DOCSLIB.ORG

LIST of ANNEXURES SR. NO. NAME of ANNEXURE I List of Products with Their Production Capacity II Layout Map of the Plant III Brie

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
LIST of ANNEXURES SR. NO. NAME of ANNEXURE I List of Products with Their Production Capacity II Layout Map of the Plant III Brie LIST OF ANNEXURES SR. NO. NAME OF ANNEXURE I List of products with their production capacity II Layout Map of the Plant III Brief Manufacturing Process Descrip tion with Chemical and Mass Balance IV Details of Water Consumption Wastewater Generation V Effluent Treatment Scheme VI Details of Hazardous /Solid Waste Generation, Handling and Disposal VII Details of Air pollution Control System (Stack & Vent) VI II Details of Hazardous Chemicals Storage & Handling IX Socio-economic Impacts X Proposed Terms of Reference for EIA studies ANNEXURE – 1 LIST OF PRODUCTS WITH THEIR PRODUCTION CAPACITY Production (MT/Month) LD Sr. Product Name CAS No. Proposed Proposed 50(mg/Kg) No. Existing Total Nytrosyl Sulphuric Acid (from 7782-78-7 467.92 2140 1 132.08 600 Sulfur) * Nytrosyl Sulphuric Acid (from 7782-78-7 00 2140 2 Sodium Thio Sulphate Solution and 468 468 Spent Acid (H2SO4)) ** 3.1 4-Met hyl Acetophenone 122 -00 -9 1400 00 60 3.2 Acetyl Furan 1192-62-7 60 1130 4.0 Diethyl Ketone 96 -22 -0 00 179 179 2737 5.1 Methyl Propyl Ketone 107 -87 -9 20001 5.2 Dipropyl Ketone 123-19-3 00 100 100 20001 5.3 Propiophenone 93-55-0 4500 6 Alpha Nitro Napthalene 86-57-7 00 100 100 2560 7 Alpha Napthylamine 134 -32 -7 00 165 165 2000 Phenyl Alpha Naphthylamine 90-30-2 90 90 2000 8 00 (PANA) Epichlorohydrin Based Polyamide 106-89-8 116 116 1580 9 00 resin 10 2,4-Dichloro Acetophenone 2234-16-4 00 60 60 1800 98-86-2 60 60 815 11 Acetophenone 00 IGBA - 3-(2- 75143-89-4 68.2652 68.2652 3580 12.1 methylpropyl)pentanedioic acid 00 KSM - 3-(2-amino-2-oxoethyl)-5- 181289-15- 12.2 methylhexanoic acid 6 5000 13 Anisole 100 -66 -3 00 100 100 3700 Pesticide Interemdiates 13 3, 5 Dichloro aniline 626-43-7 00 50 50 2870 14 D- Allethrollone 43917 -8-56 00 10 10 5000 3-Methyl 4- Nitro Imino Per 153719-38- 20 20 2000 15 00 hydro1,3,5 Oxidiazine 1 118712-89- 30 30 5000 16 Transfluthrin Acid Chloride 00 3 17 1,2,4 Triazole 288-88-0 00 50 50 1750 18 2- Chloro 5 - Chloromethyl Pyridine 70258 -18 -3 00 30 30 1289 19 4-Methoxy Acetophenone 100-06-1 00 60 60 1720 Total 600.08 1787.82 2387.9 List of Raw Materials RAW MATERIAL CONSUMPTION , PRODUCTION MT/M ONTH SR. NO. DESCRIPTION CAPACITY NAME CONSUMPTION Oleum Or 448.23 Or Sulphuric Acid 390.00 Nitric Acid Or 127.03 NytrosylSulphuric Acid 600 1 (from Sulfur or SO Gas) MT/Month 2 104.17 Sulphur Or 24.80 Or SO2 Gas 105.83 Spent H 2SO 4 285.17 Thio Solution 499.05 NytrosylSulphuric Acid H2SO 4 326.16 (from Sodium ThioSulphate 468 2 Solution and Spent Acid MT/Month HNO 3 71.08 (H2SO4)) Soda Ash 6.17 Charcoal 3.35 Anisol 207.57 Acetic 43.40 3.1 4-Methoxy Acetophenone 60 