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2021 V. 55 № 1/1 Special Issue the Organizers
ISSN 0233-528X Aerospace and Environmental Medicine 2021 V. 55 № 1/1 special issue The Organizers: INTERNATIONAL ACADEMY OF ASTRONAUTICS (IAA) STATE SPACE CORPORATION “ROSCOSMOS” MINISTRY OF SCIENCE AND HIGHER EDUCATION OF THE RUSSIAN FEDERATION RUSSIAN ACADEMY OF SCIENCES (RAS) STATE RESEARCH CENTER OF THE RUSSIAN FEDERATION – INSTITUTE OF BIOMEDICAL PROBLEMS RAS Aerospace and Environmental Medicine AVIAKOSMICHESKAYA I EKOLOGICHESKAYA MEDITSINA SCIENTIFIC JOURNAL EDITOR-IN-CHIEF Orlov O.I., M.D., Academician of RAS EDITORIAL BOARD The Organizers: Ardashev V.N., M.D., professor Baranov V.M., M.D., professor, Academician of RAS Buravkova L.B., M.D., professor, Corresponding Member of RAS Bukhtiyarov I.V., M.D., professor Vinogradova O.L., Sci.D., professor – Deputy Editor D’yachenko A.I., Tech. D., professor Ivanov I.V., M.D., professor Ilyin E.A., M.D., professor Kotov O.V., Ph.D. Krasavin E.A., Ph.D., Sci.D., professor, Corresponding Member of RAS Medenkov A.A., Ph.D. in Psychology, M.D., professor Sinyak YU.E., M.D., Tech.D., professor Sorokin O.G., Ph.D. Suvorov A.V., M.D., professor Usov V.M., M.D., professor Homenko M.N., M.D., professor Mukai Ch., M.D., Ph.D. (Japan) Sutton J., M.D., Ph.D. (USA) Suchet L.G., Ph.D. (France) ADVISORY BOARD Grigoriev A.I., M.D., professor, Academician of RAS, Сhairman Blaginin A.A., M.D., Doctor of Psychology, professor Gal’chenko V.F., Sci.D., professor, Corresponding Member of RAS Zhdan’ko I.M., M.D. Ostrovskij M.A., Sci.D., professor, Academician of RAS Rozanov A.YU., D.Geol.Mineral.S., professor, Academician of RAS Rubin A.B., Sci.D., professor, Corresponding Member of RAS Zaluckij I.V., Sci.D., professor, Corresponding Member of NASB (Belarus) Kryshtal’ O.A., Sci.D., professor, Academician of NASU (Ukraine) Makashev E.K., D.Biol.Sci., professor, Corresponding Member of ASRK (Kazakhstan) Gerzer R., M.D., Ph.D., professor (Germany) Gharib C., Ph.D., professor (France) Yinghui Li, M.D., Ph.D., professor (China) 2021 V. -
Testing the Stand-Alone Microbeam at Columbia University G
Radiation Protection Dosimetry Advance Access published December 21, 2006 Radiation Protection Dosimetry (2006), 1 of 5 doi:10.1093/rpd/ncl454 TESTING THE STAND-ALONE MICROBEAM AT COLUMBIA UNIVERSITY G. GartyÃ, G. J. Ross, A. W. Bigelow, G. Randers-Pehrson and D. J. Brenner Columbia University, Radiological Research Accelerator Facility, 136 S. Broadway, Irvington, NY 10533, USA The stand-alone microbeam at Columbia University presents a novel approach to biological microbeam irradiation studies. Foregoing a conventional accelerator as a source of energetic ions, a small, high-specific-activity, alpha emitter is used. Alpha particles emitted from this source are focused using a compound magnetic lens consisting of 24 permanent magnets arranged in two quadrupole triplets. Using a ‘home made’ 6.5 mCi polonium source, a 1 alpha particle s–1,10lm diameter microbeam can, in principle, be realised. As the alpha source energy is constant, once the microbeam has been set up, no further adjustments are necessary apart from a periodic replacement of the source. The use of permanent magnets eliminates the need for bulky power supplies and cooling systems required by other types of ion lenses and greatly simplifies operation. It also makes the microbeam simple and cheap enough to be realised in any large lab. The Microbeam design as well as first tests of its performance, using an accelerator-based beam are presented here. INTRODUCTION AND OVERALL DESIGN the lenses. In addition to providing a secondary user facility at RARAF, the design is simple and Columbia University’s Radiological Research Accel- inexpensive enough that the SAM can be reproduced erator Facility (RARAF) currently offers its users in any large radiation biology laboratory. -
The Physical Tourist Physics and New York City
