ISSN 0233-528X
Aerospace and Environmental
Medicine
2021 V. 55 № 1/1 special issue
The Organizers:
INTERNATIONAL ACADEMY OF ASTRONAUTICS (IAA) STATE SPACE CORPORATION “ROSCOSMOS”
MINISTRY OF SCIENCE AND HIGHER EDUCATION OF THE RUSSIAN FEDERATION
RUSSIAN ACADEMY OF SCIENCES (RAS) STATE RESEARCH CENTER OF THE RUSSIAN FEDERATION – INSTITUTE OF BIOMEDICAL PROBLEMS RAS
Aerospace and Environmental Medicine
AVIAKOSMICHESKAYA I EKOLOGICHESKAYA MEDITSINA
SCIENTIFIC JOURNAL
EDITOR-IN-CHIEF
Orlov O.I., M.D., Academician of RAS
EDITORIAL BOARD
Ardashev V.N., M.D., professor
Baranov V.M., M.D., professor, Academician of RAS
Buravkova L.B., M.D., professor, Corresponding Member of RAS
Bukhtiyarov I.V., M.D., professor
Vinogradova O.L., Sci.D., professor – Deputy Editor
D’yachenko A.I., Tech. D., professor
Ivanov I.V., M.D., professor Ilyin E.A., M.D., professor
Kotov O.V., Ph.D.
Krasavin E.A., Ph.D., Sci.D., professor, Corresponding Member of RAS
Medenkov A.A., Ph.D. in Psychology, M.D., professor
Sinyak YU.E., M.D., Tech.D., professor
Sorokin O.G., Ph.D.
Suvorov A.V., M.D., professor Usov V.M., M.D., professor
Homenko M.N., M.D., professor Mukai Ch., M.D., Ph.D. (Japan) Sutton J., M.D., Ph.D. (USA) Suchet L.G., Ph.D. (France)
ADVISORY BOARD
Grigoriev A.I., M.D., professor, Academician of RAS, Сhairman
Blaginin A.A., M.D., Doctor of Psychology, professor
Gal’chenko V.F., Sci.D., professor, Corresponding Member of RAS
Zhdan’ko I.M., M.D.
Ostrovskij M.A., Sci.D., professor, Academician of RAS
Rozanov A.YU., D.Geol.Mineral.S., professor, Academician of RAS Rubin A.B., Sci.D., professor, Corresponding Member of RAS
Zaluckij I.V., Sci.D., professor, Corresponding Member of NASB (Belarus)
Kryshtal’ O.A., Sci.D., professor, Academician of NASU (Ukraine)
Makashev E.K., D.Biol.Sci., professor, Corresponding Member of ASRK (Kazakhstan)
Gerzer R., M.D., Ph.D., professor (Germany)
Gharib C., Ph.D., professor (France)
Yinghui Li, M.D., Ph.D., professor (China)
2021 V. 55 № 1/1 special issue
Founded in 1967
1967 – 1974 – «Space Biology and Medicine»
1974 – 1991 – «Space Biology and Aerospace Medicine»
1991 – «Aerospace and Environmental Medicine»
INCLUDED IN THE LIST OF THE LEADING REVIEWED JOURNALS HIGHER ATTESTATION
COMMISSION OF THE RUSSIAN FEDERATION
Founder and publisher
The Russian Federation State Research Center – Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS)
The journal is registered by the State Committee of the Russian Federation for Press 28.02.1995, reg. № 01072, license ID number 05859 on 18.09.2001
© State Reseаrch Center RF – Institute of Biomedical Problems Russian Academy of Sciences, 2021
All rights reserved. No part of this journal may be reproduced in any form by any means without written permission of the Editorial Board.
Managing Editor, technical editor and proofreader – Sorokin O.G., Ph.D.
DTP – Rzaeva E.V.