MT/Month anhydride catalyst 3.60 Toluene 1441.79 3.2 4-Methyl Acetophenone 60 MT/Month Catalyst 3.60 Acetic 159.85 Anhydride Furan 46.18 Furan 6.41 (Recycle) Catalyst 0.05 3.3 Acetyl Furan 60 MT/Month Catalyst 0.88 (Recycle) Acetic 69.33 Anhydride 179 Propionic Acid 4 Diethyl Ketone 315.04 MT/Month Butyric acid 103 100 5.1 Methyl Propyl Ketone MT/Month Acetic Acid 69 100 Butyric Acid 154 5.2 Dipropyl Ketone MT/Month Benzoic acid 91.07 100 5.3 Propiophenone MT/Month Propionic acid 135.71 Naphthalene 74.93 Nitric Acid 245.86 100 60% 6 Alpha Nitro Napthalene MT/Month Ethylede Dichloride 224.78 [EDC] [Fresh + Recycle] Naphthalene 156.90 Nitric Acid 515.25 Ethylene 470.71 Dichloride Alpha Napthylamine - 165 7 IPA/Methanol 287.48 Through Continuous Process MT/Month Aniline /ODCB 391.75 Hydrogen 7.32 Catalyst 21.26 Naphthalene 157.43 Nitric Acid 258.25 IPA/Methanol 287.61 OR Alpha Napthylamine - 165 7 Through Batch wise Process MT/Month Aniline /ODCB 393.58 Hydrogen 8.78 Catalyst 21.19 Aniline (Fresh) 41.79 An iline 56.25 (Recovered) Phenyl Alpha Naphthylamine 8 90 MT/Month (PANA) Alpha 64.29 Napthylamine Catalyst 1.61 DETA 5.85 Epichlorohydrin Based 116 Adipic Acid 7.8 9 Polyamide resin MT/Month EPI 3.51 1,3 - Dichlorobenze 56.34 ne [Fresh + Recycled] 2,4-Dichloro Acetophenone Catalyst 10 60 MT/Month (Fresh + 0.98 Recycled) Acetic 34.02 Anhydride Benzene [Fresh + 47.10 Recycle] Catalyst Acetophenone 11 60 MT/Month [Fresh + 0.82 Recycle] Acetic 53.53 Anhydride CyanoAcetami 47.25 de Water 300.00 IGBA - 3-(2- 28.2652MT/M methylpropyl)pentanedioic Sulphuric Acid 247.50 12.1 onth acid Toluene 117.00 3-Methyl 24.00 Butanal CyanoAcetami 47.37 de Sulphuric Acid 248.12 Sulphuric Acid 30.70 - Recycle KSM - 3-(2-amino-2- Toluene 117.29 oxoethyl)-5-methylhexanoic 40MT/Month 12.2 3- acid 24.06 methylbutanal Ammonium 17.59 Carbamide Caustic Lye 19.55 Charcoal 2.25 Phenol 100.04 100MT/Mont Dimethyl Anisol 95.79 13 h Carbonate Catalyst 1.96 PNA 69.81 Chlorine 71.80 MCB 349.06 NSA 167.71 3, 5 DCA 50MT/Month 14 NSA - 43.50 Recovered HCHO 51.89 Sulfur 42.45 Caustic Lye 110.59 2- Methyl Furan 1.109 EDC 0.080 DMF 0.060 POCl3 1.524 Allyl Chloride 0.661 D- Allethrollone 10 15 Toluene 0.050 THF 0.060 Mg Metal 0.205 Sodium Acetate 0.170 Acetic Acid 0.534 3-Methyl 4 - Nitro Imino Per 16 hydro1,3,5 Oxidiazine Formic Acid 0.16 N-Methyl Nitro Guanidine 0.78 20 Methane Sulphonic Acid 0.05 Caustic Lye 48% 0.39 DMF 0.09 Trans Cypermethrin Acid 3.000 Transfluthrin Acid Chloride 30 17 EDC 0.050 3.742 Caustic Lye 48% HCl 30% 3.663 n-Hexane 0.040 DMF 0.006 Thionyl Chloride 0.610 Formic Acid 1.94 1,2,4 Triazole 50 Ammonia 0.87 18 Hydrazine Hydrate 0.07 Benzyl Amine 0.912 Propanaldehy de 0.494 Toluene 0.075 Acetic Anhydride 0.802 2-Chloro 5-Chloromethyl 30 DMF 0.050 19 Pyridine (CCMP) Tri ethyl amine 0.048 EDC 0.130 Acetonitrile 0.100 Phosphorus Oxy Chloride 2.125 Chlorine 0.330 Caustic Lye 47% 1.000 ANNEXURE – 2 PLANT LAYOUT ANNEXURE – 3 