Phys. perspect. 5 (2003) 87–121 © Birkha¨user Verlag, Basel, 2003 1422–6944/05/010087–35 The Physical Tourist Physics and New York City Benjamin Bederson* I discuss the contributions of physicists who have lived and worked in New York City within the context of the high schools, colleges, universities, and other institutions with which they were and are associated. I close with a walking tour of major sites of interest in Manhattan. Key words: Thomas A. Edison; Nikola Tesla; Michael I. Pupin; Hall of Fame for GreatAmericans;AlbertEinstein;OttoStern;HenryGoldman;J.RobertOppenheimer; Richard P. Feynman; Julian Schwinger; Isidor I. Rabi; Bronx High School of Science; StuyvesantHighSchool;TownsendHarrisHighSchool;NewYorkAcademyofSciences; Andrei Sakharov; Fordham University; Victor F. Hess; Cooper Union; Peter Cooper; City University of New York; City College; Brooklyn College; Melba Phillips; Hunter College; Rosalyn Yalow; Queens College; Lehman College; New York University; Courant Institute of Mathematical Sciences; Samuel F.B. Morse; John W. Draper; Columbia University; Polytechnic University; Manhattan Project; American Museum of Natural History; Rockefeller University; New York Public Library. Introduction When I was approached by the editors of Physics in Perspecti6e to prepare an article on New York City for The Physical Tourist section, I was happy to do so. I have been a New Yorker all my life, except for short-term stays elsewhere on sabbatical leaves and other visits. My professional life developed in New York, and I married and raised my family in New York and its environs. Accordingly, writing such an article seemed a natural thing to do. About halfway through its preparation, however, the attack on the World Trade Center took place. -
Abstracts of Oral and Poster Presentations
European Radiation Research 2004 The 33th Annual Meeting of the European Society for Radiation Biology Abstracts of Oral and Poster Presentations Guest Editor: Géza Sáfrány The abstracts published in this issue have not been peer-reviewed. Hence the opinions expressed in them are those of the authors and not necessarily those of the editor. The abstracts are in alphabetical order according to the first author. EUROPEAN RADIATION RESEARCH 2004, AUGUST 25–28, BUDAPEST, HUNGARY · 2004; 10: S5–S219 FACTORS INFLUENCING ON CLINICAL MANIFESTATION OF HCV IN GROUP OF CLEAN-UP WORKERS OF CHERNOBYL NPP ACCIDENT ABRAMENKO I. V., CHUMAK A. A., KOVALENKO A. N., BOYCHENKO P. K., AND PLESKACH O. Y. Research Centre for Radiation Medicine of Academy of Medical Sciences of Ukraine, Kyiv, Ukraine Imunological monitoring of 536 clean-up workers of Chornobyl NPP accident revealed significant prevalence of hepatitic C virus (HCV) infection (19.6%) compared with non- irratiated person (9.5%). Among 105 HCV carriers clinical signs of infection was found in 39 (37.41%) persons. Factors that influenced manifestation of HCV were male gender (r = 0.3553, p<0,0001), serological signs of previous hepatitic B virus (HBV) infection (r = 0.2896, p = 0.003), anti- bodies against cytomegalovirus (CMV) and T. gondii in serum (r = 0.3418, p<0.0001). –z Logistic regression (P = 1/1+e , where z = 1.5040 – 1.8405 × Mix(1) – 2.6026 × Mix(2) – 0.6567 × Mix(3); Mix(1) – serological signs of one of above menshioned infec- tions, Mix(2) – serological signs of two infections, and Mix(3) – serological signs of previous HBV, CMV and T. -
Expanding the Question-Answering Potential of Single-Cell Microbeams at RARAF, USA
J. Radiat. Res., 50: Suppl., A21-A28 (2009) Expanding the Question-answering Potential of Single-cell Microbeams at RARAF, USA Alan BIGELOW1,*, Guy GARTY1, Tomoo FUNAYAMA1,2, Gerhard RANDERS-PEHRSON1, David BRENNER1 and Charles GEARD1 Microbeam/Particle accelerator/Cell irradiation/Radiation biology. Charged-particle microbeams, developed to provide targeted irradiation of individual cells, and then of sub-cellular components, and then of 3-D tissues and now organisms, have been instrumental in chal- lenging and changing long accepted paradigms of radiation action. However the potential of these valuable tools can be enhanced by integrating additional components with the direct ability to measure biological responses in real time, or to manipulate the cell, tissue or organism of interest under conditions where information gained can be optimized. The RARAF microbeam has recently undergone an accelerator upgrade, and been modified to allow for multiple microbeam irradiation laboratories. Researchers with divergent interests have expressed desires for particular modalities to be made available and ongoing developments reflect these desires. The focus of this review is on the design, incorporation and use of mul- tiphoton and other imaging, micro-manipulation and single cell biosensor capabilities at RARAF. Addi- tionally, an update on the status of the other biology oriented microbeams in the Americas is provided. west National Laboratory,4) the Gray Cancer Institute,5,6) and INTRODUCTION Columbia University.7) Since that time, the number -