Address: 76A, Khoroshevskoe shosse, Moscow 123007, Russia
Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS)
Journal of Aerospace and Environmental Medicine. E-mail: [email protected], tel. 8 (499) 195-65-12
Fax: 8 (499) 195-22-53
Publishing office
E-mail: [email protected], tel. 8 (499) 195-68-74
Сдано в набор 26.02.2021
Подписано в печать 09.02.2021
Формат 60 × 84 1/8 Гарнитура Tahoma Печать офсетная Усл. печ. л. 17,7 Тираж 300 экз Заказ № 35
Отпечатано в типографии ООО ИПЦ «Научная книга» Адрес: 394026, г. Воронеж, Московский пр-т, д. 11б
INTERNATIONAL ACADEMY OF ASTRONAUTICS (IAA)
STATE SPACE CORPORATION «ROSCOSMOS»
MINISTRY OF SCIENCE AND HIGHER EDUCATION OF THE RUSSIAN FEDERATION
RUSSIAN ACADEMY OF SCIENCES (RAS)
STATE RESEARCH CENTER OF THE RUSSIAN FEDERATION –
INSTITUTE OF BIOMEDICAL PROBLEMS RAS
Abstracts
XXIII International Symposium
HUMAN IN SPACE
April 5–9, 2021 Moscow, Russia
- HONORARY CHAIRMEN
- HONORARY ORGANIZING COMMITTEE
J.-M. Contant, IAA, France
A. Perminov, IAA, Russia
- D. Rogozin, Roscosmos, Russia
- S. Saveliev, IAF, Roscosmos, Russia
A. Grigoriev, RAS, IBMP, Russia
INTERNATIONAL ORGANIZING COMMITTEE
PROGRAM COMMITTEE
Chairperson − O. Orlov, RAS, IBMP, Russia
Chairperson – E. Fomina, IAA/ IBMP, Russia
- Members:
- Members:
V. Medvedev, Min. of Sci. and Higher Ed., Russia I. Chugueva, Min. of Sci. and Higher Ed., Russia A. Romanov, Min. of Sci. and Higher Ed., Russia D. Pospekhov, Min. of Sci. and Higher Ed., Russia A. Bloshenko, Roscosmos, Russia S. Krikalev, Roscosmos, Russia P. Vlasov, GCTC, Russia I. Ozar, RSC “Energia”, Russia V. Soloviev, RSC “Energia”, Russia V. Tkachuk, RAS, Russia
P. Norsk, NASA, USA G. Clement, NASA, USA M. Downs, NASA, USA E. Feichtinger, IAF, France
P. Rettberg, IAA/DLR, Germany
Ch. Rogon, DLR, Germany A. Chouker, LMU, Germany S. Schneider, GSU, Germany A. Pavy-Le Traon, CNES, France Ph. Arbeille, CNES, France A. Maillet, MEDES, France S. Iwase, Aichi Medical University, Japan A. Al Rais, MBRSC, UAE
V. Dubinin, TSNIImash, Russia O. Kotov, ASE, IBMP, Russia W. Paloski, NASA, USA
- J. Fogarty, NASA, USA
- L. Yinghui, ACC, China
J. Robinson, NASA, USA B. Corbin, NASA, USA J. Hayes, NASA, USA C. Kundrot, NASA, USA C. Mukai, JAXA, Kao Corporation, Japan Y. Deng, BIT, China
T. Tishchenko, Roscosmos, Russia M. Kharlamov, GCTC, Russia V. Bogomolov, IBMP, Russia L. Buravkova, IBMP, Russia D. Anikeev, IBMP, Russia V. Sychev, IBMP, Russia
F. Zhuang, IAA, BUAA, China C. Kourtidou-Papadeli, IAA, AUTH, Greece D. Prunariu, IAA, Romanian Academy, Romania Ch. Feichtinger, IAF, France P. Gräf, DLR, Germany
Yu. Bubeev, IBMP, Russia A. Suvorov, IBMP, Russia V. Gushin, IBMP, Russia A. Shtemberg, IBMP, Russia B. Shenkman, IBMP, Russia
- V. Ilyin, IBMP, Russia
- L. Suchet, CNES, France
- J. Ngo-Anh, ESA, France
- E. Ilyin, IBMP, Russia
- M. Braun, DLR, Germany
- I. Larina, IBMP, Russia
J. Jordan, DLR, Germany S. Al Marri, KFU, UAE
L. Moukhamedieva, IBMP, Russia M. Belakovskiy, IBMP, Russia N. Artuhina, MMC, Russia E. Tomilovskaya, IBMP, Russia V. Rusanov, IBMP, Russia J. Popova, IBMP, Russia
Е. Luchitskaya, IBMP, Russia
A. Kussmaul, IBMP, Russia
LOCAL ORGANIZING COMMITTEE
Chairperson − S. Ponomarev, IBMP, Russia
Members:
A. Romanov, IBMP, Russia A. Rybalov, IBMP, Russia T. Semenkova, IBMP, Russia S. Kaminskaya, IBMP, Russia A. Smoleievskiy, IBMP, Russia O. Sorokin, IBMP, Russia M. Polyakov, IBMP, Russia
T. Zhuravleva, IBMP, Russia A. Boyko, IBMP, Russia I. Zubov, IBMP, Russia S. Fedyay, IBMP, Russia O. Ivanov, IBMP, Russia K. Vlasova, IBMP, Russia R. Zaripov, IBMP, Russia
XXIII International Symposium HUMANS IN SPACE
NASA ARTEMIS MISSIONS & HUMAN RESEARCH OPPORTUNITIES
Abadie L.J.