MANUFACTURING PROCESS, CHEMICAL REACTION WITH MASS BALANCE 1. NITROSYL SULFURIC ACID (NSA) FROM SULFUR (OR SULFUR DIOXIDE GAS) Process Description: First make mix acid of Oleum 23 % and concentrate Nitric Acid . Charge Sulfur in to the mix acid from this process reaction takes place and generation SO 2 Gas (or charge Sulphur Dioxide gas in to the mix acid). SO 2 react with concentrate Nitric Acid and Oleum convert in to Sulphuric A cid after this reaction product will be Nitrosyl Sulfuric Acid (NSA). Reaction Mechanism 6 HNO3 + 2S 3N 2O3 + 2SO 3 + 3H 2O N2O3 + 2SO 3 + H 2O 2NOHSO 4 6HNO 3 + 8H 2SO 4 + 4SO 3 + 2S 6NOHSO 4 + 8H 2SO 4 OR H2SO 4 + HNO 3 + SO 2 NOHSO 4 + H 2SO 4 Flow Chart Oleum 23 % (7590 Kg) or Sulphur [420 kg] Or Sulphuric Acid 98% [6604 kg] Sulphur Dioxide Gas [1792 kg] MIX ACID Nitric Acid 98 % [7590 kg] Or Nitric Acid 98 % [1764 kg] 10160 kg NSA Nytrosyl Sulphuric Acid from Sulfur INPUT KG PROCESS KG OUTPUT Oleum 23 % or 7590 or 6604 10160 NSA Sulphuric Acid 98 % 2151 or 1764 Nitric Acid 98 % Mix Acid Vessel 1 SO 2 Sulphar or SO2 Gas 420 or 1792 Total 10161 10161 Total PRODUCT [2] NITROSYL SULPHURIC ACID (NSA) AND SULPHUR RECOVERY FROM SODIUM THIOSUIPHATE SOLUTION 1. Process Description with Chemical Reaction: Nytrosyl Sulphuric Acid from the spent sodium thio solution shall be manufactured only after getti ng permission from the Central Pollution Control Board [i. e. utilization of the hazardous wastes under Rule 11 of the Hazardous Waste (Management, Handling & Transboundary) Rules, 2008]. Sulfur and Sodium Sulphate shall be generated, only from the man ufacturing of Nytrosyl Sulphuric Acid from Sodium Thio Sulphate Solution (used as a raw material). Take Sodium Thiosuiphate Solution. Now take this solution in one vessel and add spent acid in it, Reaction takes place and SO 2 librates, Scrub this gas in another vessel which is having mix acid of H 2SO 4 and HNO 3. Mix Acid Vessel which has scrubbed SO 2 gas will make NITROSYL SULFURIC ACID [NSA]. SO 2 + HNO 3 NOHSO 4 [NSA] After completion of Spent Addition heat the solution till SO 2 librates then cool the mass and filter. Dry the residue to obtain SULPHUR. Filtrate will be collected separately, neutralize this solution and make concentrate by distillation water, then cool the mass, and Filter it. Residue will be dried and Product will be SODIUM SULPHATE, Filtrate will be used again. Na 2S2O3 + H 2SO 4 SO 2 + S + H 2O + NA 2SO 4 Flowchart: Nytrosyl Sulphuric Acid INPUT KG PROCESS KG OUTPUT INPUT KG PROCESS KG OUTPUT Thio 13097. Solutio SO 2633.56 NSA 40 % 2 48 n 14000 2633.56 SO 2 Spent NSA H SO H SO Acidifica 19366.4 Reaction 2 4 7862.32 ScruBBer 2 4 98 % (40 %) 8000 tion 4 Mass Vessel HNO 3 2601.6 98 % 13097.4 13097. Total Total Total 22000 22000 Total 8 48 Reacti Sulfur on 19366. Sulfur 1800 1420 Sulfur Dry W/C Mass 44 1800 W/C Dryer 17566.4 Reaction Water 380 4 Mass Evaporated Filtration Total 1800 1800 Total 19366.
