facilitate delivery to India and China. has renewed interest in the application crops using conventional land and air of biological means to control pests of based spraying procedures. RESEARCH PROJECTS commercial importance. The Reid Group RESEARCH PROJECTS The laboratory has a process patent on is involved in advancing the technology > Pilot Scale Production of Helicoverpa a procedure for producing Baculoviruses necessary to reduce the cost of armigera nucleopolyhedrovirus. via fermentation. The lead product is a production of biological control agents. > Expression of the key viral FP25K Baculovirus which targets the Helicoverpa This research is concerned initially with gene in the Heliothis cell line. the effective scale-up of insect viruses. pest species which accounts for the current $US3.2 billion per annum market for traditional chemicals. At current yields PROJECTS the production costs would allow the CONTACT DETAILS Many wild type Baculoviruses can Helicoverpa species to be targeted in Dr Steve Reid specifi cally infect and kill key agricultural areas where this pest is resistant to most Telephone: + 61 7 3346 3174 caterpillar pests. These Baculoviruses low cost chemical options ($15/Ha), and Email: [email protected] are the largest viruses known (1 micron where only more expensive chemicals

Systems Biotechnology

GROUP LEADER Phase I clinical trials to investigate Renewable materials from sucrose Professor Lars Nielsen the prevention of infection in Acute Sucrose is the preferred substrate for Myeloid Leukemia patients undergoing the replacement of petrochemicals with This group focuses on the both the chemotherapy. renewable materials. To date metabolic advancement of bioengineering science In addition, work on differentiating cord engineering has focussed on glucose- and its application to specifi c problems. blood stem cells to red blood cells (RBC) based production and no platforms exist Using thermodynamic principles, has resulted in 10,000 times improvement for the group’s preferred strain, E.coli. In novel approaches are developed for on the previous best expansion, equating collaboration with Professor Sang Yup handling complex, transient dynamics to 10,000 units of red blood cells from Lee at KAIST, the team is developing in developing tissue as well as rational a single unit of cord blood. Following metabolic engineering platforms for design of complex pathways. These novel maturation, more than 90% of the cells sucrose-based biorefi neries. approaches are used in the design of produced are enucleated RBC and have bioprocesses ranging from the production Metabolic engineering normal hemoglobin content. The process of blood cells for transfusion to the of sugarcane has been scaled up to 1L in media production of industrial biopolymers. With colleagues at BSES Ltd, we without the use of animal products or are investigating the expression of stromal cells. PROJECTS polyhydoxyalkanoates (the building Metabolic engineering of blocks of plastic) in sugarcane and the The blood cell factory hyaluronic acid production potential of this as a “green factory” for Using haematopoietic stem cells, Hyaluronic acid (HA) is a high-value production of bulk and fi ne chemicals the team is exploring the potential of medical polymer produced by extraction such as polymers, enzymes and high expanding these in vitro for use in the from animal tissue and fermentation. value metabolites. production of blood products. Using genetic engineering, fermentation This has resulted in a clinically meaningful strains capable of generating high CONTACT DETAILS expansion of cord blood stem cells to molecular weight HA, have been Professor Lars Nielsen neutrophils and has been successfully developed. This was previously only Telephone: + 61 7 3346 3986 scaled to 10 L in a wave bioreactor. feasible through extraction from Email: [email protected] As a result funds are being raised for animal tissues.

AIBN ANNUAL REPORT 07 17 Tissue Engineering Vascular and Microfl uidics Research

GROUP LEADER GROUP LEADER Professor Julie Campbell Professor Justin Cooper-White The Group’s current research interest Engineering tissue and scaffolds coupled is in tissue engineering replacement with microfl uidics (the study of the arteries from the patient’s own cells using behaviour of fl uids at the micro and meso the peritoneal (abdominal) cavity as a scales), when applied to regenerative bioreactor. medicine, have great potential to alleviate many current health problems. PROJECTS It is important, however, to gain a thorough understanding of these so as The team has grown myofi broblast to maximise the opportunities presented tissue around appropriately shaped by these enabling technologies. polyethylene moulds of tubes or bulbs in the peritoneal cavity of several animal species. PROJECTS After 2-3 weeks this tissue is grafted The Group has interests in biomaterials into arteries, bladder, vas deferens or processing, tissue engineering, uterus to replace resected segments, the non-Newtonian fl uid mechanics, myofi broblast tissue differentiates into rheology and microfl uidics. structures identical to the host organ, Projects exist in all of these areas with a remaining functional for at least 16 common focus of providing fundamental months. insights into complex polymer-based The group is investigating the origin of structures and systems, with the aim of the cells that constitute the myofi broblast ultimately tailoring and controlling their capsule, as well as the factors infl uencing interactions with biological systems. differentiation. The project teams are investigating novel In collaboration with Professor methods of surface engineering of these Justin Cooper-White the group is scaffolds for drug delivery and tissue developing an artifi cial meniscus for engineering applications, new in vitro the knee by populating a novel scaffold modules for mapping cell-surface and with mesenchymal stem cells and cell scaffold interactions, manufacturing differentiating them along different cellular functional microparticles with micro pathways according to function. processing plants and complex fl uid behaviour in microdevices In addition, the group is aiming to grow functional kidneys through the Current research projects include: incorporation of ‘stem’ cells into > Micro process Plants – embryonic kidneys transplanted to the Non-Newtonian Flow and Particle peritoneal cavity of adult hosts. Synthesis in confi ned geometries Other research involves basic cellular > Mastering the microenvironment interactions in the artery wall, and the – integrated, functional, biosynthetic defi nition of signal transduction pathways scaffolds for tissue engineering through which factors act to enhance > Bioactive polymers for wound healing vascular disease regression and prevent applications disease development / progression. > Bioreactor platform for stem cell A long-term interest of the Group is expansion. also smooth muscle phenotype and factors affecting the cells’ sub-structural compartments. CONTACT DETAILS Professor Justin Cooper-White Telephone: + 61 7 3346 3858 CONTACT DETAILS Email: [email protected] Professor Julie Campbell Telephone: + 61 7 3346 3848 Email: [email protected]

18 AIBN ANNUAL REPORT 07 Stem Cell Engineering

GROUP LEADER PROJECTS > The elucidation of the molecular pathways that control undifferentiated Associate Professor Human embryonic stem cells are growth and lineage specifi c Ernst Wolvetang immortal and can differentiate into all cell lineages of the body. These properties differentiation of hESC (The role of The Stem Cell Engineering Group make hESC not only a potential source CD30 in controlling genetic stability of aims to use novel cutting-edge inter- of cells for future cell replacement hESC) disciplinary approaches to understand therapies but also allows investigation > Understanding the cause and RESEARCH PROJECTS the complex molecular mechanisms of early human developmental consequences of genetic and that govern human embryonic stem cell processes previously inaccessible to epigenetic instability of hESC, and (hESC) biology. experimentation. Furthermore, because the development of strategies how to of these remarkable characteristics hESC This knowledge is not only required for prevent this (The role of mitochondria constitute a unique model system for the rational design of bioreactors that and redox signaling in human understanding the processes associated can be used to expand and direct hESC embryonic stem cells) into clinically relevant cell types, but also with cell transformation and genetic elucidates key aspects of human biology stability as well as a platform for drug > The creation of hESC bioreactors such as early human development, screening and disease modeling. that will deliver safe and effi ciently cellular differentiation and carcinogenesis. The Stem Cell Engineering Group expanded hESC that can be used uses lentiviral delivery of shRNAs and in regenerative medicine therapies transgenes, microarray analysis, FACS (Characterisation of novel hESC CONTACT DETAILS and fl uorescent imaging techniques to maintenance factors and their use in Associate Professor Ernst Wolvetang interrogate hESC behaviour. At present the 3D bioreactors in collaboration with Telephone: + 61 7 3346 3894 group focuses on three important aspects Professors Justin Cooper-White and Email: [email protected] of human Embryonic Stem Cell biology: Peter Gray).

AIBN ANNUAL REPORT 07 19 Biopolymer Processing

GROUP LEADER PROJECTS CONTACT DETAILS Associate Professor Peter Halley Thermoplastic Associate Professor Peter Halley Telephone: + 61 7 3346 3881 starch-based plastics The Biopolymer Processing group Email: [email protected] focuses on taking novel biopolymers Work in this project has developed (polymers from natural sources), commercial biodegradable thermoplastic controlled-lifetime polymers starch polymers for the packaging (biodegradable, photodegradable, industry, and launched Australia’s fi rst Other projects include: biosorbable) and biomedical polymers, biodegradable polymer company Plantic > Photodegradable polyethylene to the next stage of research and Technologies Ltd from the CRC Food polymers in collaboration with development. They focus on the science Packaging. Current fundamental work CRC Polymers of the rheology (fl ow characterisation) is focussing on model starch studies to > Development of melt processing and small scale processing of these probe the links between starch genetics, of TPU nanocomposites with novel polymers to be able to understand structure, processing and properties to Dr Darren Martin develop new starch systems. and scale-up the processing of these > Novel starch materials for drug delivery systems. Novel lignin polymers with Professor Andrew Whittaker and This project focusses on developing Professor Peter Gray novel products, such as coatings, > Novel gels for drug delivery in composites and polymer blends from collaboration with UQ’s School of sugar cane derived lignin. This work Pharmacy and UniQuest is done in the CRC Sugar Industry > Novel processing for biomedical gels Innovation through Biotechnology. with Professor Justin Cooper-White.

20 AIBN ANNUAL REPORT 07 CONTACT DETAILS Nanotoxicology, Biomaterials Dr Darren Martin Telephone: + 61 7 3346 3870 and Tissue Engineering Email: [email protected]

GROUP LEADER PROJECTS This project aims to: Dr Darren Martin Structure-property-performance > study the nanotoxicology of carbon The primary research themes of relationships of novel biomaterials nanotubes, layered double hydroxides this group are the processing and and polymer nanocomposites and synthetic hectorites RESEARCH PROJECTS structure-property performance This research theme encompasses > develop unique nanotoxicology assays of novel biomaterials and polymer long-term efforts in developing ultra to determine the biodistribution, nanocomposites, the biomechanics strong, tough and fl exible polyurethane bioretention and bioaccumulation of of tissue engineered medical products nanocomposites for both medical and these nanoparticles. (TEMPS), and the toxicology of non-medical applications (see TenasiTech The short term aim is to provide a engineered nanoparticles. page 7). Other biomaterials research rigorous demonstration of the benefi ts of These interests overlap signifi cantly, with a includes new biomaterials for cartilage, this approach. mature initiative investigating the physical bone and vascular therapies. The in vitro stability of the nanoparticles, and biological performance of biomedical The Interaction of Engineered their interactions with biomolecules and polyurethane nanocomposites, and release from composite matrices (for the mechanics of tissues and tissue Nanoparticles with Biological example, nanocomposite elastomers engineered constructs for bone, cartilage Systems being developed for biomedical use) will (articular and meniscus), vascular and Nanoparticle toxicology is an exciting new also be investigated. abdominal wall TEMPS. initiative involving with UQ Pharmacology, the Australian Nuclear Science and Technology Organisation and Argonne National Labs.

Polymer Chemistry

GROUP LEADER PROJECTS Photolithography In the fi eld of polymer photolithography Professor Andrew Whittaker Biomaterials there are programs supported by This group is exploring the relationship The group has many projects in the SEMATECH, Intel, IMEC and the between a material’s structure and its fi eld of biomaterials supported by the Australian Research Council. We are ultimate properties. Strong research Australian Research Council, Queensland developing polymeric resists for the programs exist in the fi elds of: State Government and Tissue Therapies next generation of lithography. Specifi c > polymeric biomaterials Ltd. These projects include: projects include: > The study of the fundamentals of > polymer lithograpy > Fundamentals of polymer degradation diffusion in hydrogels > advanced NMR methodologies. > Polymers for immersion lithography > Synthesis of polymers for artifi cial The overall aim is to develop a deep > Resists for EUV lithography blood vessels understanding of materials’ properties to > Non-chemically-amplifi ed resists. allow design of novel polymer which help > Novel MRI imaging agents solve important problems. > New ultrasound contrast agents Spectroscopy > Injectable-curable dental resins The group’s expertise in physical > Artifi cial vitreous humour chemistry extends to programs in > Delivery of therapeutic proteins for spectroscopy. This work is performed CONTACT DETAILS wound healing within the Centre for Magnetic Professor Andrew Whittaker > Novel polymer foams formed using Resonance, and is supported by the Telephone: + 61 7 3346 3885 supercritical CO2 Australian Research Council. Email: [email protected] > Functional surfaces for bioarrays. Current projects include: > Nanomaterials for surface plasmon resonance > High pressure NMR > Hyperpolarised xenon NMR studies of materials structure > The properties of proteins during dehydration.