NASA Human Research Program, Houston, TX, USA E-mail: [email protected]
NASA’s Artemis program will return humans to the Moon and establish sustainable exploration, to help prepare humanity
for the next giant leap to Mars. Artemis missions offer platforms to study human health and performance in the deep space
environment, and the Human Research Program (HRP) is actively working across Artemis programs and with international partners to enable human research opportunities.
This is an exciting opportunity to collect invaluable human health data to expand our understanding on the influence of various spaceflight hazards on humans with the goal of Mars exploration-class missions. Artemis platforms for potential utilization include in-flight Gateway, lunar surface science, pre-deployed payloads, pre- and post-flight baseline data collection,
and transit in the Orion vehicle between Earth and lunar vicinity.
This session will include an overview of Artemis missions and their components, general mission timeline, plans for Initial
Capabilities, including human research opportunities, and an overview of Sustained Capabilities and Mars-forward missions. Additionally, it will describe the need to synergize human research and medical operations for Artemis missions with their limited mission opportunities and constraints.
NEUROPSYCHOLOGICAL EFFECTS OF ISOLATION AND PHYSICAL EXERCISE REGIMEN DURING SIRIUS-19
Abeln V.1, Klein T.1, Möller F.1, Hoffmann U.1, Popova J.2, Fomina E.2, Vassilieva G.2, Schneider S.1
1Centre for Health and Integrative Physiology in Space (CHIPS), German Sport University Cologne, Germany 2State Research Center of the Russian Federation – Institute of biomedical problems RAS, Moscow, Russia
Physical exercise could reduce the risk of undesired mental impairments during isolation and space missions. This project
aimed to clarify beneficial as well as adverse effects of continuous versus interval running exercise on brain health and
cognition and underlying neurophysiological mechanisms during a terrestrial simulated space mission.
Six volunteers (aged 33.6 years, 3 females) simulated a 120-day mission to the Moon (SIRIUS-19). Exercise training consisted of treadmill running during a continuous (CON) or an interval (INT) protocol. Each protocol was performed
throughout one half (either first or second) of the mission and switched in a cross-over design. Data was collected prior to (BDC-14 to BDC-7), four times during (start and end of each protocol; MD14/16, MD53/54, MD79/80, MD110/112), as well as
post isolation (R+6 to R+9), pre- and post- exercise on two separate days respectively. Cognitive performance (Cognition test
battery BHP-SM), self-perceived state of mood (MoodMeter©) and affect (PANAS), and electroencephalographic recordings
(EEG, 32-channel) were assessed. Morning blood samples were drawn to assess BDNF, IGF-1, and VEGF and saliva samples
every 2 hours from 8am to 10pm to assess cortisol levels. Effects of isolation (factor: TIME), exercise (pre vs post exercise), exercise protocol (INT vs CON) and gender were calculated using non-parametric tests. No significant changes from in to
post isolation data collections have been observed. Therefore, only BDC was compared to the end of each training protocol in
order to reduce alpha error and increase statistical power (α = 0.05, for factor time α = 0.017). As an effect of TIME, lactate decreased at fixed running speed 9km/h (p = 0.03) at the end of both training protocols compared to BDC (p = 0.046). Cortisol level increased as a factor of time (p = 0.011) from BDC to the end of both exercise protocols (p = 0.028) and cognitive performance improved (overall reaction time p = 0.006, score p= 0.016). Positive (p = 0.549) and negative affect (p= 0.717) as well as perceived physical (p= 0.568) and motivational state (p= 0.200) did not change over time. Perceived psychological strain significantly improved comparing BDC to both exercise protocol end-points (p = 0.015). Neither BDNF (p = 0.607), IGF-1 (p = 0.60) nor VEGF (p = 0.846) did change over time, but IGF-1 showed a significant effect of exercise protocol and higher values at the end of CON compared to the end of the INT protocol (p = 0.028). With this exception, no difference between pre and post exercise, exercise protocols and sex were found for all other variables. Reduced broadband power and a flattening of the 1/f spectral slope was found in resting-state EEG during isolation compared to BDC (see Weber et al. Scientific reports (2020)10: 17987).
