PRE FEASIBILITY REPORT

For

PROPOSED BULK DRUGS AND BULK DRUG INTERMEDIATES IN EXISTING THINERS FORMULATION UNIT

of

M/s. ANJU LIFE SCIENCE Plot No. 6007/1, GIDC, Ankleshwar – 393 002, Dist. Bharuch, Gujarat

0

CONTENTS

Sr. No. Description Page No. 1. Executive Summary 2 2. Introduction of the Project/Background information 21 3. Project Description 22 4. Site Analysis 28 5. Planning Brief 29 6. Proposed Infrastructure 30 7. Rehabilitation and resettlement (R & R) Plan 31 8. Project Schedule & Cost Estimates 31 9. Analysis of Proposal (Final Recommendations) 32

1

1.0 EXECUTIVE SUMMARY 1.1 Company Profile M/s. Anju Life Science engages in manufacturing of formulation of thinners unit at Plot No. 6007/1, GIDC, Ankleshwar - 393 002, Dist: Bharuch, Gujarat, INDIA. Now, company is going for new bulk drugs, bulk drug intermediates & distillation (in-house common group facility) within existing premises.

1.2 Project Details 1.2.1 Products along with Production Capacity Sr. Products Capacity CAS No. No. (MT/Month) Existing Additional Total

Existing 1. Formulation of Thinners/Reducers 500 -- 500 Proposed 1 Furosemide -- 5 5 54-31-9 2 Diaminomethyleneamino (1-amino-1- -- 100 100 -- iminomethylene) thiomethyl thiozole dihydrochloride [ITU] 3 N-Sulfomyl-3-chloropropionamide -- 100 100 123-92-2 hydrochloride[IF] 4 Famotidine -- 5 5 105-68-0 5 Fomepizole -- 14205-39-1 6 Colsevelam hydrochloride -- 88150-62-3

7 Glimepiride -- 93479-97-1

8 Betahistine Dihydrochloride -- 106649-95-0

9 Adapalene -- 76824-35-6 10 Telmisartan -- 152751-57-0 11 Tapentadol Hydrochloride -- 845273-93-0 12 Colistimethate Sodium -- 71550-12-4 13 Rusvastatin Calcium -- 7554-65-6 14 1-3 dichloro Acetone -- 182815-44-7 15 Gunylthiourea -- 10 10 93479-97-1 16 Rabeprazole Sodium -- 5579-84-0 17 Carvediol -- 106685-40-9 18 Celecoxib -- 144701-48-4

2 19 Clopidogrel Bisulfate -- 175591-09-0 20 Atoravastatin Calcium -- 8068-28-8 21 Etoricoxib -- 147098-20-2 22 Valsartan -- 534-07-6 23 Tranexamic Acid -- 2114-02-5 24 Folic Acid -- 117976-90-6 25 Zolpidic Acid --- 72956-09-3 26 Pregabaline --- 169590-42-5 27 Chlorohexidine Base --- 120202-66-6 28 Benzarone --- 134523-03-8 29 Benzbromarone -- 202409-33-4 30 Zaltoprofen -- 137862-53-4 31 Ondansetron Hydrochloride -- 1197-18-8 32 Miconazole Nitrate -- 59-30-3 33 Ecanazole Nitrate -- 189005-44-5 34 Desloratadine -- 148553-50-8 35 Loratidine -- 79794-75-5 36 Gabapentine -- 60142-96-3 37 Albendazole -- 54965-21-8 38 Citrezine Hydrochloride -- 83881-52-1 39 Lasamide -- 2736-23-4 40 Pioglitazone Hydrochloride -- 112529-15-4 41 Mesalamine -- 89-57-6 42 Febuxostat -- 144060-53-7 43 Itopride Hydrochloride -- 122892-31-3 44 Amodafinil -- 68693-11-8 45 Quetipine Fumrate -- 111974-72-2 46 Aripiprazole -- 200 200 129722-12-9 47 Amlodipine Besylate -- 111470-99-6 48 Nebivilol Hydrochloride -- 152520-56-4 49 Sevelamer Hydrochloride -- 106-27-4 50 Sevelamer Carbonate -- 103-45-7 51 Poly Allaylamine Hydrochloride -- 122-70-3 Total (A) 500 420 920 Distillation of Solvent (B) -- 200 200 Total (A+B) 500 620 1120

3 1.3 Raw Material Requirement

Sr. No. Raw Material Qu antity (MT/MT) 1. Furosemide Furfuryl Amine 0.450 Lasamide 0.850 Caustic Flake 0.234 IPA 0.240 Carbon 0.080 Acetic Acid 0.220 2. Diaminomethyleneamino (1 -amino -1- iminomethylene) thiomethyl thiozole dihydrochloride [ITU] 1,3 DCA 0.435 Gu anyl Thiourea 0.413 Acetone 3.100 Catalyst 0.004 Thiourea 0.261 Acetic Acid 0.261 3. N-Sulfomyl -3-chloropropionamide hydrochloride [IF] Acrylonitrile 1.303 Hydrogen Peroxide 0.008 HCl (Gas) 1.495 Sulfamide 0.500 Acetone 0.400 4. Famoti dine ITU 1.150 IF 0.965 Methanol 5.710 NaOH 0.690 Water 20.50 Acetic Acid 0.200 5. Colsevelam hydrochloride Monoallylamine 0.60 2,2 -dimethyl -2,2 -azopropane dihydrochloride 0.01 Concentrated Hydrochloric acid 1.15 Methanol 0.31 Pol yallylamine 0.90 Epichlorohydrin 0.01 n-Decylchloride 0.02 Trimethylammoniumhexylchloride 0.02 Sodium hydroxide 0.45 6. Glimepiride 3 Ethyl methyl Pyrroline 0.40

