ISSN 0233-528X Aerospace and Environmental Medicine 2021 V. 55 № 1/1 special issue The Organizers: INTERNATIONAL ACADEMY OF ASTRONAUTICS (IAA) STATE SPACE CORPORATION “ROSCOSMOS” MINISTRY OF SCIENCE AND HIGHER EDUCATION OF THE RUSSIAN FEDERATION RUSSIAN ACADEMY OF SCIENCES (RAS) STATE RESEARCH CENTER OF THE RUSSIAN FEDERATION – INSTITUTE OF BIOMEDICAL PROBLEMS RAS Aerospace and Environmental Medicine AVIAKOSMICHESKAYA I EKOLOGICHESKAYA MEDITSINA SCIENTIFIC JOURNAL EDITOR-IN-CHIEF Orlov O.I., M.D., Academician of RAS EDITORIAL BOARD The Organizers: Ardashev V.N., M.D., professor Baranov V.M., M.D., professor, Academician of RAS Buravkova L.B., M.D., professor, Corresponding Member of RAS Bukhtiyarov I.V., M.D., professor Vinogradova O.L., Sci.D., professor – Deputy Editor D’yachenko A.I., Tech. D., professor Ivanov I.V., M.D., professor Ilyin E.A., M.D., professor Kotov O.V., Ph.D. Krasavin E.A., Ph.D., Sci.D., professor, Corresponding Member of RAS Medenkov A.A., Ph.D. in Psychology, M.D., professor Sinyak YU.E., M.D., Tech.D., professor Sorokin O.G., Ph.D. Suvorov A.V., M.D., professor Usov V.M., M.D., professor Homenko M.N., M.D., professor Mukai Ch., M.D., Ph.D. (Japan) Sutton J., M.D., Ph.D. (USA) Suchet L.G., Ph.D. (France) ADVISORY BOARD Grigoriev A.I., M.D., professor, Academician of RAS, Сhairman Blaginin A.A., M.D., Doctor of Psychology, professor Gal’chenko V.F., Sci.D., professor, Corresponding Member of RAS Zhdan’ko I.M., M.D. Ostrovskij M.A., Sci.D., professor, Academician of RAS Rozanov A.YU., D.Geol.Mineral.S., professor, Academician of RAS Rubin A.B., Sci.D., professor, Corresponding Member of RAS Zaluckij I.V., Sci.D., professor, Corresponding Member of NASB (Belarus) Kryshtal’ O.A., Sci.D., professor, Academician of NASU (Ukraine) Makashev E.K., D.Biol.Sci., professor, Corresponding Member of ASRK (Kazakhstan) Gerzer R., M.D., Ph.D., professor (Germany) Gharib C., Ph.D., professor (France) Yinghui Li, M.D., Ph.D., professor (China) 2021 V. 55 № 1/1 special issue Founded in 1967 1967 – 1974 – «Space Biology and Medicine» 1974 – 1991 – «Space Biology and Aerospace Medicine» 1991 – «Aerospace and Environmental Medicine» INCLUDED IN THE LIST OF THE LEADING REVIEWED JOURNALS HIGHER ATTESTATION COMMISSION OF THE RUSSIAN FEDERATION Founder and publisher The Russian Federation State Research Center – Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) The journal is registered by the State Committee of the Russian Federation for Press 28.02.1995, reg. № 01072, license ID number 05859 on 18.09.2001 © State Reseаrch Center RF – Institute of Biomedical Problems Russian Academy of Sciences, 2021 All rights reserved. No part of this journal may be reproduced in any form by any means without written permission of the Editorial Board. Managing Editor, technical editor and proofreader – Sorokin O.G., Ph.D. DTP – Rzaeva E.V. Address: 76A, Khoroshevskoe shosse, Moscow 123007, Russia Institute of Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) Journal of Aerospace and Environmental Medicine. E-mail: [email protected], tel. 8 (499) 195-65-12 Fax: 8 (499) 195-22-53 Publishing office E-mail: [email protected], tel. 8 (499) 195-68-74 Сдано в набор 26.02.2021 Подписано в печать 09.02.2021 Формат 60 × 84 1/8 Гарнитура Tahoma Печать офсетная Усл. печ. л. 17,7 Тираж 300 экз Заказ № 35 Отпечатано в типографии ООО ИПЦ «Научная книга» Адрес: 394026, г. Воронеж, Московский пр-т, д. 11б INTERNATIONAL ACADEMY OF ASTRONAUTICS (IAA) STATE SPACE CORPORATION «ROSCOSMOS» MINISTRY OF SCIENCE AND HIGHER EDUCATION OF THE RUSSIAN FEDERATION RUSSIAN ACADEMY OF SCIENCES (RAS) STATE RESEARCH CENTER OF THE RUSSIAN FEDERATION – INSTITUTE OF BIOMEDICAL PROBLEMS RAS Abstracts XXIII International Symposium HUMAN IN SPACE April 5–9, 2021 Moscow, Russia HONORARY CHAIRMEN HONORARY ORGANIZING COMMITTEE J.