AIBN ANNUAL REPORT 07 21 Biomolecular Engineering

GROUP LEADER PROJECTS Research in viral vaccines is directed Professor Anton Middelberg Platform technologies receiving focused at understanding and controlling the research attention include stimuli- processing of viral vaccine particles. Professor Middelberg’s group focuses responsive Pepfactants®-stabilised The group has developed a platform on chemical self-assembly processing, emulsions and foams, and self- for the effi cient self-assembly of this with the ultimate aim of understanding assembling viral vaccines. new vaccine class, using microbial new functional products and new Pepfactants are peptide surfactants cell factories as a starting point. The process routes for the manufacture – a new class of designer surfactants technology is being researched for its of existing products. The group is affording unprecedented control over potential to develop low-cost vaccines particularly interested in developing and interfacial properties. Through facile for existing third-world diseases and understanding platform technologies change of bulk conditions, Pepfactants emergent threats such as avian infl uenza. involving the self-assembly or processing can radically alter interfacial properties of biological molecules such as proteins Finally the team has research activities and thus foam and emulsion stability. and DNA. These platform technologies in industrial biotechnology, with foci The fundamentals of this technology are then directed at multiple applications on downstream processing, protein are being actively researched and in academic or commercial spin-out aggregation, and recombinant applications are being developed in activities. biosurfactant processing. the areas of cancer treatment and personal care. CONTACT DETAILS The technology is the basis of AIBN’s Professor Anton Middelberg fi rst start-up company Pepfactants Pty Telephone: + 61 7 3346 4189 Ltd (www.pepfactants.com.au). Email: [email protected]

Advanced Materials from Complex Polymer Architectures

GROUP LEADER PROJECTS Mechanisms in living Associate Professor Next generation nanostructures radical polymerization Michael Monteiro This project aims to synthesise the Understanding the mechanisms in living radical polymerization allows for better The main research focus of this next generation of nanostructures design of the living agents and the group involves developing synthetic built from linear polymer chains. The optimal use of living polymerizations. methodologies to make complex project attempts to make a wide range The project will involve the determination polymer-based architectures from of architectures that are currently of the initiation mechanisms involved polymeric units. Uniform chain length unavailable and, in collaboration with cell in atom radical transfer and reversible and predetermined functionality within biologists, use these as vehicles for drug addition-fragmentation chain transfer the interior or exterior will provide and vaccine delivery devices. polymerizations. nanomaterials with greater functionality Smart nanopolymers and structural design. Through self- for drug delivery assembly these smart nanostructures The aim of this project is to synthesise CONTACT DETAILS can be used in a wide range of polymers with complex architectures Associate Professor Michael Monteiro biomedical applications, including drug on the nanoscale in the environmentally Telephone: + 61 7 3346 4164 or vaccine delivery devices. friendly medium; water. Once these well- Email: [email protected] defi ned nanostructures have been made their structure-property relationships will be evaluated using structural characterisation techniques to determine size and morphology. They will also be functionalised for use as drug and gene delivery devices.

22 AIBN ANNUAL REPORT 07 Gene and Drug Delivery Research

GROUP LEADER Consequently this is a multi-disciplinary Measuring key skin properties Professor Mark Kendall research team with interests in To help optimise the delivery device, biomedical engineering, diagnostics, the group is performing fundamental Professor Kendall is working to develop dermatology and vaccinology. research into key mechanical and a new method of delivering therapeutic The group has projects in the areas of: biological properties of the skin before agents into the body. Using new and after the delivery of biomolecules nanopatch technology the team hopes to Needle-free gene and drug develop new technologies which may be delivery technologies to skin Clinical applications RESEARCH PROJECTS useful in reducing the 14 million deaths The aim is to engineer next-generation (systemic responses) per year caused by infectious disease. devices to avoid the key shortcomings of Applying our delivery technologies to the needle-and syringe. key clinical applications, measuring PROJECTS Micro-nanoprojection array patch both local and systemic responses in animal models. The team is researching how (Nanopatch) technology nanotechnology, through the use of This is a patch with thousands of tiny nanopatches, might deliver drugs to the projections – invisible to the human eye Langerhans cells, important immune – dry-coated in biomolecules. When CONTACT DETAILS response cells found just below the the patch is placed against the skin, Professor Mark Kendall surface of the skin. A needle and syringe these projections push through the outer Telephone: + 61 7 3346 4203 cannot deliver biomolecules to this skin layer and deliver the biomolecules Email: [email protected] precise site as the needle is too large precisely to the target cells. and inserted too far into the skin.

AIBN ANNUAL REPORT 07 23 Single Molecule Nanotechnology GROUP LEADER GROUP LEADER Professor Matt Trau Dr Krassen Dimitrov The work of Professor Trau focuses on two main areas: The next step in personalised medicine is a new technology with the ability to provide > nano-scaled molecular biosensors cheap and accurate biological information. for early detection of cancer and diagnosis of infectious diseases

PROJECTS > artifi cial tissue matrices for implantation in the human body. Genes, mRNAs and proteins are increasingly being studied by researchers and health Both of these research areas require professionals to diagnose the onset of creation of novel materials and devices, diseases such as cancer, which cause usually microscopic or colloidal in nature, profound changes in gene expression long which have been fashioned to contain before clinical symptoms appear. designed nanostructures. Dr Dimitrov’s interests are in the area of electronic detection of single biomolecules, which pose numerous interesting challenges at the boundary of biochemistry and nanoscience. Recent advances in fabrication and characterization of nanoelectrodes open up the possibility of their use in detection of individual biomolecules, while at the same time overcoming the limitations of optical detection posed by the diffraction properties of light. Nanobarcodes for electronic detection of biomolecules Single molecule detection techniques reveal the most intricate quantitative detail, far exceeding the performance of traditional analytical methods that quantify gross statistical samplings. Single-molecule techniques allow each molecule to be individually identifi ed and counted so that the output of the assay is direct digital data, rather than an analog value. This project’s goal is to investigate and develop a highly multiplexed single molecule barcoding system based on electrical detection. The system will have the advantages of low cost, high speed and high sensitivity. To achieve this goal the following aims are being pursued: > Fabrication of an electronic nanodetector for electrochemical readout of molecular nanobarcodes > Development of DNA-based nanobarcodes, consisting of an affi nity probe and a barcode segment > Controlled movement of nanobarcodes in a mirofl uidic channel using magnetophoresis.

CONTACT DETAILS Dr Krassen Dimitrov Telephone: + 61 7 3346 3880 Email: [email protected]

24 AIBN ANNUAL REPORT 07 Nanotechnology and Biomaterials

PROJECTS Additional funding from Cancer nanotechnology with clinical applications Professor Trau, along with collaborators Australia ($0.6M) will provide an in cancer and infectious disease. from the Garvan Institute of Medical avenue to perform further technical In addition, the team is researching Research, Peter MacCallum Cancer development, assessment and validation ways to create artifi cial tissue, a Centre, University of Newcastle and of the nanoscaled biosensors for early breakthrough that would enable doctors Princess Alexandra Hospital, is part of a detection of breast cancer. A single to trigger regrowth in patients, avoiding molecule detection technology is also $5M National Breast Cancer Foundation the problem of rejection by the body. RESEARCH PROJECTS research project awarded in 2007. This being pursued. The research focusses on developing project aims to create and clinically Through a Queensland Smart State grant novel biological, degradable and ‘living’ test nanoscaled biosensor technology ($4.2M), Professor Trau’s group has implants for the human body. for early detection of advanced breast established international collaborations cancer. The biosensors have the with the Fred Hutchinson Cancer potential to augment current tumour Research Center, the Seattle Biomedical CONTACT DETAILS examination procedures, providing Research Institute and the University Professor Matt Trau a more accurate determination of of Washington. This project aims to Telephone: + 61 7 3346 4173 metastases risk. connect the latest developments in Email: [email protected]

AIBN ANNUAL REPORT 07 25 CONTACT DETAILS Energy Interface Architecture Professor John Drennan Telephone: + 61 7 3346 3966 for Power Systems Email: [email protected]

GROUP LEADER PROJECTS Nano-ionics Professor John Drennan Anode electrode/electrolyte If solid electrolyte systems are examined using electron microscopy, diffuse Power systems based on solid oxide interface design scattering is always seen in recorded fuel cells operate at high temperatures. Templating techniques, have been structural information. The nature of this An important goal in solid oxide fuel cell used to prepare a series of electrode effect is not well understood and more research is to lower this temperature microstructures that have a very high importantly, the role it plays in defi ning the without any loss in effi ciencies. One gas diffusion without compromising ionic properties of the material is not known. approach to solve this challenge is the number of interface sites within to improve the key interface regions the electrolyte. These complex Detailed microstructural analysis, in within the cell by designing systems microstructures have been shown combination with ionic measurements, that are optimised for ionic transfer. The to be stable up to high processing is providing new insights into this interface region between the electrodes temperatures and to have improved phenomenon resulting in the concept of and electrolyte are of particular interest electrochemical properties. Realistic test nano-ionics. This project, conducted in and the approach is to use modern sytems are presently being prepared with collaboration with the National Institute of templating methods to design structures a view to applying this approach to new Materials Science, Japan, is using these at the interface that have high exchange designs in fuel cells where the electrode detailed studies to redesign systems based effi ciencies over a large area. becomes an important structural unit. on structures at the nanometre scale.

26 AIBN ANNUAL REPORT 07 Functional Nanomaterials

GROUP LEADER PROJECTS Accordingly, the Centre has developed Professor Max Lu The clean energy, environmental and Mg-VTi-CNTs nanocomposites that health care industries have been identifi ed exhibit superior hydrogen absorption The ARC Centre for Functional as areas in which nanostructured properties with high capacity and ultra Nanomaterials’ research focuses on the materials will have signifi cant impacts and fast release speeds at a low temperature. novel synthesis, characterisation and so we are specifi cally interested in the The nanocomposites can absorb 4.2% applications of functional nanomaterials following technologies: hydrogen in only 30 seconds and such as nanoparticles, nanotubes, reach 5.1% in only 5 minutes at 150oC. RESEARCH PROJECTS > Clean energy: gas to liquid conversion, thin fi lms, and nanoporous and This new development has surpassed hydrogen production and storage, fuel nanocomposite materials. the International Energy Agency (IEA) cells, solar cells and supercapacitors Such materials, constructed by self- absorption target for on-board hydrogen > Environmental: photocatalytic reduction assembly at the nanometer scale (1-100 storage. of pollutants in water and air, economic nm), possess improved properties and These newly developed hydrogen removal and recovery of organic unique functionalities such as high storage materials address all the current vapours, greenhouse gas reduction surface area, nanosize and quantum limitations of hydrogen storage in a car. and utilisation and water desalination confi nement effects, ordered porosity, They enable fast storage and release and high adsorbing and sensing abilities. > Health: nanomaterials for gene therapy of hydrogen at mild temperatures and Thus, they are ideal materials for and drug delivery. reduced costs. adsorbents, catalysts, sensors, fuel cells, A research highlight of 2007 was Other exciting developments included and battery systems. demonstrating that metallic catalysts the fi ling of two patents for a layered enable molecular hydrogen dissociation titanate compound showing extraordinary and that carbon nanotubes (CNTs) visible-light photocatalytic activity. This CONTACT DETAILS enhance atomic hydrogen diffusion at compound has applications in solar Professor Max Lu low temperatures. More importantly, powered water and air purifi cation; Telephone: + 61 7 3346 3883 metals and CNTs have synergistic effects self cleaning surfaces; production of Email: [email protected] on improving both practical capacity and hydrogen from water; and effi cient reaction kinetics. solar cells.

Computational Bio and Nanotechnology

GROUP LEADER PROJECTS Fluorescent Proteins: photophysics, Professor Sean Smith Nanocomposite materials for mechanism and dynamics hydrogen storage Electronic structure calculations (cluster The group has a multithreaded and QM/MM models), molecular and research program focusing on applying Solid state electronic structure calculations quantum dynamics are used to explore computational molecular science to and structure/kinetics models are used photophysical properties and proton biotechnology, nanotechnology and to elucidate catalytic mechanisms of chain transfer in fl uorescent proteins, environmental science. The group utilizes hydrogen absorption and desorption in aimed at both fundamental mechanistic electronic structure methods, classical designed nanocomposite materials. understanding and rational design of and quantum molecular dynamics and Nanoparticle/Dendrimer – DNA improved bio-imaging agents. stochastic theories to characterize reaction interactions for gene delivery kinetics, photo-physics, catalysis, structure/ Quantum dynamics for hydrogen Molecular dynamics simulations are morphology and electronic properties in transport in confi ned systems used to explore structure and stability complex systems. Major areas of current of layer double hydroxide and dendritic Mixed quantum and classical dynamical activity include nanocomposite materials nanoparticles in aqueous solution, alone algorithms are developed for simulating for hydrogen storage; nanoparticle or and in interaction with DNA strands. quantum transport of hydrogen in solids. dendrimer mediated gene delivery; fl uorescent proteins for bioimaging; and Nanotubes and Nanoribbons: Quantum dynamics for gas phase development of computational quantum reactivity, functionalisation and reactions. dynamics methodologies. electronics Quantum wavepacket methods are Electronic structure calculations and used to compute state-to-state reaction ab initio molecular dynamics are used probabilities and thermal kinetics in CONTACT DETAILS to explore structure, reactivity and key reactions for combustion and Professor Sean Smith electronic properties of nanotube and atmospheric science, e.g. HO2 and Telephone: + 61 7 3346 3939 nanoribbon systems, with and without HOCl. Email: [email protected]. functionalisation.

AIBN ANNUAL REPORT 07 27 AIBN GRADUATE PROGRAM

The AIBN’s graduate program once again grew signifi cantly in 2007 with 25 research higher degree (RHD) students commencing their studies during the year.