4 2 Phenyl ethyl isocyanate 0.40 Toluene 0.15 Chloro Sulfonic Acid 1.00 Amm onia Solution 3.10 EDC 0.30 7. Fomepizole Propanaldehyde 1.31 Ethanol 0.015 Hexane 0.015 Phosphorus oxychloride 3.45 Hydrazine Hydrate 1.10 Potassium Carbonate 0.75 Carbon 0.15 Di isopropyl Ether 0.02 N,N -Dimethyl Formamide 0.01 Dic hloro Methane 0.03 8. Betahistine Dihydrochloride 2- vinyl pyridine 0.63 Methylamine hydrochloride 0.80 Chloroform 0.23 Sodium hydroxide 0.45 Acetic Acid 0.06 IPA 0.01 IPA HCl(20%) 1.38 9. Adapalene Adamentanol 0.48 Para Bromo Phenol 0.30 THF 0.025 Mg Turning 0.06 MDC 0.04 6-Bromo -2-methyl naphthoate 0.72 HCl 1.32 10. Telmisartan 4-Amino 3 - Methylbenzoic acid 1.484 Conc. Sulphuric Acid 1.423 Liq. Ammonia 2.968 Methanol 0.06 MDC 0.03 TEA 0.01 Butryl Chloride 1. 287 Sodium Bicarbonate 0.153 Sodium Sulphate 0.387 Hexane 0.02 Fuming Nitric Acid 4.050 11. Tapentadol Hydrochloride 3-methoxy propiophenone 1.412

5 IPA 0.350 Dimethyl Amine HCL 1.059 Paraformadehyde 0.588 Sodium Hydroxide 0.376 MDC 0.3 50 L ( -) Dibenzoyl tartaric acid 1.412 THF 0.080 Mg Turning 0.171 Ethyl Bromide 0.588 Acetic Acid 0.118 Ammonium Solution 0.506 Ethyl Acetate 0.230 Trifluroacetic anhydride 0.882 Palladium 0.070 Acetone 0.260 HBr 1.765 IPA HCl 0.882 12. Colistimethate Sodium Colistin Sulphate 1.33 Sodium Bicarbonate 0.67 Sodium Carbonate 0.33 Formaldehyde 1.33 Sodium Bisulfite 3.06 Acetic Acid 0.16 Solvent 0.80 Acetone 2.00 Methanol 3.00 13. Rusvastatin Calcium 4-Fluoro Benza ldehyde 0.52 4-Methyl -3-oxo -Pentatonic Acid Ethyl Ester 0.66 Potassium Hydroxide 0.24 Methyl Iodide 0.60 Methanol 5.50 5-Methyl Iso Thio Urea 0.35 2,3 -Dichloro -5,6 -Dicyano Benzoquinone 0.85 HMPA 1.00 MDC 8.00 Meta Chloro Peroxy Benzoic Ac id 0.11 Methyl Amine 0.10 Ethanol 2.50 Methane Sulfonyl Chloride 0.35 Sodium Hydride (60%) 0.01 Di Methoxy Ethane 3.00 Hydrogen 0.01

6 DIBAL -H 0.01 Toluene 8.00 Methyl(3R) -3-(tert butyl dimethyl silyloxy) -5-oxo -6- 1.45 triphenyl phosphoranylidene hexanoate Triethyl Amine 0.15 N,N -Dimethyl Formamide 3.00 Hydrogen Fluoride 0.05 THF 7.50 Ethyl Acetate 10.50 Diethyl Methoxy Borane 0.20 Sodium Borohydride 0.01 Calcium Chloride 0.13 14. 1-3 dichloro Acetone Epichlorohydrin 1.302 HCl (30%) 3.125 Sulfuric Acid (98%) 1.862 Sodium Dichromate 1.562 15. Gunylthiourea Phosphorus Penta Sulphide 0.827 KOH 1.000 Dicyanadiamide 0.909 Sodium Hydro Sulphite 0.181 16. Rabeprazole Sodium 2,3 -Lutidine 0.460 H2O2 (50%) 0.330 Nitric Acid 0.380 Acetic Acid 0.060 3-Methoxy 1 -Propanol 0.430 NaOH 0.155 Toluene 0.012 DMSO 0.010 Acetic Anhydride 0.390 HCl 0.200 Thionyl Chloride 0.530 MDC 0.370 Sodium Sulphate 0.100 2-Mercaptobenzimidazole 0.530 Ammonium Hyd roxide 0.125 Sodium Hypochlorite (8%) 3.270 Acetone 0.100 Sodium Hydro Sulphate 0.120 MMA 0.100 IPA 0.150