Load more

Recommended publications
  • Relative Reactivities of Some Organometallic Compounds Lester D
    Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1940 Relative reactivities of some organometallic compounds Lester D. Apperson Iowa State College Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Organic Chemistry Commons Recommended Citation Apperson, Lester D., "Relative reactivities of some organometallic compounds " (1940). Retrospective Theses and Dissertations. 13183. https://lib.dr.iastate.edu/rtd/13183 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. NOTE TO USERS This reproduction is the best copy available. UMI BELAflVI REAOflVITIES OP SOME OMANOHSTALlilO COMPOUNDS by Lester D. Apperson A thesis aateltted to the (Graduate Faculty for the Degree of DOCfOR OF PHILOSOPHX Major Subjeot Organic Chemietry Approved! Signature was redacted for privacy. In cha3%e of Major work Signature was redacted for privacy. or Department Signature was redacted for privacy. Dean of Qraduat® College^ Iowa State College 1940 UMI Number: DP12552 INFORMATION TO USERS The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleed-through, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.
    [Show full text]
  • NOTES 14 Decarboxylation Studies. 11. Preparation of Alkyl Phenyl
    MARCH, 1963 NOTES 879 concluded that no Grignard reagent is actually formed. g. (0.337 mole) of 2-dimethylaminoethyl chloride, along with the Instead a mechanism for this elimination is suggested separate addition of 125 ml. of tetrahydrofuran. At the end of the exothermic stage the mixture was refluxed 40 min. further. whereby coordination of the metal with nitrogen occurs It was then cooled and unchanged magnesium was removed by resulting in a displacement in the direction shown. decantation of the supernatant liquid without exposure to the atmosphere. The recovered magnesium was washed with ether R R several times, dried, and weighed 4.46 g. (0.184 g.-atom). The 14 n I R-?-CH:!-CHz-Hal R-N-Mg-Hal t. CPH4 Dry Ice trap was found to contain 12.4 g. of liquid which gave, - when distilled through a 6-in. Vigreux column, 11.7 ml. of tetra- hydrofuran, b.p. 64-67', further identified by its infrared spectrum. A 2.7-ml. forerun was not investigated. The bromine from the absorption flasks was combined and distilled through a Further, we note the similarity between the elimina- 6-in. Vigreux column. Isolated was 39.8 g. of ethylene bromide tion described here (I) and that observed in the Cope (0.212 mole), b.p. 127-131", 55.3% based upon the magnesium elimination of N-oxides (11) where retention of con- consumed. It was identified by comparison of its infrared spec- figuration was observed. trum with that of an authentic sample of 1,Zethylene dibromide. The residue of black tar remaining in the distillation flask weighed 10.0 g.
    [Show full text]
  • List of Lists
    United States Office of Solid Waste EPA 550-B-10-001 Environmental Protection and Emergency Response May 2010 Agency www.epa.gov/emergencies LIST OF LISTS Consolidated List of Chemicals Subject to the Emergency Planning and Community Right- To-Know Act (EPCRA), Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) and Section 112(r) of the Clean Air Act • EPCRA Section 302 Extremely Hazardous Substances • CERCLA Hazardous Substances • EPCRA Section 313 Toxic Chemicals • CAA 112(r) Regulated Chemicals For Accidental Release Prevention Office of Emergency Management This page intentionally left blank. TABLE OF CONTENTS Page Introduction................................................................................................................................................ i List of Lists – Conslidated List of Chemicals (by CAS #) Subject to the Emergency Planning and Community Right-to-Know Act (EPCRA), Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) and Section 112(r) of the Clean Air Act ................................................. 