Importantly, all but one of these students Thomas was a student representative Ambassador Awards. These awards is supported by competitive funding; an on the management committee of are based on the students’ academic indication that the quality of students the Australian Research Council’s achievements and personal qualities. applying to the AIBN is of the highest Nanotechnology Network. The Institute also implemented two new order. Anthony Musumeci was awarded an initiatives with the long term goal of The 2007 round of the International Australian Institute of Nuclear Science attracting high quality local and interstate Postgraduate Research Scholarship and Engineering (AINSE) post graduate students to undertake research higher was remarkable in that six international award scholarship, providing extra degrees in the AIBN. students were able to join the AIBN fi nancial support throughout the duration The fi rst of these was the Winter under this program. These students of Anthony’s PhD. School, in which interstate students come from China, Scotland, USA, Jennifer Turner won the Open prize in were exposed to the breadth and Indonesia and Chile; highlighting the the 2007 UQ Trailblazer competition depth of AIBN research through a international nature of postgraduate for her presentation on her “Oxygen week long series of seminars and study, as well as the reach of AIBN and Concentration Cell Culture Diagnostic laboratory experiments. The Summer UQ into this global market. Device”. Internship was an eight week In addition, 18 students progressed Drew Titmarsh and James Hudson won opportunity for motivated and high from provisional to confi rmed PhD student prizes for their presentations achieving undergraduate students to candidates; a signifi cant milestone in on “CellChip – a high through-put gain valuable experience in a research PhD candidature in which students screening cell culture lab-on-a-chip” laboratory thereby supplementing their receive important formative advice about and “Engineered cardiac muscle patch undergraduate studies. Eleven students their progress toward the submission of for heart failure reversal/prevention” were hosted by seven AIBN groups for an assessable thesis in the appropriate respectively. this eight week program. timeframe. Annie Chen was awarded 50,000 yen AIBN is now looking to grow these The diligence with which AIBN’s current in competitive funding from the Young initiatives to ensure a steady fl ow of high student cohort pursued their studies Scientists and Students from Overseas in 2007 has also been recognised with Organisation to attend the Second quality and motivated students keen to further merit based scholarships and Japan-Australia Symposium and the undertake RHD studies at the Institute. awards. 60th Divisional Meeting on Colloid and In conclusion, 2007 should be Thomas Rufford was awarded an Interface Chemistry, of the Chemical remembered as a year of substantial Endeavour Research Fellowship to Society of Japan. growth in the Graduate Program and one undertake a four month research visit Yunyi Wong, Akshat Tanksale and in which several foundation stones for with Professor Hui-Ming Cheng’s Carl Urbani were awarded Australian continued successes were laid. Advanced Carbon Group at the Institute Academy of Technical Sciences and of Metals Research of the Chinese Engineering (ATSE) Young Science Professor Lars Nielsen Academy of Sciences. Additionally Ambassador and Young Nanotechnology AIBN POSTGRADUATE COORDINATOR

28 AIBN ANNUAL REPORT 07 STUDENT PROFILE

AIBN’s Warren Pilbrough is a rare Hamster Ovary cells (CHO) so that they Merck recognised the importance of breed of PhD student, he had secured can produce complex proteins, broadly the linkages with AIBN and Warren’s his fi rst post doctoral position prior to known as biopharmaceuticals, to be research potential. commencing his studies as the recipient used in the treatment of cancer. The benefi ts are obvious, Warren returns of a Merck Doctoral Study Program By improving cell growth, cell survival to Merck with a new skill set and fresh scholarship. and protein secretion, Warren hopes to ideas as a result of working in a leading The Program is an initiative by the global increase the amount of protein produced edge research facility, while AIBN gains pharmaceutical giant Merck, offering per millilitre of cells. This work underpins from the presence of an outstanding employees the opportunity to undertake the production of commercial quantities research student driving the project a research higher degree on a fraction of biopharmaceuticals. forward with extensive funding support. of their salary and then return to their A desire to reconnect with Australian Additionally AIBN recognises there are previous employment at the company. science after eight years working with potential long term relationships with Warren is the fi rst recipient of this Merck in the US coupled with a small Merck to be built on the back of having scholarship to undertake his PhD dose of homesickness proved to be the Warren undertake a productive PhD in Australia. catalyst for his application. at the Institute. This relationship will Working in the laboratory of AIBN The decision was relatively easy; hopefully contribute to the development Director Professor Peter Gray, Warren AIBN had the facilities, expertise and of collaborations and agreements is researching how to improve a strain the best people in the country to between the two parties for years of mammalian cells called Chinese support him during his project, while to come.

AIBN ANNUAL REPORT 07 29 30 AIBN ANNUAL REPORT 07 RESEARCH TRANSLATION AND COMMERCIALISATION

2007 FAST FACTS AIBN’s core commitment to research excellence is supported IP portfolio management by a strong culture of commercialisation and industrial linkages. > 11 new patent fi lings > 6 complete patent fi lings > 3 national phase entry fi lings A signifi cant emphasis is placed on Professor Andrew Whittaker is leading an > 3 granted patents achieving traditional commercialisation extensive, multi year, research program milestones such as patents, partnerships for Sematech, an international consortium Start-ups and start-ups, however AIBN’s research addressing the technical challenges in > Pepfactants Pty Ltd raised expertise and infrastructure capabilities semiconductor and emerging technology pre-seed investment from also provide an important bridge and development. Sematec members a syndicate investment by resource for local small to medium represent about half of the world’s UniSeed and Symbiosis Group enterprises, as well as major international semiconductor producers, and include > DendriMed Pty Ltd was formed companies. IBM, Intel and Hewlett Packard. > TenasiTech Pty Ltd was formed The Institute’s National Collaborative AIBN’s facilities and commercial focus Research Infrastructure Strategy (NCRIS) have also made AIBN a viable career facilities and expertise support the wider option for those moving from industry to Australian research community and are an academic research environment. The available to commercial organisations. AIBN has attracted several researchers This provides services and capabilities to who have left positions with leading companies in areas such as: national and multi-national companies to join AIBN. Additionally, the Institute’s > Bio-nanodevice fabrication commercially focussed research training > Mammalian protein expression and programs have been successful in purifi cation attracting students from industry. > Metabolomic fl ux analysis. AIBN’s research translation and In addition AIBN Group Leaders have commercialisation would not occur but signifi cant links with industry, engaged for the Institute’s research excellence, in contract research for companies such industry focus and dynamic research as Proctor and Gamble, Dow Benelux, environment. Australian Red Cross Blood Services, The sum of these features is a unique and Sematech to name a few. A recent research institute with industry relevance. example of these linkages is Professor Justin Cooper-White, who spent two Dr Craig Belcher months working with UniLever in AIBN, MANAGER OF INNOVATION England on advanced food formulation. AND COMMERCIAL DEVELOPMENT

AIBN ANNUAL REPORT 07 31 APPENDICES

32 AIBN ANNUAL REPORT 07 Research grants Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive Scheme Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive Type Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive Grant Income Commonwealth Competitive – DiscoveryProjects Australian Research Council – DiscoveryProjects Australian Research Council A/Professor Fund Inc Australian DentalResearch ARC QEIIFellowship Professor ARC FederationFellowship Professor ARC FederationFellowship Professor MaxLu ARC FederationFellowship – DiscoveryProjects Australian Research Council – DiscoveryProjects Australian Research Council – DiscoveryProjects Australian Research Council – DiscoveryProjects Australian Research Council – DiscoveryProjects Australian Research Council – DiscoveryProjects Australian Research Council – DiscoveryProjects Australian Research Council – DiscoveryProjects Australian Research Council – DiscoveryProjects Australian Research Council Julie Campbell Professor Michael Monteiro A/Professor Cooper-White Professor Justin Michael Monteiro Matt Trau Anton Middelberg Leader/Investigator AIBN Group Cooper-White Professor Justin Anton Middelberg Professor Mark Kendall Professor Anton Middelberg Professor rfso a uDrHelenCooper, Professor MaxLu Julie Campbell Professor Professor MaxLu Cooper-White Professor Justin Sean Smith Professor A/Professor William YoungA/Professor William Dr JosephRalphSmid, rAde vai Cytorefractometry –anew Dr Andrei Zvyagin Professor Percec Virgil Dr JoanneBlanchfi eld, 2007 Duration Project Title Other ChiefInvestigators A/Professor KerryLandman Dr Andrea O’Connor, Dr DavidLeavesley, Microfl uidic Studiesof Dr AnnetteDexter rfso ihe oet Micro-nanoprojectionfor patches Professor MichaelRoberts Dr Hwee-LinLua Dr SamuelPeterMickan, Mr ZhiXu Dr MichaelDoran Mr Tristan Croll, Professor SergeKaliaguine A/Professor JinZou, Dr LianzhouWang, Gareth HuwMcKinley R Davidson,Professor A/Professor Malcolm for AdvancedFuelCells Molecular Engineered Nanomaterials Scaffolds withAdultStemCells Combining NovelBiomimeticHybrid EngineeringtheMeniscus: Tissue with cysticfi brosis Enamel mineralizationinchildren Polymers withTargeted Properties Synthesis ofNanocomposite Throughput BiologicalScreening Nano-Scaled DevicesforHigh Beyond Microarrays: Bio-Inspired Products Engineering Nanostructured tomography oflivingcells technique forrefractive index Nanostructures Next GenerationPolymer scaffolds fortissueengineering Integrated functionalbiosynthetic Mastering theMicroenvironment – Stimuli-Responsive Emulsions technology platform to skincells:from conceptto delivery ofgenesanddrugs minimally-invasive andtargeted Manufactured Vaccines Viral Terahertz Spectroscopy ofMass- Active PeptidesandcDNAs Effective DeliveryofBiologically Hydroxide Nanoparticlesfor Tailoring ofLayered Double and oxidenanoparticles nanocomposites ofionicpolymers Charge-driven self-assemblyof Chromophores Molecules toProtein-Embedded Dynamics: from Isolated Quantum UnimolecularReaction synthesis inconfi ned geometries Newtonian fl ow andparticle Micro Process Plants–Non- AIBN ANNUAL REPORT 2003- 2007- 2004- 2004- 2003- 2004- 2006- 2005- 2007- 2007- 2007- 2005- 2007- 2005- 2007 2010 15,400 2007 2008 2008 2007 2007 2008 2007 2009 2009 2009 2007 2009 2009 Award $ 296,353 150,000 172,480 296,353 180,000 150,000 190,000 220,000 196,148 200,000 100,945 190,000 296,353 07 57,703 80,000 33

APPENDICES Research grants

Type Scheme AIBN Group Other Chief Investigators Project Title Duration 2007 Leader/Investigator Award $

Commonwealth Competitive Australian Research Council Professor Dr Gwendolyn Lawrie, Multiplexed Molecular Reading 2005- 50,000 Grant Income – Discovery Projects Matt Trau Professor Pamela A Silver of Protein Associations via 2007 Nanoscaled Devices

Commonwealth Competitive Australian Research Council Professor The Polymer Pharmaceutical/Drug 2007 230,000 Grant Income – Linkage Infrastructure Andrew Whittaker Characterisation and Processing Facility

Commonwealth Competitive Australian Research Council Professor A High Resolution Analytical 2007 388,000 Grant Income – Linkage Infrastructure John Drennan Scanning Electron Microscope for South-East Queensland

Commonwealth Competitive Australian Research Council A/Professor Professor Luc Averous, Functionable Renewable Plastics: 2007- 12,500 Grant Income – Linkage International Peter Halley Dr Darren Martin, Developing Novel Polysaccharide, 2009 A/Professor Bhesh Protein and Natural Polyester Bhandari, Dr Peter Torley, Based Polymer Nanocomposites A/Professor Eric Pollet

Commonwealth Competitive Australian Research Council Professor Dr Idriss Blakey, Development of Novel Detergents 2007- 14,000 Grant Income – Linkage International Andrew Whittaker Professor Steven Melvyn for Green Solvent Systems 2009 Howdle, Dr Kristofer and Their Self-Assembly into James Thurecht Nanostructures

Commonwealth Competitive Australian Research Council Professor A/Professor Bhesh The Molecular Mechanism of 2007- 169,500 Grant Income – Linkage Projects Andrew Whittaker Bhandari, Professor Mike Protein Instability in Dairy Powder 2010 Gidley, Dr Hilton Deeth Systems

Commonwealth Competitive Australian Research Council Professor Dr Idriss Blakey, Synthesis and Performance of 2006- 357,158 Grant Income – Linkage Projects Andrew Whittaker Dr David Hill, Professor Novel Polymer Resists for 193 nm 2008 Graeme Allan George, Immersion Lithography Dr John Stanley Forsythe, Mr Will Conley

Commonwealth Competitive Australian Research Council Professor Max Lu Nanostructured Magnesium-base 2006- 162,500 Grant Income – Linkage Projects Composites for High-density 2009 Hydrogen Storage

Commonwealth Competitive Australian Research Council Professor Dr Robyn Myra Minchinton, Ex vivo production of neutrophils 2006- 107,060 Grant Income – Linkage Projects Lars Nielsen Yoke Fung, 2008

Commonwealth Competitive Australian Research Council Professor Professor Justin Bioactive Polymers for Wound 2005- 146,182 Grant Income – Linkage Projects Andrew Whittaker Cooper-White, Healing Applications 2008 Dr Edeline Wentrup-Byrne, Dr Jos Malda

Commonwealth Competitive Australian Research Council Professor Max Lu Dr Zhonghua Zhu Hydrogen Production by 2005- 64,337 Grant Income – Linkage Projects Non-thermal Plasma Assisted 2009 Catalytic Pyrolysis of Natural Gas

Commonwealth Competitive Australian Research Council Professor Max Lu Dr Yinghe He, Nanostructured Magnesium-base 2005- 54,166 Grant Income – Linkage Projects Mr Xiangdong Yao Composites for High-density 2008 Hydrogen Storage

Commonwealth Competitive Australian Stem Cell Centre Professor Professor Lars Nielsen, Australian Stem Cell Centre 2006- 550,000 Grant Income Peter Gray Professor Justin Project Agreement Bioreactor 2008 Cooper-White Program

Commonwealth Competitive DEST International Science Professor Max Lu Fabrication of Qrganic and 2006- 11,000 Grant Income Linkages / Competitive Grants Inorganic Hybrid Materials Using 2007 Nano Core-shel Structures

Commonwealth Competitive DEST International Science Professor Vascular smooth muscle cell 2007 Grant Income Linkages / Competitive Grants Julie Campbell senescence and the effect of estrogen