Norman M. Kroll 1922–2004
Norman M. Kroll 1922–2004 A Biographical Memoir by Joseph Kroll, Julius Kuti, and Mal Ruderman ©2015 National Academy of Sciences. Any opinions expressed in this memoir are those of the authors and do not necessarily reflect the views of the National Academy of Sciences. NORMAN MYLES KROLL April 6, 1922–August 8, 2004 Elected to the NAS, 1974 Norman M. Kroll was one of the pioneers of the field of quantum electrodynamics and a brilliant theoretical phys- icist with deep physical insight and broad scientific inter- ests. His career began at Columbia University, where he and Willis Lamb published the first relativistic calculation of the Lamb Shift. He established himself as one of the pioneers in the field of quantum electrodynamics, and he rose quickly to the rank of full professor. Kroll was one of the founding faculty members of the Department of Physics at the University of California, San Diego, arriving in 1962 as a professor of physics after 20 years at Columbia BNL. Palmer, Robert Photograph courtesy University. He spent 40 years at UCSD, conducting research on electrodynamics, atomic physics, particle By Joseph Kroll, Julius Kuti physics, free electron lasers, and the design of subatomic and Mal Ruderman particle accelerators. In addition, he made numerous contributions to the development of UCSD as one of the nation’s leading research universities and served twice as chair of UCSD’s Department of Physics. A member of the National Academy of Sciences and the American Academy of Arts and Sciences and a fellow of the American Physical Society, he was regarded by his colleagues as one of the physics department’s most distinguished faculty members. -
Tesla's Connection to Columbia University by Dr. Kenneth L. Corum
* Tesla’s Connection to Columbia University by Kenneth L. Corum and James F. Corum, Ph.D. “The invention of the wheel was perhaps rather obvious; but the invention of an invisible wheel, made of nothing but a magnetic field, was far from obvious, and that is what we owe to Nikola Tesla.” Professor Reginald Kapp, 1956 INTRODUCTION The Electrical Engineering curriculum at Columbia University, though not the first in the US, is one of the oldest and most respected EE programs in the world. From the beginning, a conscientious effort was made to base it on a foundation of science. It has been guided by the specific philosophy stated by Professor Michael Pupin: “Professor Crocker and I maintained that there is an ‘electrical science’ which is the real soul of electrical engineering.” Arguably the most stunning and significant lecture in modern history was presented one spring evening, more than a century ago, at Columbia University. The wealth of nations turned on its merits. Weighing on the balances would be our vast cities, civilization, and quality of life. But, what was it? . .Whatever it was, its impact has been as momentous for the progress and prosperity of civilization as the invention of the wheel! . It was Tesla’s great discovery and analysis of the rotating magnetic field, and a means for the electrical distribution of energy.1 As a result of the analysis presented in this lecture, the great Falls of Niagara would soon be harnessed for the benefit of mankind and launch civilization into the “Electromagnetic Century”. The Engineering Council for Professional Development (now called ABET) has defined “Engineering” as “that profession which utilizes the resources of the planet for the benefit of mankind”. -
Exploring Cool New Worlds Beyond Our Solar System