7 Activated Carbon 0.100 17. Carvediol 4-Hydroxy Carbazole 0.447 Epichlorohydrin 0.790 Hydrose 0.116 Methanol 0.067 Ethyl Acetat e 0.029 Carbon 0.022 Hyflo 0.005 Monoethylene Glycol Dimethyl Ether 2.330 2-(2 -Methoxy Phenoxy) Ethyl Amine 0.956 Acetone 0.101 Potassium Carbonate 0.372 Oxalic Acid 0.532 IPA 0.052 Sodium Sulphate 0.207 Ortho Phosphoric Acid 0.442 18. Celecoxib 4 SPH 0.70 Dione Deri 0.65 Toluene 2.80 Carbon 0.01 19. Clopidogrel Bisulfate amino(2 -chlorophenyl)acetic acid 1.25 methanol 0.20 Potassium salt 0.7 MDC 0.50 Liq. ammonia 0.62 Thiophene -2-Ethanol 0.5 p-toluene sulphonyl chloride 1.05 Toluene 0.16 Sodium hydroxide 1.25 Acetonitrile 0.32 Dipotassium phosphate 0.87 Ethyl acetate 0.28 HCL 0.85 P-Formaldehyde 0.53 MDC 1.02 Liq. Ammonia 0.60 Acetone 1.10 Tartaric acid 0.82 MDC 0.67 Sodium carbonate 0.70

8 Acetone 0.24 Activated carbon 0.15 Sulfuric acid 0.31 20. Atoravastatin Calcium Ethyl -4-Cyano -3-hydroxy butanaote 1.00 THF 0.85 Diisopropyl amine 1.22 N-Butyl Lithium 0.6 Tert -Butyl acetate 1.68 HCl 0.76 Ethyl Acetate 1.5 NaC l 1.20 Methanol 1.02 DEMB (50 % Soln) 0.70 Sodium Borohydride 0.44 Acetic Acid 0.98 Dimethoxy Propane 1.81 Methane Sulphonic Acid 0.03 Sodium Bicarbonate 2.00 n-Hexane 0.023 Raney Nickel 1.00 Pivalic Acid 0.240 Toluene 0.45 Activate d Carbon 0.100 Methyl Tert Butyl 0.410 21. Etoricoxib Acetic Acid 1.520 Acetone 2.80 Ammonia Solution 5.80 CPT -Phosphate 1.520 D M Water 26.00 Hydroxylamine Hydrochloride 0.115 Hyflow 0.177 Isopropyl Alcohol 10.00 Ketosulfon e 0.574 Methanol 10.00 Potassium Tertrabutoxide (KTB) 0.664 Sodium Acetate 0.297 Sodium Hydroxide 2.153 Toluene 55.000 THF 23.00 Trifluro Acetic Acid 0.465 Activated Carbon 0.022

9 Hexane 0.250 22. Valsartan L-Valine 1.44 Metha nol 0.23 Thionyl Chloride 6.90 Toluene 0.38 DCM 2.41 NaOH 0.65 NaCL 0.29 4-Bromo Methyl 2 -Cyano biphenyl 2.17 Acetonitrile 1.00 Potassium Carbonate 1.49 Oxalic Acid 1.00 o-Xylene 1.16 Valeoryl Chloride 1.24 Sodium Bicarbonate 0.28 HCl 0.65 Tributyl Tin Chloride 5.55 Calcium Hydroxide 0.42 Ethyl Acetate 0.35 Diisopropyl ether 7.17 TBAB 0.14 23. Tranexamic Acid 4-aminomethyl 1.060 HCl 0.440 Ruthenium 0.300 Sodium hydroxide 0.252 Methanol 2.000 24. Folic Acid PABGA 1.00 TAPS 0.90 TCA 0.64 SMBS 0.36 NaHCO3 1.20 HCl 30% 6.00 NaOH 0.22 Acetic Acid 0.32 25. Zolpidic Acid Toluene 0.128 Methyl Phenacyl bromide 1.000 2- Amino -5-methyl pyridine 0.611 Triethyl amine 0.531 Oxalyl chloride 0.700 Methylene Dichloride 1.000 Potassium hydroxide 1.340

10 Acetic acid 1.651 Hydrazine hydrate 0.431 Methanol 1.000 26. Pregabaline Sodium Hydroxide 1.90 4-CMH 1.37 Liquid Bromine 1.23 Activated carbon 0.07 Hyflo 0.02 Hydro chloric acid 2.46 IPA 7.06 Morpholine 0.08 Methyl -3-Amino Crotonate : 294 Kg. 1.47 Mono Ethanol Amine 0.625 27. Chlorohexidine Base Hexamethelinediamine 0.30 Butanol 3.51 Hydrochloric acid 0.63 Sodiumdicynamide 0.46 Parachloroaniline HC l 0.85 Sodium hydroxide 0.21 Methanol 0.12 28. Benzarone Salicylaldehyde 0.98 Chloroacetone 0.87 Hydrazine hydrate 1.075 KOH 1.300 Methanol 0.200 MEG 0.05 Toluene 0.150 p-Anisoyl chloride 1.32 Ferric chloride 1.00 Aluminium chlori de 2.475 HCl 2.25 Activated carbon 1.25 Ethyl Acetate 0.158 29. Benzbromarone Salicylaldehyde 0.670 Chloroacetone 0.600 Hydrazine hydrate 0.730 KOH 0.880 Methanol 0.100 MEG 0.600 Toluene 0.140 p-Anisoyl chloride 0.900