Commonwealth Competitive DEST International Science Professor Anton Dr Hwee-Lin Lua, Bio-based Functional 2005- 141,510 Grant Income Linkages / French-Australian Middelberg Dr Waltraud Kaar Materials from Engineered 2008 Science & Technology (FAST) Self-Assembling Peptides (BASE) Program

Commonwealth Competitive Monash University Professor Professor Towards renal regeneration: 2003- 100,000 Grant Income Julie Campbell Gordon Campbell isolation, characterization and 2007 functional analysis of renal stem cells

Commonwealth Competitive NHMRC (Potential Avian Professor Anton Dr Marcus Niebert, Simplifi ed Process Methods for 2006- 22,000 Grant Income Infl uenza – induced pandemic) Middelberg Dr Hwee-Lin Lua Mass Vaccine Manufacture 2007

Commonwealth Competitive NHMRC Equipment Grant Professor Time-lapse and OptiGrid 2007 7834 Grant Income Julie Campbell Fluorescence Imaging Suite

34 AIBN ANNUAL REPORT 07 Type Scheme AIBN Group Other Chief Investigators Project Title Duration 2007 Leader/Investigator Award $

Commonwealth Competitive NHMRC Fellowship Grant Professor Senior Principal Research 2006- 144,250 Grant Income Julie Campbell Fellowship 2010

Commonwealth Competitive NHMRC Project Grant Professor Professor David Craik Bioengineering of cyclotides with 2006- 175,000 Grant Income (All Project Grants) Julie Campbell angiogenic properties 2008

Commonwealth Competitive NHMRC Project Grant Professor Dr Barbara Rolfe, Origin of cells in the ‘artifi cial’ 2005- 160,500 Grant Income (All Project Grants) Julie Campbell Professor Gordon artery grown in the peritoneal 2007 Campbell cavity

Commonwealth Competitive NHMRC Project Grant Professor Dr Sarah Waters, MPM non-invasive imaging of 2007- 137,750 Grant Income (All Project Grants) Mark Kendall Professor Ian Frazer biological interactions following drug 2009 delivery with micro-nanoprojection patches APPENDICES

Commonwealth Competitive University of Melbourne A/Professor Dr K M Abberton, Characterization and Optimisation 2005- 53,000 Grant Income Peter Halley Dr Aurora Messina, of Myomatrix: A Novel Extracellular 2007 Professor Erik Walter Matrix Hydrogel From Muscle Thompson, Dr Wayne A Morrison

Other National and Novozymes Biopolymer A/S Professor Optimization of hyaluronic acid 2007- 8780 International Grant Income Lars Nielsen production by fermentation of the 2008 strain streptococcus Equi

Other National and Australian Institute Nuclear A/Professor Radiolabelling of industrially- 2007 15,750 International Grant Income Science & Engineering Peter Halley relevant nanoparticles for use in nanotoxicology investigations

Other National and Australian Institute Nuclear Dr Darren Martin Mr Anthony Musumeci Tailored nanoparticles for 2007 7150 International Grant Income Science & Engineering nanotoxicological studies

Other National and Centre for Low Emission Professor Max Lu A/Professor Joao Diniz da Proof-of-Concept Engineering 2005- 110,000 International Grant Income Technology Costa, Dr Mikel Duke, Systems for Membranes and 2009 Dr Jorge Beltramini, Catalytic Membrane Reactors Dr Michael Macrossan (CMR) in Coal Gasifi cation. (cLET project).

Other National and CRC for Sugar Industry Professor Dr Stevens Brumbley The Production of PHB/PHAs in 2006- 737,042 International Grant Income Innovation through Lars Nielsen Plants 2007 Biotechnology

Other National and CRC for Sugar Industry Professor Use of endogenous bacteriocins 2006- 259,600 International Grant Income Innovation through Lars Nielsen to manipulate the rumen microbial 2008 Biotechnology ecology

Other National and CRC for Sugar Industry Professor Mr Peter Abeydeera Microbial Metabolic Engineering 2006- 111,375 International Grant Income Innovation through Lars Nielsen 2010 Biotechnology

Other National and CSIRO Flagships Professor Max Lu Dr Lianzhou Wang, Flagship Collaboration Research 2007- 57,457 International Grant Income Collaboration Fund A/Professor Joao Diniz Fund: Advanced Membrane 2010 da Costa Technologies for Water Treatment

Other National and Dow Benelux B.V. Professor Bio-based Functional 2005- 25,000 International Grant Income Anton Middelberg Materials from Engineered 2007 Self-Assembling Peptides

Other National and Queensland Government Professor Dr Firas Rasoul, International Biomaterials 2007- 33,500 International Grant Income Smart State National and Andrew Whittaker Dr Anne Symons, Research Alliance 2011 International Research Dr Craig Jon Hawker, Alliances Program Professor Karen Lynn Wooley, Professor Julie Campbell, Professor Traian Chirila, Professor David M Haddleton, A/Professor Stephen Rose, Professor Steven Melvyn Howdle

Other National and Queensland Government Professor Professor Leland (Lee) Novel Nanotechnology Platforms 2007- 357,500 International Grant Income Smart State National and Matt Trau Hartwell, Professor for Disease Biomarker Diagnostics 2010 International Research Kenneth D Stuart, Alliances Program Professor Nancy B Kiviat

Other National and Unilever UK Central Professor Justin Continuous manufacturing 2005- 50,442 International Grant Income Resources Limited Cooper-White processes for encapsulation 2007

AIBN ANNUAL REPORT 07 35 AIBN journal publications

* Authors as listed on publication

1. Prime, E.L., Hamid, Z.A.A., Cooper-White, 11. Russo, Melissa A L, Strounina, Ekaterina, Justin J, Qiao, G.G. (2007) Addition of Waret, Muriel, Nicholson, Timothy, Truss, Biological Functionality to Poly (-caprolactone) Rowan W, Halley, Peter J (2007) A study of Films, Biomacromolecules 8 2416–2421 water diffusion into a high-amylose starch blend: The effect of moisture content and 2. Wanno, B. Du, Aijun, Ruangpornvisuti, temperature. Biomacromolecules 8(1) V., Smith, Sean (2007), Addition of 296–301 diazomethane to armchair single- walled carbon nanotubes and reaction 12. Pantelic, Radosav S, Ericksson, Geoffery sequences: A computational study. B, Hamilton, Nicholas A, Hankamer, Chemical Physics Letters 436 218–223 Benjamin (2007), Bilateral edge fi lter: Photometrically weighted, discontinuity 3. Walewijk, A., Cooper-White, Justin based edge detection. Journal of Structural J, Dunstan, D.E. (2007) Adhesion Biology 160(1) 93–102 measurements between alginate gel surfaces via texture analysis, Food 13. Liu, Shaomin, Liu, L, Xu, Gordon, Yu, Hydrocolloids 22(1) 91–96 Aimin, Lu, Max, Diniz Da Costa, Joao C (2007) Bioceramic macrocapsules for cell 4. Vashi, A.V., Keramidaris, E., Abberton, immunoisolation. Angewandte Chemie- K.M., Morrison, W.A., Wilson, J.L., international Edition 46(17) 3062–3065 O’connor, A.J., Cooper-White, Justin J, Thompson, E.W. (2007) Adipose 14. Chirila, Traian V, Zainuddin, Zainuddin, differentiation of bone marrow-derived (2007), Calcifi cation of synthetic polymers mesenchymal stem cells using Pluronic functionalized with negatively ionizable F-127 hydrogel in vitro. Biomaterials 29(5) groups: A critical review. Reactive & 573–579 Functional Polymers 67(3) 165–172 5. Tang, Y.B., Liu, T.Q., Sun, Chenghua, 15. Ng, P.F., Li, Li, Wang, S.B., Zhu, John, Lu, Cong, H.T. (2007) AIN nanowire for Max, Yan, Z.F. (2007) Catalytic ammonia AI-based composites with high strength decomposition over industrial-waste- and low thermal expansion. Journal of supported Ru catalysts. Environmental Material Research, 22 2711–2718 Science & Technology 41(10) 3758–3762 6. Tan, Ihwa, Flanagan, Bernadine M, Halley, 16. Li, Li, Zhu, John, Yan, Z.F., Lu, Max, Rintoul, Peter J, Whittaker, Andrew K, Gidley, Mike L (2007) Catalytic ammonia decomposition (2007) A method for estimating the nature over Ru/carbon catalysts: The importance and relative proportions of amorphous, of the structure of carbon support. Applied single, and double-helical components in Catalysis A-general,320 166–172 starch granules by 13C CP/MAS NMR. 17. Hall, Geoffrey C, Stenzel, M.H., Davis, T.P., Biomacromolecules 8(3) 885–891 Barner-Kowollik, C., Monteiro, Michael J. 7. Lubansky, A.S., Boger, D.V., Servais, C., (2007) Chain length dependent termination Burbidge, A.S., Cooper-White, Justin J rate coeffi cients of methyl methacrylate (2007) An approximate solution to fl ow (MMA) in the gel regime: Accessing k(t)(i,i) through a contraction for high Trouton ratio using reversible addition-fragmentation fl uids, Journal of Non-Newtonian Fluid chain transfer (RAFT) polymerization. Mechanics 144(2–3) 87–97 Macromolecules 40(8) 2730–2736 8. Hu, Qiuhong, Xu, Gordon, Qiao, Shizhang, 18. Jack, Kevin S, Vizcarra, T.G., Trau, Matt Haghseresht, F, Wilson, M, Lu, Max, (2007) Characterization and surface (2007), A novel color removal adsorbent properties of amino-acid-modifi ed, from heterocoagulation of cationic and carbonate-containing hydroxyapatite anionic clays. Journal of Colloid And particles. Langmuir 23(24) 12233–12242 Interface Science 308(1) 191–199 19. Kim, J-T., Martin, Darren J, Halley, Peter J, 9. Harvie, D.J.E., Davidson, M.R., Kim, D.S. (2007) Chemorheological studies Cooper-White, Justin J, Rudman, M., on a thermoset PU/clay nanocomposite (2007) A parametric study of droplet system. Composite Interfaces 14(5–6) deformation through a microfl uidic 449–465 contraction: Shear thinning liquids, 20. Tan, Ihwa, Torley, Peter, Halley, Peter J International Journal of Multiphase Flow (2007) Combined rheological and optical 33(5) 545–556 investigation of maize, barley and wheat 10. Battad, J.M., Wilmann, P.G., Olsen, Seth, starch gelatinisation, Carbohydrates Byres, E., Smith, Sean, Dove, Sophie, Polymers 72(2) 272–286 Turcic, K.N., Devenish, R.J., Rossjohn, J., 21. Ye, F., Mori, Toshiyuki, Ou, D.R., Zou, Prescott, M. (2007) A structural basis for Jin, Auchterlonie, Graeme J, Drennan, the pH-dependent increase in fl uorescence John (2007) Compositional and valent effi ciency of chromoproteins. Journal of state inhomogeneities and ordering of Molecular Biology, 368(4) 998–1010 oxygen vacancies in terbium-doped ceria. Journal of Applied Physics, 101(11) Article: 113528–Article: 113528

36 AIBN ANNUAL REPORT 07 23. Nguyen, Q.,Wang, Liguang,Lu, 22. Prime, E.,Cooper-White, JustinJ, 31. Yu, J.J.,Wang, X.P., Tao, Y.X., Hao, 30. Altmann, Nara,Halley, PeterJ.,Nicholson, 29. Campbell, Gordon R.,Campbell,JulieH. 28. Brumbley, Matthew StevensM.,Purnell, 27. Takahashi, M.,Mori,Toshiyuki, Ye, F., Vinu, 26. Lonsdale, DariaE.,Hall,Geoffrey C., 25. Chu, T.S., Han,K.L.,Hankel,Marlies, 24. Olsen, Seth,Riesz,Jenny, Mahadevan, Journal ofNanotechnology electrochemical behaviour, electrodeposition ofcobaltfi lms andtheir Max (2007)Controllable cathodic 1272–1279 fi lms. and poly[(lacticacid)-co-(glycolicacid)] bioactive groups topoly(lacticacid) Qiao, G.G.(2007)Conjugationof Chemistry Research Chemistry double hydroxides. over mixedoxidesderivedfrom layered decomposition andstorage/reduction Z.P., Xu, Gordon (2007)Effective NOx Rheology Journal Monte Carlosimulation. (2007) Dynamicpercolation grid Timothy Biotechnology vascular grafts (2007) Developmentoftissueengineered 109 (1297)5–15 biomaterials. sugarcane biofactoryforhigh-value K., Twine, P.H. (2007)Developingthe P., Petrasovits,LarsA.,Nielsen, 90(4) 1291–1294 Journal oftheAmericanCeramicSociety direct methanolfuelcellapplication. anodes supportedbycarbonblackfor Design ofhigh-qualityPt-CeO2composite A., Kobayashi,H.,Drennan, John(2007) 45(16) 3620–3625 Polymer SciencePartA-polymerChemistry using tolueneassolvent. transfer invinylacetatepolymerizations Michael J.(2007)Degradativechain Carl N.,Whittaker, MichaelR.,Monteiro, Fawcett, Amanda,Bell,CraigA.,Urbani, Physics the H+D-2reaction. integral anddifferential cross sectionsfor effects inthecalculationofstate-to-state Balint-Kurti, G.G.(2007)Corioliscoupling 6672–6673 American ChemicalSociety Symmetry inaKeyMelaninMonomer. Mirror-imagePhotocycles Violate Paul (2007)ConvergentProton-transfer Ross H.,Smith,SeanC.,Meredith, Jacques P., Powell,BenjaminJ.,Mckenzie, Indumathy, Coutts,Aaron M.,Bothma, Macromolecular Bioscience 126(21)214303-1–214303-9 International SugarJournal 8(1) 43–50 Current Pharmaceutical 19(1) 7–16 Industrial &Engineering Journal ofChemical 46(17) 5794–5797 Korea-Australia Journal of 4(5)588–596 International 129(21) 7(12)