1 Appendix A: Alphabetical Listing of Consolidated List ..................................................................... A-1 Appendix B: Radionuclides Listed Under CERCLA .......................................................................... B-1 Appendix C: RCRA Waste Streams and Unlisted Hazardous Wastes................................................ C-1 This page intentionally left blank. LIST OF LISTS Consolidated List of Chemicals
    [Show full text]
  • United States Patent Office Patented Aug
    3,461,164 United States Patent Office Patented Aug. 12, 1969 2 3,461,64 propyl-(1), 1-phenoxypropyl-(2), o-, m- or p-hydroxy HYDROXY-2AMNO-1-PHENYLALKANES benzyl, o-, m- or p-methoxybenzyl, o-, m- or p-ethoxy AND THE SALTS THEREOF benzyl, 3,4-dihydroxybenzyl, 3,4-dimethoxybenzyi, 3,4,5- Karl Schulte and Wolfgang Fruhstorfer, Darmstadt, Hein trihydroxybenzyl, 3,4,5-trimethoxybenzyl or 3.4-methyl rich Muller, Pfungstadt, Hans Friebel, Darmstadt-Eber endioxybenzyl. stadt, Hans Joachim Enenkel, Darmstadt, and Josef Particularly preferred compounds are: Gilissen, Escholbrucken, Germany, assignors to E. Merck Aktiengesellschaft, Darmstadt, Germany N-1-(3'-tert, butyl-4'-hydroxy-5'-methyl-phenyl)- No Drawing. Filed Apr. 27, 1964, Ser. No. 364,355 1-hydroxy-butyl-2-N-isopropylamine Claims priority, application Germany, Apr. 25, 1963, N-(1-(3'-tert.butyl-4'-hydroxy-5'-methyl-phenyl)- M 56,597; May 25, 1963, M 56,960 O 1-hydroxy-propyl-2)-N-methylamine Int, C. CO7 91/18 N-1-(3'-tert.butyl-4'-hydroxy-5'-methyl-phenyl)- U.S. C. 260-570.6 22 Claims 1-hydroxy-propyl-2-N-ethylamine N-(1-(3'-tert.butyl-4-hydroxy-5'-methyl-phenyl)- This invention relates to substituted 1-hydroxy-2-amino 1-hydroxy-propyl-2-N-isopropylamine 1-phenyl-alkanes. 5 N-1-(3'-tert.butyl-4'-hydroxy-5'-methyl-phenyl)- It is a principal object of this invention to provide novel 1-hydroxy-propyl-2-N-(4-phenyl-butyl-2)-amine and unobvious chemical compounds. N-E1-(3'-tert.butyl-4'-hydroxy-5'-methyl-phenyl)- Another object is to provide processes for the produc 1-hydroxy-propyl-2-N-(1-phenoxy-propyl-2)-amine tion of these compounds.
    [Show full text]
  • Project Feasibility Report
    PRE FEASIBILITY REPORT For PROPOSED BULK DRUGS AND BULK DRUG INTERMEDIATES IN EXISTING THINERS FORMULATION UNIT of M/s. ANJU LIFE SCIENCE Plot No. 6007/1, GIDC, Ankleshwar – 393 002, Dist. Bharuch, Gujarat 0 CONTENTS Sr. No. Description Page No. 1. Executive Summary 2 2. Introduction of the Project/Background information 21 3. Project Description 22 4. Site Analysis 28 5. Planning Brief 29 6. Proposed Infrastructure 30 7. Rehabilitation and resettlement (R & R) Plan 31 8. Project Schedule & Cost Estimates 31 9. Analysis of Proposal (Final Recommendations) 32 1 1.0 EXECUTIVE SUMMARY 1.1 Company Profile M/s. Anju Life Science engages in manufacturing of formulation of thinners unit at Plot No. 6007/1, GIDC, Ankleshwar - 393 002, Dist: Bharuch, Gujarat, INDIA. Now, company is going for new bulk drugs, bulk drug intermediates & solvent distillation (in-house common group facility) within existing premises. 1.2 Project Details 1.2.1 Products along with Production Capacity Sr. Products Capacity CAS No. No. (MT/Month) Existing Additional Total Existing 1. Formulation of Thinners/Reducers 500 -- 500 Proposed 1 Furosemide -- 5 5 54-31-9 2 Diaminomethyleneamino (1-amino-1- -- 100 100 -- iminomethylene) thiomethyl thiozole dihydrochloride [ITU] 3 N-Sulfomyl-3-chloropropionamide -- 100 100 123-92-2 hydrochloride[IF] 4 Famotidine -- 5 5 105-68-0 5 Fomepizole -- 14205-39-1 6 Colsevelam hydrochloride -- 88150-62-3 7 Glimepiride -- 93479-97-1 8 Betahistine Dihydrochloride -- 106649-95-0 9 Adapalene -- 76824-35-6 10 Telmisartan -- 152751-57-0 11 Tapentadol
