Princeton’s Nathaniel Fisch Page 2 Number 169 October 18, 2004 Research HIV dementia mechanism Theory offers new view of the discovered nucleus Highlights . A brain-imaging study at DOE's Scientists have known for more than 30 Brookhaven Lab shows that human years that protons and neutrons are immunodeficiency virus (HIV) damages built of quarks and gluons. But they dopamine-associated brain cells in interpret data from experiments on the patients with HIV dementia—a type of nucleus with "effective theories" which cognitive decline in the later stages of ignore this internal structure for the sake HIV infection. The brain images, of simplicity. Now a new study from obtained with positron emission DOE's Jefferson Lab, together with the tomography (PET) at Brookhaven’s CEA in France, proposes a theory that Center for Translational Neuroimaging, for the first time incorporates the reveal that patients with HIV dementia dynamical changes in the quark-gluon have fewer dopamine transporters— structure of protons and neutrons in the proteins that help to recycle the nucleus. Published Sept. 23 in Physical neurotransmitter dopamine—than HIV- Review Letters, it is a first step towards a negative subjects or HIV-positive patients truly fundamental theory of nuclear without dementia. These findings may structure. lead to new, more effective therapies. [Kandice Carter, 757/269-7263; Future studies will also look at whether
[email protected]] treatments to suppress HIV lead to recovery of the dopamine system. [Karen McNulty Walsh, 631/344-8350;
[email protected]] Ames research a boon to bioanalysis Studies of individual enzyme molecules New method for medical by Edward S.