35. Chirila, Traian V., HillA.,RichensD.(2007) 40. Rospigliosi, A.,Ehlich,R.,Hoerber, H., 39. Glushenkov, A.M.,Zhang,H.Z.,Lu, 38. Konik-Rose, C.,Thistleton,J.,Chanvrier, 37. Sun, C.H.,Yao, D.,Lu,Max,Cheng,H.M. 36. Takagi, H.,Soneda,Y., Hatori,H.,Zhu, 34. Martens, P., Blundo,J.,Nilasaroya, 33. Chirila, Traian V., Zainuddin, 32. Jayasooriya, SriyaniD.,Torley, Peter, 41. Cho, Y.H., Cho,P.S., Auchterlonie,Graeme Australian Journal of Chemistry Australian JournalofChemistry (2-Hydroxyethyl Methacrylate)Hydrogels. the UptakeofCalciumPhosphateinPoly Effect ofRedundantChainPackingon 2641–2648 DNA SAMs. (2007) Electron transferofplurimodifi ed Middelberg, AntonP.J., Moggridge,G. Nanotechnology ball millingandannealingmethod. production ofZnOnanowires bya Max, Chen,Y., Zou,Jin(2007)Effi cient 115(8) 1053–1065 of wheat on grain,protein andstarch inendosperm Effects ofstarch synthaseIIagenedosage Rahman, S.,Morell, M.,Li,Z.Y. (2007) O., Ikea,J.,Mcmaugh,S.,Regina,A., Kosar-Hashemi, B.,Wang, H.,Larroque, H., Tan, Ihwa,Halley, PeterJ.,Gidley, Mike, 434(1–3) 160–164 corannulene. of hyperhomodesmoticreactions for nonplanar strainenergyonthereliability (2007) Effects ofresonance energyand 60(7) 519–523 nanotubes. adsorption ofsingle-walledcarbon acid andheattreatment onhydrogen John, Lu,Max(2007)Effects ofnitric properties. chain interactionsonhydrogel mechanical poly(vinyl alcohol)macromer chemistryand J., Poole-Warren, L.A.(2007)Effect of A., Odell,R.A.,Cooper-White, Justin Biomaterialia capacity ofacrylichydrogels. functional groups onthecalcifi cation Kemp, AnneR.(2007)Effect ofphosphate Hill, DavidJ.T., Whittaker, Andrew K., Meat Science Semitendinosus andLongissimusmuscles. ageing onthephysicalproperties ofbovine (2007) Effect ofhighpowerultrasoundand D’arcy, BruceR.,Bhandari,BheshR. 55(14) 4807–4815 resistive siliceousphase. doped ceriabythescavengingofhighly grain-boundary conductioningadolinia- H., Drennan, John(2007)Enhancementof J., Kim,D.K.,Lee,J.H.,D.Y., Park, Theoretical AndAppliedGenetics Chemistry ofMaterials Chemistry Australian Journal of Chemistry Australian JournalofChemistry Langmuir 3(1) 95–102 Chemical PhysicsLetters 75(4) 628–639 18(17) 175604–175609 23(15) 8264–8271 ACTA Materialia Acta 60 439–443 19(10) 48. Zhao, M.W., Zhu,John,Gale,J.D.,Xia, 46. Mckinley, G.H.,Rodd,L.E.,Oliveria, 47. Li, L.D.,Shen,Q.,Yu, J.J.,Hao,Z.P., Xu, 43. Sopade, PeterA.,Xun,P.Y., Halley, Peter 42. Xu, Gordon, Nyoman Kurniawan, 49. Du, Aijun,Smith,Sean,Lu,Max(2007) 44. Sun, C.H.,Chen,Y.N., Lu,Max,Cheng, 45. Ou, D.R.,Mori,Toshiyuki, Ye, F., Zou, 51. Vogel, Robert,Surawski,PeterPT., 50. Du, Aijun,Smith,Sean,Lu,Max(2007) 52. Du, Aijun,Smith,Sean,Lu,Max(2007) Physical Chemistry C Physical Chemistry monolayers andnanorings. of well-ordered silicananotubesfrom silica Y.Y., Lu,Max(2007)First-principlesdesign Technology University ofTechnology geometries. in microfl uidic converging/diverging Extensional fl ows ofpolymersolutions M., COOPER-WHITE,JustinJ.(2007) nitrous oxide. catalyst foreffective decompositionof Gordon, Lu,Max.(2007)Fe-USYzeolite Journal ofFoodEngineering models forwaterabsorptioninfood. of thePeleg,PilosofandSingh-Kulshrestha J., Hardin, MatthewT. (2007)Equivalence 2824–2830 EuropeanJournal Chemistry–A layered doublehydroxide nanoparticles. DTPA complexesbyintercalation into Enhancement ofrelaxivity ratesofGd- D., Bartlett,Perry, Lu,Max.(2007) Letters nitride nanoribbon. structure andC-dopingeffect inboron First-principle studiesofelectronic centered motifs. of formationfullerenes usingpentagon- H.M. (2007)Estimationofstandard heats Chemistry C Chemistry Solid StateLetters yttrium-doped ceria. segregation ofdopantcationsinheavily John (2007)Evidenceofintragranular Jin, Auchterlonie,GraemeJ.,Drennan, Chemistry C Chemistry Interface Science controllable size. organosilica micro- andnanoparticleswith Bronwyn J.,Trau, Matt.(2007)Flourescent B., Lawrie,GwendolynA.,Battersby, Littleton, BradleyN.,Miller, Christopher magnesium hydride. and diffusion ofhydrogen vacanciesin First-principle studiesoftheformation 3354 calculations. nanoribbons: Abinitiodensityfunctional nanotube viatheinteractionofgraphene Formation ofsingle-walledcarbon 447(4-6) 181–186 41(22) 7901–7906 Journal ofCentralSouth Nano Letters 111(50) 18503–18506 111(23) 8360–8365 Environmental Science& AIBN Journal ofPhysical Journal ofColloidand 310(1) 144–150 10(1) 1–3 Chemical Physics Electrochemical and Journal ofPhysical 111(27) 9652–9657 ANNUAL REPORT 14(1) 6–9 7(11) 3349– Journal of 78 730–734 13(10) 07 37

APPENDICES 53. Whittaker, Michael R., Urbani, Carl N., 66. Lu, Max, Diniz Da Costa, Joao C., Monteiro, Michael J. (2007) Formation of Duke, M., Giessler, S., Socolow, R., tethered polyacrylic acid loops in core-shell Williams, R.H., Kreutz, T. (2007) Inorganic micelles. Langmuir 23(15) 7887–7890 membranes for hydrogen production and purifi cation: A critical review and 54. Liu, Shaomin, Liu, M., Shao, Z., Diniz Da perspective. Journal of Colloid and Costa, Joao C., Xu, Gordon (2007) From Interface Science 314(2) 589–603 chelating precursor to perovskite oxides and hollow fi ber membranes. Journal of The 67. Lawrie, Gwendolyn A., Keen, Imelda, American Ceramic Society 90(1) 84–91 Drew, Barry, Chandler-Temple, Adrienne F., Rintoul, L., Fredericks, P., Grondahl, 55. Rowlands, Andrew, Hudson, James E., Lisbeth (2007) Interactions between Cooper-White, Justin J. (2007) From scrawny alginate and chitosan biopolymers to brawny: the quest for neomusculogenesis; characterized using FTIR and XPS. smart surfaces and scaffolds for muscle Biomacromolecules 8(8) 2533–2541 tissue engineering. Expert Review of Medical Devices 4(5) 709–728 68. Keen, Imelda, Raggatt, Liza-Jane, Cool, Simon M., Nurcombe, Victor, Fredericks, 56. Yin, L.C., Wang, P., Kang, X.D., Sun, P., Trau, Matt, Grondahl, Lisbeth (2007) Chenghua, Cheng, H.M. (2007) Functional Investigations into poly(3-hydroxybutyrate- anion concept: effect of fl uorine anion co-3-hydroxyvalerate) surface properties on hydrogen storage of sodium alanate. causing delayed osteoblast growth. Physical chemistry chemical physics 9(1) Journal of Biomaterials Science-polymer 1499–1502 Edition 18(9) 1101–1123 57. Sopade, Peter A., Lee, S.B., White, Edward 69. Styan, K.E., Martin, Darren J, Poole- T., Halley, Peter J. (2007) Glass transition Warren, L.A. (2007) In vitro fi broblast phenomena in molasses. LWT–Food response to polyurethane organosilicate Science and Technology 40(6) 1117–1122 nanocomposites. Journal of Biomedical 58. Zeng, Q.H., Jiang, X.C., Yu, A.B. Lu, Materials Research Part A 1–11 Max (2007) Growth mechanisms of silver 70. Ye, F., Mori, Toshiyuki, Ou, D.R., Takahashi, nanoparticles: a molecular dynamics study. Marissa, Zou, Jin, Drennan, John (2007) Nanotechnology 18(3) 035708–035714 Ionic conductivities and microstructures 59. Chen, Z.G., Chen, Zhongxin, Zou, Jin, Li, of ytterbium-doped ceria. Journal of The F., Liu, G., Tang, D.M., Li, D., Liu, C., Ma, Electrochemical Society 154(2) B180–B185 X.L., Cheng, H.M., Lu, Max, Zhang, Z.D. 71. Hall, Geoffrey C., Monteiro, Michael J. (2007) (2007) Growth of magnetic yard-glass Kinetic modeling of “living” and conventional shaped boron nitride nanotubes with free radical polymerizations of methyl periodic iron nanoparticles. Advanced methacrylate in dilute and gel regimes. Functional Materials 17(16) 3371–3376 Macromolecules 40(20) 7171–7179 60. Chen, Y., Liu, C.G., Liu, C., Lu, Max, 72. Monteiro, Michael J., Guliashvili,T., Cheng, H.M. (2007) Growth of single- Percec,V. (2007) Kinetic simulation of crystal alpha-MnO2 nanorods on single electron transfer-living radical multi-walled carbon nanotubes. Materials polymerisation of methyl acrylate at 25C. Research Bulletin 42(11) 1935–1941 Journal of Polymer Science Part A-polymer 61. Tang, J.W., Zhou, X.F., Zhao, D.Y., Lu, Chemistry 45(10) 1835–1847 Max, Zou, Jin, Yu, Chengzhong (2007). 73. Xu, Gordon, Walker, Tara L., Liu, K.-L., Hard-sphere packing and icosahedral Cooper, Helen, Lu, Max, Bartlett, Perry assembly in the formation of mesoporous (2007) Layered double hydroxide materials. Journal of The American nanoparticles as cellular delivery vectors Chemical Society 129(29) 9044–9048 of supercoiled plasmid DNA. International 62. Du, Aijun, Smith, Sean, Yao, Xiangdong, Journal of Nanomedicine 2(2) 163–174 Lu, Max (2007) Hydrogen spillover 74. Blakey, Idriss, George, G.A., Hill, David J mechanism on a Pd-doped Mg surface T., Liu, Heping, Rasoul, Firas, Zimmerman, as revealed by ab initio density functional P.A., Whittaker, Andrew K. (2007) calculation. Journal of The American Mechanism of 157 nm photodegradation Chemical Society 129(33) 10201–10204 of poly[4,5-difl uoro-2,2-bis(trifl uoromethyl)- 63. Jin, Yonggang, Qiao, Shizhang, Diniz Da 1,3-dioxole-co-tetrafl uorethylene] (Tefl on Costa, Joao C., Wood, Barry J., Ladewig, AF). Macromolecules 40(25) 8954–8961 Bradley P., Lu, Max (2007) Hydrolytically 75. Yao, Xiangdong, Wu, C., Du, Aijun, Zou, stable phosphorylated hybrid silicas for Jin, Zhu, John, Wang, P., Cheng, H., proton conduction. Advanced Functional Smith, Sean, Lu, Max. (2007) Metallic Materials 17(16) 3304–3311 and carbon nanotube-catalyzed coupling 64. Hawkins, John C., Mahony, Donna, of hydrogenation in magnesium. Journal Maetschke, Stefan, Wakabayashi, Mark, of The American Chemical Society 129 Teasdale, Rohan D., Boden, Mikael B. 15650–15654 (2007) Identifying novel peroxisomal 76. Ye, F., Mori, Toshiyuki, Ou, D.R., Zou, proteins. Proteins: Structure Function and Jin, Drennan, John (2007) Microstructural Bioinformatics 69(3) 606–616 characterization of terbium-doped 65. Finnigan, Bradley P., Casey, P., Cookson, ceria. Materials Research Bulletin. 42 (5) D., Halley, Peter J., Jack, Kevin S., 943–949 Truss, Rowan W., Martin, Darren J. 77. Ou, D. R., Mori, T., Ye, F., Zou, Jin, (2007) Impact of controlled particle size Auchterlonie, Graeme J., Drennan, John nanofi llers on the mechanical properties of (2007) Microstructural inhomogeneity in segmented polyurethane nanocomposites. holmium-doped ceria and its infl uence International Journal of Nanotechnology on the ionic conduction. Journal of The 4(5) 496–515 Electrochemical Society 154(7) B616–B622