    [Show full text]
  • Production of Propiophenone
    Europâisches Patentamt O 008 464 qD European Patent Office (jj) Publication number Office européen des brevets Bl 02 EUROPEAN PATENT SPECIFICATION @ Date of publication of patent spécification: 06.04.83 @ Int. Cl.3: C 07 C 49/76, C 07 C 45/00 @ Application number: 79103115.6 @) Date of filing : 23 .08 .79 (54) Production of propiophenone. (30) Priority: 25.08.78 US 936843 (73) Proprietor: UNION CARBIDE CORPORATION Old Ridgebury Road Danbury Connecticut 0681 7 (US) @ Date of publication of application: 05.03.80 Bulletin 80/5 @ Inventor: Smith, Charles Arnold 1812 Littlepage Avenue (45) Publication of the grant of the patent: Charleston West Virginia (US) 06.04.83 Bulletin 83/14 Inventor: Theiling, Louis Foster, Jr. 1408 Woodmere Park Charleston, West Virginia (US) (84) Designated Contracting States: DE @ Représentative: Weinhold, Peter, Dr. Patentanwâlte Dipl.-lng. P. Wirth Dr. V. Schmied- @ Références cited: Kowarzik Dipl.-lng. G. Dannenberg Dr. P. Chemical Abstracts vol. 50, no. 14, 25 July Weinhold Dr. D. Gudel Dipl.-lng. S. Schubert 1 956, Columbus, Ohio, USA Siegfriedstr. 8 R. I. REED "Isotopic studies on the formation of D-8000 Miïnchen 40 (DE) ketones by the catalytic décomposition of certain acids" column 10 038f-h (56) Références cited: Chemical Abstracts vol. 88, no. 15, 19 April T. MUKAIYAMA et al. "A new method for the 1978, Columbus, Ohio, USA préparation of ketones by decarbonylation of alpha-hydroxycarboxylic acid with 2- chlorobenzoxazolium sait" page 475, column 1 , abstract no. 104 175u — in combination with the subject index, vol. 88, 1978, page 4124CS, column 1, lines 65 to 66 Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted.
    [Show full text]
  • Chemical Safety and Waste Management Manual
    Chemical Safety and Waste Management Manual University of Alabama at Birmingham Department of Occupational Health & Safety Chemical Safety Division 2002 EDITION 1. INTRODUCTION In a comparatively short time, the University of Alabama at Birmingham has gained significant recognition as a center of excellence for teaching, medical services and research programs. This is a highly commendable achievement and one that could not have been realized without the continued support and dedication of faculty, staff members, and employees. Similar unfailing cooperation and support are necessary for the institution to be equally successful in its development of a comprehensive occupational health and safety program for the protection of University personnel, students, and the surrounding community. An important part of this program is concerned with the safe and prudent handling of chemicals and their proper legal disposal as regulated by the Environmental Protection Agency (EPA) and the Alabama Department of Environmental Management (ADEM). Almost every laboratory and many allied and support personnel at UAB use chemicals in their daily activities. It is the purpose of this manual to describe the operation of the Chemical Safety Program and to provide guidance in establishing safe work practices for the use of chemicals. This program applies to all work operations at this University where employees may be exposed to hazardous substances under normal working conditions or during an emergency. The Chemical Safety and Waste Management Manual combines both the Chemical Hygiene Plan for laboratories and the Hazard Communication Program for maintenance, environmental services, and other support personnel. The Occupational Safety and Health Administration (OSHA) Hazard Communication Standard may be found at : http://www.osha- slc.gov/OshStd_data/1910_1200.html.