WINTER 2017-18 COLUMBIA MAGAZINE COLUMBIA COLUMBIAMAGAZINE WINTER 2017-18 Exploring cool new worlds beyond our solar system 4.17_Cover_FINAL.indd 1 11/13/17 12:42 PM JOIN THE CLUB Since 1901, the Columbia University Club of New York has been a social, intellectual, cultural, recreational, and professional center of activity for alumni of the eighteen schools and divisions of Columbia University, Barnard College, Teachers College, and affiliate schools. ENGAGE IN THE LEGACY OF ALUMNI FELLOWSHIP BECOME A MEMBER TODAY DAVE WHEELER DAVE www.columbiaclub.org Columbia4.17_Contents_FINAL.indd Mag_Nov_2017_final.indd 1 1 11/15/1711/2/17 12:463:13 PM PM WINTER 2017-18 PAGE 28 CONTENTS FEATURES 14 BRAVE NEW WORLDS By Bill Retherford ’14JRN Columbia astronomers are going beyond our solar system to understand exoplanets, fi nd exomoons, and explore all sorts of surreal estate 22 NURSES FIRST By Paul Hond How three women in New York are improving health care in Liberia with one simple but e ective strategy 28 JOIN THE CLUB LETTER HEAD By Paul Hond Scrabble prodigy Mack Meller Since 1901, the Columbia University Club of minds his Ps and Qs, catches a few Zs, and is never at a loss for words New York has been a social, intellectual, cultural, recreational, and professional center of activity for 32 CONFESSIONS alumni of the eighteen schools and divisions of OF A RELUCTANT REVOLUTIONARY Columbia University, Barnard College, By Phillip Lopate ’64CC Teachers College, and affiliate schools. During the campus protests of 1968, the author joined an alumni group supporting the student radicals ENGAGE IN THE LEGACY OF ALUMNI FELLOWSHIP 38 FARSIGHTED FORECASTS By David J. -
Meeting Summary President's Cancer Panel
MEETING SUMMARY PRESIDENT’S CANCER PANEL ENVIRONMENTAL FACTORS IN CANCER January 27, 2009 Phoenix, Arizona OVERVIEW This meeting was the last in the President’s Cancer Panel’s (PCP, the Panel) 2008/2009 series, Environmental Factors in Cancer. The meeting focused on radiation exposures as they relate to cancer risk. The agenda for the meeting was organized into three discussion panels. PARTICIPANTS President’s Cancer Panel LaSalle D. Leffall, Jr., M.D., F.A.C.S., Chair Margaret Kripke, Ph.D. National Cancer Institute (NCI), National Institutes of Health (NIH) Abby Sandler, Ph.D., Executive Secretary, PCP, NCI Beverly Laird, Ph.D., Vice-Chair, Director’s Consumer Liaison Group Panelists David J. Brenner, Ph.D., D.Sc., Director and Higgins Professor of Radiation Biophysics, Center for Radiological Research, Columbia University Medical Center David O. Carpenter, M.D., Director, Institute for Health and Environment, University at Albany School of Public Health Thomas H. Essig, M.S., Rehired Annuitant, Office of Federal and State Materials and Environmental Management Programs, U.S. Nuclear Regulatory Commission (NRC) Michael Lerner, Ph.D., President and Founder, Commonweal Martha S. Linet, M.D., M.P.H., Chief and Senior Investigator, Radiation Epidemiology Branch, National Cancer Institute Mahadevappa Mahesh, Ph.D., M.S., Associate Professor of Radiology and Cardiology, Johns Hopkins University School of Medicine Fred A. Mettler, M.D., M.P.H., Professor Emeritus, Department of Radiology, New Mexico VA Healthcare System Neal A. Palafox, M.D., M.P.H., Professor and Chair, Family Medicine and Community Health, John A. Burns School of Medicine, University of Hawai’i at Manoa Trisha Thompson Pritikin, Esq., M.Ed., Hanford Downwinder, Berkeley, CA Jonathan Samet, M.D., M.S., Professor and Chair, Department of Preventive Medicine, University of Southern California (USC)/Norris Comprehensive Cancer Center William A. -
Columbia Blue Great Urban University
Added 3/4 pt Stroke From a one-room classroom with one professor and eight students, today’s Columbia has grown to become the quintessential Office of Undergraduate Admissions Dive in. Columbia University Columbia Blue great urban university. 212 Hamilton Hall, MC 2807 1130 Amsterdam Avenue New York, NY 10027 For more information about Columbia University, please call our office or visit our website: 212-854-2522 undergrad.admissions.columbia.edu Columbia Blue D3 E3 A B C D E F G H Riverside Drive Columbia University New York City 116th Street 116th 114th Street 114th in the City of New York Street 115th 1 1 Columbia Alumni Casa Center Hispánica Bank Street Kraft School of Knox Center Education Union Theological New Jersey Seminary Barnard College Manhattan School of Music The Cloisters Columbia University Museum & Gardens Subway 2 Subway 2 Broadway Lincoln Center Grant’s Tomb for the Performing Arts Bookstore Northwest Furnald Lewisohn Mathematics Chandler Empire State Washington Heights Miller Corner Building Hudson River Chelsea Building Alfred Lerner Theatre Pulitzer Earl Havemeyer Clinton Carman Hall Cathedral of Morningside Heights Intercultural Dodge Statue of Liberty West Village Flatiron Theater St. John the Divine Resource Hall Dodge Fitness One World Trade Building Upper West Side Center Pupin District Center Center Greenwich Village Jewish Theological Central Park Harlem Tribeca 110th Street 110th 113th Street113th 112th Street112th 111th Street Seminary NYC Subway — No. 1 Train The Metropolitan Midtown Apollo Theater SoHo Museum of Art Sundial 3 Butler University Teachers 3 Low Library Uris Schapiro Washington Flatiron Library Hall College Financial Chinatown Square Arch District Upper East Side District East Harlem Noho Gramercy Park Chrysler College Staten Island New York Building Walk Stock Exchange Murray Lenox Hill Yorkville Hill East Village The Bronx Buell Avery Fairchild Lower East Side Mudd East River St. -