38 AIBN ANNUAL REPORT 07 89. Gemici, H.,Legge,T.M., Whittaker, Michael 88. Battersby, Bronwyn J.,Trau, Matt(2007) 87. Li, L.D.,Yu, J.J.,Hao,Z.P., Xu,Gordon. 86. Yu, J.J.,Tao, Y.X., Liu,C.C.,Hao,Z.P., 85. Yu, J.H.,Wang, X.P., Li,L.D.,Hao, 84. Zhang, H.L.,Sun,Chenghua,Li,F., Liu,C., 83. LIU, Shaomin,XU,Gordon, YU,Aimin,Su, 82. Ladewig, BradleyP., Knott,R.B., 81. Sopade, PeterA.,Liang,Siqi,Halley, Peter 80. Zhang, Hong,Smith,Sean(2007)Model 79. Kim, D.K.,Cho,P.S., Lee,J.H.,Kim,D.Y., 78. Zainuddin, Hill,DavidJT., 2334–2340 Science PartA-polymerChemistry transfer polymerization. via reversible addition-fragmentationchain Original approach tomultiblockcopolymers R., Monteiro, MichaelJ.,Perrier, S.(2007) 60(5) 343–353 assays. applications inmultiplexedbiomedical Optically encodedparticlesandtheir 10552–10559 C Journal ofPhysicalChemistry storage/decomposition/reduction from hydrotalcite-like compoundforNO (2007) NovelRu-Mg-Al-Ocatalystderived 1399–1404 Environmental Science&Technology Mn, Zr, La) hydrotalcite-like compounds. catalysts derivedfrom Co-Mg/X-Al(X=Fe, Xu, Gordon. (2007)NovelNOtrapping 17(17) 3598–3606 reduction. effective NOxcapture, decomposition,and multi-functional mixed-oxidecatalystsfor Z.P., Xu,Gordon, Lu,Max(2007)Novel 4740–4748 C Journal ofPhysicalChemistry anode materialforlithiumionbatteries. carbonate-based electrolytes andgraphite into theinteractionbetweenpropylene Tan, J.,Cheng,H.M.(2007)Newinsight Structures nano-optical tags. specially designedtransparent chipswith H., Liu,L.(2007)Newbiosensorsmadeof Communications methanol permeability. nanocomposite membraneswithlow C, Lu,Max.(2007)Nafi on-MPMDMS Martin, Darren J,DinizDa Costa, Joao 224(5) 555–560 European FoodResearchandTechnology management ofswallowingdysfunctions. of foodthickenersusedforthe (2007) Moisture absorptioncharacteristics J., Cichero, JulieAY., Ward, LeighC. computational chemistry protein (GFP). of proton transferinthegreen fl uorescent real-time quantumdynamicalsimulations 10(5) B91–B95 Electrochemical andSolidStateLetters doped ceriabytheadditionofSrO. resistive grain-boundaryphaseingadolinia- Drennan, John.(2007)Mitigationofhighly Park, H.M.,Auchterlonie,GraemeJ., 83A(2) 354–361 of BiomedicalMaterialsResearchPartA polyvinyl pyrrolidone hydrogels. of radiation-crosslinked polyvinylalcohol/ Whittaker, Andrew K.(2007)Mineralization Australian Journal of Chemistry Australian JournalofChemistry Advanced FunctionalMaterials 16(6) 2214–2221 Journal oftheoreticaland 9(4) 781–786 Smart Materialsand Electrochemistry Electrochemistry Journal ofPolymer 6(4) 789–802 Journal 111(28) 111(1) 45(11) 41(4) The 90. Ladewig, BradleyP., Knott,R.B.,Hill, 92. Rowlands, StevenA.,Lim,SueMartin, 91. Cool, SimonM.,Kenny, BryanM.,Wu, 100. Whittaker, Andrew K.,Blakey, Idriss, 99. Olsen, Seth,Smith,Sean.(2007) 98. Jin, Yonggang, DinizDaCosta,Joao 97. Hogarth, Warren H.J.,Muir, SeanS., 96. Dai, Yu, Yuan, Zhiguo,Ku,JackJ.,Keller, 95. MatthewP.,Petrasovits, LarsA.,Purnell, 94. Zainuddin, Hill,DavidJT., 93. Song, Jiangning,Yuan, Zheng,Tan, H., induced phaseseparation. composite scaffolds fabricatedbythermally Polyurethane/poly(lactic-co-glycolic) acid Darren J.,Cooper-White, JustinJ.(2007) 82A(3) 599–610 Biomedical MaterialsResearchPartA proinflresponse. ammatory and resorption, andmacrophage proliferation, osteoclastadhesion performance assessedbyosteoblast for bonetissueregeneration: Invitro hydroxyvalerate) compositebiomaterials (2007) Poly(3-hydroxybutyrate-co-3- Cassady, AlanIan,Grondahl, Lisbeth Andy, Nurcombe, Victor, Trau, Matt, 2372–2381 silicon oxide. membranes ofNafi on andfunctionalized characterization ofnanocomposite Max (2007)Physicalandelectrochemical Darren J.,DinizDaCosta,JoaoC.,Lu, A.J., Riches,J.D.,White,J.W., Martin, 129(7) 2054–2065 Journal ofTheAmericanChemicalSociety intramolecular charge-transferstates. protein chromophore modelsviatwisted Radiationless decayofred fl uorescent 178(13-14) 937–942 and polyvinylalcohol. composite membraneofphosphosilicate C., Lu,Max.(2007)Proton conductive Ionics sol-gel titaniumphosphates. conduction mechanismandthestabilityof C., Drennan, John,Lu,Max.(2007)Proton Whittaker, Andrew K.,DinizDaCosta,Joao biotechnology Acetate asSoleCarbonSource. Glycogen AccumulatingOrganismsUsing (3-hydroxyalkanoates) Copolymersby Jurg. (2007)Production of Targeted Poly 5(1) 162–172 in sugarcane. (2007) Production ofpolyhydroxybutyrate Nielsen, LarsK.,Brumbley, StevensM. Medicine Journal ofMaterialsScience-materialsIn hydroxyethyl methacrylate)hydrogels. interactions ofcalciumionsinpoly(2- K., Chirila,Traian V. (2007)Preferential Whittaker, Andrew K.,Lambert,Lynette Bioinformatics feature vectorsandsecondarystructure. protein sequenceusingmultiple Predicting disulfi de connectivityfrom Huber, ThomasL.,Burrage,Kevin(2007) 28(12) 2109–2121 20(5) 665–671 of PhotopolymerScienceandTechnology for 193nmimmersionlithography. (2007) Rationaldesignofhigh-RIresists Heping, Conley, W., Zimmerman,P.A. Chen, Lan,Dargaville,Bronwin L.,Liu, 177(39-40) 3389–3394 18(6) 1141–1149 Chemistry ofMaterials Chemistry Plant BiotechnologyJournal 129(3) 489–497 23(23) 3147–3154 Solid StateIonics Biomaterials Journal of Solid State Journal of Journal 19(9) 101. Urbani, CarlN.,Bell,CraigA.,Lonsdale, 111. MatthewP.,Purnell, Petrasovits,LarsA., 110. Chirila, Traian V., Barnard Z.,Zainuddin, 109. Yang, S.,Zhou,X.F., Yuan, P., Yu, 108. Smart, SimonK.,Ren,W.C., Cheng, 107. Merican, Zul,Schiller, T.L., Hawker, C.J., 106. Rodd, L.E.,Cooper-White, JustinJ, 105. Du, Aijun,Smith,Sean,Yao, Xiangdong, 103. Sopade, PeterA.,Halley, PeterJ., 104. Sopade, PeterA.,Halley, PeterJ., 102. Seet, Katrina,Vogel, Robert,Nieminen, Macromolecules dendrimers viathe“click”reaction. and purityofnovelpolymericstars azide solidsupportstoincrease yield Michael J.(2007)Reactivealkyneand Daria E.,Whittaker, MichaelR.,Monteiro, 5(1) 173–184 sugarcane. of polyhydroxybutyrate accumulationin (2007) Spatio-temporalcharacterization Nielsen, LarsK.,Brumbley, StevensM. 561–565 1549–1552 proliferation. substratum forcellattachmentand Zainuddin, HarkinD.(2007)Silkas 46(45) 8579–8582 Angewandte Chemie-internationalEdition compromised dual-templatingapproach. C.Z. (2007)Siliceousnanopodsfrom a M.H., Xie,S.G.,Zou,Jin,Lu,Max,Yu, 4(5) 618–633 International JournalofNanotechnology nanotubes byhigh-energyballmilling. Shortened double-walledcarbon H.M., Lu,Max,Martin,Darren J.(2007) Langmuir enhanced Ramanreporter molecules. stabilized goldnanoparticleswithsurface- Self-assembly andencodingofpolymer- Fredericks, P.M., Blakey, Idriss(2007) 143(2–3) 170–191 of Non-NewtonianFluidMechanics fabricated contractiongeometries. of dilutepolymersolutionsinmicro- of theelasticitynumberinentryfl ow Boger, D.V., Mckinley, G.H.(2007)Role C initio study kinetics onaLiBH4(010)surface:Anab in acceleratingthedehydrogenation Lu, Max(2007)Roleoflithiumvacancies Food Engineering juice asadispersingmedium. the managementofdysphagia.III.Fruit marketed inAustraliavariousmediafor characterisation offoodthickeners J., Subashini,Varlivell (2007)Rheological Cichero, JulieA.Y., Ward, LeighC.,Liu, 46(9) 1554–1561 Engineering as adispersingmedium. the managementofdysphagia.II.Milk marketed inAustraliavariousmediafor characterisation offoodthickeners Hui, L.S.,Teo, K.H.(2007)Rheological Cichero, JulieA.Y., Ward, LeighC., organosilica microspheres. Andrei V. (2007)Refractometryof Dunlop, Halina,Trau, Matt,Zvyagin, A.,Knoener,Timo Gregor, Rubinsztein- 111(32) 12124–12128 23 10539–10545 Journal of Physical Chemistry Journal ofPhysicalChemistry Plant BiotechnologyJournal 84(4) 553–562 Materials ScienceForum AIBN 40(19) 7056–7059 84(4) 553–562 ANNUAL REPORT Journal ofFood Applied Optics Journal of Journal 07 39