    [Show full text]
  • EAFUS: a Food Additive Database
    U. S. Food and Drug Administration Center for Food Safety and Applied Nutrition Office of Premarket Approval EAFUS: A Food Additive Database This is an informational database maintained by the U.S. Food and Drug Administration (FDA) Center for Food Safety and Applied Nutrition (CFSAN) under an ongoing program known as the Priority-based Assessment of Food Additives (PAFA). It contains administrative, chemical and toxicological information on over 2000 substances directly added to food, including substances regulated by the U.S. Food and Drug Administration (FDA) as direct, "secondary" direct, and color additives, and Generally Recognized As Safe (GRAS) and prior-sanctioned substances. In addition, the database contains only administrative and chemical information on less than 1000 such substances. The more than 3000 total substances together comprise an inventory often referred to as "Everything" Added to Food in the United States (EAFUS). This list of substances contains ingredients added directly to food that FDA has either approved as food additives or listed or affirmed as GRAS. Nevertheless, it contains only a partial list of all food ingredients that may in fact be lawfully added to food, because under federal law some ingredients may be added to food under a GRAS determination made independently from the FDA. The list contains many, but not all, of the substances subject to independent GRAS determinations. The list below is an alphabetical inventory representing only five of 196 fields in FDA/CFSAN's PAFA database. To obtain the entire database, including abstractions of over 7,000 toxicology studies performed on substances added to food as well as a search engine to locate desired information, order Food Additives: Toxicology, Regulation, and Properties, available in CD-ROM format from CRC Press.
    [Show full text]
  • Carbon-14 Isotope Effects in the Decarboxylation of 2-Benzoylpropionic Acid Richard Lee Rowton Doctor of Philosophy
    / . CARBON-14 ISOTOPE EFFECTS IN THE DECARBOXYLATION OF 2-BENZOYLPROPIONIC ACID by RICHARD LEE ROWTON 1, Bachelor of Science Missouri School of Mines and Metallurgy Rolla, Missouri 1950 Master of Science Missouri School of Mines and Metallurgy Rolla, Missouri 1952 Submitted to the facµlty of the Graduate School of the Oklahoma S'tate University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY May, 1959 Vr\l...."\Ml STATE UNI\I LIBRAf FEB 29 CARBON-14 ISOTOPE EFFECTS IN THE DECARBOXYLATION OF 2-BENZOYLPROPIONIC ACID Thesis Approved: Thesis Advisor / Dean of the Graduate School 438735 ii ACKNOWLEDGMENT Grateful acknowledgment is made to Dr. E. M. Hodnett, thesis adviser, for his assistance and guidance throughout this work, to J. J. Sparapany for invaluable assistance in the construction of apparatus, and to others at the Radioisotope and Radiations Laboratory for stimulating discussions and suggestions. Acknowledgment is also made for financial support by the Department of Chemistry and by a grant from the Dow Chemical Company through the Research Foundation. iii TABLE OF CONTENTS Page INTRODUCTION 1 HISTORICAL. 2 The Kinetic Isotope E~fect. 2 The Mechanism of 13-Keto Acid Decarboxylation. 11 Isotope Effects in the Decarboxylation of 13-Keto Acids. 14 INTRODUCTION TO EXPERIMENTAL WORK. 16 Syntheses of Compounds. 16 2-Benzoylpropionic Acid by Ester Hydrolysis. 17 2-Benioylpropionic Acid from Propiophenone, Sodium and Carbon Dioxide .•••••.•. 18 2-Berizoylpropionic Acid from Propiophenone, Sodium Amide and Carbon Dioxide. • • • . • • •. 19 Preparation of 2-Benzoylpropionic Acid-1-cl4 ••••. • 20 Preparation of 2-Benzoylpropionic Acid-Carbonyl-cl4. 20 Preparation of 2-Benzoylpropionic Acid-2-cl4 .
