bioRxiv preprint doi: https://doi.org/10.1101/582908; this version posted March 20, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 Neuronal histone methyltransferase EZH2 regulates neuronal morphogenesis, synaptic plasticity, 2 and cognitive behavior of mice 3 4 Mei Zhang1,5, Yong Zhang2, Qian Xu2, Joshua Crawford3, Cheng Qian1, Guo-Hua Wang4, Eastman Lewis2, 5 Philip Hall, Gül Dolen2, Richard L. Huganir2, Jiang Qian4, Xin-Zhong Dong2, Mikhail V. Pletnikov3, 6 Chang-Mei Liu6, *, Feng-Quan Zhou1,2, * 7 8 1Department of Orthopaedic Surgery, 2The Solomon H. Snyder Department of Neuroscience, 3Department 9 of Psychiatry and Behavioral Sciences, 4Department of Ophthalmology, Johns Hopkins University School 10 of Medicine, Baltimore, Maryland 21205, USA,5School of Life Sciences, University of Science and 11 Technology of China, Hefei 230026, China. 6State Key Laboratory of Reproductive Biology, Institute of 12 Zoology, Chinese Academy of Sciences, Beijing 100190, China 13 14 *Correspondence to Feng-Quan Zhou, Room 291, The John G. Rangos Sr. Bldg., 855 North Wolfe Street, 15 Departments of Orthopaedic Surgery and Neuroscience, Johns Hopkins University School of Medicine, 16 Baltimore, MD 21205, Email:
[email protected], or to Chang-Mei Liu, State Key Laboratory of 17 Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100190, China, Email: 18
[email protected] 19 20 21 Running head: Neuronal EZH2 regulates neuronal morphogenesis and cognition 22 23 bioRxiv preprint doi: https://doi.org/10.1101/582908; this version posted March 20, 2019.