APPENDICES 112. Hankel, Marlies, Smith, Sean, Meijer, 123. Du, Aijun, Smith, Sean, Lu, Max (2007) A.J.H.M. (2007) State-to-state reaction The location of Ti atom in sodium probabilities for the H+O-2(v,j)-> alanate: an ab initio spin-polarised study. O+OH(v(‘),j(‘)) reaction on three potential International Journal of Nanotechnology Refereed Conference Papers energy surfaces. Journal of Chemical 4(5) 564–573 Physics 127(6) 064316–064325 1. Suzuki, S., Rintoul, L., Monteiro, M. J., 124. Rintoul, L., Micallef, Aaron S., Bottle, S. Wentrup-Byrne, E. and Grondahl, L. 113. Zimmerman, P.A., Van Peski, C., Rice, B., (2007) The vibrational group frequency of (2007). In vitro mineralization of phosphate- Byers, J., Turro, N.J., Lei, X., Gejo, J.L., the N-Oâ ¢ stretching band of nitroxide containing polymer ad-layers. In: Division of Liberman, V., Palmacci, S., Rothschild, stable free radicals. Spectrochimica Polymer Chemistry, Chicago, June 2007. M., Whittaker, Andrew K., Blakey, Idriss, Acta Part A: Molecular and Biomolecular 2. Wanno, B., Du, A., Ruangpornvisuti, V. and Chen, Lan, Dargaville, Bronwin L., Liu, Spectroscopy 1–5 Heping. (2007) Status of high-index Smith, S. (2007) Addition of diazomethane 125. Sharpe, Kendall K., Ward, Leigh C., materials for generation-three 193nm to armchair single-walled carbon Cichero, Julie A. Y., Sopade, Peter A., immersion lithography. Journal of nanotubes and reaction sequences: Halley, Peter J. (2007) Thickened fl uids Photopolymer Science and Technology A computational study. Chemical Physics and water absorption in rats and humans. 20(5) 643–650 Letters, 436 : 218–223. Dysphagia 22(3) 193–203 114. Wang, Lianzhou, Yan, Z., Qiao, Shizhang, 3. Ou, D.R., Mori, T., Ye, F., Zou, J. and 126. Lees, J.G., LIM, Sue A., CROLL, Tristan Lu, Max, Huang, Y. (2007) Structural Drennan, J. (2007). Aggregation of Dopant I., Williams, G., Lui, S., COOPER-WHITE, and morphological transformations of Cations and their effect on Electrical Justin J., Mcquade L.R., Mathiualagan, mesostructured titanium phosphate Conductivity of Yttrium Doped Ceria. B., Tuch B.E. (2007) Transplantation of 3D through hydrothermal treatment. Journal In: Freiman, S. 1st International Congress scaffolds seeded with human embryonic of Colloid And Interface Science 316(2) on Ceramics: A Global Roadmap, Canada, stem cells: biological features of surrogate 954–961 25–29 June 2006. tissue and teratoma-forming potential. 4. Ou, D.R., Mori, T., Ye, F., Zou, J. and 115. Collins, Brett, Norwood, Suzanne J., Kerr, Regenerative Medicine 2 (3) 289–300 Markus C, Mahony, Donna, Seaman, M. Drennan, J. (2007). Infl uence of Sintering 127. Yu, Aimin, Lu, Max, Drennan, John, N., Teasdale, Rohan D. (2007) Structure Processes on Microstructures and Gentle, Ian R. (2007) Tubular Titania of Vps26B and Mapping of its Interaction Electrical Properties of Yttrium-Doped nanostructures via layer-by-layer self- with the Retromer Protein Complex. Traffi c Ceria. In: The 24th International Japan- assembly Advanced Functional Materials 9(3) 366–379 Korea Seminar on Ceramics, Shizuoka, 17(14) 2600–2605 Japan, 20–22 November 2007. 116. Doherty, W., Halley, Peter J., Edye, L., 128. Nogita, Kazuhiro, Drennan, John, Knibbe, Rogers, D., Cardona, F., Park, Yoo S., Ruth, Noguchi, T., Tatenuma, K., Liu, P., Woo, Tim (2007) Studies on polymers and Book Chapters Arai, F., Yashima, E., Nishiwaki, M., Kato, composites from lignin and fi ber derived S. (2007) Ultrahigh electron emissive 1. Halley, P., Truss, R., Markotsis, M.G., from sugar cane. Polymers for Advanced carbon nanotubes with nano-sized Chaleat, C., Russo, M., Sargent, A.L., Technologies 18(8) 673–678 Tan, I. and Sopade, P.A. (2007). A Review RuO2 particles deposition. Journal of of Biodegradable Thermoplastic Starch 117. Dexter, Annette F., Middelberg, Anton P. Nanoparticle Research 9(6) 1201–1204 J. (2007) Switchable peptide surfactants Polymers. In Celina, M.C. and Assink, R.A. 129. Blakey, Idriss, Billingham, N., with designed metal binding capacity. (Ed.), Polymer Durability and Radiation George, G.A. (2007) Use of 9,10- Journal of Physical Chemistry C 111(28) Effects (pp. 287–300) United States: diphenylanthracene as a contrast agent 10484–10492 American Chemical Society. in chemiluminescence imaging: the 2. Timmins, N. E. and Nielsen, L. K. (2007). 118. Ye, F., Mori, T., Ou, D.R., Zou, Jin, observation of spreading of oxidative Generation of Multicellular Tumour Drennan, John (2007) Synthesis and degradation in thin polypropylene fi lms. Spheroids by the Hanging Drop Method. In microstructural characterization of Polymer Degradation and Stability 92 Tissue Engineering Methods in Molecular Ce1-xTbxO2-delta (0 <= x <= 1) nano- 2101–2109 powders. Journal of Nanoscience And Medicene 140 2nd Edition ed. (pp. 130. Du, Aijun, Smith, Sean, Lu, Max (2007) Nanotechnology 7(7) 2521–2525 141–151) Totowa, N. J.: Humana. Vacancy mediated desorption of hydrogen 3. Bingley, J., Campbell, J.H., Campbell, 119. Chen, Z.G., Ni, A., Li, F., Cong, H.T., from a sodium alanate surface: An ab G. and Walker, P. (2007). Restenosis: Cheng, H.M., Lu, Max (2007) Synthesis initio spin-polarized study. Applied Physics Treatment options current and future. and photoluminescence of tetrapod ZnO Letters 90(14) 143119–143121 nanostructures. Chemical Physics Letters In Fitridge, R. and Thompson, M. (Ed.), 131. Goh, Yong K., Whittaker, Andrew K., 434(4-6) 301–305 Mechanisms of Vascular Disease (pp. Monteiro, Michael J. (2007) Versatile 191–210) New York, U.S.A.: Cambridge 120. Qiao, Shizhang, Wang, Lianzhou, Hu, synthetic approach to reversible University Press. Qiuhong, Zhu, John, Lu, Max (2007) crosslinked polystyrene networks via 4. Vacroe K. M., Blakey I., Chirila, T. V., Hill, A. Synthesis of highly ordered large-pore RAFT polymerization. Journal of Polymer J. and Whittaker, A. K. (2007). The effect periodic mesoporous organosilica rods. Science Part A-polymer Chemistry 45(17) of synthetic conditions on the free volume Solid State Phenomena. 121–123(1) 4150 – 4153 381–384 of poly (2-hydroxyethyl methacrylate) as 132. Chen, Zhongxin, Zou, Jin, Lu, Max, Liu, studied by 1H NMR, 129 Xe NMR, and 121. Zhou, X.F., Qiao, Shizhang, Hao, N., G. (2007) ZnS nanowires and their coaxial position annihilation spectroscopy. In Wang, X.L., Yu, C.Z., Wang, Lianzhou, lateral nanowire heterostructures with BN. Kneipp, K., Aroca, R., Kneipp, H. and Zhao, D.Y., Lu, Max (2007) Synthesis Applied Physics Letters 90(10) 1 – 3 Wentrup-Byrne, E. (Ed.), New Approaches of ordered cubic periodic mesoporous to Biomedical Spectroscopy 1 ed. (pp. organosilicas with ultra-large pores. 391–409) Washington DC: American Chemistry of Materials 19(7) 1870 – 1876 Chemical Society, Washington DC. 122. Du, Aijun, Smith, Sean, Lu, Max (2007) 5. Zainuddin,. Hill, D., Whittaker, A., Kemp, The catalytic role of an isolated-Ti atom A. and Chirila, T. (2007). The role of in the hydrogenation of Ti-doped A1(001) citrate anions in prevention of calcifi cation surface: An ab initio density functional of poly(2-hydroxyethyl methacrylate) theory calculation. Chemical Physics hydrogels. In Celina, M. and Assink, R. Letters 450 80–85 (Ed.), Polymer Durability and Radiation Effects (pp. 301–316) United States: American Chemical Society.

40 AIBN ANNUAL REPORT 07 AIBN research higher degree students

Student name Project title Principal advisor Commenced Ian Aird Cytokine Immobilisation on Microbeads. A NovelApproach to Mimic Signalling in the Prof Lars Nielsen 2005 Haematopoietic Stem Cell Niche Colin Archer * Metabolic engineering of E. coli Prof Lars Nielsen 2007 Yalun Arifi n Metabolic engineering of peptide production in Ecoli Prof Lars Nielsen 2006 Sandy Budihartono * Functionalised Mesoporous Silica for Trichodermareesei Cellulase Immobilization Confi rmed Prof Max Lu 2006 Andrew Cameron Development of a novel polymer scaffold to encourage the differentiation and growth of progenito Prof Justin Cooper-White 2007 cells for hernia repair applications Jessica Cameron Bioactive Polymers for Wound Healing Applications Prof Andrew Whittaker 2006 Lien Chau Ex Vivo Tissue Vascularisation Prof Justin Cooper-White 2006 Annie Chen Nanotechnology based proteomic biosensors Prof Matt Trau 2006 Wendy Chen Effect of gene dose on hyaluronic acid metabolism Prof Lars Nielsen 2005 Kwok Cheung Fuel cell optimisation through data integration and model harmonisation Prof John Drennan 2005 Yap Chuan Self-assembly of virus-like particles (VLPs) in cell-free reactor Prof Anton Middelberg 2005 Giuseppe Codamo Process development and characterisation of transient expression technology in CHO cells Prof Peter Gray 2006 Natalie Connors Identifi cation of properties that affect In vitro virus-like particle assembly Prof Anton Middelberg 2005 Michael Crichton Engineering micro-nanprojection array patches for needle free vaccine delivery Prof Mark Kendall 2007 Stefanie Dietmair Design of analytical platform to support metabolic engineering of mammalian cells Prof Lars Nielsen 2007 Mirjana Dimitrijev Microfl uidic emulsions using designed peptide surfactants Dr Annette Dexter 2007 Tao (Michael) Ding Computational prediction of biomolecular teraherz spectra Prof Anton Middelberg 2007 APPENDICES Zi (Sophia) Gu Control release and effective cellular delivery of anti-restinosis drugs via inorganic LDH Prof Max Lu 2007 nanoparticles Jia (Jeff) Hou Limits to expression levels in mammalian cell cultures expressing complex proteins Prof Peter Gray 2007 Kaiyin Hu Interfacially active and stimuli-responsive Pepfactants – a new class of emulsifying agents for the Prof Anton Middelberg 2007 manufacture of biocompatible and stable emulsions for drug delivery James Hudson The regeneration or restoration of heart muscletissue using novel approaches Prof Justin Cooper-White 2007 Daisy Irawan Development of 3-Dimensional Biodegradable Elastomer for Tissue Engineering Prof Justin Cooper-White 2007 Sani Jahnke Origin of myofi broblast in cutaneous wound healing and the foreign body response Dr Barbara Rolfe 2005 Chalida Klaysom Novel inorganic-organic nanocomposite membranes for electrodalysis application in water Prof Max Lu 2007 recovery Kirsten Lawrie Development of non-chemically amplifi ed photoresists for EUV lithography Prof Andrew Whittaker 2007 Pearl Lee Development of a novel DNA detection and amplifi cation method to be applied in cancer diagnosis Prof Matt Trau 2007 Daria Lonsdale Synthesis of complex polymer architectures for vaccine delivery services A/Prof Michael Monteiro 2006 Paul Luckman Non-cell based and cell-based epithelial membrane mimics Prof Justin Cooper-White 2007 Esteban Marcellin Understanding molecular weight control of hyaluronic acid production in Streptococcus Prof Lars Nielsen 2005 zooepidemicus: a systems approach Richard Mills The investigation of geometric environment on cell migration, recruitment, differentiation and Prof Justin Cooper-White 2007 Proliferation Jane Mooney Monocyte/Macrophage Involvement in the Peritoneal Foreign Body Response Dr Barbara Rolfe 2006 Anthony Musumeci Tailored nanoparticles for nanotoxicologial studies Dr Darren Martin 2007 Geety Nabi Functional testing of bioengineering virus-inspired nanoparticles for gene therapy Prof Andrew Whittaker 2006 Wadcharawadee Nano-Hydroxyapatite composite scaffolds for tissue engineering Dr Kevin Jack 2005 Noohom Warren Pilbrough Evolutionary engineering of improved mammalian host cells for biopharmaceutical production Prof Peter Gray 2006 Katharina Porazik Nanoparticles with application in the delivery of DNA to mammalian cell lines for the production of Prof Max Lu 2005 recombinant proteins Anthony Raphael Dry coating vaccines to micro-nanoprojections for needle-free vaccine delivery to skin Prof Mark Kendall 2008 Tania Rivera Bioengineering chimeric virus-like particles for mass vaccination Prof Anton Middelberg 2008 Andrew Rowlands Conducting porous scaffolds for muscle engineering Prof Justin Cooper-White 2005 Anne Sandstrom 3D Polymer Scaffolds for muscular tissue engineering Prof Justin Cooper-White 2008 Oliver Squires The Production of Novel Fluorinated Contrast Agents for Magnetic Resonance Imaging Prof Andrew Whittaker 2006 Peter Stickler Factors affecting the differentiation of biotubes Prof Julie Campbell 2006 Guak-Kim Tan Development of tissue engineered 3D-scaffolds for the pancreatic islet’s reconstruction Prof Justin Cooper-White 2007 Akshat Tanksale Nanostructured catalysts for hydrogen production by aqueous phase reforming of biomass Prof Max Lu 2004 Drew Titmarsh Microenvironmental control in coordinating cellular fate processes of stem cells Prof Justin Cooper-White 2007 Xuan Truong Preparation and Properties of Controlled Polymer Hydrogel Network Dr Idriss Blakey 2007 Jennifer Turner Investigation and development of new tissue culture methods that mimic the In vivo Prof Justin Cooper-White 2007 microenvironment to aid in research into hernia treatments Kylie Varcoe The development of 129 Xenon NMR methods for the study of polymer structure and dynamics Prof Andrew Whittaker 2005 David Wang Design and Synthesis of Injectable Biodegradable Scaffolds for the Repair of Dental Bone Dr Firas Rasoul 2007 Joshua Watts Nanostructural semiconducting materials for a new generation of solar cells Prof Max Lu 2007 Yunyi Wong Layered Double Hydroxide (LDH) Nanoparticle-based Nuclei Acid Delivery Carrier Prof Max Lu 2006 Xiao Xia Yan Mesoporous Bioactive Glass as Composites for Bone Repair and Treatment of Bone Tumour Prof Max Lu 2007 Hidayatul Zakaria Terahertz spectroscopy of mass-manufactured viral vaccines Prof Anton Middelberg 2007

* Students studying Master of Philosophy. All other students are PhD candidates.