UV Microspot Irradiator at Columbia University
Radiat Environ Biophys (2013) 52:411–417 DOI 10.1007/s00411-013-0474-9 SHORT COMMUNICATION UV microspot irradiator at Columbia University Alan W. Bigelow • Brian Ponnaiya • Kimara L. Targoff • David J. Brenner Received: 8 February 2013 / Accepted: 13 May 2013 / Published online: 26 May 2013 Ó Springer-Verlag Berlin Heidelberg 2013 Abstract The Radiological Research Accelerator Facility Accelerator Facility (RARAF), Columbia University at Columbia University has recently added a UV microspot (Bigelow et al. 2011). While ion beams from the HVE irradiator to a microbeam irradiation platform. This UV 5.5 MeV Singletron particle accelerator at the facility also microspot irradiator applies multiphoton excitation at the support secondary X-ray and neutron microbeam develop- focal point of an incident laser as the source for cell ments (Harken et al. 2011; Xu et al. 2011), a UV microspot damage, and with this approach, a single cell within a 3D irradiator is now combined with a charged-particle micro- sample can be targeted and exposed to damaging UV. The beam irradiator to enable experiments that require both UV microspot’s ability to impart cellular damage within photon and particle irradiations on the same platform. In 3D is an advantage over all other microbeam techniques, contrast to cellular damage along the particle tracks from which instead impart damage to numerous cells along charged-particle microbeam irradiators, the UV microspot microbeam tracks. This short communication is an over- delivers damage through multiphoton excitation at localized view, and a description of the UV microspot including the cellular regions within a 3D sample. This integrated design following applications and demonstrations of selective allows the UV microspot to operate in two modes: (1) as a damage to live single cell targets: DNA damage foci for- stand-alone UV microspot irradiator and (2) as a probe to mation, patterned irradiation, photoactivation, targeting of work in concert with ion-beam irradiation experiments. -
Development of a Robotically-Based Automated Biodosimetry Tool for High-Throughput Radiological Triage
Int. J. Biomechatronics and Biomedical Robotics, Vol. 1, No. 2, 2010 115 Development of a robotically-based automated biodosimetry tool for high-throughput radiological triage Youhua Chen*, Jian Zhang, Hongliang Wang, Nabil Simaan and Y. Lawrence Yao Columbia University, 220 S.W. Mudd Building, 500 West 120th Street, New York, NY 10027 USA E-mail: [email protected] E-mail: [email protected] E-mail: [email protected] E-mail: [email protected] E-mail: [email protected] *Corresponding author Guy Garty, Yanping Xu, Oleksandra V. Lyulko, Helen C. Turner, Gerhard Randers-Pehrson and D.J. Brenner Columbia University, 136 S. Broadway, Irvington, NY 10533 USA E-mail: [email protected] E-mail: [email protected] E-mail: [email protected] E-mail: [email protected] E-mail: [email protected] E-mail: [email protected] Abstract: To provide the best opportunities for life-saving interventions in the event of a radiological or nuclear threat, there is an urgent need to improve the speed and efficiency of biodosimetric assays for triage and therapy. A rapid automated biodosimetric system used to assess thousands of individual radiation exposure doses is helpful to curb mass panic, and to conserve limited medical resources. This paper presents the development of a new robotically-based automated biodosimetry tool (RABiT). The RABiT is capable of automating two mature biodosimetry assays: the micronucleus and γ-H2AX assay. The design considerations guiding the hardware and software architecture are presented with focus on ease of implementation, methods of communication and need for real-time control versus soft time control cycles.