-M. Contant, IAA, France A. Perminov, IAA, Russia D. Rogozin, Roscosmos, Russia S. Saveliev, IAF, Roscosmos, Russia A. Grigoriev, RAS, IBMP, Russia INTERNATIONAL ORGANIZING COMMITTEE PROGRAM COMMITTEE Chairperson − O. Orlov, RAS, IBMP, Russia Chairperson – E. Fomina, IAA/ IBMP, Russia Members: Members: V. Medvedev, Min. of Sci. and Higher Ed., Russia P. Norsk, NASA, USA I. Chugueva, Min. of Sci. and Higher Ed., Russia G. Clement, NASA, USA A. Romanov, Min. of Sci. and Higher Ed., Russia M. Downs, NASA, USA D. Pospekhov, Min. of Sci. and Higher Ed., Russia E. Feichtinger, IAF, France A. Bloshenko, Roscosmos, Russia P. Rettberg, IAA/DLR, Germany S. Krikalev, Roscosmos, Russia Ch. Rogon, DLR, Germany P. Vlasov, GCTC, Russia A. Chouker, LMU, Germany I. Ozar, RSC “Energia”, Russia S. Schneider, GSU, Germany V. Soloviev, RSC “Energia”, Russia A. Pavy-Le Traon, CNES, France V. Tkachuk, RAS, Russia Ph. Arbeille, CNES, France V. Dubinin, TSNIImash, Russia A. Maillet, MEDES, France O. Kotov, ASE, IBMP, Russia S. Iwase, Aichi Medical University, Japan W. Paloski, NASA, USA A. Al Rais, MBRSC, UAE J. Fogarty, NASA, USA L. Yinghui, ACC, China J. Robinson, NASA, USA T. Tishchenko, Roscosmos, Russia B. Corbin, NASA, USA M. Kharlamov, GCTC, Russia J. Hayes, NASA, USA V. Bogomolov, IBMP, Russia C. Kundrot, NASA, USA L. Buravkova, IBMP, Russia C. Mukai, JAXA, Kao Corporation, Japan D. Anikeev, IBMP, Russia Y. Deng, BIT, China V. Sychev, IBMP, Russia F. Zhuang, IAA, BUAA, China Yu. Bubeev, IBMP, Russia C. Kourtidou-Papadeli, IAA, AUTH, Greece A. Suvorov, IBMP, Russia D. Prunariu, IAA, Romanian Academy, Romania V. Gushin, IBMP, Russia Ch. Feichtinger, IAF, France A. Shtemberg, IBMP, Russia P. Gräf, DLR, Germany B. Shenkman, IBMP, Russia L. Suchet, CNES, France V. Ilyin, IBMP, Russia J. Ngo-Anh, ESA, France E. Ilyin, IBMP, Russia M. Braun, DLR, Germany I. Larina, IBMP, Russia J. Jordan, DLR, Germany L. Moukhamedieva, IBMP, Russia S. Al Marri, KFU, UAE M. Belakovskiy, IBMP, Russia N. Artuhina, MMC, Russia E. Tomilovskaya, IBMP, Russia V. Rusanov, IBMP, Russia J. Popova, IBMP, Russia Е. Luchitskaya, IBMP, Russia A. Kussmaul, IBMP, Russia LOCAL ORGANIZING COMMITTEE Chairperson − S. Ponomarev, IBMP, Russia Members: A. Romanov, IBMP, Russia T. Zhuravleva, IBMP, Russia A. Rybalov, IBMP, Russia A. Boyko, IBMP, Russia T. Semenkova, IBMP, Russia I. Zubov, IBMP, Russia S. Kaminskaya, IBMP, Russia S. Fedyay, IBMP, Russia A. Smoleievskiy, IBMP, Russia O. Ivanov, IBMP, Russia O. Sorokin, IBMP, Russia K. Vlasova, IBMP, Russia M. Polyakov, IBMP, Russia R. Zaripov, IBMP, Russia XXIII International Symposium HUMANS IN SPACE NASA ARTEMIS MISSIONS & HUMAN RESEARCH OPPORTUNITIES Abadie L.J. NASA Human Research Program, Houston, TX, USA E-mail: [email protected] NASA’s Artemis program will return humans to the Moon and establish sustainable exploration, to help