    [Show full text]
  • Unlabelled and Radioactive Labelled Derivatives of Butylamino Propiophenone and Their Preparation
    Consumer and Consommation Corporate Affairs Canada et Corporations Canada (11) (A) No. 1 205 089 (45) ISSUED 860527 (52) CLASS 260-515.1 C.R. CL. 260-552; 260-579.2 4 (51) INT. CL. C07C 97/18,131/00 (54) Unlabelled and Radioactive Labelled Derivatives of Butylamino Propiophenone and Their Preparation (72) Pindlay, John W.A.; Butz, Robert F.; Welch, Richard M., U.S.A. (73) Granted to Wellcome Foundation Limited (The) U.K. (21) APPLICATION No. 460,126 (22) FILED 840731 (62) DIV'N OF APPL'N No. 375,361 FILED 810413 (30) PRIORITY DATE U.S.A. (140,158) 800414 U.S.A. (140,160) 800414 U.S.A. (140,165) 800414 NO. OF CLAIMS 16 Canada DISTRIBUTED BY THE PATENT OFFICE, OTTAWA. CCA-274 (11-82) - à° ABSTRACT Unlabelled and radioactive labelled compounds of formula: R12 wherein: i) R-jq is OH, R^ is a radioisotope and is 0; or ii) R1n is H, R,, is Cl and R is a radical of formula : =N-0(CH2) C0--X1 wherein q is an integer from 1 to 3, and X^ is OH or a radical of formula: wherein Rg is a radiocative nuclide, R^ is hydroxyl and s is an integer from 1 to 4 are provided; the unlabelled compounds can be coupled with an immunogenic carrier to give an immunogen which can be used to raise antisera containing antibodies specific to the antidepressant bupropion; the ,0 ^ (0 labelled derivatives can be employed in a radioimmunoassay for determining bupropion in biological fluids. - 1 - This invention relates to new un'labelled and radio- active labelled derivatives of butylamino propiophenone and their preparation.
    [Show full text]
  • Consideration of the Cathinones
    ACMD Advisory Council on the Misuse of Drugs Consideration of the cathinones Page 1 of 50 ACMD Advisory Council on the Misuse of Drugs Chair: Professor Les Iversen Secretary: Will Reynolds 3rd Floor (SW), Seacole Building 2 Marsham Street London SW1P 4DF Tel: 020 7035 0454 [email protected] Rt Hon Alan Johnson MP 2 Marsham Street London SW1P 4DF 31st March 2010 Dear Home Secretary, I have pleasure in attaching the Advisory Council on the Misuse of Drugs report on the ‘Consideration of the cathinones’. The ACMD recommends that the cathinone compounds be brought under control of the Misuse of Drugs Act 1971 in Class B, Schedule I by way of a generic definition. Based on the attached evidence and by analogy with the amphetamines, the ACMD consider that the harms associated with the cathinones most closely equate with other compounds in Class B. The ACMD also recommend that particular attention is focussed on credible and consistent public health messages that are promulgated both to the public and health professionals – the latter for the purposes of providing advice. The ACMD is concerned that, particularly in the case of mephedrone, the internet plays a significant part in the marketing, sale and distribution of the drug and social networking sites may also play a role. The ACMD therefore believes that resources should initially be focussed on supply side activities with a concurrent emphasis on educating users of this drug so as to highlight the real dangers of mephedrone and the cathinones. The ACMD indicated, in its letter to the Home Secretary, of the 22nd December 2009, its concerns about the sale of mephedrone and its plans for review.
    [Show full text]
  • Recommended Methods for the Identification and Analysis of Synthetic Cathinones in Seized Materials
    Recommended methods for the Identification and Analysis of Synthetic Cathinones in Seized Materials MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES Photo credits: UNODC Photo Library; UNODC/Ioulia Kondratovitch; Alessandro Scotti. Laboratory and Scientific Section UNITED NATIONS OFFICE ON DRUGS AND CRIME Vienna Recommended Methods for the Identification and Analysis of Synthetic Cathinones in Seized Materials MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES UNITED NATIONS New York, 2015 Note Operating and experimental conditions are reproduced from the original reference materials, including unpublished methods, validated and used in selected national laboratories as per the list of references. A number of alternative conditions and substitution of named commercial products may provide comparable results in many cases, but any modification has to be validated before it is integrated into laboratory routines. ST/NAR/49 Original language: English © United Nations, September 2015. All rights reserved, worldwide. The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. Mention of names of firms and commercial products does not imply the endorse- ment of the United Nations. This publication has not been formally edited. Publishing production: English, Publishing and Library Section, United Nations Office at Vienna. Acknowledgements UNODC’s Laboratory and Scientific Section (LSS), headed by Dr. Justice Tettey, wishes to express its appreciation and thanks to Professor Niamh Nic Daeid of the Centre for Anatomy and Human Identification, University of Dundee, for the prepar­ ation of the first draft of this manual.
    [Show full text]