11 Ferric chlor ide 0.680 Aluminium chloride 1.680 HCl 2.540 Activated carbon 0.07 Bromine 1.190 TEA 0.690 IPA 0.200 30. Zaltoprofen 2-(2 -(phenylthio) -5- propionylphenyl)acetic 1.414 acid Methanol 8.485 Sulfuric Acid 0.141 Sodium Carbonate 0.263 Tr imethyl Ortho 1.232 Formate Zinc Dust 0.061 Bromine 0.919 Sodium Hydroxide 0.778 Toluene 3.242 Polyphosphoric acid 5.657 EDC 3.536 Ethanol 2.823 Acetic Acid 0.894 Sodium Carbonate 0.258 31. Ondansetron HCL Ondensetron Base 0.90 IPA 3.54 HCl 0.21 32. Miconzole Nitrate 1,3 -dichloro 0.40 Aluminum chloride 0.40 Chloro Acetyl Chloride 0.32 2,2’,4’ Trichloro 0.56

NaOH 0.10 MeOH 0.08 Sodium Borohydrate 0.04 Imidazole 0.17 Toluene 0.16 2,4 -DBC 0.46 Activated Charcoal 0.008 Nitric Acid 0.24 33. Ecanzole Nitrate 1-(2,4 -Dichloro phenyl) - 0.80 2-(1H-Imidazol-1yl)Ethanol

12 Toluene 0.20 NaOH 0.35 4-Chloro benzyl Chloride 0.50 TBAB 0.02 Nitric acid 0.20 Methanol 0.30 34. Desloratadine Loratidine 2.95 Methanol 0.30 KOH 3.93 MIBK 0.45 35. Loratidine M-5 2.90 Sulphuric Acid 0.90 NaOH 3.25 MDC 4.00

SOCl 2 3.31 DMF 0.13

AlCl 3 0.72 Hyflow 0.63 Ethylene Dibromide 0.23 THF 0.9 Iodine 0.005 HCl 1.50 Chloroform 1.50 Hexane 2.20 Toluene 1.50

NaHCO 3 1.75 Acetonitrile 0.20 36. Gabapentine 1-1, Cycloacetic Acid 1.67 Urea 1.00 NaOH 0.62 Xylene 0.58 Conc. HCl 2.34 Methanol 0.30 Ethyl Acetate 0.30 37. Albendazole Ortho Nitro Aniline 1.06 Ammonium Thiocynate 1.24 Methanol 0.20 Chlorine Gas 0.76 Caustic Soda 0.91 N- Propanol 0.383 N-Propyl Bromide 0.90 Toluene 0.380

13 Sodium Hydrosulphide Diluted 4.50 Cyaanamide Solution (L -50 0) 0.52 Methyl Chloro Format 0.65 Acetone 0.18 38. Citrizine HCL P-Chloro benzophenone 1.00 Methyl Alcohol 1.35 Sodium Borohydrate 0.07 Sodium Hydroxide 0.01 Toluene 0.25 Thionyl Chloride 0.85 Hydroxy Ethyl Piperazine 0.80 Sodium Hydr oxide Lye 2.00 Sodium Mono Chloro Acetate 0.38 Dimethyl Formamide 0.15 Potassium Hydroxide 0.65 Acetone 0.20 Activated carbon 0.02 HCl gas 0.20 39. Lasamide 2,4 Dichloro Benzoic acid 0.950 Chlorosulfonic acid 4.720 Ammonia 0.720 HCl 1.296 40. MESALMINE POTASSIUM HYDROXIDE 2.54 2-chloro -5- nitro benzoic acid 1.82 HYDROCHLORIC ACID 3.10 SODIUM CARBONATE 0.60 RANEY NICKEL 0.30 SODIUM HYDROXIDE 4.73 HYDROCHLORIC ACID 2.70 CHARCOAL 0.20 SODIUM BICARBONATE 0.54 41. FEBUX OSTAT Ethyl -2-(3 -cyano -4-isobutoxyphenyl) -4-methyl -5- 1.250 thiazolecarboxylate Methanol 12.50 Toluene 7.50 Caustic soda flakes 0.125 HCl 0.250 42. ITOPRIDE HYDROCHLORIDE Veratric acid 0.667 Thionyl chloride 0.667 Toluene 3.270 4-[2 -(Di methylamino) 0.667