prepare humanity for the next giant leap to Mars. Artemis missions offer platforms to study human health and performance in the deep space environment, and the Human Research Program (HRP) is actively working across Artemis programs and with international partners to enable human research opportunities. This is an exciting opportunity to collect invaluable human health data to expand our understanding on the influence of various spaceflight hazards on humans with the goal of Mars exploration-class missions. Artemis platforms for potential utilization include in-flight Gateway, lunar surface science, pre-deployed payloads, pre- and post-flight baseline data collection, and transit in the Orion vehicle between Earth and lunar vicinity. This session will include an overview of Artemis missions and their components, general mission timeline, plans for Initial Capabilities, including human research opportunities, and an overview of Sustained Capabilities and Mars-forward missions. Additionally, it will describe the need to synergize human research and medical operations for Artemis missions with their limited mission opportunities and constraints. NEUROPSYCHOLOGICAL EFFECTS OF ISOLATION AND PHYSICAL EXERCISE REGIMEN DURING SIRIUS-19 Abeln V.1, Klein T.1, Möller F.1, Hoffmann U.1, Popova J.2, Fomina E.2, Vassilieva G.2, Schneider S.1 1Centre for Health and Integrative Physiology in Space (CHIPS), German Sport University Cologne, Germany 2State Research Center of the Russian Federation – Institute of biomedical problems RAS, Moscow, Russia Physical exercise could reduce the risk of undesired mental impairments during isolation and space missions. This project aimed to clarify beneficial as well as adverse effects of continuous versus interval running exercise on brain health and cognition and underlying neurophysiological mechanisms during a terrestrial simulated space mission. Six volunteers (aged 33.6 years, 3 females) simulated a 120-day mission to the Moon (SIRIUS-19). Exercise training consisted of treadmill running during a continuous (CON) or an interval (INT) protocol. Each protocol was performed throughout one half (either first or second) of the mission and switched in a cross-over design. Data was collected prior to (BDC-14 to BDC-7), four times during (start and end of each protocol; MD14/16, MD53/54, MD79/80, MD110/112), as well as post isolation (R+6 to R+9), pre- and post- exercise on two separate days respectively. Cognitive performance (Cognition test battery BHP-SM), self-perceived state of mood (MoodMeter©) and affect (PANAS), and electroencephalographic recordings (EEG, 32-channel) were assessed. Morning blood samples were drawn to assess BDNF, IGF-1, and VEGF and saliva samples every 2 hours from 8am to 10pm to assess cortisol levels. Effects of isolation (factor: TIME), exercise (pre vs post exercise), exercise protocol (INT vs CON) and gender were calculated using non-parametric tests. No significant changes from in to post isolation data collections have been observed. Therefore, only BDC was compared to the end of each training protocol in order to reduce alpha error and increase statistical power (α = 0.05, for factor time α = 0.017). As an effect of TIME, lactate decreased at fixed running speed 9km/h (p = 0.03) at the end of both training protocols compared to BDC (p = 0.046).