Words from the Chairman

Department of Surgery Annual Research Report 2007 Words from the Chairman Surgical Research is part of any contemporary, first class, Department of Surgery and the Beth Israel Deaconess Medical Center is no exception. As the Department grew, so did its research effort and level of funding. Until recently, continual growth in research funding for the Department of Surgery was gratifying indeed. The Department’s research funding from all sources, both NIH and non-NIH, increased from about $10 to more than $21 million annually, during the period of 2002-2005. This growth was impressive, taking the Department from approximately 22nd in the country in total NIH funding, to about 5th or 6th. It is difficult to obtain our exact position amongst NIH-funded Departments of Surgery because this number is calculated by the NIH as a total of all Departments of Surgery at Harvard Medical School, including totals for all Harvard affiliated hospitals. Since 2005, our NIH and other funding for research have been declining. The NIH seems to view its funding for research as discretionary, which is particularly unfortunate given the number of people and planning that must go in to building one’s research holdings, and also the nature of individuals that need to be supported. When there is little money, as there currently is not going to various military needs and other non-discretionary activity, NIH funding declines. Just as others have experienced a downturn in NIH funding, so have we. Our NIH and other funding have diminished, including a reduction in the total dollar amount for each awarded grant and the total number of NIH grants that are funded, including competing renewals of long-standing projects. It is unlikely that this trend will reverse soon and from my conversations with other Department chairs, this downturn is being experienced all over. Nonetheless, the Department of Surgery at the Beth Israel Deaconess Medical Center has a robust research effort and continues to pursue academic productivity as well as research productivity with its excellent faculty. This fact is demonstrated in the following report that summarizes our research effort in 2007. Whether or not the current trend in NIH funding will reverse, is anybody’s guess. At present, it looks like it will not. However, we are grateful for the fine clinical and research faculty that we have and the ability to support first class research that goes on in the Department. We look forward to better days. Josef E. Fischer, MD Chairman, Department of Surgery Beth Israel Deaconess Medical Center William V. McDermott Professor of Surgery Harvard Medical School Beth Israel Deaconess Medical Center i Department of Surgery Annual Research Report 2007 ii Beth Israel Deaconess Medical Center Department of Surgery Annual Research Report 2007 TABLE OF CONTENTS Words from the Chairman................................................................... i Table of Contents.................................................................................... iii Division of Surgical Research.............................................................. 1 Division of Cardiothoracic Surgery Introduction and Division Members................................................. 31 Sidney Levitsky, MD James D. McCully, PhD..................................................................... 33 Frank W. Sellke, MD Cesario Bianchi, MD, PhD................................................................. 37 Division of General Surgery Introduction and Division Members................................................. 45 George L. Blackburn, MD, PhD Jin-Rong Zhou, PhD.......................................................................... 49 Mark P. Callery, MD Charles M. Vollmer, Jr., MD Tara S. Kent, MD……………………………………………………………………. 61 Rosemary B. Duda, MD, MPH.......................................................... 67 Sandra M. Gaston, PhD..................................................................... 71 Susan J. Hagen, PhD......................................................................... 79 Per-Olof Hasselgren, MD, PhD......................................................... 85 Carl J. Hauser, MD, FACS, FCCM..................................................... 91 Daniel B. Jones, MD, MS, FACS........................................................ 93 Wolfgang Junger, MD……………………………………………………………… 105 John T. Mullen, MD, FASC……………………………………………………… 111 Division of Plastic and Reconstructive Surgery Division Members.............................................................................. 113 Divisional Report – Sumner A. Slavin, MD...................................... 115 Beth Israel Deaconess Medical Center iii Department of Surgery Annual Research Report 2007 Division of Podiatry Division Members.............................................................................. 129 Aristidis Veves, MD........................................................................... 131 Division of Transplantation Division Members.............................................................................. 137 Fritz H. Bach, MD.............................................................................. 139 Douglas W. Hanto, MD, PhD............................................................ 141 Seth Karp, MD................................................................................... 145 Maria Koulmanda, MSc, PhD............................................................ 147 Anthony P. Monaco, MD Takashi Maki, MD, PhD.................................................................... 151 Leo E. Otterbein, PhD........................................................................ 153 Terry B. Strom, MD........................................................................... 157 Division of Urology Division Members.............................................................................. 163 Mohamed Arredouani, PhD.............................................................. 165 William C. DeWolf, MD Mike Schopperle, PhD....................................................................... 169 Ann A. Kiessling, PhD Robert C. Eyre, MD Paul Church, MD............................................................................... 173 Martin Sanda, MD............................................................................. 179 Division of Vascular and Endovascular Surgery Division Members.............................................................................. 183 Divisional Report……………………………………………………………………. 185 iv Beth Israel Deaconess Medical Center Department of Surgery Annual Research Report 2007 Division of Surgical Research DIVISION OF SURGICAL RESEARCH Per-Olof Hasselgren, MD, PhD Vice Chairman for Surgical Research Director of Endocrine Surgery George H. A. Clowes, Jr. Professor of Surgery Susan J. Hagen, PhD Associate Director for Surgical Research Associate Professor of Surgery Sabrina Pinder, BS Administrative Coordinator A. Introduction In this section of the Annual Report, we provide an overall description of the goals and responsibilities of the Division of Surgical Research, a summary of research faculty in the Department, funding and publications generated by researchers in the Department of Surgery, and other aspects of research within the Department. More detailed research updates are found for individual members of the different Divisions in subsequent sections of the report. The Division of Surgical Research is an administrative division with an aim to facilitate both basic and clinical research in the Department of Surgery at the Beth Israel Deaconess Medical Center (BIDMC). The Division of Surgical Research is headed by Per-Olof Hasselgren, MD, PhD, who is Vice Chairman for Research in Surgery at BIDMC and the George H.A. Clowes Jr. Professor of Surgery at Harvard Medical School, and Susan J. Hagen, PhD, who is Associate Director for Surgical Research in Surgery at BIDMC and Associate Professor of Surgery at Harvard Medical School. The division is also supported by an administrative coordinator, Ms. Sabrina Pinder. The Division of Surgical Research has the following responsibilities: 1) Pre-award review and approval of all grant submissions in the Department of Surgery. This includes assisting in the process of submission of grant applications and interaction with the BIDMC Office of Sponsored Programs. 2) Management of research space, including laboratory and office space, and shared research equipment. For this, the allocation of research space within the Department is overseen, shared tissue culture facilities are maintained, and the Department is represented at various institutional committees and subcommittees dealing with research space at the BIDMC. 3) Organizing monthly Surgical Research Seminars, open for both clinical and research faculty in the Department as well as other members of the BIDMC community. 4) Preparing the Department of Surgery Annual Research Report. 5) Organizing laboratory and shared equipment maintenance and telecommunications. 6) Supporting and mentoring junior faculty in the establishment of research laboratories. 7) Interacting with and providing information to Surgical Residents who plan to spend time in the research laboratory. 8) Obtaining visas for foreign scholars in Beth Israel Deaconess Medical Center 1 Department of Surgery Annual Research Report 2007 Division of Surgical Research Research and in preparing applications for Harvard Medical School appointments for Research Fellows and Instructors in Surgery Research.

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