In conclusion, this exercise training protocol during 120 days of isolation improved physical fitness. Although cortisol level increased and brain cortical activity decreased during isolation, cognitive performance, mood, affect and neurotrophic factors
remained stable independent of gender and the exercise protocol (except IGF-1 increased for CON). Longer duration missions with manipulations of the exercise protocol are needed to further optimize training protocols.
Aerospace and Environmental Medicine 2021 V. 55 № 1/1 special issue
7
XXIII International Symposium HUMANS IN SPACE
HUMAN SPACEFLIGHT OUTREACH – CHALLENGES AND STRATEGY FOR A DEVELOPING NATION
Abhijeet Kibe, Abhishek Jha, Anurag Kumar Sinha
Indian Space Research Organisation, Directorate of Human Spaceflight Programme, Bengaluru, India
As humanity celebrates the 60th anniversary of the first human spaceflight endeavor, human spaceflight activities are
evincing greater interest from around the globe. This is truly democratization phase of human space activities as more nations
are beginning to understand the benefits of a sus-tained human spaceflight program. Human space programs pursued by
nations have undergone a transformational shift from being a tool of projection of national power and technological prowess
to symbols of international cooperation. Today, these programs are transcending national borders as the benefits of scientific research and spin offs, are percolating to the common masses. Yet the classic argument on the benefits of human spaceflight
vis-a-vis its economic costs still constrain many poli-cymakers to take bold national initiatives in this area. This is especially true in the case of developing nations where public resources are scarce.
Space education and outreach activities provide an effective tool to address this issue as an ena-bler for mass participation
in human space activities. This is evident from the fact that space travelers have been regarded as role models to society and ambassadors of humanity beyond their national borders. There is a need to utilize space education and outreach tools innovatively for information dissemination, taking into account the information needs of all the stakeholders. This improves trans-parency about the program goals and outcomes.
In the case of human spaceflight activities in developing nations, this becomes especially im-portant as public enthusiasm, participation, and support of human spaceflight activities is an im-portant investment driver. Effective outreach program also facilitates international cooperation. In addition to this, space education and outreach also help in the development of scientific
tempera-ment and curiosity among the masses, especially youth. This is the main driver for technological in-novations, entrepreneurship, and spurring business growth, which is essential for the economic de-velopment of any nation.
This paper discusses the contribution of space education and outreach activities in the domain of human spaceflight and
its socio-economic impact. This paper also addresses the challenges in space education and outreach activities that are unique to developing nations and proposes strategies to overcome. This paper also argues that Space agencies especially from the developing world who as-pire to pursue human space activities must implement a comprehensive Space education and outreach strategy.
GOVERNANCE OF SPACE TOURISM
Abhishek Jha, Abhijeet Kibe, Anurag Kumar Sinha, V.R Lalithambika
Indian Space Research Organisation, Directorate of Human Space Programme, Bengaluru, India
Tourism has been a key driver for socio-economic development in many countries around the world. In the year 2019, global travel and tourism activities contributed around 10 % to the world’s GDP and 1 in 10 jobs around the world was generated by tourism industry. This is a consumer driven industry where the demand is met by various service providers and competition drives the quality of services.