14 ethoxy]Benzyl amine Caustic soda flakes 0.095 IPA 2.857 IPA HCl 0.317 Methanol 0.159 Acetone 0.635 43. Amrodafinil Benzhydrolthiol 2.90 Chloroacetic Acid 1.37 Sodium Hydroxide 0.58 HCL (30%) 0.20 Acetic Acid 6.62 Hydrogen Peroxide 0.88 L( -)Phenyl Ethyl Amine 0.30 Methanol 0.14 Ammonium Solution 0.52 Carbon 0.12 Hyflow 0.12 44. QUETIAPINE FUMARATE 2- Amino diphenyle sulfide 1.11 Sodium Hydroxide flakes 0.32 Toluene 6.67 Phenyl chloroformate 1.27 Hydrochloric acid 0.66 Polyphospheric acid 8.89 Acetone 3.48 Dibenzo [b,f] [1,4] Thiazepin -11(1 OH) - ONE 0.6 N,N - Dimethyl ANILINE 0.4 Phosphorous oxychloride 0.3 Hydrochloric acid 0.5 Sodium Sulphate 0.1 Toluene 5.2 Triethanolamine 0.4 Hydroxy ethoxyrthyl piparazine 0.4 Sodium bicarbonate 0.1 1 N HCl 0.1 Hyflosupercel 0.0 Methanol 7.7 Fumaric acid 0.2 45. ARIPIPERAZOLE 7- Hydroxy -3,4 - dihydroQuinoline 0.74 1- Bromo -4- Chloro Butane 4.44 Sodium Hydroxide 0.24 n- Propanol 3.70 Cyclohexane 1.48 Triethylamine 0.59

15 DCPP HCl 0.59 Methanol 0.37 46. Amlodipine Besylate Phthaloyl Amlodipine 1.09 Mono Methyl Amine 1.68 Methanol 4.38 Ethyl Acetate 3.09 Benzene Sulfonic Acid 0.38 Carbon 0.75 47. NEBIV OLOL AND ITS INTERMEDIATE Maleic Anhydride 1.4

AlCl 3 3.50 EDC 5.00 Para Fluoro Anisole 1.42 HCl 3.20 Hexane 4.25 Acetic Acid 0.95 Sulphuric Acid 1.20 Pd/c 0.41 Hyflow 0.80 Sodium Borohydride 1.20 THF 4.00 MDC 5.6 Sodium Carbon ate 0.9 DMSO 0.80 Oxahl Chloride 3.25 TEA 6.50 Sodium Hydride 1.00 Methanol 1.00 Benzyl Amine 0.33 Acetonitrile 0.8 48. Sevelamer Hydrochloride Allylamine 0.75 2,2 -Dimethyl -2,2 -azopropane dihydrochloride 0.03 HCl 1.25 Epichlorhydrin 0.11 NaOH Flakes 0.37 49. Sevelamer Carbonate SevelamerHCl 1.111 Caustic soda flakes 0.333 Carbon dioxide 0.278 50. Poly Allaylamine Hydrochloride Allylamine 0.333 2,2 -Dimethyl -2,2 -azopropane dihydrochloride 0.117 HCl 0.600

16 51. Iso Amy l Acetate Amyl alcohol 0.70 Catalyst 0.05 Toluene 0.60 Acetic acid 0.55 52. Iso Amyl Propionate Amyl alcohol 0.70 Catalyst 0.05 Toluene 0.60 0.55

53. Iso Amyl Butyrate Amyl alcohol 0.60 Catalyst 0.05 Tolue ne 0.60 Butyric acid 0.60 54. Phenyl Ethyl Acetate Toluene 1.00 Acetic Acid 0.65 Phenyl Ethyl Alcohol 1.25 PTSA 0.06 55. Phenyl Ethyl Propionate

Toluene 1.00 Propionic Acid 0.75 Phenyl Ethyl Alcohol 1.15 PTSA 0.06 56. Methyl -3-Am ino Crotonate Methyl Aceto Acetate 5.62 Liq. Ammonia 4.50 Methanol 1.50 57. Phthalimido Amlodipine Xylene 7.50 Phthalic Anhydride 1.50 Mono Ehanol Amine 0.625 Benzene 8.25 Sodium hydride 0.415 E4CAA 0.81 Acetic Acid 1.73 Methano l 2.925 Ortho Chloro Benzaldehyde : 129 Kg. 0.645 Morpholine 0.08

Methyl -3-Amino Crotonate : 294 Kg. 1.47 Mono Ethanol Amine 0.625

17 1.4 Water Requirement, Waste Water Generation and Treatment Total water requirement will be 55 KL/Day which will be met through GIDC water supply. The wastewater generation will be 16.6 KL/Day. The Low COD effluent (12 KLD) will be sent to proposed ETP consists of primary treatment facility and then after sent to CETP, Ankleshwar & High COD/TDS stream (3 KL/Day) shall be sent to common MEE of ACPTCL for further treatment & disposal. Domestic Wastewater (1.6 KL/Day) will be disposed to soak pit & septic tank.

1.5 Air Pollution Source and Control Management There will be emission from Steam Boiler and Process Vents. To control the emission from process vents, adequate two stage scrubbers will be installed.