AIBN ANNUAL REPORT 07 41 AIBN seminars

Speaker Professor Brian Vincent, Speaker Dr Stuart Hazell, CEO PANBIO University of Bristol, UK Title Development of panDA Homogeneous Title Monodisperse Silicone Oil Droplets Assay Technology and their Encapsulation with Silica Date Thursday, April 12, 2007 Date Friday, 9 February, 2007 Speaker Dr Heike Reents, Research Scientist, Speaker Professor David James, Fine Chemicals and Biocatalysis Research, Department of Chemical and Process BASF AG, Ludwigshafen, Germany Engineering, University of Sheffi eld, UK Title Performance Proteins at BASF Title Mammalian Cell Factories: Translating Date Tuesday, April 17, 2007 Bioscience into Bioprocessing Speaker Dr Kerry D Fisher, Department of Date Tuesday, February 20, 2007 Clinical Pharmacology, University of Oxford Speaker Professor Can Li, Dalian Institute Title Systemic delivery of ‘stealth’ virus of Chemical Physics, Chinese Academy of particles for the treatment of cancer Sciences Date Tuesday, April 17, 2007 Title UV Raman Spectroscopy and Its Speaker Professor John Mattick AO, Applications in the Characterizations of Institute for Molecular Bioscience Catalytic Materials Title The human genome as an RNA machine Date Friday, March 2, 2007 Date Thursday, April 19, 2007 Speaker Dr Ernst Wolvetang, Australian Stem Speaker Dr Hans Kocher, Executive Director Cell Centre, Dept of Anatomy and Cell biology, of the Biologics Centre, Novartis Institutes for Monash University Biomedical Research Title Towards a basic understanding of hESC Title Proteins as Pharmaceuticals biology Date Friday, April 20, 2007 Date Wednesday, March 7, 2007 Speaker Professor Aibing Yu, Centre for Speaker Professor Jean-Marie Lehn, Nobel Simulation and Modelling of Particulate Laureate (Chemistry 1987), ISIS, Université Louis Systems, School of Materials Science and Pasteur, Strasbourg and Collège de France Engineering, UNSW Title From Supramolecular Chemistry to Title Discrete Particle Simulation of Particulate Constitutional Dynamic Chemistry Systems Date Friday, March 9, 2007 Date Thursday, April 26, 2007 Speaker Professor Paul Mulvaney, School of Speaker Dr Werner Baschong Chemistry and Bio21 Institute, University of i) Clinic for Dental Surgery, University Clinics Melbourne for Dentistry Title Single Particle Spectroscopy ii) M E Muller Institute for Structural Biology at Date Thursday, March 15, 2007 the Biozentrum, Switzerland Speaker Professor Hans J Griesser, Ian Wark Title AFM-assessed elasticity of articular Research Institute, University of South Australia cartilage at the glycosamino-glycan level, an Title Bioactive Materials Surfaces early indicator for functional degeneration? Date Thursday, May 17, 2007 Date Wednesday, May 2, 2007 Speaker Associate Professor Andrew Elefanty Speaker Professor Chennupati Jagadish, and Dr Ed Stanley, Embryonic Stem Cell Department of Electronic Materials Engineering, Differentiation Laboratory, Monash Immunology Research School of Physical Sciences and and Stem Cell Laboratories, Monash University Engineering, Australian National University Title Genetic Modifi cation of Embryonic Stem Title Quantum Dots and Nanowires for Cells (Dr Stanley) Optoelectronic Device Applications Directed Differentiation of Embryonic Stem Cells Date Thursday, May 10, 2007 (Professor Elefanty) Speaker Dr Bernd M Fischer, The Adelaide Date Tuesday, March 20, 2007 T-ray Group, School of Electrical and Electronic Speaker Dr Mark Raftery, Engineering, University of Adelaide Bioanalytical Mass Spectrometry Facility, Title Bioactive Materials Surfaces University of New South Wales Date Thursday, May 24, 2007 Title Multi-dimensional liquid chromatography Speaker Dr Stephen Holt, ISIS, tandem mass spectrometry for the Rutherford Appleton Laboratory, UK identifi cation of proteins in complex mixtures Title Membrane Proteins as Sensors: Device Date Thursday, March 22, 2007 Characterisation Speaker Dr Silas Villas-Bôas, AgResearch, Date Monday, May 28, 2007 New Zealand Speaker Dr Martina Stenzel, Centre for Title Metabolomics an Emerging Field of Advanced Macromolecular Design School of Biotechnology Chemical Sciences and Engineering, University Date Thursday, March 29, 2007 of New South Wales Speaker Professor John Orr, Queen’s Title The versatility of the RAFT process in the University Belfast preparation of nanocontainers for biomedical Title Load Bearing Biomaterials-Polymers at applications the Hip Joint Date Thursday, May 31, 2007 Date Monday, April 2, 2007

42 42 AIBN ANNUAL REPORT 07 Speaker Professor Hsueh-Chia Chang, Speaker Professor Feng-Huei Lin, Speaker Dr Eric Pollet, Laboratoire d’Ingénierie Center for Microfl uidics and Medical Institute of Biomedical Engineering, des Polymères pour les Hautes Technologies Diagnostics, University of Notre Dame, USA National Taiwan University, Taipei, Taiwan (LIPHT), Université Louis Pasteur, Title A Dielectrophoretic Platform for Nano- Title Tissue Engineering in Blood Vessel Strasbourg, France Colloid Manipulation and Analysis on Biochips Date Thursday, July 26, 2007 Title Biodegradable nanocomposite materials Date Friday, June 1, 2007 based on polyester / montmorillonite Speaker Professor Sang Yup Lee, Institute for Date Wednesday, October 10, 2007 Speaker Dr Anita Hill, CSIRO Manufacturing the BioCentury, Korea Advanced Institute of and Materials Technology Science and Technology (KAIST) Speaker Professor Milton Hearn, Title Pore-based Design of Dense Membranes Title Systems and Synthetic Biotechnology ARC Special Research Centre for Green Date Thursday, June 14, 2007 Date Thursday, August 9, 2007 Chemistry, Monash University Title How to build innovation into Speaker Dr Bernd H A Rehm, Speaker Geoffrey Osborne, Director of biotechnological process developments at the Institute of Molecular Biosciences, Flow Cytometry, Queensland Brain Institute downstream end of the business Massey University, New Zealand / Australian Institute for Bioengineering and Date Thursday, October 11, 2007 Title Polyhydroxyalkanoate granules: Nanotechnology Self-assembly and potential applications Title Strategies for ensuring the quality of Speaker Professor Maree Smith, Date Thursday, June 21, 2007 sample data generated by fl ow cytometry Director, Centre for Integrated Preclinical Drug Date Thursday, August 16, 2007 Development, School of Pharmacy Speaker Professor John White, Title Neuropathic Pain: Drug Targets and Research School of Chemistry, Speaker Dr Ben Hankamer, New Therapeutics in Development The Australian National University Institute of Molecular Biology, APPENDICES Date Thursday, October 18, 2007 Title The Structure of Proteins at Interfaces The University of Queensland Date Thursday, June 21, 2007 Title The Solar Bio-fuels consortium: Developing Speaker Professor Frederick F Lange, advanced bio-fuel production systems University of California, Santa Barbara Speaker Professor James M Piret, Date Thursday, August 23, 2007 Title Superhydrophobicity and Making Silicon Michael Smith Laboratories & Department Superhydrophobic of Chemical and Biological Engineering, Speaker Professor Irene Yarovsky, Date Monday, October 22, 2007 University of British Columbia RMIT University Title Stem Cell Bioengineering Title Theoretical Nanoscale Design of Speaker Professor Melissa Little, Chief Date Friday, June 22, 2007 Novel Materials Scientifi c Offi cer, Australian Stem Cell Centre Date Thursday, August 30, 2007 – Queensland Node Speaker Professor James R McMillan, Dept Title Approaches to renal regeneration from of Dermatology & Creative Research Institute Speaker Dr John Power, Associate Director, the top and the bottom Sousei (CRIS), Hokkaido University, Japan Bios Development, Biologicals VMRD, Pfi zer Date Thursday, October 25, 2007 Title Babes, blisters and basement Animal Health membranes: from cell biology and genetics to Title Overview of Pfi zer’s animal health R&D Speaker Professor May-Britt Hagg, nanobiotechnology-based therapies interests /activities in Australia Department of Chemical Engineering, Date Thursday, June 28, 2007 Date Friday, August 31, 2007 The Norwegian University of Science and Technology (NTNU), Norway Speaker Professor Luc Averous, University Speaker Professor Gerard J Milburn, Title Material and Membrane Development for Louis Pasteur, Strasbourg, France Centre for Quantum Computer Technology, Gas Applications at NTNU, Norway Title Towards the Improvement of Green School of Physical Sciences, Date Monday, October 29, 2007 Plastics The University of Queensland Date Wednesday, July 4, 2007 Title Quantum nanomechanics Speaker Dr Rudolf Grimm, Date Thursday, September 2, 2007 Worldwide Proteomics and Metabolomics Speaker Dr Paul A Midgley, Department Market Development Manager of Materials and Metallurgy, University of Speaker Professor Brij M Moudgil, Title A Tale of Two ‘Omics – Proteomics and Cambridge Department of Materials Science & Metabolomics Title 3D Electron Tomography – A New Engineering, and Particle Engineering Date Monday October 29, 2007 Perspective for Materials Microscopy Research Center, University of Florida Date Friday, July 6, 2007 Title Nanoengineered Particulate Systems for Speaker Dr Easan Sivaniah, Leeds University Bio Applications Title Preparation of biocompatible, Speaker Professor Douglas MacFarlane, Date Monday, September 3, 2007 biodegradable polymer coatings Monash University Date Thursday, November 1, 2007 Title Ionic Liquids – Applications in the Speaker Professor Derek Hart, Chemical- and Bio- Sciences Mater Medical Research Institute Speaker Mr Martin Albrecht AC, Date Wednesday, July 11, 2007 Title Moving Towards the Generation of Chairman of Thiess Pty Ltd Dendritic Cell Targeted Therapeutics Title Geodynamics Speaker Professor Ramanath, Date Thursday, September 13, 2007 Date Thursday, November 15, 2007 Nanotechnology Center, and Center for Integrated Electronics, Rensselaer Polytechnic Speaker Dr José Alarco, Speaker Professor Michelle Simmons, Institute, NY, USA Very Small Particle Company Pty Ltd Atomic Fabrication Facility, University of New Title Sculpture and novel properties of Title Nanotechnology at VSPC South Wales nanostructures and their assemblies for Date Thursday, September 27, 2007 Title Atomic-Electronics – when will scaling applications reach its limit? Speaker Dr Sarah Schmitz, Date Thursday, July 12, 2007 Date Thursday, November 22, 2007 UQ Centre for Nutrition and Food Sciences Speaker Dr Rudy Koopmans, Dow Benelux Title Microwaves in polymer chemistry: Speaker Professor Ian Frazer, Title Overview of Dow’s operations Dow Benelux Synthesis of monomers and additives Diamantina Institute for Cancer Immunology Date Friday, July 20, 2007 Date Thursday, September 27, 2007 and Metabolic Medicine Title Progress and pitfalls in vaccine Speaker Dr Mike Johns, Magnetic Resonance Speaker Dr Andrei A Gusev, Institute of development Research Centre, Department of Chemical Polymers, Department of Materials, Date Thursday, November 29, 2007 Engineering, University of Cambridge ETH Zurich, Switzerland Title Magnetic Resonance Characterisation of Title Finite Element Approaches to Multiple Emulsions and other Pharmaceutical Mesoscopic Materials Modeling Systems Date Friday, October 5, 2007 Date Friday, July 20, 2007

AIBN ANNUAL REPORT 07 43 AIBN media coverage

Date Headline Media 23 Jan 2007 No-pain all-gain with needle-free vaccination www.abc.net.au 19 Feb 2007 The Medical Journal of Australia: Micro-nanoprojection patch www.mja.com.au 27 Feb 2007 Two top research institutes open in Queensland SD Magazine; Other – magazines and newsletters 17 Mar 2007 Forum to focus on cane uses Herbert River Express, Pg 3; Other – newspapers 20 Mar 2007 Looking at alternatives Mackay Bush Telegraph, Pg 4; Other – newspapers 21 Mar 2007 Conference focus on uses for sugar Tablelands Advertiser, Pg 7; Other – newspapers 17 Apr 2007 Honey, I shrank the doctor Bulletin with Newsweek, Pg 28; Other – magazines and newsletters 18 Apr 2007 Nanotech testing IQ, Courier-Mail, Pg 28 18 Apr 2007 Pap smear end? General, Herald Sun (Melbourne), Pg 24 25 Apr 2007 Big hopes for nano Business Acumen Queensland, Pg 34; Other – magazines and newsletters 8 May 2007 No more pricks: Vaccine patch set to replace risky syringes MX Brisbane, Pg 1; Other – newspapers 17 May 2007 Sugarcane ’biofactory’ of future Queensland Country Life, Pg 43; Other – newspapers 21 May 2007 Sugarcane will be biofactory of the future Australian Canegrower, Pg 6; Other – newspapers 24 May 2007 Cane conference details advances North Queensland Register, Pg 9; Ten Cairns News Channel 10 TV; Other – newspapers 11 Jun 2007 It’s a small world after all Age Education, The Age, Pg 7 25 Jun 2007 Desalination – Opportunities and Challenges Water, Pg 30 2 Jul 2007 Acting small, thinking big Queensland Business Review, Pg 20; Other – magazines and newsletters 31 Jul 2007 New-age science careers Headstart – Pg 40 Courier-Mail 4 Sep 2007 Better chance for arteries The Australian; General News; Hot FM Mackay; River FM (Ipswich); ABC Radio; ABC Western Qld Longreach; ABC North West Qld Mt Isa; 4BC Brisbane ; 4BC Brisbane; Radio 4BC; Other – radio 8 Sep 2007 Drugs reduce heart surgery risks Northern Daily Leader, Pg 24; Western Advocate, Pg 16; National AAP Newswire; Other – newspapers 10 Sep 2007 Fresh Science and arteries ABC Northern Tasmania ABC Radio 27 Sep 2007 Unis win funding: ARC grants awarded for range of projects IQ, Courier-Mail, Pg 72 4 Oct 2007 Nanotech researchers building better golf ball IQ, Courier-Mail, Pg 74 5 Oct 2007 Blood test to diagnose breast cancer Launceston Examiner, Pg 15; Illawarra Mercury, Pg 18; National Barrier Daily Truth, Pg 6; Border Mail, Pg 4; AAP Newswire; Other – newspapers 6 Oct 2007 Nanoscience could diagnose cancer earlier General News, Canberra Times, Pg 13 22 Oct 2007 Embarking on bold new research Western Advocate, Pg 8 22 Oct 2007 Quick blood test the great hope for breast cancer Illawarra Mercury, Pg 18 28 Oct 2007 Our Bio Boom Agenda, Sunday Mail, Pg 53 4 Nov 2007 Stem cell breakthrough: Transfusion blood in controversial technique General News, Sunday Mail, Pg 41 25 Nov 2007 Hitting golf balls Business Acumen Queensland, Pg 36; Magazines and Newsletters 6 Dec 2007 Aussies in research deal with Dow Chemical of US IQ, Courier-Mail, Pg 72 10 Dec 2007 Hay turns fascinating ideas into funded projects Education, Australian Financial Review, Pg 31 17 Dec 2007 Former Qld Premier to receive honorary doctorate ABC 612 Brisbane

44 AIBN ANNUAL REPORT 07 www.aibn.uq.edu.au CRICOS Provider Number 00025B

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