Space travel and tourism holds a promising future as an economic activity and adds another di-mension to the present travel and tourism activity on earth. This paper aims to present a model for the space travel and tourism industry and analyses
the role of different stakeholders. Space activities have played a major role in the development of humanity through the planetary exploration; micro-gravity based scientific research and spin-offs. Space travel has been the domain of governmental
space agencies in space faring nations. However, with the entry of private players in space activities, space tourism may become a reality in near future.
Compared to the travel and tourism activities on earth, space travel and tourism has additional dimensions and therefore
stakeholders. This paper proposes a governance model involving different stakeholders in space tourism sector. This is done while factoring in various consumer profiles and the demand scenarios. Since space travel is inherently a hazardous activity,
role and jurisdiction of regulatory agencies is also discussed.
SOLVING NUTRITION PROBLEMS IN INTERPLANETARY SPACE FLIGHTS
Agureev A.N., Shef K.A.
State Research Center of the Russian Federation – Institute of biomedical problems RAS, Moscow, Russia E-mail: [email protected]; [email protected]
The solution of issues on the development of products and food rations that ensure the preservation of the health and
performance of crews when exposed to the body of adverse environmental factors during flights into deep space is one of the
main areas of work in the creation of food supply systems (SOP) for crews of interplanetary manned transport ships. 8
Aerospace and Environmental Medicine 2021 V. 55 № 1/1 special issue
XXIII International Symposium HUMANS IN SPACE
When developing SOPs for interplanetary flights, the principle of continuity should be observed, when the design and
layout of a new system uses well-proven and improved SOP elements of previous manned transport ships and orbital stations.
The conditions of interplanetary flights determine a number of additional problems that need to be solved in the process of creating an SOP. These include, first of all, long flight autonomy and high levels of ionizing radiation when passing through
radiation belts.
The lack of the possibility of periodic replenishment of stocks during interplanetary space flight is associated with special
requirements for food rations in general and for their constituent products. The main of these requirements are:
•••••minimum dimensions and weight; - ease of use and storage in a spacecraft; convenience of food intake and its “unfeasibility” for a long time; minimal time spent on cooking and the possibility of using them both hot and cold; good digestibility and assimilation; microbiological safety during the entire storage period.
To ensure the safety of crews during the passage of radiation belts, it is necessary to develop and introduce into the diet
products with radioprotective properties and biologically active products, which will significantly expand the arsenal of means
for protecting the body from ionizing radiation and preventing functional changes developing in the body when exposed to
extreme factors during flights into deep space.
In addition to the main diet on board the interplanetary spacecraft, a wide range of additional food sets and special food and food additives should be available. They will make it possible to introduce variety in nutrition, to correct the nutritional composition of rations in accordance with the changing needs of the body at various stages of a space expedition, to ensure the normal functioning of the gastrointestinal tract, excretory system and other physiological processes in the body.
Conclusion. In order to provide physiologically adequate nutrition for spacecraft crews during flights into deep space, it is
necessary to start developing:
•••
Technical equipment for modernization of the SOP on an interplanetary manned spacecraft; Technologies for the manufacture of a new range of products for long-term (at least 3 years) storage; Products with radioprotective properties and biologically active products that increase the body’s resistance to adverse
environmental influences and reduce the risks of developing certain diseases.
APPROACH FOR EVOLVING MEDICAL CRITERIONS & HUMAN TOLERANCE LIMITS FOR FUTURE SPACE TOURISTS
Ajay Kumar1, Abhishek Jha2, Abhijeet Kibe2, Anurag Kumar Sinha2
1Indian Air Force, Institute of Aerospace Medicine, Bengaluru, India
2Indian Space Research Organisation, Directorate of Human Spaceflight Programme, Bengaluru, India
As Space Tourism is an upcoming lucrative sector with immense commercial potential. With the ad-vent of private players in commercial human space sector the space tourism sector is only expected to grow further. Unlike the Space Mission in
pursuance of scientific objectives, a commercial tourist flight is likely to change the philosophy of designing a Space Mission significantly.
Designing a space mission is a challenging task which in turn strives to strike a balance technical limitations in terms of the capability of rocket system, weight of crew module, operational requirement for safe recovery at all stages of launch and recovery and need to keep various physical stressors like acceleration, vibration, noise and temperature etc. within the tolerance range of the subjects occupying the crew module.