Sr. Source of Stack/Vent Fuel name & Type of APCE No. Emission (meter) Quantity use Emission Height Diameter Existing 1 Baby Boiler 11.0 0.1 Wood or LDO = SPM --

(Capacity: 0.6TPH) 7.2 MT/Day SO 2 NOx

Total Proposed TOTAL PROPOSED EXPANSION Flue Gas Emission 1 Baby Boiler 11.0 0.1 Agro waste or SPM --

(Existing) LDO = SO 2 7.2 MT/Day NOx 2 Boiler (Proposed) 30 0.5 Agro waste = 5 SPM Multicyclone

(Capacity: 2.0 TPH) MT/Day SO 2 separator with bag NOx filter 3 Thermic fluid 30 0.5 Agro waste = 2 SPM Multicyclone

heater (Proposed) MT/Day SO 2 separator with bag (Capacity: 2 Lakh NOx filter K. Cal/Hr.) 4 D. G. Set 11 0.1 HSD SPM --

SO 2

18 NOx Process Gas Emission

5 Process Vent 11.0 0.2 -- Cl 2 Two Stage Water &

(Reactor Vessel) NH 3 Caustic scrubber (Proposed) HCl 6 Process Vent 11.0 0.2 -- HCl Two Stage Water &

(Reactor Vessel) SO 2 Caustic scrubber (Proposed)

1.6 Hazardous Waste Sr. Hazardous/Solid Category Quantity Mode Of Disposal No. Waste Existing Total after proposed expansion 1 Discarded HDPE 33.1 1000 Nos./ 1500 Collection, Storage, Drums/Bags Month Nos./Month Transportation and sell to Register vendors after decontamination. 2 Used / Spent Oil 5.1 99 5 Lit/Month Collection, Storage, Transportation and sell to registered recycler. 3 ETP Sludge 35.3 -- 5 MT/Month Collection, Storage, Transportation and sent to common TSDF of BEIL. 4 Distillation 28.1 -- 10 Collection, Storage, Residue MT/Month Transportation and sent for co-processing in cement industry or sent to common incineration at BEIL. 5 Spent Carbon 28.2 -- 1 MT/Month Collection, Storage, Transportation and send for co-processing in cement industry or sent to common incineration at BEIL. 6 HCL (30 %) C15 -- 50 Collection, Storage, MT/Month Transportation and sell to end user. 7 Spent Catalyst 28.3 -- 1 MT/Month Collection, Storage, Transportation and send to

19 regenerator 8 Inorganic Salt 28.1 -- 10 Collection, Storage, MT/Month Transportation and sent to common TSDF of BEIL. 9 Organic Process 28.1 -- 15 Collection, Storage, Waste MT/Month Transportation and send for co-processing in cement industry or sent to common incineration at BEIL. 10. Spent 28.6 -- 500 Receipt, Storage, MT/Month Transportation and recovery in-house.

1.7 Green Belt Total 1862 m2 land area is available at site; out of this area about 615 sq. meter (33 %) area will be covered as greenbelt and other forms of greenery. 1.8 Power & Fuel Requirements Power required from DGVCL is 100 KVA (Existing) Power required from DGVCL will 500 KVA (Proposed) D. G. Set – 250 KVA (Proposed)

Fuel Wood/LDO = 7.2 MT/Day (Existing), Agro Waste/Briquettes = 14.2 MT/Day (Proposed) Diesel = 25 Liter/Hr (Proposed) )

20 2.0 INTRODUCTION OF THE PROJECT/BACKGROUND INFORMATION 2.1 Identification of the project and project proponent. In case of mining project, a copy of mining lease/letter of intent should be given. Identification of the project Expansion of existing manufacturing unit by addition of new products (bulk drugs & bulk drug intermediates) and solvent distillation unit (in-house common group facility).

Identification of the project proponent SR. NAME DESIGNATION ADDRESS NO. 1 Mr. Ramesh Nanjibhai Partner 206, Akash Gankga Co Opretive Patel Society, GIDC, Ankleshwar. Mob: +91 98284014578 2 Mr. Lalit Laxmichand Partner 408/14, Sardar Patel Society, Gami GIDC, Ankleshwar. Mob: +91 9828406461 3 Mr. Kailash Partner 408/14, Sardar Patel Society, Laxmichand Patel GIDC, Ankleshwar. Mob: +91 9924115437 4 Mrs. Bharti Partner 408/14, Sardar Patel Society, Laxmichand Patel GIDC, Ankleshwar Mob: +91-2646-226676

2.2 Brief description of nature of the Project Expansion of existing manufacturing unit by addition of new products (bulk drugs & bulk drug intermediates) and solvent distillation unit (in-house common group facility).

2.3 Need for the project and its importance to the country and or region The Indian pharmaceutical industries currently tops amongst India’s science based industries with wide ranging capabilities in the complex field of pharmaceutical. The pharmaceutical industries in India meets around 60% of the country’s demand. But in world market also Indian pharmaceutical products are well accepted. There is a good potential for us to fulfill the need of domestic market as well as contribute in earning foreign Exchange.

21 2.4 Demands-Supply Gap Based on our informal survey of the market with our current customers and various traders, we have found that there is a big potential for the range of the products we are planning.

2.5 Imports vs. Indigenous production Based on the current cost of indigenous raw materials and the non availability of some materials, we will have to import, if require, some of the key raw materials as they are not available indigenously. This will make us very competitive against imported finished products and we will export our finished products in the international market.

2.6 Export possibility We shall explore the possibility of export the products.

2.7 Domestic/Export Markets Our products have good demand in international market. We shall explore the possibility of export the products.

2.8 Employment Generation (Direct and Indirect) due to project.

M/s. Anju Life Science will give direct employment, if require, to local people based on qualification and requirement after proposed expansion. In addition to direct employment, indirect employment shall generate ancillary business to some extent for the local population.

3.0 Project Description 3.1 Type of Project including interlinked and interdependent projects, if any.

No interlinked project has been submitted .

22 3.2 Location (map showing general location, specific location and project boundary & project site layout) with coordinates. • Map showing general location

(Courtesy: Environmental Information Center, New Delhi)

23 • Specific location and project boundary

15 Plot Layout

16 3.3 Details of alternate sites considered and the basis of selecting the proposed site, particularly the environmental considerations gone into should be highlighted. Major factors involved in the selection of site are listed below: • Existing operational industry • Site is very well connected by road • Proximity to Raw Material suppliers • Availability of sufficient land free from cultivation • Availability of power evacuation facilities • Availability of water for industrial use • Availability of CETP, CHWIF, common MEE, common TSDF, etc. Modern infrastructure support and amenities at par with industrial estates in other global markets, including: ° Efficient transport facilities within the industrial estate and to & fro the city area. ° Environment-friendly zone. ° Uninterrupted power supply.

3.4 Size or Magnitude of Operation Please refer Section-1.2.1, Page No. 2.

3.5 Project Description with process details (a schematic diagram/flow chart showing the project layout, components of the project, etc. should be given) Please refer Please refer Form-I, Annexure-3.

3.6 Raw Material required along with estimated quantity, likely source, marketing area of final product/s, mode of transport of raw material and Finished product. For raw material required along with quantity; Please refer Section-1.3, Page No. 3. We shall procure the raw material as much as possible from domestic market and if there is no availability of any raw material we will import. We shall explore the possibility of export the finished products.

3.7 Resource optimization/recycling and reuse envisaged in the project, if any, should be briefly outlined.

26 Resource optimization/recycling and reuse shall be envisaged 3.8 Availability of water its source, energy/power requirement and source should be given. Water Source Present water requirement is met through GIDC water supply and will be the same after proposed expansion.

Power & Fuel Requirement Power required from DGVCL is 100 KVA (Existing) Power required from DGVCL will 500 KVA (Proposed) D. G. Set – 250 KVA (Proposed) Fuel Wood/LDO = 7.2 MT/Day (Existing), Agro Waste/Briquettes = 14.2 MT/Day (Proposed) Diesel = 25 Liter/Hr (Proposed)

3.9 Quantity of wastes to be generated (liquid and solid) and scheme for their management/disposal. Please refer Form-I, Annexure-IV & V.

3.10 Schematic representations of the feasibility drawing which give information of EIA purpose.

ACTIVITIES OVERVIEW OF SOURCE OF INFORMATION E. I. A. STUDIES

ANNUAL REPORT RECONNAISSANCE SURVEY OF EXISTING PLANT INTRODUCTION MARKET ASSESSMENT FINANCIAL REPORT PROJECT REPORT BASELINE

ENVIRONMENTAL ENVIRONMENTAL INFORMATION CENTRE MONITORING OF AIR, WATER & SOIL QUALITY & NOISE CENTRAL GROUND WATER BOARD STATUS LEVELS. DATA ON METEOROLOGY SOCIO-ECONOMIC STATUS GUJARAT POLLUTION CONTROL BOARD (GPCB) & BASIC AMENITIES. SITE VISITS BY AND INTERVIEWS WITH PUBLIC HEALTH ENGINEERING DEPT. LOCALS AGRICULTURE DEPARTMENT SOCIOECONOMIC FOREST DEPARTMENT STATUS & IRRIGATION DEPARTMENT INFRASTRUCTURE EMPLOYMENT EXCHANGE HEALTH CENTER CENSUS DEPT. PROPOSED INDIAN METEOROLOGICA L DEPT. PLANT FACILITY DESCRIPTION IDENTIFICATION & ASSESSMENT OF IMPACTS IMPACTS EVALUATION OF IMPACTS BY MATRIX METHOD METHODOLOGY OF IMPACT ASSESSMENT

DESCRIPTION OF EFFLUENT TREATMENT PLAN, AIR POLLUTION CONTROL, HAZARDOUS WASTE MANAGEMENT, ENVIRONMENTAL GREEN BELT DEVELOPMENT MONITORING PROGRAM MANAGEMENT PLAN

RISK ANALYSIS SAFETY, HEALTH & ENVIRONMENTAL POLICY, GUIDELINES BY CONSEQUENCE ANALYSIS STUDIES & DIRECTOR GENERAL OF FACTORY SAFETY, MINISTRY OF LABOR. PREPARATION OF DISASTER MANAGEMENT PLAN DISASTER 27 MANAGEMENT PLAN 4.0 Site Analysis 4.1 Connectivity • Site is very well connected by road • Availability of water, power, etc.

4.2 Land Form, Land Use and Land Ownership It will be incorporated in EIA Report.

4.3 Existing land use pattern (agriculture, non-agriculture, forest, water bodies (including area under CRZ)), shortest distances from the periphery of the project to periphery of the forests, national park, wild life sanctuary, eco sensitive areas, water bodies (distance from HFL of the river), CRZ. In case of the notified industrial area, a copy of the Gazette notification should be given. It will be incorporated in EIA Report. 4.4 Existing Infrastructure Processing Area (Plant facilities, R&D, ETP Area and Engineering / Utility Services) = 862 m2 Non Processing Area (Green belt, Raw material storage area, finished storage area, Administration Building, Parking, road and open area) = 1200 m2 4.5 Soil Classification It will be incorporated in EIA Report. 4.6 Climatic data from secondary sources. Climatic data from primary & secondary sources will be incorporated in EIA Study. 4.7 Social infrastructure available. Various Programs/ Projects related to Social & Economic development of surrounded area has been planned, which are as follows. A) Natural Resource Management – The main focus of this program will be to maximize the yield returns of the farmers through efficient management of existing resources & extension of new agricultural practices. 1) Integrated Agricultural Growth Project – For improvement and use of the modern techniques and thereby would certainly contribute to prosperity in the agriculture

28 sector and reduce the rural poverty by programs like Farmers Training, Nursery Growing Trainings, Modern agriculture equipment distribution programs etc. 2) Animal Husbandry Projects – Various programs like health checkups & treatment, vaccination program, Anti sterility camps, breed improvement etc. will be carried out. B) Income Generation Program - 1) Establishment of Self help groups. 2) Rural Entrepreneurship Development Program 3) Handcrafts Development Program 4) Vocational Training 5) Business process outsourcing C) Health, Education & Infrastructure 1) Aids Awareness Program 2) General Health Camps 3) Innovative Teaching Methods 4) Adult Education 5) Sanitation 6) Infrastructure Development Projects 5.0 Planning Brief 5.1 Planning Concept (type of industries, facilities, transportation etc) Town and Country planning/Development authority classification. Expansion of existing manufacturing unit by addition of new products (bulk drugs & bulk drug intermediates) and solvent distillation unit (in-house common group facility) within existing premises.

5.2 Population Projection Population data will be incorporated in EIA Study.

29 5.3 Land use planning (breakup along with green belt etc.) Industrial Area (Processing Area) Processing Area (Plant facilities, R&D, ETP Area and Engineering / Utility Services) = 662 m2

Residential Area (Non Processing Area) Non Processing Area (Green belt, Raw material storage area, finished storage area, Administration Building, Parking, road and open area) = 1200 m2

Total 1862 m2 land area is available at site; out of this area about 615 sq. meter (33 %) area will be covered as greenbelt and other forms of greenery.

5.4 Assessment of Infrastructure Demand (Physical & Social) • Employment would be as per prevailing norms of state government for skilled and unskilled people for the proposed project activity.

• Social Welfare

• Cordial relation with the industry shall be established and representation shall be made to villagers for help for creation of facilities related to health, education, etc.

5.5 Amenities/Facilities It will be incorporated in EIA Report.

6.0 Proposed Infrastructure 6.1 Industrial Area (Processing Area) Processing Area (Plant facilities, R&D, ETP Area and Engineering / Utility Services) = 662 m2

6.2 Residential Area (Non Processing Area) Non Processing Area (Green belt, Raw material storage area, finished storage area, Administration Building, Parking, road and open area) = 1200 m2

6.3 Green Belt Total 1862 m2 land area is available at site; out of this area about 615 sq. meter (33 %) area will be covered as greenbelt and other forms of greenery.

30 6.4 Social Infrastructure • Water Supply by GIDC • Power supply by DGVCL

6.5 Connectivity (Traffic and Transportation Road/ Rail/Metro/ Water ways etc) Major factors involved in the selection of site are listed below: • Site is very well connected by road • Proximity to Raw Material suppliers • Availability of sufficient land free from cultivation • Availability of power facilities • Availability of water for industrial use

6.6 Drinking water Management (Source & Supply of water) Total water requirement shall be met through GIDC supply.

6.7 Sewerage System Sewage pipes are laid in entire company for the removal and disposal of mainly non- harmful liquid wastes from the offices, canteen and domestic waste coming from different sections of industry. These liquid wastes are sent to septic tank & soak pit.

6.8 Solid Waste Management Please refer Form-I, Annexure-V.

6.9 Power Requirement & Supply/Source Please refer Section 1.8, Page No.6 of this report.

7.0 Rehabilitation and Resettlement (R & R) Plan 7.1 Policy to be adopted (central/state) in respect of the project affected including home oustees, land oustees and landless laborers (a brief outline to be given)

There is no habitation on the proposed project activity area and it is open land, so R & R policy is not applicable to this project. There shall not be displacement of any population in project area. The increasing industrial activity will boost the commercial and economical status of the locality up to some extent.

8. Project Schedule & Cost Estimates 8.1 Likely date of start of construction and likely date of completion (Time schedule for the project to be given).

We shall start construction after getting EC & CTE. We shall start manufacturing after applying for CCA.

31 8.2 Estimated Project cost along with analysis in terms of economic viability of the project.

Total Project Cost for proposed project activity is Rs. 2.0 Crores. Capital cost of air & water pollution control system and environmental monitoring equipments will be Rs. 0.4 Crore.

9. Analysis of Proposal (Final Recommendations) 9.1 Financial and social benefits with special emphasis on the benefit to be local people including tribal population, if any, in the area.

• Employment would be as per prevailing norms of state government for skilled and unskilled people for the proposed project. • Social Welfare shall be done. • Cordial relation with the industry shall be established and representation shall be made to villagers for help for creation of facilities related to health, education, etc.

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